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14324

Public health. 2025:251.DOI: 10.1016/j.puhe.2025.106102

Public reporting guidelines for outbreak data: Enabling accountability for effective outbreak response by developing standards for transparency and uniformity

Grégoire, V; Zhu, A W; Brown, C M; Brownstein, J S; Cardo, D; Cumming, F; Danila, R; Donnelly, C A; Duchin, J S; Fill, M A; Fullerton, K; Funk, S; George, D; Hopkins, S; Kraemer, M U G; Layton, M; Lessler, J; Lynfield, R; McCaw, J M; McPherson, T D; Moore, Z; Morgan, O; Riley, S; Rosenfeld, R; Samoff, E; Schaffner, W; Shaffner, J; Sturm, R; Terashita, D; Walke, H; Washington, R E; Rivers, C M
OBJECTIVES/OBJECTIVE:There are few standards for what information about an infectious disease outbreak should be reported to the public and when. To address this problem, we undertook a consensus process to develop recommendations for what epidemiological information public health authorities should report to the public during an outbreak. STUDY DESIGN/METHODS:We conducted a Delphi study following the steps outlined in the ACcurate COnsensus Reporting Document (ACCORD) for health-related activities or research. METHODS:We assembled a steering committee of nine experts representing federal and state public health, academia, and international partners to develop a candidate list of reporting items. We then invited 45 experts, 35 of whom agreed to participate in a Delphi panel. Of those, 25 participated in voting in the first round, 25 in the second round, and 25 in the third round, demonstrating consistent engagement in the consensus-building process. The final stage of the Delphi process consisted of a hybrid consensus meeting to finalize the voting items. RESULTS:The Delphi process yielded nine core reporting items representing a minimum standard for public outbreak reporting: numbers of new confirmed cases, new hospital admissions, new deaths, cumulative confirmed cases, cumulative hospital admissions, and cumulative deaths, each reported weekly and at Administrative Level 1 (typically state or province), and stratified by sex, age group, and race/ethnicity. CONCLUSIONS:This minimum reporting standard creates a strong framework for uniform sharing of outbreak information and promotes consistency of data between jurisdictions, enabling effective response by promoting access to information about an unfolding epidemic.
PMID: 41420992
ISSN: 1476-5616
CID: 5979862
Journal of human hypertension. 2025:39(12):822-830.DOI: 10.1038/s41371-025-01078-6

Role of hypertension in the cardiovascular-kidney-metabolic syndrome among black adults: The Jackson Heart Study

Ghazi, Lama; Dubal, Medha; Bertoni, Alain; Carson, April; Young, Bessie A; Lewis, Cora E; Alanaeme, Chibuike J; Johnson, Dayna A; Shimbo, Daichi; Foti, Kathryn; Colantonio, Lisandro D; Arabadjian, Milla; Tanner, Rikki; Muntner, Paul
The cardiovascular-kidney-metabolic (CKM) syndrome consists of four progressive stages and is characterized by the interaction of metabolic risk factors, chronic kidney disease (CKD), and cardiovascular disease (CVD). We assessed the prevalence of hypertension in CKM and its role in progression to more advanced stages. We included 2118 Black adults from the Jackson Heart Study without a history of coronary heart disease, heart failure, stroke or stage 0 CKM (normal weight, no metabolic risk factors or CVD) at baseline. Participants were categorized into CKD stage: Stage 1: overweight/obesity, abdominal obesity or dysfunctional adipose tissue without metabolic risk factors or subclinical CVD; Stage 2: metabolic risk factors (hypertension, diabetes, hypertriglyceridemia, metabolic syndrome or CKD); or Stage 3: subclinical CVD. We used Cox proportional hazards regression to estimate the hazard ratio (HR) of developing stage 4 CKM, defined by a CVD event, in participants with hypertension and stages 2 and 3 CKM. At baseline, 20.2, 69.1 and 10.6% of participants had stage 1, 2 and 3 CKM, respectively. Hypertension was the most common metabolic risk factor in participants with stage 2 and 3 CKM with a prevalence of 80 and 95%, respectively. Incidence rates (95%CI) of stage 4 CKM per 1000 person-years were 1.4 (0.4, 2.4) for stage 1 CKM, 7.5 (6.1, 8.9) for stage 2 CKM with hypertension, and 26.6 (19.8, 33.3) for stage 3 CKM with hypertension. The HRs (95% CI) for developing stage 4 CKM were 3.25 (1.56, 6.80) and 5.11 (2.05,12.78) among participants with hypertension and stage 2 and 3 CKM versus stage 1 CKM, respectively. Hypertension was associated with an increased risk for progression to stage 4 CKM among Black adults.
