Faculty Bibliography

In the year since an AIDS patient in San Francisco received an experimental transplant of baboon bone marrow, he has gained weight and strength, and remained free of severe infections, even though the transplant did not take. The transplanted baboon cells stayed in [Jeff] Getty's body for about two weeks and failed to grow. 'Clearly, the baboon bone marrow transplant did not take,' said Dr. Paul Volberding, a member of Getty's research team at San Francisco General Hospital and the University of California, where the experimental procedure was performed. Yet Getty's astonishing improvement has led the University of California researchers to design new experiments aimed at restoring immune function. The new studies focus on the radiation and chemotherapy that he received to kill some cells in his marrow to make space for the baboon cells. The new experiments also include combinations of drugs that attack HIV, the virus that causes AIDS

The transplanted baboon cells stayed in Mr. [Jeff Getty]'s body for about two weeks and failed to grow. 'Clearly, the baboon bone marrow transplant did not take,' said Dr. Paul Volberding, a member of Mr. Getty's research team at San Francisco General Hospital and the University of California, where the experimental procedure was performed

Jeff Getty, a San Francisco AIDS patient who received a baboon bone marrow transplant in 1995, has seen vast improvements in his health in the year since the transplant. Scientists are unable to determine the exact cause of Getty's improved health since his body rejected the transplant and he used other forms of treatment in conjunction with the transplant

In the year since an AIDS patient in San Francisco received an experimental transplant of baboon bone marrow, he has gained weight and strength and remained free of severe infections, even though the transplant did not take. The transplanted baboon cells stayed in Getty's body for about two weeks and failed to grow. ``Clearly, the baboon bone-marrow transplant did not take,'' said Dr. Paul Volberding, a member of Getty's research team at San Francisco General Hospital and the University of California, where the experimental procedure was performed

In the year since an AIDS patient in San Francisco received an experimental transplant of baboon bone marrow, he has gained weight and strength and remained free of severe infections, even though the transplant did not take. [Jeff] Getty, a 39-year-old from Oakland, has gained 17 pounds, bringing his weight to 172, has become strong enough to bench-press 180 pounds, has traveled to Europe and has escaped new bouts of the serious opportunistic infections that had threatened his life before the procedure. The transplanted baboon cells stayed in Getty's body for about two weeks and failed to grow. 'Clearly, the baboon bone marrow transplant did not take,' said Dr. Paul Volberding, a member of Getty's University of California research team at San Francisco General Hospital, where the experimental procedure was performed

Oshinsky reviews "Radical Son: A Generational Odyssey" by David Horowitz

Human polymorphonuclear leukocytes (PMN) respond to LPS with strongly increased integrin-mediated adhesion. While the first step of this process has been identified as the interaction of LPS with CD14 on the cell surface, subsequent steps remain to be elucidated. The experiments presented here suggest that monomeric LPS is internalized in vesicles, and uptake may be required for signaling. Fluorescently labeled LPS presented as monomeric complexes with soluble CD14 appeared in the plasma membrane of PMN by 5 min and was concentrated in cytoplasmic vesicles by 20 min. Adhesion in response to LPS/soluble CD14 occurred only after a 15- to 20-min lag period, consistent with endocytosis occurring before signal generation. In contrast, there was no time lag for adhesion in response to the formyl peptide formyl-norleucyl-leucyl-phenylalanine (fNLLP). Adhesion in response to LPS, but not fNLLP, was completely blocked by lowering the temperature to 19 degrees C, a procedure that prevents vesicle fusion. These studies indicated that an event with the time and temperature dependence of endocytosis precedes signaling by LPS. Cytochalasin D, an inhibitor of phagocytosis, and wortmannin, an inhibitor of phosphatidylinositol 3-kinase that blocks vesicle fusion and phagocytosis, both completely blocked adhesion in response to LPS but not in response to fNLLP. These results support the idea that LPS internalization and early endosomal fusion may be required for signal transduction. Parallel studies showed that the adhesion response to TNF had time, temperature, and inhibitor sensitivities nearly identical with those of LPS, suggesting that responses to TNF may also include an obligate vesicle fusion step.

Russian President Boris Yeltsin's heart function has improved significantly since his bypass surgery in Nov 1996 and his recuperation continues smoothly, according to an American consultant in Yeltsin's case

A modification of standard CT scan X-rays that are available in most large hospitals promises to enable doctors to diagnose appendicitis more accurately and to reduce the number of appendectomies significantly, radiologists from Boston told a scientific meeting of the Radiological Society of North America in Chicago on Dec 3, 1996. The technique, called FACT (Focused appendix CT), involves inserting a dye through a tube in the rectum to show the appendix