Faculty Bibliography

The science on the H5N1 bird flu virus may not support these conclusions. Two important studies published just last month in top science journals show that this bird flu virus is still multiple mutations away from being able to pass easily among humans. This bird flu appears to be better absorbed by the deep pockets of bird lungs, whereas human flu is absorbed by the cells of our upper airways. Dr. David Swayne, director of the Southeast Poultry Laboratory at the U.S. Department of Agriculture, has worked on avian influenza for many years. He takes all highly pathogenic bird flus seriously, including H5N1, but he feels they can most often be controlled. Swayne told me that H5N1 might still be eradicated in birds with the help of 'better diagnostic tools and improved strategies to protect birds from infection.'

The science on the H5N1 bird flu virus may not support these conclusions. Two important studies published just last month in top science journals show that this bird flu virus is still multiple mutations away from being able to pass easily among humans. This bird flu appears to be better absorbed by the deep pockets of bird lungs, whereas human flu is absorbed by the cells of our upper airways. Dr. David Swayne, director of the Southeast Poultry Laboratory at the U.S. Department of Agriculture, has worked on avian influenza for many years. He takes all highly pathogenic bird flus seriously, including H5N1, but he feels they can most often be controlled. Swayne told me that H5N1 might still be eradicated in birds with the help of 'better diagnostic tools and improved strategies to protect birds from infection.'

Cats, tigers and leopards are known to have been infected with the virus in Asia and Europe. An author of the article, Dr. Albert Osterhaus, a virologist and veterinarian at Erasmus Medical Center, has performed experiments showing that cats can give the virus to other cats. But whether they do so in real life, and if so how often, is unknown. Among the many unknowns is how long cats can excrete the virus, the minimal amount of virus it takes to cause infection and whether cats can excrete the virus without developing signs of illness. Dogs, foxes, seals and other carnivores may be vulnerable to the H5N1 virus, Osterhaus said. Tests in Thailand have shown the virus has infected dogs without causing apparent symptoms

Cats, tigers and leopards are known to have been infected with the virus in Asia and Europe. An author of the article, Albert Osterhaus, a virologist and veterinarian at Erasmus Medical Center, has performed experiments showing that cats can give the virus to other cats. But whether they do so in real life, and if so how often, is unknown. Dick Thompson, spokesman for the World Health Organization, said Wednesday that it agreed that more work was needed to determine the role of cats and other carnivores in the epidemiology of avian influenza. Epidemiologists have found no change in the way the virus is spreading or causing illness, Thompson said. But he added, 'Obviously, there still are major gaps in our knowledge and risk assessment.'

Histone amino termini are post-translationally modified by both transcriptional coactivators and corepressors, but the extent to which the relevant histone modifications contribute to gene expression, and the mechanisms by which they do so, are incompletely understood. To address this issue, we have examined the contributions of the histone H3 and H4 amino termini, and of the coactivator and histone acetyltransferase Gcn5p, to activation of a small group of Gcn4p-activated genes. The histone H3 tail exerts a modest (about 2-fold) but significant effect on activation that correlates with a requirement for Gcn5p and is distributed over multiple lysine residues. The H4 tail also plays a positive role in activation of some of those genes tested, but this does not correlate as closely with Gcn5p coactivation. Microarray experiments did not reveal a close correspondence between those genes activated by Gcn4p and genes requiring the H3 or H4 tail, and analysis of published microarray data indicates that Gcn4p-regulated genes are not in general strongly dependent on Gcn5p. However, a large fraction of genes activated by Gcn4p were found to be repressed by the H3 and H4 amino termini under non-inducing conditions, indicating that one role for Gcn4p is to overcome repression mediated by the histone tails