PMCID:12685740
PMID: 41046247
ISSN: 1476-5527
CID: 5976992
Journal of clinical medicine. 2025:14(23).DOI: 10.3390/jcm14238466

Meta-Analysis of AI Integration in Abdominal Imaging for Liver Fibrosis and MASLD: Evaluating Diagnostic Accuracy and Clinical Impact

Pugliesi, Rosa Alba; Ben Mansour, Karim; Apitzsch, Jonas; Papachristodoulou, Angeliki; Rafailidis, Vasileios; Katz, Douglas S
PMCID:12693291
PMID: 41375769
ISSN: 2077-0383
CID: 5977612
Canadian journal of surgery = Journal canadien de chirurgie. 2025:68(6suppl3):S58-S132.DOI: 10.1503/cjs.020125

Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Manoir Richelieu, La Malbaie, Charlevoix, Que., Canada

Chan, Vivien; Gausper, Adeesya; Liu, Andy; Andras, Lindsay M; Illingworth, Kenneth D; Skaggs, David L; Imbeault, Rachelle; Dufresne, Justin; Parent, Stefan; Deschênes, Sylvain; Roy-Beaudry, Marjolaine; Legler, Jack; Benaroch, Lee; Pirshahid, Ali Ahmadi; Serhan, Olivia; Cheng, Draydon; Bartley, Debra; Carey, Timothy; Rasoulinejad, Parham; Singh, Supriya; Thornley, Patrick; Skaik, Khaled; Belanger, Genevieve; Phan, Philippe; Stratton, Alexandra; Matthew, Coyle; Kingwell, Stephen; Tsai, Eve; Wai, Eugene; Fonteyne, Hannah; Hryniuk, Sarah Southon; Parent, Eric; Huang, Eric; Stampe, Kyle; Beaulieu, Marie J; Chan, Monica; Thevasagayam, Gloria; Marino-Merlo, Gabriela; Malhotra, Armaan K; Lozano, Christopher S; Salaheen, Zaid; Malvea, Anahita; Shakil, Husain; Yefet, Leeor; Moghaddamjou, Ali; Molot-Toker, Sam; Witiw, Christopher D; Wilson, Jefferson R; Christian, Eisha; Quon, Jennifer L; Dirks, Peter B; Drake, James M; Rutka, James T; Kulkarni, Abhaya V; Zeller, Reinhard; Lebel, David E; Ibrahim, George M; Dionne, Antoine; Joncas, Julie; Barchi, Soraya; Parent, Stefan; Mac-Thiong, Jean-Marc; Yoon, Samuel; Aboelmagd, Karim; Sivakuganandan, Archana; Zulfiqar, Amna; Murphy, Anne; Moll, Stanley; Sorbara, Julia; Rocos, Brett; Lebel, David; Camp, Mark; Chan, Vivien; Shumilak, Geoffrey; Malhotra, Armaan K; Dansby, Jalen; Liu, Andy M; Chan-Tai-Kong, Andrew Michael; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Lu, Daisy A; Wang, Zhi; Clar, Monique; Al-Shakfa, M Fidaa; Shen, Jesse; Rasoulinejad, Parham; Miyanji, Firoz; Kantar, Karim; Carey, Timothy; Bailey, Chris; Ghag, Ravi; Lanting, Brent; Singh, Supriya; Urquhart, Jennifer; Lung, Tiffany; Sardar, Zeeshan; Basu, Saumayajit; Gupta, Manish; Lewis, Stephen; Eissa, Abdullah T; Kato, So; Lenke, Lawrence; Jones, Kristen; Nielsen, Christopher; Basu, Saumyajit; Kelly, Michael; Smith, Justin; Strantzas, Samuel; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Quraishi, Nasir; Gray, Randolph; Yoshida, Go; Aziz, Amer; Lewis, Stephen; Chaves, Jennyfer Paulla