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A COMPARISON OF INTRAVENOUS IRON ADMINISTRATION IN HEART FAILURE PATIENTS WITH OR WITHOUT MECHANICAL CIRCULATORY SUPPORT [Meeting Abstract]

Peters, Carli J.; Domenico, Chris; Zhang, Robert; Hanff, Thomas; Wald, Joyce; Mazurek, Jeremy Aryeh; Genuardi, Michael; Birati, Edo
ISI:000522979100971
ISSN: 0735-1097
CID: 4410052

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Richardson, Safiya; Hirsch, Jamie S; Narasimhan, Mangala; Crawford, James M; McGinn, Thomas; Davidson, Karina W; Barnaby, Douglas P; Becker, Lance B; Chelico, John D; Cohen, Stuart L; Cookingham, Jennifer; Coppa, Kevin; Diefenbach, Michael A; Dominello, Andrew J; Duer-Hefele, Joan; Falzon, Louise; Gitlin, Jordan; Hajizadeh, Negin; Harvin, Tiffany G; Hirschwerk, David A; Kim, Eun Ji; Kozel, Zachary M; Marrast, Lyndonna M; Mogavero, Jazmin N; Osorio, Gabrielle A; Qiu, Michael; Zanos, Theodoros P
Importance/UNASSIGNED:There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19). Objective/UNASSIGNED:To describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system. Design, Setting, and Participants/UNASSIGNED:Case series of patients with COVID-19 admitted to 12 hospitals in New York City, Long Island, and Westchester County, New York, within the Northwell Health system. The study included all sequentially hospitalized patients between March 1, 2020, and April 4, 2020, inclusive of these dates. Exposures/UNASSIGNED:Confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample among patients requiring admission. Main Outcomes and Measures/UNASSIGNED:Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. Demographics, baseline comorbidities, presenting vital signs, and test results were also collected. Results/UNASSIGNED:A total of 5700 patients were included (median age, 63 years [interquartile range {IQR}, 52-75; range, 0-107 years]; 39.7% female). The most common comorbidities were hypertension (3026; 56.6%), obesity (1737; 41.7%), and diabetes (1808; 33.8%). At triage, 30.7% of patients were febrile, 17.3% had a respiratory rate greater than 24 breaths/minute, and 27.8% received supplemental oxygen. The rate of respiratory virus co-infection was 2.1%. Outcomes were assessed for 2634 patients who were discharged or had died at the study end point. During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. Mortality for those requiring mechanical ventilation was 88.1%. The median postdischarge follow-up time was 4.4 days (IQR, 2.2-9.3). A total of 45 patients (2.2%) were readmitted during the study period. The median time to readmission was 3 days (IQR, 1.0-4.5) for readmitted patients. Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1). Conclusions and Relevance/UNASSIGNED:This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area.
PMID: 32320003
ISSN: 1538-3598
CID: 4397182

Patient Experience With Notification of Radiology Results: A Comparison of Direct Communication and Patient Portal Use

Garry, Kira; Blecker, Saul; Saag, Harry; Szerencsy, Adam; Jones, Simon A; Testa, Paul; Kang, Stella
OBJECTIVE:Patients increasingly access radiology results through digital portals. We compared patient satisfaction and understanding of radiology results when received through an electronic patient portal versus direct communication from providers. METHODS:tests and logistic regression. RESULTS:Of 1,005 survey respondents, 87.8% (882 of 1,005) reported having received their imaging test results, with 486 (48.4%) first being notified through the patient portal and 396 (39.4%) via direct provider communication. Patients reported high levels of satisfaction with timing regardless of whether they first received the results through the patient portal or through direct provider communication (88.8%-89.9%). Patients who first received their results through the patient portal reported a lesser degree of perceived understanding than those who first received their results through direct provider communication (26.7% versus 47.8%; P < .001). Patients were less likely to report clear understanding for advanced imaging (CT or MRI) than ultrasound or x-rays (29.3% versus 40.3% versus 38.2%, respectively; P = .02). Patient characteristics showed no association with understanding in multivariable analysis. CONCLUSION/CONCLUSIONS:As online portal release of radiology results to patients becomes commonplace, efforts may be warranted to improve patient experience when first receiving their radiology results online.
PMID: 32289281
ISSN: 1558-349x
CID: 4401322

Challenges and Responsibilities in Caring for the Most Vulnerable during the COVID-19 Pandemic [Letter]

Siegler, Eugenia L
PMID: 32311068
ISSN: 1532-5415
CID: 4396862

From Stigma to Validation: A Qualitative Assessment of a Novel National Program to Improve Retention of Physician-Scientists with Caregiving Responsibilities

