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department:Medicine. General Internal Medicine

recentyears:2

school:SOM

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Association between overcrowded households, multigenerational households, and COVID-19: a cohort study

Ghosh, A K; Venkatraman, S; Soroka, O; Reshetnyak, E; Rajan, M; An, A; Chae, J K; Gonzalez, C; Prince, J; DiMaggio, C; Ibrahim, S; Safford, M M; Hupert, N
OBJECTIVES/OBJECTIVE:The role of overcrowded and multigenerational households as a risk factor for COVID-19 remains unmeasured. The objective of this study is to examine and quantify the association between overcrowded and multigenerational households and COVID-19 in New York City (NYC). STUDY DESIGN/METHODS:Cohort study. METHODS:We conducted a Bayesian ecological time series analysis at the ZIP Code Tabulation Area (ZCTA) level in NYC to assess whether ZCTAs with higher proportions of overcrowded (defined as the proportion of the estimated number of housing units with more than one occupant per room) and multigenerational households (defined as the estimated percentage of residences occupied by a grandparent and a grandchild less than 18 years of age) were independently associated with higher suspected COVID-19 case rates (from NYC Department of Health Syndromic Surveillance data for March 1 to 30, 2020). Our main measure was an adjusted incidence rate ratio (IRR) of suspected COVID-19 cases per 10,000 population. Our final model controlled for ZCTA-level sociodemographic factors (median income, poverty status, White race, essential workers), the prevalence of clinical conditions related to COVID-19 severity (obesity, hypertension, coronary heart disease, diabetes, asthma, smoking status, and chronic obstructive pulmonary disease), and spatial clustering. RESULTS: = 0.99, 95% CI: 0.99-1.00). CONCLUSIONS:Overcrowdedness and multigenerational housing are independent risk factors for suspected COVID-19. In the early phase of the surge in COVID cases, social distancing measures that increase house-bound populations may inadvertently but temporarily increase SARS-CoV-2 transmission risk and COVID-19 disease in these populations.
PMID: 34492508
ISSN: 1476-5616
CID: 5011952

Overuse of Primary Thromboprophylaxis in Medical Inpatients at Low Risk of Venous Thromboembolism [Letter]

Djulbegovic, Mia; Chen, Kevin; Sureshanand, Soundari; Chaudhry, Sarwat
PMID: 33464465
ISSN: 1525-1497
CID: 4774192

The Most Undertreated Chronic Disease: Addressing Obesity in Primary Care Settings

Tucker, Shanna; Bramante, Carolyn; Conroy, Molly; Fitch, Angela; Gilden, Adam; Wittleder, Sandra; Jay, Melanie
PURPOSE OF REVIEW/OBJECTIVE:While obesity-related comorbidities are frequently addressed and treated in primary care (PC), obesity itself is undertreated. We review the current treatments for obesity and provide potential provider and system-level strategies for integrating weight management and improving longer term obesity care within PC settings. RECENT FINDINGS/RESULTS:We now understand that the body develops multiple mechanisms to resist weight loss and promote weight regain, making both weight loss and weight loss maintenance challenging. Therefore, weight management often requires medically supervised interventions and should be treated on a long-term basis. However, there are multiple barriers to improving obesity care within PC settings. Clinically, utilizing strategies such as a shared decision-making approach and the 5As to discuss treatment options can facilitate formulating an obesity treatment plan. Utilizing telehealth, a team-based approach, and community partnering can increase patient access to intensive behavioral interventions. Future studies should evaluate other cost-effective methods to implement obesity care into the PC setting.
PMCID:8300078
PMID: 34297343
ISSN: 2162-4968
CID: 4979762

Clinical Trial Protocol for a Randomized Trial of Community Health Worker-led Decision Coaching to Promote Shared Decision-making on Prostate Cancer Screening Among Black Male Patients and Their Providers

Makarov, Danil V; Ciprut, Shannon; Martinez-Lopez, Natalia; Fagerlin, Angela; Thomas, Jerry; Shedlin, Michele; Gold, Heather T; Li, Huilin; Bhat, Sandeep; Warren, Rueben; Ubel, Peter; Ravenell, Joseph E
We propose a randomized controlled trial to evaluate the effectiveness of a community health worker-led decision-coaching program to facilitate shared decision-making for prostate cancer screening decisions by Black men at a primary care federally qualified health center.
PMID: 34426097
ISSN: 2405-4569
CID: 5061072

Black carbon accumulation in extrapulmonary human tissues

Florsheim, Rebecca; Bressler, Joseph P; Tsai, Gwendolyn; Drichko, Natalia; Steenbergen, Charles
ORIGINAL:0016324
ISSN: 2006-9820
CID: 5364642

A Vital Layer of Support: One Safety Net Hospital's Palliative Care Response to the Pandemic

Xu, Yijie; Zhang, Luyi K; Smeltz, Robert L; Cohen, Susan E
PMID: 33555977
ISSN: 1557-7740
CID: 4780802

