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POINT OF CARE MATERNAL ULTRASOUND IN OBSTETRICS
Easter, Sarah Rae; Hameed, Afshan B; Shamshirsaz, Amir; Fox, Karin; Zelop, Carolyn M
Ultrasound is the hallmark imaging modality traditionally used by obstetricians for fetal diagnosis and surveillance. The COVID-19 pandemic highlighted the role of point of care ultrasound (POCUS) for expeditious assessment of maternal cardiopulmonary status. The familiarity of obstetricians with ultrasound coupled with the availability of ultrasound equipment without the need to transport the patient make POCUS particularly valuable on labor and delivery. The rising contribution of cardiopulmonary disorders to maternal morbidity and mortality carves out many potential applications for POCUS on labor and delivery. Obstetricians have access to the technology and skills to obtain the basic views required to assess for the presence of pulmonary edema, ventricular dysfunction, or intraabdominal free fluid. POCUS can routinely be used for the evaluation of pulmonary complaints or in the assessment of hypotension and may play an essential role in the diagnosis and management of life-threatening emergencies such as shock, amniotic fluid embolism, or cardiac arrest. We review the currently established POCUS protocols for the evaluation of cardiopulmonary complaints through the lens of the obstetrician. We call upon educators and academic leaders to incorporate maternal POCUS into existing curricula. POCUS is of enormous value for providers with limited access to diagnostic imaging or subspecialty providers. With the growing complexity of the obstetric population, acquiring clinical skills to meet these evolving needs is a requisite step in the ongoing efforts to reduce maternal morbidity and mortality.
PMID: 36183775
ISSN: 1097-6868
CID: 5361422
Guidance for Cardiopulmonary Resuscitation of Children With Suspected or Confirmed COVID-19
Morgan, Ryan W; Atkins, Dianne L; Hsu, Antony; Kamath-Rayne, Beena D; Aziz, Khalid; Berg, Robert A; Bhanji, Farhan; Chan, Melissa; Cheng, Adam; Chiotos, Kathleen; de Caen, Allan; Duff, Jonathan P; Fuchs, Susan; Joyner, Benny L; Kleinman, Monica; Lasa, Javier J; Lee, Henry C; Lehotzky, Rebecca E; Levy, Arielle; McBride, Mary E; Meckler, Garth; Nadkarni, Vinay; Raymond, Tia; Roberts, Kathryn; Schexnayder, Stephen M; Sutton, Robert M; Terry, Mark; Walsh, Brian; Zelop, Carolyn M; Sasson, Comilla; Topjian, Alexis
This document aims to provide guidance to healthcare workers for the provision of basic and advanced life support to children and neonates with suspected or confirmed COVID-19. It aligns with the 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care while providing strategies for reducing risk of transmission of SARS-CoV-2 to healthcare providers. Patients with suspected or confirmed COVID-19 and cardiac arrest should receive chest compressions and defibrillation, when indicated, as soon as possible. Due to the importance of ventilation during pediatric and neonatal resuscitation, oxygenation and ventilation should be prioritized. All CPR events should therefore be considered aerosol-generating procedures (AGPs). Thus, personal protective equipment (PPE) appropriate for AGPs (including N95 respirators or an equivalent) should be donned prior to resuscitation and high-efficiency particulate air (HEPA) filters should be utilized. Any personnel without appropriate PPE should be immediately excused by providers wearing appropriate PPE. Neonatal resuscitation guidance is unchanged from standard algorithms except for specific attention to infection prevention and control. In summary, healthcare personnel should continue to reduce the risk of SARS-CoV-2 transmission through vaccination and use of appropriate PPE during pediatric resuscitations. Healthcare organizations should ensure the availability and appropriate use of PPE. As delays or withheld CPR increases the risk to patients for poor clinical outcomes, children and neonates with suspected or confirmed COVID-19 should receive prompt, high-quality CPR in accordance with evidence-based guidelines.