Jones, Rochelle D; Miller, Jacquelyn; Vitous, C Ann; Krenz, Chris; Brady, Kathleen T; Brown, Ann J; Daumit, Gail L; Drake, Amelia F; Fraser, Victoria J; Hartmann, Katherine E; Hochman, Judith S; Girdler, Susan; Kalet, Adina L; Libby, Anne M; Mangurian, Christina; Regensteiner, Judith G; Yonkers, Kimberly; Jagsi, Reshma
PMID: 32286931
ISSN: 1931-843x
CID: 4383322

Connecting healthcare professionals in Central America through management and leadership development: a social network analysis

Prado, Andrea M; Pearson, Andy A; Bertelsen, Nathan S; Pagán, José A
BACKGROUND:Leadership and management training has become increasingly important in the education of health care professionals. Previous research has shown the benefits that a network provides to its members, such as access to resources and information, but ideas for creating these networks vary. This study used social network analysis to explore the interactions among Central American Healthcare Initiative (CAHI) Fellowship alumni and learn more about information sharing, mentoring, and project development activities among alumni. The CAHI Fellowship provides leadership and management training for multidisciplinary healthcare professionals to reduce health inequities in the region. Access to a network was previously reported as one of the top benefits of the program. RESULTS:Information shared from the work of 100 CAHI fellows from six countries, especially within the same country, was analyzed. Mentoring relationships clustered around professions and project types, and networks of joint projects clustered by country. Mentorship, which CAHI management promoted, and joint project networks, in which members voluntarily engaged, had similar inclusiveness ratios. CONCLUSION/CONCLUSIONS:Social networks are strategic tools for health care leadership development programs to increase their impact by promoting interactions among participants. These programs can amplify intergenerational and intercountry ties by organizing events, provide opportunities for alumni to meet, assign mentors, and support collaborative action groups. Collaborative networks have great value to potentiate health professionals' leadership and management capabilities in a resource-constrained setting, such as the Global South.
PMID: 32295622
ISSN: 1744-8603
CID: 4383592

Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes

Bhatraju, Pavan K; Zelnick, Leila R; Chinchilli, Vernon M; Moledina, Dennis G; Coca, Steve G; Parikh, Chirag R; Garg, Amit X; Hsu, Chi-Yuan; Go, Alan S; Liu, Kathleen D; Ikizler, T Alp; Siew, Edward D; Kaufman, James S; Kimmel, Paul L; Himmelfarb, Jonathan; Wurfel, Mark M
Importance/UNASSIGNED:The severity of acute kidney injury (AKI) is usually determined based on the maximum serum creatinine concentration. However, the trajectory of kidney function recovery could be an additional important dimension of AKI severity. Objective/UNASSIGNED:To assess whether the trajectory of kidney function recovery within 72 hours after AKI is associated with long-term risk of clinical outcomes. Design, Setting, and Participants/UNASSIGNED:This prospective, multicenter cohort study enrolled 1538 adults with or without AKI 3 months after hospital discharge between December 1, 2009, and February 28, 2015. Statistical analyses were completed November 1, 2018. Participants with or without AKI were matched based on demographic characteristics, site, comorbidities, and prehospitalization estimated glomerular filtration rate. Participants with AKI were classified as having resolving or nonresolving AKI based on previously published definitions. Resolving AKI was defined as a decrease in serum creatinine concentration of 0.3 mg/dL or more or 25% or more from maximum in the first 72 hours after AKI diagnosis. Nonresolving AKI was defined as AKI not meeting the definition for resolving AKI. Main Outcomes and Measures/UNASSIGNED:The primary outcome was a composite of major adverse kidney events (MAKE), defined as incident or progressive chronic kidney disease, long-term dialysis, or all-cause death during study follow-up. Results/UNASSIGNED:Among 1538 participants (964 men; mean [SD] age, 64.6 [12.7] years), 769 (50%) had no AKI, 475 (31%) had a resolving AKI pattern, and 294 (19%) had a nonresolving AKI pattern. After a median follow-up of 4.7 years, the outcome of MAKE occurred in 550 (36%) of all participants. The adjusted hazard ratio for MAKE was higher for patients with resolving AKI (adjusted hazard ratio, 1.52; 95% CI, 1.01-2.29; P = .04) and those with nonresolving AKI (adjusted hazard ratio 2.30; 95% CI, 1.52-3.48; P < .001) compared with participants without AKI. Within the population of patients with AKI, nonresolving AKI was associated with a 51% greater risk of MAKE (95% CI, 22%-88%; P < .001) compared with resolving AKI. The higher risk of MAKE among patients with nonresolving AKI was explained by a higher risk of incident and progressive chronic kidney disease. Conclusions and Relevance/UNASSIGNED:This study suggests that the 72-hour period immediately after AKI distinguishes the risk of clinically important kidney-specific long-term outcomes. The identification of different AKI recovery patterns may improve patient risk stratification, facilitate prognostic enrichment in clinical trials, and enable recognition of patients who may benefit from nephrology consultation.
PMID: 32282046
ISSN: 2574-3805
CID: 4383172

