Faculty Bibliography
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department:Medicine. General Internal Medicine
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14818
The case for simplifying and using absolute targets for viral hepatitis elimination goals
The 69th World Health Assembly endorsed the Global Health Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as a public health threat by 2030. This was followed by the World Health Organization's (WHO) global targets for the care and management of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These announcements and targets were important in raising awareness and calling for action; however, tracking countries' progress towards these elimination goals has provided insights to the limitations of these targets. The existing targets compare a country's progress relative to its 2015 values, penalizing countries who started their programmes prior to 2015, countries with a young population, or countries with a low prevalence. We recommend that (1) WHO simplify the hepatitis elimination targets, (2) change to absolute targets and (3) allow countries to achieve these disease targets with their own service coverage initiatives that will have the maximum impact. The recommended targets are as follows: reduce HCV new chronic cases to ≤5 per 100 000, reduce HBV prevalence among 1-year-olds to ≤0.1%, reduce HBV and HCV mortality to ≤5 per 100 000, and demonstrate HBV and HCV year-to-year decrease in new HCV- and HBV-related HCC cases. The objective of our recommendations is not to lower expectations or diminish the hepatitis elimination standards, but to provide clearer targets that recognize the past and current elimination efforts by countries, help measure progress towards true elimination, and motivate other countries to follow suit.
PMID: 32979881
ISSN: 1365-2893
CID: 4679282
Practice of Psycho-oncology with Latino Patients: An International Study
Cancer is the second leading cause of death globally, approximately 70% of deaths from cancer occur in low- and middle-income countries.1 About 1.3 million new cancer cases and 666,000 cancer deaths were estimated to have occurred in 2018 in Latin America and the Caribbean. Cancer is also the leading cause of death of Latinos in the U.S., accounting for approximately 42,700 deaths/year in the U.S. Latino population.2 This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
PMID: 32914912
ISSN: 1099-1611
CID: 4589592
Respiratory impedance measured using impulse oscillometry in a healthy urban population
This study derives normative prediction equations for respiratory impedance in a healthy asymptomatic urban population using an impulse oscillation system (IOS). In addition, this study uses body mass index (BMI) in the equations to describe the effect of obesity on respiratory impedance. Data from an urban population comprising 472 healthy asymptomatic subjects that resided or worked in lower Manhattan, New York City were retrospectively analysed. This population was the control group from a previously completed case-control study of the health effects of exposure to World Trade Center dust. Since all subjects underwent spirometry and oscillometry, these previously collected data allowed a unique opportunity to derive normative prediction equations for oscillometry in an urban, lifetime non-smoking, asymptomatic population without underlying respiratory disease. Normative prediction equations for men and women were successfully developed for a broad range of respiratory oscillometry variables with narrow confidence bands. Models that used BMI as an independent predictor of oscillometry variables (in addition to age and height) demonstrated equivalent or better fit when compared with models that used weight. With increasing BMI, resistance and reactance increased compatible with lung and airway compression from mass loading. This study represents the largest cohort of healthy urban subjects assessed with an IOS device. Normative prediction equations were derived that should facilitate application of IOS in the clinical setting. In addition, the data suggest that modelling of lung function may be best performed using height and BMI as independent variables rather than the traditional approach of using height and weight.
