Faculty Bibliography

BACKGROUND: Electronic health record (EHR)-based clinical decision support tools (CDS) incorporate individualized data to produce patient-specific recommendations at the point-of-care. However, these tools are often limited in their effectiveness, which may be due to poor consideration of usability. The purpose of this study was to evaluate the utilization of a CDS intervention to increase prescription of Angiotensin Converting Enzyme inhibitor (ACEi) or Angiotensin Receptor Blocker (ARB) for patients with heart failure. METHODS: We performed a retrospective study of hospitalized patients with heart failure from the time of CDS implementation, 7/10/13, through 11/30/15. The CDS that we investigated offers providers an opportunity to prescribe an ACEi or ARB or report a contraindication to therapy for patients with documented heart failure. All patients with an EF < 40% who were not on an ACEi or ARB at time of discharge were included in the study. We identified the number of patients for whom the CDS triggered; of those, we categorized provider response as: dismissed, ordered an ACEi/ARB, or contraindication reported. We then performed manual chart review to identify the CDS reported contraindication and structured chart abstraction with standard guidelines to identify gold standard contraindications. We compared each CDS contraindication to gold standard contraindications to determine their accuracy. RESULTS: Out of the 618 subjects who had an EF < 40% but no ACEi or ARB at the time or discharge, 435/618 (70%) had a triggered CDS. Of these 435 subjects for who a CDS was triggered, 180 (41%) were dismissed, 225 (52%) had a contraindication response and 30 (7%) had a prescription for an ACEi/ARB therapy. Overall the accuracy of the documented CDS was 42% (Table 1). CONCLUSIONS: The CDS that we reviewed was poorly utilized and contraindications documented in the tool poorly correlated with patient clinical status reflected elsewhere in the EHR. These findings identify this CDS as a possible impedance to user workflow. One way to improve CDS tools at the point of care is through thorough usability testing and consideration of physician workflow prior to implementation. (Table Presented)

NEEDS AND OBJECTIVES: To address the need for sustainable, efficient interprofessional education and practice (IPEP) at the graduate level health professions education (GHPE), the NYU School of Medicine (SoM) and NYU RoryMeyers College of Nursing (NYUMeyers) designed IPEP, a mobile learning solution. We aimed to: * Provide learners with applicable interprofessional (IP) practice skills * Encourage reflection on IP care planning * Develop an accessible and sustainable IP geriatric education curriculum for GHPE * Collect residents' reflection on IP practice for future curriculum design SETTING AND PARTICIPANTS: IPEP was housed on the NYU SOM learning management system. Since 2014, about 3500 learners from Health Professions schools across the U.S. have completed the 6 I.E. modules. DESCRIPTION: Approach/Methods To overcome barriers (e.g. limited learning space, lack of faculty, heterogeneous curricula) NYU SoM and NYU Meyers developed a series of 10-min e-learning materials including didactic modules and virtual geriatric primary care patient (VP) cases. These are based on the undergraduate online IP modules, NYU3T: Teaching, Technology, and Teamwork. The modules address: * IP teams/responsibility * Effective healthcare teams * Teamwork skills * Communication skills Conflict resolution * IP care planning 4 VP cases include IP assessment and management of older adults with chronic conditions. Reflective questions are integrated into modules and VP cases to stimulate critical thinking and attitude shift. In order to facilitate use, online modules and VP cases are designed in bite-size 10-min modules without heavy multimedia components. Thus, residents, nurse practitioners, and other graduate level providers can complete the modules via phone, tablets, or computers. EVALUATION: Users rated modules very positively (4.2 out of 5). More than 80% of users responded the length of the modules were "just right"; about 90% agreed to "recommend the modules to others". About 500 learners completed four VP cases this last year. According to the validated questionnaire measuring attitudes toward IP teams, there was a significant change toward team value (p = .006) but no significant changes around team efficiency or physician's shared role on team. DISCUSSION/REFLECTION/LESSONS LEARNED: Scheduling of IP activities, with joint clinical experiences and OSCEs, takes time, effort, and coordination of multiple schedules. The IPEP e-modules help smoother dissemination of IPE knowledge and skills to busy trainees. IP learners have found these a valuable resource. More VP cases for different populations may increase the application of IPE skills

