Faculty Bibliography

[Leland Hartwell], cited for discovering a specific class of genes that controls the cell cycle, knew he was being considered for the award. But the Nobel committee could not call him because he had an unlisted telephone number, Hartwell said. Word came when his wife, Teresa Naujack, awakened him about 3 a.m. after she received a call from a public relations worker at the Hutchinson cancer center, who was waiting to learn who had won. A turning point in Hartwell's research was [Paul M. Nurse]'s discovery of a gene known as cdc2 in a different type of yeast. The gene was essential in controlling a phase of cell division, and it turned out to be the same gene that Hartwell had identified in baker's yeast. The Nobel committee cited Hartwell for discovering more than 100 genes that coordinate the four-stage process by which one cell grows, duplicates its chromosomes, verifies this duplication and then divides, leaving two daughter cells to begin the cycle again. Each step in the complex sequence must be perfectly timed to ensure that the next phase proceeds to produce exact, healthy replicas of the parent cell

Tuberculosis among Tibetans increased in New York City between 1995 and 1999. We examined characteristics of 68 Tibetan patients compared to 702 non-Tibetan patients from Nepal, India, or China, diagnosed between January 1995 and December 1999. The number of Tibetan patients increased each year after 1995 whereas non-Tibetans remained stable during the same period. Tibetans were younger (27 vs. 44 years), more likely to be infectious (63% vs. 46%), have multidrug resistance (7% vs. 2%) and shorter time to diagnosis after arrival (9 vs. 79 months, p < 0.01). For Tibetan patients, 68% of identified contacts were evaluated. The prevalence of tuberculosis infection was 65%. In contrast, among non-Tibetan patients 88.8% of contacts were evaluated and 45.2% were infected. Outreach efforts with community leaders and educational presentations at community events have been implemented in an effort to ensure continuity of care and completion of treatment

Forensic use of DNA testing began in 1985 and has evolved into what law enforcement experts call the most powerful tool since the development of fingerprinting in the late 19th century. In the mid- 1990s DNA testing was used to identify exhumed bones as those of Czar Nicholas II and members of his family who were executed in Russia in 1918. In 1998, DNA testing identified the 'unknown soldier' killed in Vietnam. [Robert Shaler] said his laboratory had extracted DNA from 3,200 of the 3,600 tissues it has received and has produced DNA profiles of 839 among them. He added that this week he expected to send the extracted DNA to the private laboratories, where scientists will try to match them with DNA submitted by relatives or from personal items. In tests of preserved tissue, the forensic experts can directly match the DNA extracted from the nucleus of cells from the victim with DNA recovered from personal effects like a toothbrush. Also, the victim's DNA can be compared with that of close relatives

Dr. [Gray, Jr.]; his partner, Dr. Robert D. Dowling; hospital officials and the device's manufacturer, Abiomed of Danvers, Mass., took precautions to map the city's electrical grid and did a test run with an artificial heart to make sure there were no signals that would interfere with Mr. Tools's device