PMCID:8005688
PMID: 33816605
ISSN: 2312-0541
CID: 4838882
In vitro Optimization of Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae
Ceftazidime/avibactam is an important treatment option for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp), however, resistance can emerge during treatment. The objective of the study was to define the ceftazidime/avibactam concentrations required to suppress bacterial regrowth in ceftazidime/avibactam susceptible isolates and identify active therapies against ceftazidime/avibactam-resistant KPC-Kp. Time-kill assays were performed against twelve ST258 KPC-Kp isolates that harbored blaKPC-2 or blaKPC-3. Nine KPC-Kp isolates (KPC-Kp 5A, 6A, 7A, 8A, 9A, 24A, 25A, 26A, and 27A) were susceptible to ceftazidime/avibactam, two (KPC-Kp 6B and 7B) were ceftazidime/avibactam resistant and meropenem susceptible, and one (KPC-Kp 1244) was resistant to both ceftazidime/avibactam and meropenem. Sequencing of the blaKPC genes revealed mutations in KPC-Kp 6B (D179Y substitution) and 7B (novel 21 base pair deletion) that both affected the Ω-loop encoding portion of the gene. Time-kill assays showed that against ceftazidime/avibactam-susceptible KPC-Kp, ceftazidime/avibactam concentrations ≥40/7.5 mg/L caused mean 5.42 log10CFU/mL killing and suppressed regrowth. However, regrowth occurred for some KPC-Kp isolates with a ceftazidime/avibactam concentration of 20/3.75 mg/L. Against ceftazidime/avibactam-resistant and meropenem-susceptible KPC-Kp 6B and 7B, bactericidal activity and synergy was observed for ceftazidime/avibactam in combination with meropenem ≤3.125 mg/L, while meropenem concentrations ≥50 mg/L were bactericidal as monotherapy. In contrast, clinically achievable concentrations of ceftazidime/avibactam were bactericidal against KPC-Kp 1244, which was ceftazidime/avibactam-resistant and meropenem-resistant due to outer membrane porin mutations and elevated blaKPC expression. Achieving high ceftazidime/avibactam concentrations may help to suppress bacterial regrowth in the presence of ceftazidime/avibactam. The optimal treatment approach for ceftazidime/avibactam-resistant KPC-Kp likely depends on the mechanism of resistance. Additional studies are warranted to confirm these findings.
PMCID:7982837
PMID: 33763041
ISSN: 1664-302x
CID: 4822782
Describing trends from a decade of resident performance on core clinical skills as measured by unannounced standardized patients [Meeting Abstract]
BACKGROUND: Primary care (PC) residency training is a period that provides opportunity to develop skills required for independent practice. Unannounced Standardized Patients (USPs), or secret shoppers, are a controlled measure of clinical skills in actual practice. We sought to describe differences in core clinical communication skills over the last decade for PC residents.
METHOD(S): USPs presented as a new patient for a comprehensive visit while portraying one of six unique, outpatient cases (with either chronic or acute symptomology). Actors received extensive training to ensure accurate case portrayal. Each completed a post-visit, behaviorally anchored checklist (not, partly, or well done) in order to provide extensive, actionable feedback. A standardized checklist was used, consisting of individual items across domains including information gathering, relationship development, patient education, activation and satisfaction. Chronbach's alpha for domains ranged from 0.62- 0.89. Summary scores (mean % well done) were calculated by domain and compared by year for all learners and by PGY within year for the primary care (PC) residency. Differences were assessed using ANOVA. Case portrayal accuracy was ensured using audio tape review.
RESULT(S): 396 visits were conducted with PC residents in our urban, safetynet hospital system between 2013 and 2020. While looking across the 8 years, there was variation in mean scores per domain, though Kruskal-Wallis H test did not show any statistical difference. Relationship development and info gathering were the highest rated skills, at 75% and 76% well done, respectively, on average. Patient satisfaction and activation remained uniformly low across years, with scores averaging 36% and 39% well done, respectively. Multi-variate analysis showed no significant changes across domains by cohort (grad year) and PGY levels. Further, there were no significant differences by PGY year or cohort in terms of scoring using a two-way ANOVA, though there was a slight upward trend in relationship development skills since 2017 for all PGY levels. There were similar trends in most domains, with 2020 scores being higher than previous years. There were no significant differences across domains while looking at PGY1 learners only.
