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For the first time since AIDS was discovered nearly 20 years ago, more black and Hispanic gay men were diagnosed with AIDS than white gay men over a year's period, federal health officials reported Thursday. A total of 18,153 AIDS cases were diagnosed among gay men in 1998, the most recent year available, and blacks and Hispanics represented 9,182, or 51 percent, of the cases, the Centers for Disease Control and Prevention said in its weekly report. This compares with 8,678 cases, or 48 percent, for white gay men. Black gay men made up one- third of all AIDS cases among gays, Hispanics 18 percent and Asian and Pacific Islanders 1 percent of the cases in that year, the centers said. The percentages have steadily risen for black and Hispanic gay men as those for white gay men decreased. For the years from 1989 to 1998, the percentage of AIDS cases diagnosed among black and Hispanic gay men rose to 51 percent from 30 percent, and for white gay men it dropped to 48 percent from 69 percent

A total of 18,153 AIDS cases were diagnosed among gay men in 1998, the most recent year for which figures were available, 9,182 of them, or 51 percent of the cases, among black and Hispanic men, the Centers for Disease Control and Prevention said yesterday in a weekly report. This compares with 8,678 cases, or 48 percent, for white gay men. Black gay men made up one-third of the AIDS cases among gay men in 1998, Hispanic men 18 percent and Asian and Pacific Islanders 1 percent, the centers said. Since the AIDS epidemic began, most of the cases have occurred among gay men, and white gay men have made up the largest subgroup. But through the years the percentages have steadily risen for black and Hispanic gay men as those for white gay men decreased

For the first time since AIDS was discovered nearly 20 years ago, more black and Hispanic gay men were diagnosed with AIDS than white gay men over a year's period, federal health officials reported yesterday. A total of 18,153 AIDS cases were diagnosed among gay men in 1998, the most recent year available, and blacks and Hispanics represented 9,182, or 51 percent, of the cases, the Centers for Disease Control and Prevention said in its weekly report. This compares with 8,678 cases, or 48 percent, for white gay men. Black gay men made up one- third of all AIDS cases among gays, Hispanics 18 percent and Asian and Pacific Islanders 1 percent of the cases in that year, the centers said. Since the AIDS epidemic began, most AIDS cases have been among gay men, and white gay men have made up the largest subgroup. But through the years, the percentages have steadily risen for black and Hispanic gay men as those for white gay men decreased

There were 18,153 AIDS cases diagnosed among gay men in 1998, the most recent year available, and blacks and Hispanics represented 9,182, or 51 percent, of the cases, the Centers for Disease Control and Prevention said in its weekly report. This compares with 8,678 cases, or 48 percent, for white gay men. Black gay men made up one- third of all AIDS cases among gays, Hispanics 18 percent and Asian and Pacific Islanders 1 percent of the cases in that year, the centers said. Since the AIDS epidemic began, most AIDS cases have been among gay men, and white gay men have made up the largest subgroup. But through the years the percentages have steadily risen for black and Hispanic gay men as those for white gay men decreased

Lipoarabinomannan (LAM) is a component of the mycobacterial surface which has been associated with a variety of deleterious effects on immune system function. Despite the importance of LAM to the pathogenesis of mycobacterial infection, there is no information available on its fate in vivo. In this study, we determined the pharmacokinetics and tissue distribution of exogenously administered LAM in mice. For measurements of serum and tissue LAM concentrations, we developed an enzyme-linked immunosorbent assay which used monoclonal antibodies of different isotypes to capture and detect LAM at concentrations of >/=0.4 microg/ml. Intravenous administration of LAM to mice resulted in transient serum levels with organ deposition in the spleen and in the liver. Immunohistochemical studies localized LAM to the spleen marginal zone macrophages and, to a lesser degree, to liver macrophages. When LAM was administered to mice previously given a LAM-binding immunoglobulin M (IgM), LAM was very rapidly cleared from circulation. In those mice, deposition of LAM in the spleen was significantly reduced while LAM deposition in the liver increased. Administration of LAM-binding IgM resulted in significant levels of IgM to LAM in bile consistent with an increased hepatobiliary excretion of LAM in the presence of specific antibody. Bile, liver extracts, and bile salts were found to rapidly inactivate the immunoreactivity of LAM. The results indicate that serum clearance and organ deposition of LAM in mice are affected by the presence of LAM-binding antibody and suggest a mechanism by which antibody could modify the course of mycobacterial infection.