Galdino; Hsu, Brian; Sima, Stone; Singh, Bhisham; Kulkarni, Vinay; Diwan, Ashish; Ludwig, Taryn; Moghaddam, Farbod; Aminghafari, Mina; Choi, May; Nicholls, Fred; Seider, Eliana; Daunt, Lauren; Vashishth, Vanessa; Abbas, Aazad; Cadieux, Chloe; Lewis, Stephen; Ahmadi, Ali; Brzozowski, Pawel; Toobaie, Asra; Rasoulinejad, Parham; Fernandes, Renan Rodrigues; Young, James J; Urquhart, Jennifer; Bailey, Chris; McIntosh, Greg; Glennie, Andrew; Fisher, Charles; Perruccio, Anthony V; Rampersaud, Raja; Glennie, Andrew; Urquhart, Jennifer; Mishreky, Amir; Fisher, Charles; Rampersaud, Raja; Bailey, Chris; MacLean, Mark A; Julien, Lisa; Patriquin, Glenn; Leblanc, Jason; Greene, Ryan; Alant, Jacob; Barry, Sean; Glennie, R Andrew; Oxner, William; Christie, Sean D; Pedro, Karlo; Abbas, Aazad; Bailey, Christopher; Urquhart, Jennifer; MacIntosh, Greg; Glennie, Andrew; Fisher, Charles; Phan, Philippe; Rampersaud, Y Raja; Smith, Daniel P; Bigney, Erin E; Hebert, Jeffrey; Richardson, Eden A; Manson, Neil A; Abraham, Edward; Zein, Abdullah; Holt, Kyra; Isaac, Hannah; Kearney, Jill; Small, Chris; Evaniew, Nathan; Alduwaisan, Abdullah; Smith, Victoria; Whittaker, Tara; Eckenswiller, Denise; Soumbasis, Elias; Tanguay, Robert; Jacobs, W Bradley; Thomas, Kenneth C; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Nahanni, Celina; Lung, Tiffany S; Young, James J; Cadieux, Chloe N; Du, Jin Tong; Rampersaud, Raja; Glennie, Andrew; Dunning, Cynthia; Jones, Emma; Oxner, William; Lobo, Kaike; Łajczak, Paweł; Santos, Claudia; Rajab, Numa; Oliveira, Rafael; Silva, Yasmin Picanco; Barbosa, Ramon Guerra; Silva, Yan G M D; Abbas, Aazad; Sahi, Gurjovan; Du, Jin Tong; Johnson, Michael; Buchel, Edward; Toor, Jay; Kulkarni, Ronit; Bertolino, Melanie; Walton, Chase; Rivas, Gabriella; Glaser, John; Reitman, Charles A; Lawrence, James; Ravinsky, Robert; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan K; Nathens, Avery B; Badhiwala, Jetan; Yuan, Eva Y; He, Yingshi; Mathieu, Francois; Sklar, Michael C; Wilson, Jefferson; Witiw, Christopher D; Yoon, Samuel; Reda, Luke A; Malhotra, Armaan; Shakil, Hussain; Fehlings, Michael G; Witiw, Christopher D; Wilson, Jefferson R; Badhiwala, Jetan H; Sadiqi, Said; Muijs, Sander P J; Dandurand, Charlotte; Dvorak, Marcel F; Oner, F Cumhur; ,; Dionne, Antoine; Richard-Denis, Andréane; Phan, Philippe; Mputu, Pascal Mputu; Mac-Thiong, Jean-Marc; Le, Vivian Huong Hoang Thien; Mputu, Pascal Mputu; Richard-Denis, Andreane; Bernard, Francis; Cavayas, Yiorgos Alexandros; Dionne, Antoine; Mac-Thiong, Jean-Marc; Attabib, Najmedden A; Hong, Heather A; Kurban, Dilnur; Yang, Tianyu; Fallah, Nader; Cheng, Christiana L; Humphreys, Suzanne; Noonan, Vanessa