CONCLUSION(S): While there were no significant differences in scores, we can postulate that PC residents enter the residency with consistent foundational communication skills, possibly attributable to training. We elected to use the visit itself as the unit of analysis, which does not allow us to tease out differences in individual learners. We also have small sample sizes for earlier years of the USP visit program, which may hinder results. Regardless, results warrant further research in order to gain a more thorough understanding, possibly in relation to curricular trends. Further study will look at individual resident differences and ideally provide insight into curricular improvement areas. LEARNING OBJECTIVE #1: Describe assessment measures LEARNING OBJECTIVE #2: Explore clinical competency
METHOD(S): USPs presented as a new patient for a comprehensive visit while portraying one of six unique, outpatient cases (with either chronic or acute symptomology). Actors received extensive training to ensure accurate case portrayal. Each completed a post-visit, behaviorally anchored checklist (not, partly, or well done) in order to provide extensive, actionable feedback. A standardized checklist was used, consisting of individual items across domains including information gathering, relationship development, patient education, activation and satisfaction. Chronbach's alpha for domains ranged from 0.62- 0.89. Summary scores (mean % well done) were calculated by domain and compared by year for all learners and by PGY within year for the primary care (PC) residency. Differences were assessed using ANOVA. Case portrayal accuracy was ensured using audio tape review.
RESULT(S): 396 visits were conducted with PC residents in our urban, safetynet hospital system between 2013 and 2020. While looking across the 8 years, there was variation in mean scores per domain, though Kruskal-Wallis H test did not show any statistical difference. Relationship development and info gathering were the highest rated skills, at 75% and 76% well done, respectively, on average. Patient satisfaction and activation remained uniformly low across years, with scores averaging 36% and 39% well done, respectively. Multi-variate analysis showed no significant changes across domains by cohort (grad year) and PGY levels. Further, there were no significant differences by PGY year or cohort in terms of scoring using a two-way ANOVA, though there was a slight upward trend in relationship development skills since 2017 for all PGY levels. There were similar trends in most domains, with 2020 scores being higher than previous years. There were no significant differences across domains while looking at PGY1 learners only.
CONCLUSION(S): While there were no significant differences in scores, we can postulate that PC residents enter the residency with consistent foundational communication skills, possibly attributable to training. We elected to use the visit itself as the unit of analysis, which does not allow us to tease out differences in individual learners. We also have small sample sizes for earlier years of the USP visit program, which may hinder results. Regardless, results warrant further research in order to gain a more thorough understanding, possibly in relation to curricular trends. Further study will look at individual resident differences and ideally provide insight into curricular improvement areas. LEARNING OBJECTIVE #1: Describe assessment measures LEARNING OBJECTIVE #2: Explore clinical competency
EMBASE:635796783
ISSN: 1525-1497
CID: 4986582
Internal medicine tele-takeover: Lessons learned from the emerging pandemic [Meeting Abstract]
BACKGROUND: Healthcare systems rose to the challenges of COVID-19 by creating or expanding telehealth programs to ensure that patients could access care from home. Traditionally, though, physicians receive limited formal telemedicine training, which made preparedness for this transition uneven. We designed a survey for General Internal Medicine (GIM) physicians within our diverse health system to describe experiences with providing virtual patient care; with the ultimate goal of identifying actionable recommendations for health system leaders and medical educators.
METHOD(S): Surveys were sent to all faculty outpatient GIM physicians working at NYU Langone Health, NYC Health + Hospitals/Bellevue and Gouverneur, and the VA NY Harbor Health System (n=378) in May & June of 2020. Survey items consisted of Likert and open-ended questions on experience with televisits (13 items) and attitudes toward care (24 items). Specific questions covered barriers to communication over remote modalities.
RESULT(S): 195/378 (52%) responded to the survey. 96% of providers reported having problems establishing a connection from the patient's end while 84% reported difficultly establishing connection on the provider's end. Using interpreter services over the phone was also problematic for providers, with 38% reporting troubles. Regarding teamness, 35% of physicians found it difficult to share information with healthcare team members during virtual visits and 42% found it difficult to work collaboratively with team members, both when compared to in-person visits. When subdivided, 24% of private and 40% of public providers found info sharing more difficult (p<0.04). 31% of private providers and 45% of public found team collaboration more difficult (ns). Physicians also identified challenges in several domains including physical exams (97%), establishing relationships with new patients (74%), taking a good history (48%), and educating patients (35%). In thematic analysis of open-ended comments, themes emerged related to technological challenges, new systems issues, and new patient/provider communication experiences. Positives noted by physicians included easier communication with patients who often struggle with keeping in-person appointments, easier remote monitoring, and a more thorough understanding of patients' home lives.