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the in vitro efficacy of a unique combination of CAZ-AVI and ATM against 21 representative Enterobacteriaceae isolates with a complex molecular background that included bla_IMP, bla_NDM, bla_OXA-48, bla_CTX-M, bla_AmpC, and combinations thereof. Time-kill assays were conducted, and the in vivo efficacy of this combination was assessed in a murine neutropenic thigh infection model. By disk diffusion assay, all 21 isolates were resistant to CAZ-AVI alone, and 19/21 were resistant to ATM. The in vitro activity of CAZ-AVI in combination with ATM against diverse Enterobacteriaceae possessing MBLs was demonstrated in 17/21 isolates, where the zone of inhibition was ≥21 mm. All isolates demonstrated a reduction in CAZ-AVI agar dilution MICs with the addition of ATM. At 2 h, time-kill assays demonstrated a ≥4-log₁₀-CFU decrease for all groups that had CAZ-AVI with ATM (8 μg/ml) added, compared to the group treated with CAZ-AVI alone. In the murine neutropenic thigh infection model, an almost 4-log₁₀-CFU reduction was noted at 24 h for CAZ-AVI (32 mg/kg every 8 h [q8h]) plus ATM (32 mg/kg q8h) versus CAZ-AVI (32 mg/kg q8h) alone. The data presented herein require us to carefully consider this new therapeutic combination to treat infections caused by MBL-producing Enterobacteriaceae.

Klebsiella pneumoniae is a prominent cause of nosocomial infections worldwide. Bloodstream infections caused by carbapenem-resistant K. pneumoniae, including the epidemic lineage known as multilocus sequence type 258 (ST258), are difficult to treat, and the rate of mortality from such infections is high. Thus, it is imperative that we gain a better understanding of host defense against this pathogen as a step toward developing novel therapies. Here we tested the hypothesis that the resistance of ST258 to bactericidal components of human blood, such as serum complement, is linked to virulence capacity in the context of bacteremia. There was significant variance in the survival of ST258 clinical isolates in heparinized human blood or normal human serum. The rate of survival of ST258 isolates in human blood was, in general, similar to that in normal human serum, suggesting a prominent role for complement (rather than leukocytes) in the healthy host defense against ST258 isolates and related organisms. Indeed, deposition of serum complement-the C5b to C9 (C5b-C9) membrane attack complex-onto the surface of ST258 isolates accompanied serum bactericidal activity. Human serum treated with pharmacological inhibitors of complement, depleted of antibody, or heated at 56°C for 30 min had significantly reduced or absent bactericidal activity. In contrast to heparinized blood from humans, that from BALB/c mice lacked bactericidal activity toward the ST258 isolates tested, but the virulence of these ST258 isolates in a mouse bacteremia model was inexplicably limited. Our data highlight the importance of the complement system in host defense against ST258 bacteremia, and we propose that there is the potential to enhance complement-mediated bactericidal activity using an antibody-based approach.

NEEDS AND OBJECTIVES: Skillful research staff members are critical to productive translational research teams and yet their ongoing professional development is rarely formally addressed. Through the Strategic Teamwork for Effective Practice-Mentor Development Program (STEP-MDP), we aimed to both create a community of practice (COP) for research staff and build the skills needed to enhance research team performance. SETTING AND PARTICIPANTS: We selected 16 participants of 32 stafflevel applicants from among the NYU Schools of Medicine, SocialWork and Nursing for the first STEP-MDP cohort. Participants included research assistants, coordinators, managers and directors. DESCRIPTION: We delivered 3, two-hour workshops, scheduled 3 weeks apart, focused on team communication, identifying team areas for improvement, and mentorship/coaching skills. Peer-Coaching Teams (PCTs) were created by paring participants at the same position level, and PCTs worked together at each session to explore and practice learned skills. Sessions featured brief didactics, group learning and exercises based on participants' real issues. A variety of active learning techniques such as brainstorming, role-playing, problem solving, and peer coaching were used. Practical core readings, worksheets and summary cards were provided. PCTs met between sessions to practice coaching skills, and troubleshoot problems. EVALUATION: Participants (N = 16) completed a 37-item (4 point scale) retrospective pre/post self-assessment of team behaviors and skills, and a STEP-MDP evaluation survey at the end. We saw pre-post improvements in each of 5 self-assessment domains: Communication (4 items, Pre-mean 2.66, Post mean 3.36, p = <.001), Leadership (8 items, Pre-mean 2.76, Post mean 3.55, p = <.001), Empowerment and Motivation (12 items, Pre-mean 2.86, Post mean 3.51, p = <.001), Coaching (6 items, Pre-mean 2.40, Post mean 3.58, p = <.001), and Community (3 items, Pre-mean 2.33, Post mean 3.76, p = <.001). On average, PCTs met twice (range 2-4 times) between workshop sessions. One commented on the value of working with peers in PCTs, having no one in a similar position within his immediate work environment. Participants' written comments strongly endorsed the value of the workshops for their work, with the coaching skills session seen as the most valuable. Some participants worry that skills will decrease over time without continued reinforcement. All but one participant reported that they planned to continue with the PCT. DISCUSSION/REFLECTION/LESSONS LEARNED: The number of applicants to our program suggests a need and motivation for staff to participate in the STEP-MDP. Participants' reported improved skills and sense of community. To maintain the COP and address worry about degradation of skills we are planning to remind PCTs to meet once a month and will follow up with them 3 and 6 months post intervention to evaluate their continued development. This spring we will enroll a 2nd cohort. We believe developing these core teamwork skills will lead to more collaborative, efficient, and innovative research