K; El-Mughayyar, Dana; Craig, Michael; O'Connell, Colleen; ,; Shakil, Husain; Hu, Zixuan; Smith, Christopher W; Malhotra, Armaan K; Essa, Ahmad; Ling, Hui M; Khan, Zakariya M; Sejdic, Ervin; Colak, Errol; Witiw, Christopher D; Duguay, Maude; Hernandez, Juan David Cifuentes; Mac-Thiong, Jean-Marc; Dionne, Antoine; Bensoussan, Natan; Richard-Denis, Andreane; Carrier, Louis; Blanchard, Jocelyn; LaRue, Bernard; Paquette, Ariane; Silva, Yan Gabriel Morais; Nielsen, Christopher J; Bhatt, Vaidehi; Lewis, Stephen J; Rampersaud, Y Raja; Rosenstein, Brent; Montpetit, Chanelle; Vaillancourt, Nicolas; Dover, Geoffrey; Weiss, Christina; Papula, Lee Ann; Melek, Antonys; Fortin, Maryse; Fazlollahi, Ali M; Barak, Uri; Kalhor, Samira; Nguyen, Joshua Hien; Santaguida, Carlo; Raj, Ruheksh; Lewkonia, Peter; Rogan, Kyle; Marchuk, Allison; Barrett, Erin; Masson, Anand; Pratt, Brandy; Michaud, Danielle; Skyrda, Kateryna; Simms, Sierra; Yang, Michael; Herrington, Brandon J; Urquhart, Jennifer C; Rasoulinejad, Parham; Siddiqi, Fawaz; Gurr, Kevin; Bailey, Christopher S; Chayer, Mathieu; Phan, Philippe; Arnoux, Pierre-Jean; Wang, Zhi; Rawlinson, Jeremy; Aruwajoye, Olumide; Aubin, Carl-Éric; Samhat, Hussein; Pedro, Karlo M; Pirshahid, Ali Ahmadi; Charest-Morin, Raphaële; Gore, Genevieve; Filion, Kristian B; Lasry, Oliver; Levett, Jordan J; Dea, Nicolas; Evanview, Nathan; McIntosh, Greg; Weber, Michael H; Rinott, Nadav; Laflamme, Mathieu; McIntosh, Greg; Evaniew, Nathan; Weber, Michael H; Dea, Nicolas; Liu, Andy; Tuchman, Alexander; Mikhail, Christopher; Chan, Vivien; McDonald, James; Zaldivar, Julien; Dea, Nicolas; Koegl, Nikolaus; McIntosh, Greg; Evaniew, Nathan; Lonjon, Guillaume; Vassal, Matthieu; Dhenin, Alexandre; Perez, Alexis; Dupuy, Martin; Challier, Vincent; Castelain, Jean-Etienne; Ghailane, Soufiane; Campana, Matthieu; Lebhar, Jonathan; Guerin, Gilles; Pellet, Nicolas; Sabah, Yann; Chevillotte, Thomas; Darnis, Alice; Cristini, Joseph; Ferracci, François-Xavier; Delambre, Jérôme; Queinnec, Steffen; Delmotte, Alexandre; Marinho, Paulo; Gauthe, Rémi; Hannequin, Pierre; Gilard, Vianney; Meyblum, Jean; Perrin, Alexis; Pietton, Raphaël; Lonjon, Nicolas; Gennari, Antoine; Malhotra, Armaan K; Shakil, Husain; Essa, Ahmad; Evaniew, Nathan; ,; Witiw, Christopher D; Wilson, Jefferson R; Dea, Nicolas; Al-Shawwa, Abdul; Craig, Michael; Ost, Kalum; Jacobs, W Bradley; Evaniew, Nathan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth C; Yang, Michael M H; Adad, Julien-Cohen; Cadotte, David