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Postnatal steroid management in preterm infants with evolving bronchopulmonary dysplasia

Htun, Zeyar T; Schulz, Elizabeth V; Desai, Riddhi K; Marasch, Jaime L; McPherson, Christopher C; Mastrandrea, Lucy D; Jobe, Alan H; Ryan, Rita M
Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly affecting extremely preterm infants. Although mechanical ventilation and oxygen requirements in premature infants are identified as inciting mechanisms for inflammation and the development of BPD over time, data now support an array of perinatal events that may stimulate the inflammatory cascade prior to delivery. Corticosteroids, such as dexamethasone and hydrocortisone, have proven beneficial for the prevention and management of BPD postnatally due to their anti-inflammatory characteristics. This review aims to examine the pharmacologic properties of several corticosteroids, appraise the existing evidence for postnatal corticosteroid use in preterm infants, and assess steroid management strategies to ameliorate BPD. Finally, we aim to provide guidance based on clinical experience for managing adrenal suppression resulting from prolonged steroid exposure since this is an area less well-studied.
PMID: 34012057
ISSN: 1476-5543
CID: 5228722

Antenatal Corticosteroids: Extending the Practice for Late-Preterm and Scheduled Early-Term Deliveries?

Htun, Zeyar T; Hairston, Jacqueline C; Gyamfi-Bannerman, Cynthia; Marasch, Jaime; Duarte Ribeiro, Ana Paula
Respiratory distress in late-preterm and early term infants generally may warrant admission to a special care nursery or an intensive care unit. In particular, respiratory distress syndrome and transient tachypnea of the newborn are the two most common respiratory morbidities. Antenatal corticosteroids (ACS) facilitate surfactant production and lung fluid resorption. The use of ACS has been proven to be beneficial for preterm infants delivered at less than 34 weeks' gestation. Literature suggests that the benefits of giving antenatal corticosteroids may extend to late-preterm and early term infants as well. This review discusses the short-term benefits of ACS administration in reducing respiratory morbidities, in addition to potential long term adverse effects. An update on the current practices of ACS use in pregnancies greater than 34 weeks' gestation and considerations of possibly extending versus restricting this practice to certain settings will also be provided.
PMID: 33916116
ISSN: 2227-9067
CID: 5228712

A Quality Improvement Initiative to Improve Perioperative Hypothermia Rates in the NICU Utilizing Checklists

Hanna, Morcos; Htun, Zeyar; Islam, Shahidul; Hanna, Nazeeh; Kothari, Ulka; Nayak, Amrita
Premature infants are at high risk for heat loss. Infants undergoing surgical procedures outside of the neonatal intensive care unit have an increased risk of hypothermia. Hypothermia can lead to delayed recovery, hypoglycemia, metabolic acidosis, sepsis, and emotional stress for the parents. We aimed to reduce the incidence of hypothermia for infants undergoing surgical procedures from a baseline of 44.4% to less than 25% over 3 years (2016-2018) with the utilization of a checklist and education.
PMID: 33062906
ISSN: 2472-0054
CID: 4642982

Catastrophic Delayed Hemolytic Transfusion Reaction in a Patient with Sickle Cell Disease: Case Report and Review of Literature [Meeting Abstract]

Jasinski, Sylwia; Htun, Zeyar; Glasser, Chana
ISSN: 1545-5009
CID: 3496562