PROBLEM/CONDITION: Survivors of collapsed or damaged buildings from the attack on the World Trade Center (WTC) were among those most exposed to injury hazards, air pollution, and traumatic events. REPORTING PERIOD: This report summarizes data from health outcomes collected during interviews conducted from September 5, 2003, to the close of the World Trade Center Health Registry (WTCHR) enrollment on November 20, 2004. DESCRIPTION OF SYSTEM: WTCHR will be used to monitor periodically the mental and physical health of 71,437 enrollees for 20 years. The analysis is limited to 8,418 adult survivors of collapsed buildings (n = 5,095) and buildings with major or moderate damage (n = 3,323), excluding those who were involved in rescue and recovery. RESULTS: A total of 62.4% of survivors of collapsed or damaged buildings were caught in the dust and debris cloud that resulted from the collapse of the WTC towers, and 63.8% experienced three or more potentially psychologically traumatizing events. Injuries were common (43.6%), but few survivors reported injuries that would have required extensive treatment. More than half (56.6%) of survivors reported experiencing new or worsening respiratory symptoms after the attacks, 23.9% had heartburn/reflux, and 21.0% had severe headaches. At the time of the interview, 10.7% of building survivors screened positive for serious psychological distress (SPD) using the K6 instrument. After multiple adjustments, data indicated that survivors caught in the dust and debris cloud were more likely to report any injuries (adjusted odds ratio [AOR] = 3.9; p< or =0.05); any respiratory symptom (AOR = 2.7; p< or =0.05); severe headaches (AOR = 2.0; p< or =0.05); skin rash/irritation (AOR = 1.7; p< or =0.05); hearing problems or loss (AOR = 1.7; p< or =0.05); heartburn (AOR = 1.7; p< or =0.05); diagnosed stroke (AOR = 5.6; p< or =0.05); self-reported depression, anxiety, or other emotional problem (AOR = 1.4; p< or =0.05); and current SPD (AOR = 2.2; p< or =0.05). Adjustment for SPD did not diminish the observed associations between dust cloud exposure and physical health outcomes. Building type and time of evacuation were associated with injuries on September 11, 2001 and reported symptoms; building type (collapsed versus damaged) also was associated with mental distress. INTERPRETATION: Two to three years after September 11, survivors of buildings that collapsed or that were damaged as a result of the WTC attack reported substantial physical and mental health problems. The long-term ramifications of these effects are unknown. Many survivors were caught directly in the dust and debris of collapsing towers, a dense cloud of particulate matter that might have produced or exacerbated these health effects. PUBLIC HEALTH ACTION RECOMMENDED: Long-term follow-up of building survivors and all other persons enrolled in WTCHR should be maintained, with particular attention to those persons exposed to the dust cloud. Some of these findings might lead to building designs that can minimize injury hazards.

Cats, tigers and leopards are known to have been infected with the virus in Asia and Europe. An author of the article, Dr. Albert Osterhaus, a virologist and veterinarian at Erasmus Medical Center, has performed experiments showing that cats can give the virus to other cats. But whether they do so in real life, and if so how often, is unknown. The team has found that cats can be infected through the respiratory tract. Cats can also be infected when they ingest the virus, which is a novel route for influenza transmission in mammals. But cats excrete only one-thousandth the amount of virus that chickens do, or less, he said. Among the many unknowns is how long cats can excrete the virus, the minimal amount of virus it takes to cause infection and whether cats can excrete the virus without developing signs of illness

The science on the H5N1bird flu virus may not support these conclusions. In fact, two important studies published just last month in top science journals show that this bird flu virus is still multiple mutations away from being able to pass easily among humans. This bird flu appears to be better absorbed by the deep pockets of bird lungs, whereas human flu is absorbed by the cells of our upper airways. Dr. David Swayne, director of the Southeast Poultry Laboratory at the U.S. Department of Agriculture, has worked on avian influenza for many years. He takes all highly pathogenic bird flus seriously, including H5N1, but he feels they can most often be controlled. Swayne told me that H5N1 might still be eradicated in birds with the help of 'better diagnostic tools and improved strategies to protect birds from infection.'

It takes about two months to grow the new bladder on a scaffold outside the body. After implantation, the engineered bladder enlarges over time in the recipient. The researchers say they expect that the new bladder will last a patient's lifetime, but the longevity will be known only as the children grow older. A major advantage of his technique is that rejection cannot occur because the cells used to create a new bladder are from the patient, not from another individual. So an ultimate aim -- still years off -- is to develop the technique to grow a wide variety of other tissues, possibly even organs, to help relieve the shortage of donor organs available for transplanting, said the research team's leader, Dr. Anthony Atala. He directs the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center in Winston-Salem, N.C. After the new bladder formed, in about seven to eight weeks, Dr. Atala removed a large portion of the patient's bladder. Then he sewed the newly created tissue to what is known as the neck of the bladder and to the rest of the remaining portion of the patient's natural bladder