W; Wangai, Isaac; Nataraj, Andrew; Hojanepesov, Osman; Cadotte, David; Skarsgard, Matthew; Evaniew, Nathan; Paquet, Jerome; Dhaliwal, Perry; Attabib, Najmedden; Urquhart, Jennifer; Dea, Nicolas; Bailey, Chris; Karthikeyan, Vishwathsen; Shakil, Husain; Malhotra, Armaan; Lozano, Christopher; Wilson, Jefferson; Fehlings, Michael; Badhiwala, Jetan; Koegl, Nikolaus; McIntosh, Greg; Dea, Nicolas; Evaniew, Nathan; Charest-Morin, Raphaële; Kurtz, Daniel; Phan, Philippe; Sun, Christopher; Cho, Newton; Al-Shawwa, Abdul; Jacobs, Bradley; Evaniew, Nathan; Bouchard, Jacques; Casha, Steven; duPlessis, Stephan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth; Yang, Michael; Cohen-Adad, Julien; Cadotte, David; Charest-Morin, Raphaële; Hansen, Landon; Yip, Stephen; Dea, Nicolas; Goodwin, Rory C; Fisher, Charles G; Bettegowda, Chetan; Versteeg, Anne L; Sahgal, Arjun; Laufer, Ilya; Rhines, Laurence; Sciubba, Daniel; Schuster, James; Weber, Michael; Lazary, Aron; Boriani, Stefano; Bettegowda, Chetan; Fehlings, Michael; Clarke, Michelle; Arnold, Paul; Gokaslan, Ziya; Fisher, Charles; Versteeg, Anne; Weber, Michael; De La Garza Ramos, Rafael; Shin, John; Pahuta, Mark; Luzatti, Alessandro; Disch, Alexander; Gasbarrini, Alessandro; Verlaan, Jorrit-Jan; Teixeira, William; Sahgal, Arjun; Laufer, Ilya; Lazary, Aron; Chou, Dean; Fisher, Charles; Gokaslan, Ziya; Fehlings, Michael; Rhines, Laurence; Mesfin, Addisu; Sciubba, Daniel; Bettegowda, Chetan; Goldschlager, Tony; Netzer, Cordula; Clarke, Michelle; O'Toole, John; Boriani, Stefano; Barzilai, Ori; Kawahara, Nori; Kumar, Naresh; Dea, Nicolas; Reynolds, Jeremy; Goodwin, Rory; Charest-Morin, Raphaële; ,; Shakil, Husain; Malhotra, Armaan K; Essa, Ahmad; Karthikeyan, Vishwathsen; Lozano, Christopher S; Badhiwala, Jetan H; Sahgal, Arjun; Dea, Nicolas; Fehlings, Michael G; Kiss, Alex; Witiw, Christopher D; Redelmeier, Donald A; Wilson, Jefferson R; Kwan, William Chu; Koegl, Nikolaus; Dea, Nicolas; Fisher, Charles; Charest-Morin, Raphaële; Rocha, Alexandra; Renaud, Matthew; Urquhart, Jennifer; Singh, Supriya; Caceres, Marco Perez; Ahmed, Omer; Freire, Véronique; Shen, Jesse; Al-Shakfa, Fidaa; Boulé, Danielle; Wang, Zhi; Lozano, Christopher S; Malhotra, Armaan K; Karthikeyan, Vishwathsen; Shakil, Husain; Balasubramaniam, Neevya; Wilson, Jefferson R; Witiw, Christopher; Jacobs, W Bradley; Wang, Zhi; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Chris; Bangsboll, Emily; Roach, Koren; Duncan, Neil; Salo, Paul; Bouchard, Jacques; Ronsky, Janet; Swamy, Ganesh; Ngana, Germain Sophie; Nassrullah, Zain; Alhantoobi, Mohamed; Al-Assiri, Suhail S; Al-Zailaie, Abdulaziz; Ngetich, Geofrey; Kwok, Desmond; Pahuta, Markian; Martinyuk, Amanda; Guha, Daipayan; Evaniew, Nathan; Malholtra, Armaan K; Charest-Morin, Raphaële; Soroceanu, Alex; Jacobs, W Bradley; Cadotte, David W; Dea, Nicolas; Halabian, Negeen; Deng, Jiawen; Alvi, Mohammed