Faculty Bibliography

A cell that throws off these controls and divides repeatedly will form a group of identical descendant cells known as a clone. The new test scans the DNA sequence of cells for certain subtle fingerprints of these aberrant clones. Leading cancer experts praised the theory of the research, saying the test could help refine the diagnosis and recognition of the stages of cancer. It might also help detect the spread of malignant cells in the body and monitor the effects of drugs and other anti-cancer therapies. ''This is definitely a research advance, elegant work, science at its very best,'' said Dr. Samuel Broder, who heads the National Cancer Institute in Bethesda, Md. ''But it is very important to have no illusions about the difficult challenges that we would face'' in harnessing it for screening healthy people for cancer

A new test that can detect several kinds of cancerous human cells was reported yesterday by scientists from the Johns Hopkins School of Medicine in Baltimore. The scientists say they can quickly develop the test into a general method for screening healthy people for the incipient stages of most kinds of cancer. A cell that throws off these controls and divides repeatedly will form a group of identical descendant cells known as a clone. The new test scans the DNA sequence of cells for certain subtle fingerprints of these aberrant clones. Leading cancer experts praised the theory of the research, saying the test could help refine the diagnosis and recognition of the stages of cancer. It might also help detect the spread of malignant cells in the body and monitor the effects of drugs and other anti- cancer therapies, the experts said

A new test that can detect several kinds of cancerous human cells was reported on Oct 10, 1994 by scientists from the Johns Hopkins School of Medicine. The scientists say they can quickly develop the test into a general method for screening healthy people for the incipient stages of most kinds of cancer. Other experts say the team appears to have made an important advance but that the work is preliminary and much more remains to be done to make the test available for widespread use. The team's studies are being reported in the Proceedings of the National Academy of Sciences on Oct 11

Two Americans, Alfred G. Gilman and Martin Rodbell, won the Nobel Prize in Physiology or Medicine on Oct 10, 1994 for discovering natural substances known as G-proteins and how they help cells convert signals from the environment and from within the body into cellular chain reactions that control fundamental life processes. The Nobel-Prize winning research has helped scientists begin to understand how the body receives signals from outside stimuli like light and odor, and from a variety of hormones in the body, and transmits the signals to the interior of cells

The test is being developed by a team at Johns Hopkins headed by Dr. David Sidransky that has just begun the first of a series of larger trials to validate the test's accuracy. The team needs to determine whether its test actually detects cancer earlier than standard methods and, if so, whether earlier diagnosis would improve therapy and survival rates. Sidransky has worked with Dr. Bert Vogelstein at Johns Hopkins in pioneering research that has identified defective genes that lead to colon and bladder cancer. Using an early version of tests for clonal markers developed from such research, the Johns Hopkins team detected cancer in 26 of 100 patients. In May, Sidransky's team reported that it had used the test on frozen tissues saved from Hubert H. Humphrey's bladder and was able to show that the former vice president did have bladder cancer in 1967 when he developed bloody urine

Two Americans, Dr. Alfred G. Gilman and Dr. Martin Rodbell, won the NobelPrize in medicine yesterday for discovering natural substances known as G-proteins and how they help cells convert signals into cellular chain reactions that control fundamental life processes. Gilman and Rodbell's independent discoveries have helped scientists begin to understand how the body receives signals from outside sources such as light and sound, and from a variety of hormones in the body, and transmits the signals to the interior of cells, the Karolinska Institute in Stockholm said in announcing the award. PHOTO (2), (1) Dr. Martin Rodbell / BY REUTERS, (2) Dr. Alfred G. Gilman / BY ASSOCIATED PRESS GRAPHIC: ROLE OF THE G-PROTEIN / NEW YORK TIMES GRAPHIC

A new test that can detect several kinds of cancerous human cells was reported yesterday by scientists from the Johns Hopkins School of Medicine in Baltimore. The scientists say they can quickly develop the test into a general method for screening healthy people for the incipient stages of most kinds of cancer. A cell that throws off these controls and divides repeatedly will form a group of identical descendant cells known as a clone. The new test scans the DNA sequence of cells for certain subtle fingerprints of these aberrant clones. 'But it is very important to have no illusions about the difficult challenges that we would face' in harnessing it for screening healthy people for cancer, he said. 'We have to be cautious about talking about a universal screening test being just around the corner.'

A cell that throws off these controls and divides repeatedly will form a group of identical descendant cells known as a clone. The new test scans the DNA sequence of cells for certain subtle fingerprints of these aberrant clones. The test is being developed by a team at Johns Hopkins headed by Dr. David Sidransky that has just begun the first of a series of larger trials to validate the test's accuracy. The team needs to determine whether its test actually detects cancer earlier than standard methods and, if so, whether earlier diagnosis would improve therapy and survival rates. Leading cancer experts praised the theory of the research, saying the test could help refine the diagnosis and recognition of the stages of cancer. It might also help detect the spread of malignant cells in the body and monitor the effects of drugs and other anti-cancer therapies, the experts said

A new test that can detect several kinds of cancerous human cells was reported yesterday by scientists from Johns Hopkins School of Medicine in Baltimore. A cell that throws off these controls and divides repeatedly will form a group of identical descendant cells known as a clone. The new test scans the DNA sequence of cells for certain subtle fingerprints of these aberrant clones. Leading cancer experts praised the theory of the research, saying the test could help refine the diagnosis and recognition of the stages of cancer. It might also help detect the spread of malignant cells in the body and monitor the effects of drugs and other anti-cancer therapies, the experts said

A new test that can detect several kinds of cancerous human cells was reported Monday by scientists from the Johns Hopkins School of Medicine in Baltimore. The scientists say they can quickly develop the test into a general method for screening healthy people for the incipient stages of most kinds of cancer. The test is being developed by a team at Johns Hopkins headed by Dr. David Sidransky that has just begun the first of a series of larger trials to validate the test's accuracy. The team needs to determine whether its test actually detects cancer earlier than standard methods and, if so, whether earlier diagnosis would improve survival rates. Leading cancer experts praised the theory of the research, saying the test could help refine the diagnosis and recognition of the stages of cancer. It might also help detect the spread of malignant cells in the body and monitor the effects of drugs and other anti-cancer therapies, the experts said