Faculty Bibliography

BACKGROUND: Immediate reconstruction following segmental mandibulectomy is an accepted surgical technique. The benefits and patient selection criteria need to be established. PATIENTS AND METHODS: Forty-seven patients who underwent immediate reconstruction of the mandible were followed for up to 14 years. Survival, complication rates, and functional results were analyzed. RESULTS: Median survival was 39 months and actuarial 5-year survival was 40%. Two patients died in the postoperative period, and 9 suffered major reconstruction-related complications. The majority of these complications were related to the use of reconstruction plates, and occurred when the mandibular defect included the arch or when the plates were covered by pectoralis flaps. Half of the patients interviewed were able to eat a regular diet. CONCLUSIONS: Mandibular reconstruction can be performed safely and expeditiously in nearly all patients undergoing segmental mandibulectomy. Functional results and long-term survival will be acceptable in many cases

We identify early predictors of multidrug-resistant tuberculosis and describe improved clinical outcomes, including survival, for patients with human immunodeficiency virus (HIV)-related multidrug-resistant tuberculosis (MDR-TB) when they are prospectively identified and receive treatment under direct observation. Analysis by means of a Cox proportional hazards model revealed that failure to defervesce while receiving a standard four-drug antituberculous regimen was independently associated with multidrug resistance (P = .004). When patients with HIV-related MDR-TB were prospectively identified and treated with at least two agents that were active in vitro, 100% bacteriologic conversion and improved survival (> or = 4 months for 88% of patients and > or = 1 year for 59% of patients) were observed. For patients with HIV-related tuberculosis, poorer survival was associated with a CD4+ lymphocyte count of < 25 mm3 (P = .03); multidrug resistance was not a predictor of poor outcome (P = .82). These data suggest that patients with prolonged fever who are receiving antituberculous therapy may be an appropriate subgroup to target for broader empirical therapy. The findings also demonstrate that improved outcomes can be achieved with HIV-related MDR-TB when patients are prospectively identified and treated with agents that are active in vitro

Depression is common and treatable, but the burden of awareness is the patient's. It is the physical symptoms of depression that bring people into a doctor's office

The Dana-Farber Cancer Institute in Boston said on Oct 30, 1995 that two committees had concluded that its top leadership was weak and that the quality assurance of its clinical care and training were seriously flawed

David Oshinsky reviews the biography "Man of the People: A Life of Harry S. Truman" by Alonzo L. Hamby

A 91-year-old man in Florida has become infected with the AIDS virus after a prostitute bit his hand, health officials said yesterday. Although there is apparently only one previous case on record of the AIDS virus being transmitted through a bite, health officials do not believe the new case significantly changes the way scientists believe the disease is spread. The incident was similar to the earlier bite case, reported in 1987, in which two adult sisters got in a fight. One sister, a drug abuser who was infected with HIV, the virus that causes AIDS, had several teeth broken when she was punched in the mouth. She then bit her uninfected sister, severely tearing the skin and spreading blood between the two women

Health officials said on Oct 27, 1995 that 91-year-old Elmer Hutto became the second person to become infected with the AIDS virus through a human bite. The AP reported that Naomi Morrison, a prostitute, bit the Florida man while trying to rob him in Aug 1994. Morrison's gums were bleeding at the time of the attack, and the virus almost certainly came from her blood, and not her saliva. The CDC said that no cases of HIV transmission are clearly attributable only to saliva

A 91-year-old man in Florida has become infected with the AIDS virus after a prostitute bit his hand, health officials said Friday. Although there is apparently only one previous case on record of the AIDS virus being transmitted through a bite, health officials do not believe the new case significantly changes the way scientists believe the disease is spread

A 91-year-old man in West Palm Beach has become infected with the AIDS virus after a prostitute bit his hand, health officials said yesterday. Although there is apparently only one previous case on record of HIV, the virus that causes AIDS, being transmitted through a bite, health officials do not believe the new case significantly changes the understanding of how the disease is spread. The incident was similar to the earlier bite case, reported in 1987, in which two adult sisters got in a fight. One sister, a drug abuser who was infected with HIV, had several teeth broken when she was punched in the mouth. She then bit her uninfected sister, severely tearing the skin and spreading blood between the two women

Summary: Health officials say an infected prostitute with bleeding gums wounded an aged Florida man she was trying to rob A 91-year-old man in Florida has become infected with the AIDS virus after a prostitute bit his hand, health officials said Friday. The incident was similar to the earlier bite case, reported in 1987, in which two adult sisters got in a fight. One sister, a drug abuser who was infected with HIV, the virus that causes AIDS, had several teeth broken when she was punched in the mouth. She then bit her uninfected sister, severely tearing the skin and spreading blood between the two women