PMID: 35818123
ISSN: 1098-4275
CID: 5269052
2022 Interim Guidance to Healthcare Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates with Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists
Atkins, Dianne L; Sasson, Comilla; Hsu, Antony; Aziz, Khalid; Becker, Lance B; Berg, Robert A; Bhanji, Farhan; Bradley, Steven M; Brooks, Steven C; Chan, Melissa; Chan, Paul S; Cheng, Adam; Clemency, Brian; de Caen, Allan; Duff, Jonathan P; Edelson, Dana P; Flores, Gustavo E; Fuchs, Susan; Girotra, Saket; Hinkson, Carl; Joyner, Benny L; Kamath-Rayne, Beena D; Kleinman, Monica; Kudenchuk, Peter J; Lasa, Javier J; Lavonas, Eric J; Lee, Henry C; Lehotzky, Rebecca E; Levy, Arielle; McBride, Mary E; Meckler, Garth; Merchant, Raina M; Moitra, Vivek; Nadkarni, Vinay; Panchal, Ashish R; Peberdy, Mary Ann; Raymond, Tia; Roberts, Kathryn; Sayre, Michael R; Schexnayder, Stephen M; Sutton, Robert M; Terry, Mark; Topjian, Alexis; Walsh, Brian; Wang, David S; Zelop, Carolyn M; Morgan, Ryan W
PMID: 35072519
ISSN: 1941-7705
CID: 5152522
2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19
Hsu, Antony; Sasson, Comilla; Kudenchuk, Peter J; Atkins, Dianne L; Aziz, Khalid; Becker, Lance B; Berg, Robert A; Bhanji, Farhan; Bradley, Steven M; Brooks, Steven C; Chan, Melissa; Chan, Paul S; Cheng, Adam; Clemency, Brian M; de Caen, Allan; Duff, Jonathan P; Edelson, Dana P; Flores, Gustavo E; Fuchs, Susan; Girotra, Saket; Hinkson, Carl; Joyner, Benny L; Kamath-Rayne, Beena D; Kleinman, Monica; Lasa, Javier J; Lavonas, Eric J; Lee, Henry C; Lehotzky, Rebecca E; Levy, Arielle; Mancini, Mary E; McBride, Mary E; Meckler, Garth; Merchant, Raina M; Moitra, Vivek K; Morgan, Ryan W; Nadkarni, Vinay; Panchal, Ashish R; Peberdy, Mary Ann; Raymond, Tia; Roberts, Kathryn; Sayre, Michael R; Schexnayder, Stephen M; Sutton, Robert M; Terry, Mark; Walsh, Brian; Wang, David S; Zelop, Carolyn M; Topjian, Alexis
PMCID:8522336
PMID: 34641719
ISSN: 1941-7705
CID: 5037192
Factors Associated with Non-Survival from In-Hospital Maternal Cardiac Arrest: An Analysis of Get With The Guidelines® (GWTG) Data
Zelop, Carolyn M; Shaw, Richard E; Edelson, Dana P; Lipman, Steven S; Mhyre, Jill M; Arafeh, Julie; Jeejeebhoy, Farida M; Einav, Sharon
INTRODUCTION/BACKGROUND:century. Factors influencing outcome of maternal cardiac arrest (MCA) remain largely unexplored. OBJECTIVE:We sought to further elucidate the factors affecting maternal death from in-hospital (IH) MCA. METHODS:Our query of the American Heart Association's GWTG®-Resuscitation voluntary registry from 2000-2017 revealed 561 index cases of IH MCA with complete outcome data. Logistic regression was performed using hospital death as the primary outcome and included variables with a p value = 0.1 or less based upon univariate analysis. Age, race, year of arrest, pre-existing conditions, first documented pulseless rhythm and location of arrest were used in the model. Sensitivity analyses and assessment of variable interaction were also performed to test model stability. Institutional review deemed this research exempt from ethical approval. RESULTS:Among 561 cases of MCA, 57.2% (321/561) did not survive to hospital discharge. IH death was not associated with maternal age, race and year of event. In the final model, IH death was significantly associated with pre-arrest hypotension/hypoperfusion (OR = 1.80 (95% CI, 1.16-2.79); p = 0.009). The occurrence of MCA outside of the delivery suite (referent group) or operating room was associated with a significantly higher risk of death: ICU/Post-Anesthesia Care Unit (PACU) (OR = 3.32 (95% CI, 2.00- 5.52); p < 0.001) and ER/other (OR = 1.89 (95% CI, 1.15-3.11); p = 0.012). While MCA cases with a shockable vs. non-shockable first documented pulseless rhythm had similar outcomes, those with an indeterminate rhythm were less likely to die, (OR = 0.41(95% CI, 0.20-0.84); p = 0.014). In a sensitivity analysis, removal of the indeterminate group did not alter outcomes regarding first documented pulseless rhythm or arrest location. Area under the curve for the final model was 0.715 (95% CI 0.673- 0.757). CONCLUSIONS:Our study identified several novel factors associated with IH death of our MCA cohort. More research is required to further understand the pathophysiologic dynamics affecting outcomes of IH MCA in this unique population.