Ali; Pedro, Karlo M; Fehlings, Michael G; Cho, Newton; Al-Shawwa, Abdul; Jacobs, Bradley; Evaniew, Nathan; Lewkonia, Peter; Nicholls, Fred; Soroceanu, Alex; Swamy, Ganesh; Thomas, Kenneth; Yang, Michael; Cadotte, David; Siddiqi, Omar; Urquhart, Jennifer; Fernandes, Renan Rodrigues; Wangai, Isaac; Walker, Taryn; Alanezi, Turki; Raj, Ruheksh; Bailey, Chris; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Tobin, Jacqueline; Martin, John; Kouame, Mark; Rivas, Gabriella; Reitman, Charles; Glaser, John; Lawrence, James; Ravinsky, Robert; Alfawaz, Thamer; Zhang, Tinghua; Dea, Nicolas; Evaniew, Nathan; Phan, Philippe; Outcomes, Canadian Spine; Network, Research; Karthikeyan, Vishwathsen; Shakil, Husain; Malhotra, Armaan; Lozano, Christopher; Wilson, Jefferson; Silva, Yan G M D; Barbosa, Ramon; de Souza Rodrigues Júnior, Erenaldo; Filho, Carlos Alberto Assunção; Gomes, Rodrigo; de Oliveira, Luis Fernando Weber; Fay, Mary; Christie, Sean; Barry, Sean; Lethbridge, Lynn; Oxner, William; Johnston, Emily; Glennie, Andrew; Belanger, Geneviève L; Wai, Eugene K; Skaik, Khaled; Smith-Forrester, Jenna; Rowicki, Michelle; Gillis, Justina; Jones, Karen; Freeman, Jason; Mitchell, Matt; MacLean, Emily; Hollahan, Renee; Hardy, Leslie; MacDonald, Christina; Decker, Alissa; Barry, Sean; Glennie, Andrew; Oxner, William; Weise, Lutz; Christie, Sean; Barter, Lauren; Glennie, Andrew; Christie, Sean; Zwicker, Cynthia Dunning; Oxner, Bill; Jaffe, Rachael; Malhotra, Armaan; Shakil, Husain; Witiw, Christopher; Bradley, Sarah; Martin, John; Rivas, Gabriella; Seeger, Sydney; Glaser, John; Reitman, Charles; Lawrence, James; Ravinsky, Robert; Daunt, Lauren I; Vashishth, Vanessa; Seider, Eliana; Abbas, Aazad; Daziano, Mauricio Campos; Rienmüller, Anna C; Ames, Christopher; Lewis, Stephen J; Kow, Chien Yew; Moghaddam, Farbod; Choi, May; Nicholls, Fred; Cadieux, Chloe; Rienmüller, Anna C; Kwan, Kenny Yat Hong; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Smith, Justin; Quraishi, Nasir; Gray, Randolph; Basu, Saumyajii; Yoshida, Go; Lenke, Lawrence; Lewis, Stephen J; Nielsen, Christopher J; Alavi, Fatemeh; Dantas, Francois; Rampersaud, Y Raja; Lewis, Stephen J; Łajczak, Paweł; Silva, Yasmin Picanco; Ayesha, Ayesha; Von Quednow, Enzo; Jabbar, Rabbia; Zottele, Mariana Zamprogno; Nascimento, Gabriela Fonseca; Rocha, Fabio Victor Vieira; Sahin, Oguz Kagan; Sharma, Eshita; Barbosa, Ramon; Fagundes, Walter; Silva, Yan G M D; Kow, Chien Yew; Moghaddam, Farbod; Choi, May; Nicholls, Fred; Chaves, Jennyfer Paulla