CONCLUSION(S): Provider experience differences were rooted in the type of technology employed. Safety-net physicians conducted mostly telephonic visits while private outpatient physicians utilized video visits, despite both using the same brand of electronic medical record system. As we consider a new normal and prolonged community transmission of COVID-19, it is essential to establish telemedicine training, tools, and protocols that meet the needs of both patients and physicians across diverse settings. LEARNING OBJECTIVE #1: Describe challenges and barriers to effective communication and clinical skill utilization during televisits LEARNING OBJECTIVE #2: Conceptualize recommendations for educational curricula and health service improvement areas
METHOD(S): Surveys were sent to all faculty outpatient GIM physicians working at NYU Langone Health, NYC Health + Hospitals/Bellevue and Gouverneur, and the VA NY Harbor Health System (n=378) in May & June of 2020. Survey items consisted of Likert and open-ended questions on experience with televisits (13 items) and attitudes toward care (24 items). Specific questions covered barriers to communication over remote modalities.
RESULT(S): 195/378 (52%) responded to the survey. 96% of providers reported having problems establishing a connection from the patient's end while 84% reported difficultly establishing connection on the provider's end. Using interpreter services over the phone was also problematic for providers, with 38% reporting troubles. Regarding teamness, 35% of physicians found it difficult to share information with healthcare team members during virtual visits and 42% found it difficult to work collaboratively with team members, both when compared to in-person visits. When subdivided, 24% of private and 40% of public providers found info sharing more difficult (p<0.04). 31% of private providers and 45% of public found team collaboration more difficult (ns). Physicians also identified challenges in several domains including physical exams (97%), establishing relationships with new patients (74%), taking a good history (48%), and educating patients (35%). In thematic analysis of open-ended comments, themes emerged related to technological challenges, new systems issues, and new patient/provider communication experiences. Positives noted by physicians included easier communication with patients who often struggle with keeping in-person appointments, easier remote monitoring, and a more thorough understanding of patients' home lives.
CONCLUSION(S): Provider experience differences were rooted in the type of technology employed. Safety-net physicians conducted mostly telephonic visits while private outpatient physicians utilized video visits, despite both using the same brand of electronic medical record system. As we consider a new normal and prolonged community transmission of COVID-19, it is essential to establish telemedicine training, tools, and protocols that meet the needs of both patients and physicians across diverse settings. LEARNING OBJECTIVE #1: Describe challenges and barriers to effective communication and clinical skill utilization during televisits LEARNING OBJECTIVE #2: Conceptualize recommendations for educational curricula and health service improvement areas
EMBASE:635796421
ISSN: 1525-1497
CID: 4985022
Use of a QR Code Accessed Debrief Tool is Associated With Higher Rates of Debrief After In-Hospital Cardiac Arrest [Meeting Abstract]
ISI:000750132100112
ISSN: 0009-7322
CID: 5263722
Teamwork and Leadership Under Fire at the Epicenter of the COVID-19 Epidemic in the Bronx
The first Covid-19 patient was admitted to Montefiore Medical Center (MMC) on March 10, 2020. Soon thereafter there was a rapid and exponential surge of Covid-19 admissions to MMC that could have resulted in catastrophic consequences if MMC had been overwhelmed, as happened in Europe. To adjust to this crisis our institution, under the inspiring leadership of Dr. Philip Ozuah, President and CEO of Montefiore Medicine, adopted an "all hands on deck" approach, mobilizing our entire workforce to expand our units to accommodate the growing number of patients being admitted. Given that the internal medicine (IM) and ICU units are part of the department of medicine (DOM), the DOM was at the center of this mobilization. The DOM is the largest department at MMC and mobilizing it required careful planning, seamless teamwork, and strong leadership. To achieve that goal, we applied a framework that we designate the "3C framework," denoting Coordination, Communication, and Collaboration. In this report we describe the many initiatives the Montefiore Einstein DOM implemented during the Covid-19 pandemic using the 3C framework. These included establishing the Medicine Covid-19 Taskforce to lead our efforts, starting a daily newsletter for up-to-date communications, rapidly expanding the ICU and IM units, converting most specialty inpatient consults to eConsults, coordinating research studies, and more. The goal of this report is to serve as a guide on how the 3C framework helped us organize, mobilize, and energize the department of medicine effectively and efficiently during this unprecedented crisis.
