Faculty Bibliography

In a radical cross-species experiment fraught with risk but with implications for treating many diseases, scientists on Dec 14, 1995 injected bone marrow removed from a baboon into a man with AIDS. The hope is that the transplanted marrow cells, which are believed to be resistant to the AIDS virus, will proliferate to reduce the severely damaged immune system of the patient, 38-year-old Jeff Getty

In a radical cross-species experiment fraught with risk but with implications for treating many diseases, scientists last night injected bone marrow removed from a baboon into a 38-year-old man with AIDS. The hope is that the millions of transplanted marrow cells, believed to be resistant to the AIDS virus, will proliferate to rescue the man's severely damaged immune system. Because [Jeff] Getty's own cells will remain infected with HIV, the virus that causes AIDS, a successful procedure would not cure AIDS. But it would produce a double, or chimeric, immune system that could resist further infection from HIV and fight opportunistic infections, the otherwise-minor illnesses that can be fatal for someone with AIDS

Government scientists announced their finding that conception is most likely when intercourse occurs on the day of ovulation or the five days before it.Earlier studies had shown that women are fertile from about three days before ovulation to about three days after it. But these were handicapped because they relied on 'very fuzzy measures of ovulation,' said Dr

Conception is most likely when intercourse occurs on the day of ovulation or the five days before it, government scientists have found in a study that challenges some previously held beliefs. THe study was published in the New England Journal of Medicine on Dec 7, 1995

Three reports on breast cancer have confirmed earlier findings that for small tumors detected at an early stage of the disease, less extensive surgery followed by radiation is as effective as removing the entire breast. The less extensive surgery entails cutting out the cancer and small amounts of adjacent tissue in a procedure known as a lumpectomy. The new reports, in the current issue of The New England Journal of Medicine, include an audit of a trial of breast cancer treatment in which a Canadian doctor admittedly falsified some records. The audit was conducted by the National Cancer Institute, the government agency that paid for the flawed study, one of a series known as the National Surgical Adjuvant Breast and Bowel Project, conducted by the University of Pittsburgh. The audit was undertaken in March 1994 after news reports that Dr. Roger Poisson of St. Luc Hospital in Montreal had been found in 1990 to have falsified data in the study. Officials of the National Cancer Institute and others criticized Dr. Bernard Fisher, the head of the Pittsburgh team, for failing to detect the falsified data years earlier and for delay in the publishing of a re-analysis of the data

Three reports on breast cancer have confirmed earlier findings that for small tumors detected at an early stage of the disease, less extensive surgery followed by radiation is as effective as removing the entire breast. The less extensive surgery entails cutting out the cancer and small amounts of adjacent tissue in a procedure known as a lumpectomy. The new reports, in the current issue of The New England Journal of Medicine, include an audit of a trial of breast cancer treatment in which a Canadian doctor admittedly falsified some records. The audit was conducted by the National Cancer Institute, the government agency that paid for the flawed study, one of a series known as the National Surgical Adjuvant Breast and Bowel Project, conducted by the University of Pittsburgh

NEW YORK - Three reports on breast cancer have confirmed earlier findings that for small tumors detected at an early stage of the disease, less extensive surgery followed by radiation is as effective as removing the entire breast. The new reports, in the current issue of The New England Journal of Medicine, include an audit of a trial of breast cancer treatment in which a Canadian doctor admittedly falsified some records. The audit was conducted by the National Cancer Institute, the government agency that paid for the flawed study, one of a series known as the National Surgical Adjuvant Breast and Bowel Project, conducted by the University of Pittsburgh

In dealing with a famous patient in an emergency, a doctor's reaction, like anyone's, can be emotional, and [Josh] Schwartzberg is one of the rare ones to publicly bare his feelings about the experience. In the first few seconds, Schwartzberg said, he was shocked by the sudden, inexplicable collapse of an apparently healthy world-class athlete. But Schwartzberg quickly joined in a drill that he had led many times in 22 years as a family practitioner in the Lake Placid area. Whether [Sergei] Grinkov's regular doctors felt the world was looking over their shoulders is not known. If they had taken his high blood pressure seriously, Schwartzberg now believes, they might have detected Grinkov's heart disease when treatment could have saved his life. Grinkov's heart stopped while he and [Yekaterina] Gordeyeva were practicing for an ice show. Grinkov said he felt dizzy and gently slumped to the ice. At first, those around Grinkov thought he had been seized with a recurrence of low back pain and sciatica and wanted to rest on the ice. But Grinkov did not respond. So his coach immediately started CPR in front of Gordeyeva and other shocked onlookers. He was soon joined by an emergency medical technician who was in the arena

'Quality control was surely compromised by the use of a very large number of auditors -- 76 -- in order to complete the work quickly,' wrote Dr. Bailar, who once worked at the National Cancer Institute. He also said, 'The auditors' training period was short, and there is no indication that any were experienced in the forensic examination of documents.' 'A major problem,' Dr. Bailar wrote, is that documentation of signed informed consent before surgery was found in only two-thirds of the 1,554 records reviewed. 'This incompleteness is unjustifiable, contrary to protocol and, one may fear, scarcely limited to' this study. Since 'informed consent is critically important to the protection of patients' rights, to the individual patient-doctor relationship and to public acceptance of research on human subjects,' he said, 'to find that large numbers of investigators treat consent so casually is disheartening.'

Three reports on breast cancer have confirmed earlier findings that for small tumors detected at an early stage of the disease, less extensive surgery followed by radiation is as effective as removing the entire breast. The less extensive surgery entails cutting out the cancer and small amounts of adjacent tissue in a procedure known as a lumpectomy. The new reports, in the current issue of The New England Journal of Medicine, include an audit of a trial of breast cancer treatment in which a Canadian doctor admittedly falsified some records. The audit was conducted by the National Cancer Institute, the government agency that paid for the flawed study, one of a series known as the National Surgical Adjuvant Breast and Bowel Project, conducted by the University of Pittsburgh. The audit was undertaken in March 1994 after news reports that Dr. Roger Poisson of St. Luc Hospital in Montreal had been found in 1990 to have falsified data in the study. Officials of the National Cancer Institute and others criticized Dr. Bernard Fisher, the head of the Pittsburgh team, for failing to detect the falsified data years earlier and for delay in the publishing of a re-analysis of the data