Faculty Bibliography

Anthony S. Fauci, a top AIDS researcher and pioneering immunologist, received the nation's richest medical award, the $500,000 Albany Medical Center Prize. Dr

Most health officials are not advocating resumption of mass vaccination against smallpox, because the vaccine itself can kill and cause injuries, including brain damage. But the disclosure that vaccine supplies are more abundant than had been thought is likely to reignite the debate about how the government should prepare for what most consider the remote possibility of a terrorist attack involving smallpox. Richard J. Markham, chief executive for the American operations of Aventis Pharma, the parent company of [Aventis Pasteur], said in an interview yesterday that the company had told the Department of Health and Human Services about its vaccine stockpile years ago but that the government had shown little interest until after the terrorist attacks last fall. Federal officials, who spoke on condition of anonymity, said the government began negotiations with the company about the stockpile in October but did not disclose its existence because of national security concerns, legal issues and questions about whether the vaccine was effective. Writing for the April 25 issue of The New England Journal of Medicine, Dr. [Anthony Fauci], Dr. Jeffrey M. Drazen, the journal's editor, and Dr. [William J. Bicknell] urge the public to consider agonizing choices: Voluntarily immunize everyone with a vaccine that could kill about 200 Americans, leave some alive but brain damaged, and disfigure others with deep and permanent scars. Or save the vaccine for an attack and use ring vaccination and assume it would contain the epidemic

Dr. [Anthony S. Fauci] turned his attention to AIDS shortly after the disease was recognized in 1981. His research has focused on how H.I.V., the AIDS virus, impairs the immune system and on ways to develop more effective therapies and a vaccine. Ten years later, Dr. Fauci discovered that H.I.V. constantly replicates even very early in the infection and that it occurs in lymph nodes. His team's report on that seminal advance was the most-cited paper in AIDS research worldwide from 1993 to 1995. Dr. Fauci was reported to be Mr. [Tommy G. Thompson]'s choice for director of the National Institutes of Health, but this week the White House instead chose Dr. Elias A. Zerhouni of Johns Hopkins University. Administration officials said they did not want to grant Dr. Fauci's request to keep his current job while directing the institutes. Conservatives opposed him because of his remarks 14 years ago supporting fetal tissue research

Also, there were rumors that Dr. [Jeffrey P. Koplan] had threatened to resign in the first days of the anthrax attack unless his agency was allowed to talk. ''That is absolutely untrue,'' Dr. Koplan said yesterday. He also said that to have resigned ''in the midst of the anthrax attack would have been both unprofessional, unpatriotic and inappropriate.'' Dr. Koplan said: ''What's most important in an investigation of an outbreak like this is not the rough and tumble of Washington politics but the rough and tumble of dealing with a dangerous infectious agent when loose in the field, and that is where we apply our attention. That is the wrestling match I prefer for us to get into, not Washington politics. Let those up there dwell with that.'' ''There has become a certain tendency for an opposition party to say, 'You guys are not doing enough or are not doing it fast enough or are not doing it well enough,' '' Dr. Koplan said. ''Then if, even just two weeks later, the other party is in charge, then it takes the issue on,'' Dr. Koplan said

In October, when the first anthrax-laden envelopes were received, the FBI froze the Centers for Disease Control and Prevention out of the high-profile investigation, according to CDC officials. The US safety net against bioterror was porous because of a turf battle initiated by FBI autocrats, and five people died.

The manufacturer, Olympus America in Melville, N.Y., issued a statement saying it had 'initiated an immediate and vigorous investigation resulting in a prompt recall' and that notices had been sent to 2,361 health-care institutions. The company said it had confirmations that more than 90 percent of the recall notices had been received. The recall was started because in September an infection-control nurse at a hospital in Tennessee noticed an unusually high number of cultures performed on lung secretions collected from bronchoscopes were coming back positive for a bacterium called pseudomonas. Health officials have not identified the hospital. Suspecting contamination, the nurse alerted the state health department. On Monday, Hopkins officials said they did not receive the Nov. 30 recall letter until late January, because it was addressed to an unrelated department loading dock across the street. The letter had a return receipt requested. No one signed for it, and as far as they knew, Hopkins officials said, Olympus didn't follow up