Galdino; Hsu, Brian; Sima, Stone; Singh, Bhisham; Diwan, Ashish; Smith, Victoria; Evaniew, Nathan; Soroceanu, Alex; Lewis, Steve; Nicholls, Fred; Swamy, Ganesh; Abdelnour, Mark; Cierson, Tanya; Mumtaz, Rohail; Zhang, TingHua; Alhowsawi, Mamdoh; Swamy, Ganesh; Thomas, Kenneth; Soroceanu, Alex; Wang, Zhi; Stratton, Alexandra; Kingwell, Stephen; Wai, Eugene; Tsai, Eve; Phan, Philippe Tran Nhut; Cadieux, Chloe; Kato, So; Klineberg, Eric; Yilgor, Caglar; Kelly, Michael; Lenke, Lawrence; Shaffrey, Christopher; Cheung, Kenneth; Berven, Sigurd; Matsuyama, Yukihiro; Pellise, Ferran; Dahl, Benny N; Spruit, Maarten; Alanay, Ahmet; Lewis, Stephen J; Eissa, Abdullah T; Kato, So; Lenke, Lawrence; Jones, Kristen; Nielsen, Christopher; Basu, Saumyajit; Kelly, Michael; Strantzas, Samuel; Qiu, Yong; Pellise, Ferran; Alanay, Ahmet; Quraishi, Nasir; Gray, Randolph; Yoshida, Go; Aziz, Amer; Lewis, Stephen; Chan, Vivien; Etigunta, Suhas; Malhotra, Armaan K; Shumilak, Geoffrey; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Kato, So; Sardar, Zeeshan; Lenke, Lawrence G; Lewis, Stephen J; Switzer, Lily; Aboelmagd, Karim; Anthony, Alison; Nadler, Emma; Dermott, Jennifer A; Camp, Mark; Lebel, David E; Aboelmagd, Karim; Versteeg, Anne; Camp, Mark; Zeller, Reinhard; Lebel, David; Batista, Nuno M; Liu, Taylor; Romeo, Jessica; Tice, Andrew; Jarvis, James; Smit, Kevin; Imbeault, Rachelle; Shen, Jesse; Parent, Stefan; Alzakri, Abdulmajeed; Turcot, Olivier; Beauséjour, Marie; Roy-Beaudry, Marjolaine; Barchi, Soraya; Turgeon, Isabelle; Yoon, Samuel; Rutz, Erich; Percival, Mia; Johnson, Michael B; Lundine, Kris; Chan, Vivien; Shumilak, Geoffrey; Malhotra, Armaan K; Lebel, David E; Illingworth, Kenneth D; Skaggs, David L; Nielsen, Christopher J; Alavi, Fatemeh; Dantas, Francois; Rampersaud, Y Raja; Lewis, Stephen J; Chan, Vivien; Kong, Andrew Michael Chan Tai; Gausper, Adeesya; Etigunta, Suhas; Liu, Andy M; Illingworth, Kenneth D; Skaggs, David L; Łajczak, Paweł; Sharma, Eshita; Petry, Iago Nathan Simon; Jabbar, Rabbia; Silva, Yasmin Picanço; Rocha, Fabio Victor Vieira; Sahin, Oguz Kagan; da Silva Lobo, Kaike Eduardo; Ayesha, Ayesha; Ahmed, Aisha Rizwan; Fagundes, Walter; Silva, Yan G M D; Abbas, Aazad; Pedro, Karlo; Bailey, Christopher; Phan, Philippe; Uruqhurt, Jennifer; McIntosh, Greg; Rampersaud, Y Raja; Cadieux, Chloe; Lung, Tiffany; Du, Jin Tong; Nahanni, Celina; Nielsen, Christopher; Lewis, Stephen J; Rampersaud, Raja Y; Ross, Nicolas; Aleman, Carlos; Dhenin, Alexandre; Vassal, Matthieu; Lonjon, Guillaume; Salimi, Hamidullah; Terai, Hidetomi; Tamai, Koji; Uematsu, Masato; Katsuda, Hiroshi; Sharma, Eshita; Ayesha, Ayesha; Lobo, Kaike Eduardo Silva; Pomianoski, Beatriz Westphalen; Kotochinsky, Jose Martin; Silva, Yan G M D; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Kim, Jieun; Roberts, Richard; Kortbeek, Frank; MacLean, Mark A; Rampersaud, Y