PMCID:8012527
PMID: 33816518
ISSN: 2296-858x
CID: 4838872
Mothers of children with major congenital anomalies have increased health care utilization over a 20-year post-birth time horizon
OBJECTIVE:This population-based, matched cohort study aimed to evaluate utilization of health care services by mothers of children with major congenital anomalies (MCAs), compared to mothers of children without MCAs over a 20-year post-birth time horizon in Denmark. METHODS:Our analytic sample included mothers who gave birth to an infant with a MCA (n = 23,927) and a cohort of mothers matched to them by maternal age, parity and infant's year of birth (n = 239,076). Primary outcomes were period prevalence and mothers' quantity of health care utilization (primary, inpatient, outpatient, surgical, and psychiatric services) stratified by their child's age (i.e., ages 0-6 = before school, ages 7-13 = pre-school + primary education, and ages 14-18 = secondary education or higher). The secondary outcome measure was length of hospital stays. Outcome measures were adjusted for maternal age at delivery, parity, marital status, income quartile, level of education in the year prior to the index birth, previous spontaneous abortions, maternal pregnancy complications, maternal diabetes, hypertension, alcohol-related diseases, and maternal smoking. RESULTS:In both cohorts the majority of mothers were between 26 and 35 years of age, married, and employed, and 47% were primiparous. Mothers of infants with anomalies had greater utilization of outpatient, inpatient, surgical, and psychiatric services, compared with mothers in the matched cohort. Inpatient service utilization was greater in the exposed cohort up to 13 years after a child's birth, with the highest risk in the first six years after birth [adjusted risk ratio, 1.13; 95% confidence interval (CI), 1.12-1.14], with a decrease over time. Regarding the quantity of health care utilization, the greatest difference between the two groups was in inpatient service utilization, with a 39% increased rate in the exposed cohort during the first six years after birth (adjusted rate ratio, 1.39; 95% CI, 1.37-1.42). During the first 6 years after birth, mothers of children with anomalies stayed a median of 6 days (interquartile range [IQR], 3-13) in hospital overall, while the comparison cohort stayed a median of 4 days (IQR, 2-7) in hospital overall. Rates of utilization of outpatient clinics (adjusted rate ratio, 1.36; 95% CI, 1.29-1.42), as well as inpatient (adjusted rate ratio, 1.77; 95% CI, 1.68-1.87), and surgical services (adjusted rate ratio, 1.33; 95% CI, 1.26-1.41) was higher in mothers of children with multiple-organ MCAs during 0 to 6 years after birth. Among mothers at the lowest income levels, utilization of psychiatric clinic services increased to 59% and when their child was 7 to 13 years of age (adjusted rate ratio, 1.59; 95% CI, 1.24-2.03). CONCLUSION:Mothers of infants with a major congenital anomaly had greater health care utilization across services. Health care utilization decreased over time or remained stable for outpatient, inpatient, and surgical care services, whereas psychiatric utilization increased for up to 13 years after an affected child's birth. Healthcare utilization was significantly elevated among mothers of children with multiple MCAs and among those at the lowest income levels.
PMCID:8654179
PMID: 34879106
ISSN: 1932-6203
CID: 5116002
OUTCOMES OF ATRIAL FIBRILLATION/FLUTTER PATIENTS HOSPITALIZED FOR LOWER GASTROINTESTINAL BLEEDING: RESULTS OF A NATIONAL COHORT [Meeting Abstract]
ISI:000656222900215
ISSN: 0016-5107
CID: 5046302