BACKGROUND: Training residents to effectively practice value-based care is challenging. We hypothesized that residents with better communication skills would order fewer unnecessary tests and prescribe more appropriate care. We used a USP case of a patient with uncontrolled asthma to examine the relationship between value-based care and communication skills. METHODS: A 25 year-old female USP presented as a new patient to a medicine resident's clinic, reporting asthma since childhood with worsening symptoms over the past few months. At the time of the visit, she was using her albuterol inhaler multiple times daily, without any additional asthma treatment, and was unsure whether she was using it properly. Data was collected using two forms of assessment: a post-visit USP checklist and a systematic review of the corresponding clinic note to examine treatment recommendations including referrals and quality of documentation. The USP checklist measured communication, patient education, and assessment skills. Each response option included descriptive behavioral anchors and was rated as not done, partly done, or well done. Domain scores were calculated as percent items rated well done. RESULTS: 141 USP visits were made from 2009 to 2016 with a mean visit length = 88 min, SD= 28 min (range: 40 to 180 min). Almost all residents (92%) evaluated the patient's asthma with a pulmonary examination. The most common treatment prescribed was albuterol and an inhaled steroid, with or without a spacer (79%). The majority of residents (53%) did not order any additional studies; 21% ordered one study, and 26% ordered two or more studies. Study orders fell into one of three categories: gold (appropriate/recommended: PFTs, flu shot, HIV), grey (pulmonary consult, HCG), or inappropriate (TSH, A1C). Across the 141 visits, 129 studies were ordered; 46% were gold, 5% were grey, and 49% were inappropriate. The most common study ordered was a PFT (31%). 87% of single study orders were gold, but 92% of multiple orders included at least one inappropriate study. Residents who did not order any studies had significantly higher patient education and counseling skills than residents who ordered one or more studies (54% vs 34%, p = 0.00) and were more likely to explain how to correctly use an inhaler than residents who ordered one or more studies (48% vs 27%, p = 0.01). These residents also had significantly higher management and treatment skills (61% vs 39%, p = 0.00) and overall communication skills (68% vs 55%, p = 0.01). There were no significant differences between groups in medications prescribed or in quality of documentation. CONCLUSIONS: Effective communication skills may contribute to valuebased care through appropriate patient education and ordering of fewer inappropriate studies. Rigorous curricula and assessment of resident's patient education skills should be in place to help both patients and health care system achieve value-based care