PMID: 34004263
ISSN: 1873-1570
CID: 4877002
ACR Appropriateness Criteria® Second and Third Trimester Screening for Fetal Anomaly
Sussman, Betsy L; Chopra, Prajna; Poder, Liina; Bulas, Dorothy I; Burger, Ingrid; Feldstein, Vickie A; Laifer-Narin, Sherelle L; Oliver, Edward R; Strachowski, Loretta M; Wang, Eileen Y; Winter, Tom; Zelop, Carolyn M; Glanc, Phyllis
The Appropriateness Criteria for the imaging screening of second and third trimester fetuses for anomalies are presented for fetuses that are low risk, high risk, have had soft markers detected on ultrasound, and have had major anomalies detected on ultrasound. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
PMID: 33958112
ISSN: 1558-349x
CID: 4866722
Cardiovascular Health After Preeclampsia: Patient and Provider Perspective
Seely, Ellen W; Celi, Ann C; Chausmer, Jaimie; Graves, Cornelia; Kilpatrick, Sarah; Nicklas, Jacinda M; Rosser, Mary L; Rexrode, Kathryn M; Stuart, Jennifer J; Tsigas, Eleni; Voelker, Jennifer; Zelop, Carolyn; Rich-Edwards, Janet W
PMID: 32986503
ISSN: 1931-843x
CID: 4616542
ACR Appropriateness Criteria® Nuchal Translucency Evaluation at 11 to 14 Weeks of Gestation
Simpson, Lynn; Maturen, Katherine E; Feldstein, Vickie A; Oliver, Edward R; Poder, Liina; Strachowski, Loretta M; Sussman, Betsy L; Weber, Therese M; Winter, Tom; Zelop, Carolyn M; Glanc, Phyllis
A fetus with an increased nuchal translucency at 11 to 14 weeks gestation is at risk for aneuploidy, genetic syndromes, structural anomalies, and intrauterine fetal demise in both single and twin gestations. In addition to referral to genetics for counseling and consideration of diagnostic genetic testing, a detailed anatomic survey and fetal echocardiogram are indicated in the second trimester to screen for congenital malformations and major heart defects. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
PMID: 33153556
ISSN: 1558-349x
CID: 4664352
Adult Advanced Life Support: International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Berg, Katherine M; Soar, Jasmeet; Andersen, Lars W; Böttiger, Bernd W; Cacciola, Sofia; Callaway, Clifton W; Couper, Keith; Cronberg, Tobias; D'Arrigo, Sonia; Deakin, Charles D; Donnino, Michael W; Drennan, Ian R; Granfeldt, Asger; Hoedemaekers, Cornelia W E; Holmberg, Mathias J; Hsu, Cindy H; Kamps, Marlijn; Musiol, Szymon; Nation, Kevin J; Neumar, Robert W; Nicholson, Tonia; O'Neil, Brian J; Otto, Quentin; de Paiva, Edison Ferreira; Parr, Michael; Reynolds, Joshua C; Sandroni, Claudio; Scholefield, Barnaby R; Skrifvars, Markus B; Wang, Tzong-Luen; Wetsch, Wolfgang A; Yeung, Joyce; Morley, Peter T; Morrison, Laurie J; Welsford, Michelle; Hazinski, Mary Fran; Nolan, Jerry P; Mahmoud, Issa; Kleinman, Monica E; Ristagno, Giuseppe; Arafeh, Julie; Benoit, Justin L; Chase, Maureen; Fischberg, Bryan L; Flores, Gustavo E; Link, Mark S; Ornato, Joseph P; Perman, Sarah M; Sasson, Comilla; Zelop, Carolyn M
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recent interest within the resuscitation community and the amount of new evidence available since any previous review. Systematic reviews addressed higher-priority topics, and included double-sequential defibrillation, intravenous versus intraosseous route for drug administration during cardiac arrest, point-of-care echocardiography for intra-arrest prognostication, cardiac arrest caused by pulmonary embolism, postresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizure prophylaxis and treatment, and neuroprognostication. New or updated treatment recommendations on these topics are presented. Scoping reviews were conducted for anticipatory charging and monitoring of physiological parameters during cardiopulmonary resuscitation. Topics for which systematic reviews and new Consensuses on Science With Treatment Recommendations were completed since 2015 are also summarized here. All remaining topics reviewed were addressed with evidence updates to identify any new evidence and to help determine which topics should be the highest priority for systematic reviews in the next 1 to 2 years.
PMID: 33098922
ISSN: 1873-1570
CID: 4663522
COVID-19 in pregnancy: possible mechanisms not to be discounted
Zelop, Carolyn M; Bonney, Elizabeth A
SARS-CoV-2 has infected more than 16 million people worldwide. Related complications and death from COVID-19 disease and their underlying pathophysiology are intensely investigated. Pregnant women are among the affected. Although the severity of disease in pregnancy does not appear to be increased, the effects of infection on pregnancy should not escape careful examination. The currently known receptor for the virus, ACE2, regulates the renin-angiotensin system and is increased during pregnancy. Virus-receptor interactions may have significant effects on placental function, fetal development, and maternal immunity. The manifestation of cardiovascular complications of infection produces the hypothesis that a significant effect of the virus may be its influence on the maternal vascular system. Interference with the vascular adaptations to pregnancy and the post-partum may have implications for concurrent and future pregnancies as well as for long-term cardiovascular health. We should not miss the opportunity to learn from this virus about the physiology of pregnancy.
PMID: 32811230
ISSN: 1476-4954
CID: 4566842