Understanding medical student evidence-based medicine information seeking in an authentic clinical simulation

Nicholson, Joey; Kalet, Adina; van der Vleuten, Cees; de Bruin, Anique
Objective/UNASSIGNED:Evidence-based medicine practices of medical students in clinical scenarios are not well understood. Optimal foraging theory (OFT) is one framework that could be useful in breaking apart information-seeking patterns to determine effectiveness and efficiency of different methods of information seeking. The aims of this study were to use OFT to determine the number and type of resources used in information seeking when medical students answer a clinical question, to describe common information-seeking patterns, and identify patterns associated with higher quality answers to a clinical question. Methods/UNASSIGNED:Medical students were observed via screen recordings while they sought evidence related to a clinical question and provided a written response for what they would do for that patient based on the evidence that they found. Results/UNASSIGNED:Half (51%) of study participants used only 1 source before answering the clinical question. While the participants were able to successfully and efficiently navigate point-of-care tools and search engines, searching PubMed was not favored, with only half (48%) of PubMed searches being successful. There were no associations between information-seeking patterns and the quality of answers to the clinical question. Conclusion/UNASSIGNED:Clinically experienced medical students most frequently relied on point-of-care tools alone or in combination with PubMed to answer a clinical question. OFT can be used as a framework to understand the information-seeking practices of medical students in clinical scenarios. This has implications for both teaching and assessment of evidence-based medicine in medical students.
PMCID:7069825
PMID: 32256233
ISSN: 1558-9439
CID: 4378842

Acculturation and Diet Among Chinese American Immigrants in New York City

Kirshner, Lindsey; Yi, Stella S; Wylie-Rosett, Judith; Matthan, Nirupa R; Beasley, Jeannette M
Background/UNASSIGNED:There are limited data on the social and cultural determinants of dietary intake in Chinese Americans. Over 560,000 New York City residents are Chinese American, and there has been a growing trend over the past 30 y of permanent migration from China to the USA. Objectives/UNASSIGNED:The purpose of this secondary data analysis is to describe associations between diet, measured by self-report, and diet quality, with level of acculturation in a cross-sectional sample of urban-dwelling Chinese American immigrants. Methods/UNASSIGNED:This was a cross-sectional study involving 2071 foreign-born Chinese American adults. Acculturation was assessed using the Stephenson Multigroup Acculturation Scale, diet using a Chinese-adapted FFQ, and diet quality using the Alternative Healthy Eating Index (AHEI). Multivariable regression was used to assess associations between ethnic (ESI; Chinese) and dominant (DSI; American) society immersion scores with self-reported dietary measures. Results/UNASSIGNED: = 0.025) higher red and processed meat component score. Conclusions/UNASSIGNED:Assessment of acculturation level may help to tailor dietary strategies that are appropriate to what Chinese American immigrant communities are consuming to more effectively decrease the risk of chronic disease.
PMCID:7121198
PMID: 32270131
ISSN: 2475-2991
CID: 4378962

Elevated cardiac risk score by Atherosclerotic Cardiovascular Disease calculation is associated with albuminuria in older people living with HIV

Johnston, Carrie D; Ifeagwu, Kene-Chukwu C; Siegler, Eugenia L; Derry, Heather; Burchett, Chelsie O; Rice, Michelle C; Gupta, Samir K; Choi, Mary E; Glesby, Marshall J
: Globally, the proportion of older people living with HIV (PLWH) is growing and the burden of noncommunicable diseases, including cardiac and renal disease, is increasing. There are few studies of renal disease and cardiac risk in older PLWH. This study investigates the relationship between albuminuria and cardiac risk as estimated by the Atherosclerotic Cardiovascular Disease 10-year risk calculator. We report that albuminuria is associated with a higher Atherosclerotic Cardiovascular Disease risk score in both diabetic and nondiabetic older PLWH.
PMID: 32271253
ISSN: 1473-5571
CID: 4377612