BACKGROUND: All physicians need to be skilled at diagnosing, treating, and managing depression. We designed an unannounced standard patient (USP) case to assess residents' clinical skills in addressing depression and explored how those skills are associated with residents' general clinical skills in order to design targeted curriculum on depression. METHODS: The USP was a 26 y.o. male presenting as a new patient to a clinic complaining of fatigue and problems sleeping. Goals of the case were to diagnose a common presentation of depression and make a treatment/follow-up plan. The USP was trained to have a positive PHQ 2 &PHQ 9, family history of depression, and be willing to engage in medication and/or therapy if offered. A post-visit checklist was used by the SPs to assess communication, patient education, and assessment skills using behaviorally anchored items rated as not done, partly done, or well done. A systematic chart review was conducted to examine treatment, quality of documentation, and referrals. Case fidelity was checked by audiotape and confirmed by PHQ 9 score in the EHR. Evidence based treatment was defined as prescribing an SSRI and/or providing a psychiatric referral; if neither of those, scheduling follow-up for within 2 weeks. RESULTS: 122 residents saw the USP case from 2009-2015. Mean visit length = 45 min, SD 25 (14 to 183 min). The patient was screened for depression with a PHQ 2 in 93% of visits; 82% also had a PHQ 9. Overall, 77 residents (63%) provided appropriate treatment: 8% prescribed an SRRI, 23% provided a referral, 19% did both, 7% prescribed a sleep aid and <2 week follow-up, and 43% provided a combination of these treatments. 45 residents (37%) did not provide appropriate treatment: 27 (60%) prescribed a sleep aid and follow-up >2 weeks and 18 (40%) provided no treatment/referral and follow-up >2 weeks. There were no differences in exploration of medical history or substance use, but 83% of residents who treated appropriately had a PHQ 9 compared to 62% of residents who did not treat appropriately. 71% also included depression on the problem list compared to 13%of residents who did not treat appropriately. Residents who treated appropriately had significantly better clinical skills assessed by the USP including: overall communication (71% vs. 54%, p = 0.00), information gathering (72% vs. 55%, p = 0.01), relationship development (75% vs. 60%, p = 0.03), patient education (55% vs. 21%, p = 0.00), and patient activation skills (33% vs. 13%, p = 0.01). CONCLUSIONS: Although almost all residents obtained the relevant information, only about 50% of residents diagnosed depression. PHQ 9 appears to be associated with providing more effective treatment, supporting the importance of health system screening protocols. Residents' communication and depression-specific patient education and activation skills seem to be related to how they identify and manage depression, suggesting that interventions to build these skills may lead to higher quality care

BACKGROUND: Safe, high quality outpatient care often depends on the degree to which patients understand their situation and how to follow through on physician recommendations. However, we do not know enough about how often physicians focus on ensuring that their patients have achieved these understandings by the end of the visit and whether such end-of-visit practices are associated with physicians' communication, patient education and activating skills. METHODS: Two Unannounced Standardized Patient cases (highly trained actors who present as real patients) were delivered to 71 internal medicine residents in two clinics: one required the physician to identify a patient's depression and engage him in follow-up care, and the other required the physician to recognize a patient's failure to use her asthma medicine correctly and educate her in using it properly. End-of-visit practices were: reviewing the plan; asking if further questions; giving information about follow-up care and further contact; and helping the patient navigate the system in order to follow through on next steps. Each was assessed by the SP as not done, partly done, or well done. SPs also rated physicians' communication skills, patient activating skills, and case-specific education skills. Summary scores were calculated as% of items well done. RESULTS: Close to three-quarters of the physicians reviewed the plan with the patient and invited further questions in the depression case and slightly more than half did so in the asthma case (56 and 60%). Patients were given complete information about follow-up care and how to navigate the system in just under half of depression visits (49 and 47%) and just over half of asthma visits (58 and 58%). On average, residents were rated as performing 61% of these 8 items well (SD 28%) across both cases. Primary care residents performed significantly better than categorical internal medicine residents (67%vs 47%, p = .004). There were no differences by physician gender. End of visit scores were significantly positively correlated with both general and casespecific clinical skills, and after controlling for the variance contributed by the program (R2 = 12%, p = .004), case-specific education scores explained 10% of the variance in end of visit score (p = .005), patient activating skills 10% of the variance (p = .002) and communication skills 13% of the variance (p = .001). With all variables in the model, only the general communication domain of patient education and counseling was independently associated with end of visit scores (Std Beta = .35, p = .015). CONCLUSIONS: Had these patients been real patients, in one-quarter to onehalf of the visits, the patient would have left not fully understanding the plan or how to follow-through on care. Resident physicians with more effective communication and patient activating skills tended to provide safer end-of-visit care, suggesting that these may reflect an outpatient safety orientation or skillset

Paclitaxel-coated drug-coated balloons have significantly improved short-term and mid-term clinical outcomes in patients with symptomatic femoropopliteal peripheral artery disease. However, long-term results are awaited. Furthermore, the clinical success of drug-coated balloons in the infrapopliteal peripheral arteries has been more modest and overall similar to traditional balloon angioplasty, and remains an area of unmet clinical need. This article provides an overview of the clinical evidence for paclitaxel-coated balloons in the femoropopliteal and infrapopliteal peripheral artery distributions and future directions in this area.