Canadian Internal Medicine Ultrasound (CIMUS) Expert Consensus Statement on the Use of Lung Ultrasound for the Assessment of Medical Inpatients With Known or Suspected Coronavirus Disease 2019

Ma, Irene W Y; Hussain, Arif; Wagner, Michael; Walker, Brandie; Chee, Alex; Arishenkoff, Shane; Buchanan, Brian; Liu, Rachel B; Mints, Gregory; Wong, Tanping; Noble, Vicki; Tonelli, Ana Claudia; Dumoulin, Elaine; Miller, Daniel J; Hergott, Christopher A; Liteplo, Andrew S
OBJECTIVES/OBJECTIVE:To develop a consensus statement on the use of lung ultrasound (LUS) in the assessment of symptomatic general medical inpatients with known or suspected coronavirus disease 2019 (COVID-19). METHODS:Our LUS expert panel consisted of 14 multidisciplinary international experts. Experts voted in 3 rounds on the strength of 26 recommendations as "strong," "weak," or "do not recommend." For recommendations that reached consensus for do not recommend, a fourth round was conducted to determine the strength of those recommendations, with 2 additional recommendations considered. RESULTS:Of the 26 recommendations, experts reached consensus on 6 in the first round, 13 in the second, and 7 in the third. Four recommendations were removed because of redundancy. In the fourth round, experts considered 4 recommendations that reached consensus for do not recommend and 2 additional scenarios; consensus was reached for 4 of these. Our final recommendations consist of 24 consensus statements; for 2 of these, the strength of the recommendations did not reach consensus. CONCLUSIONS:In symptomatic medical inpatients with known or suspected COVID-19, we recommend the use of LUS to: (1) support the diagnosis of pneumonitis but not diagnose COVID-19, (2) rule out concerning ultrasound features, (3) monitor patients with a change in the clinical status, and (4) avoid unnecessary additional imaging for patients whose pretest probability of an alternative or superimposed diagnosis is low. We do not recommend the use of LUS to guide admission and discharge decisions. We do not recommend routine serial LUS in patients without a change in their clinical condition.
PMID: 33274782
ISSN: 1550-9613
CID: 4694532

Discharge Processes in a Skilled Nursing Facility affected by COVID-19 [Letter]

Weerahandi, Himali; Mak, Wingyun; Burack, Orah R; Canter, Benjamin E; Reinhardt, Joann P; Boockvar, Kenneth S
PMID: 33955557
ISSN: 1532-5415
CID: 4858962

Oncological and Functional Outcomes of Patients Undergoing Individualized Partial Gland Cryoablation of the Prostate: A Single-Institution Experience

Tan, Wei Phin; Chang, Andrew; Sze, Christina; Polascik, Thomas J
PMCID:8558074
PMID: 33559527
ISSN: 1557-900x
CID: 5149742

Interferon pathway lupus risk alleles modulate risk of death from acute covid-19 [Meeting Abstract]

Nln, I; Ruiz, R F; Muskardin, T W; Tuminello, S; Attur, M; Itturate, E; Petrilli, C; Abramson, S B; Chakravarti, A; Niewold, T
Background/Purpose: Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common alleles contribute to the genetic high IFN trait. In this study, we examine whether these common gain-of-function alleles in the type I IFN pathway are associated with protection from mortality in acute COVID-19.
Method(s): We studied IFN pathway SLE risk genes in patients with acute COVID-19 admitted to NYU Langone hospitals (751 European-American and 398 African-American ancestry). The samples were genotyped using low depth sequencing and imputation, and we analyzed data from the following SNPs: IRF5 (rs2004640, rs3807306, rs10488631, rs2280714), IRF7/PHRF (rs1131665, rs4963128), IRF8 (rs17445836, rs12444486), and PRKG1 (rs7897633). Ancestral backgrounds were analyzed separately, and mortality after acute COVID-19 was the primary outcome.
Result(s): We observed specific IRF5 haplotypes that are protective against SLE risk were associated with increased risk of mortality in acute COVID-19 patients in European-American ancestry (OR=3.74, p=0.015). Alleles of PRKG1 were also associated with mortality from COVID-19 in the European-American ancestry cohort (OR=1.80, p=0.0057), and this risk factor was particularly strong in younger patients (OR=29.2, p=0.01 in ages 45-54). IRF8 genotype at rs1244486 was associated with protection from mortality in COVID-19 in African-American subjects aged 65 and older (OR=0.34, p=0.04).
Conclusion(s): We find that a number of type I IFN pathway genes associated with risk of SLE also modulate risk of death during acute COVID-19. Similar to their associations with SLE, these alleles are variably associated with COVID-19 mortality across ancestral backgrounds, suggesting ancestral differences in the genetic regulation of the IFN pathway. These data confirm the critical role of the IFN pathway in our defense against viral infections, and support the idea that some common SLE risk alleles exert protective effects in anti-viral immunity
PMCID:
EMBASE:637275920
ISSN: 2326-5205
CID: 5164662