Raja; Bailey, Chris; Fisher, Charles; Glennie, R Andrew; Lonjon, Guillaume; Dhenin, Alexandre; Vassal, Matthieu; Van Brenk, Hannah; Bigney, Erin E; Manson, Neil A; Small, Chris; Abraham, Edward; Attabib, Najmedden; Kearney, Jill; Richardson, Eden A; deVries, Gwyneth; Dombrowski, Stephan; ,; Hebert, Jeffrey; Barbosa, Ramon Guerra; Pimenta, Newton; Silva, Yan; Fernandes, Renan Rodrigues; Jacobs, Bradley; Witiw, Christopher; Wang, Zhi; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Christopher; Faridi, Sufyan; Bigney, Erin; Hebert, Jeffrey; Manson, Neil; Abraham, Edward; Small, Chris; Richardson, Eden; Kearney, Jill; Attabib, Najmedden; Rampersaud, Y Raja; Power, J Denise; Kapoor, Mohit; Perruccio, Anthony V; Sharma, Eshita; Lobo, Kaike Eduardo Silva; Ayesha, Ayesha; Łajczak, Paweł; Pomianoski, Beatriz Westphalen; Silva, Yan G M D; Wang, Zhi; Jacobs, Bradley; Witiw, Christopher; Dhaliwal, Perry; Santaguida, Carlo; Bailey, Chris; Wright, Alicia; Rosenstein, Brent; Montpetit, Chanelle; Vaillancourt, Nicolas; Fortin, Maryse; Rosenstein, Brent; Bergevin, Maxime; Bobeuf, Florian; Bherer, Louis; Pageaux, Benjamin; Roy, Mathieu; Fortin, Maryse; Wolfe, Daniel; Dover, Geoffrey; Boily, Mathieu; Fortin, Maryse; Nadler, Emma; Lebel, David E; Kim, Dorothy J; Dermott, Jennifer A; Wagman, Emma; Kim, Dorothy J; Nadler, Emma; Lebel, David E; Dermott, Jennifer A; Provost, Myriam; Cobetto, Nikita; Beausejour, Marie; Joncas, Julie; Rojas, Francisca; Tran, Shi-Jia; Sharma, Dhawal; Balondona, Aurelien; Labelle, Hubert; Aubin, Carl-Eric; Chan, Vivien; Michael, George; Illingworth, Kenneth D; Skaggs, David L; Thibault, Jérémie; Dionne, Antoine; Mac-Thiong, Jean-Marc; Olijnyk, Leonardo; Le, Vivian Huong Hoang Thien; Al-Shakfa, Fidaa; Florial, Edisond; Shedid, Daniel; Yuh, Sung-Joo; Boubez, Ghassan; Shen, Jesse; Wang, Zhi; Le, Vivian Huong Hoang Thien; Olijnyk, Leonardo; Al-Shakfa, Fidaa; Florial, Edisond; Shedid, Daniel; Yuh, Sunj-Joo; Boubez, Ghassan; Wang, Zhi; Truong, Van Tri; Dang, The Khanh; Osman, Galil; Al-Shakfa, Fidaa; Boulé, Danielle; Phan, Philippe; Shen, Jesse; Wang, Zhi; Versteeg, Anne; Abdoelmagd, Karim; Camp, Mark; Lebel, David; Hopyan, Sevan; Lewis, Stephen; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan K; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Anekstien, Yoram; Azad, Tej D; Wilson, Jefferson R; Witiw, Christopher D; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Ryan, Gareth; Smith, Victoria; Nicholls, Fred; Lischynski, Jennifer R; Brar, Karnvir; Siddiqui, Aasiyah; Galdino, Jennyfer; Ajoku, Uchenna; Vega, Miguel; Alizadeh, Arsilan; Siddiqui, Faisal; Zeiler, Frederick; Dhaliwal, Perry; Whitten, Tara A; Rotem-Kohavi, Naama; Thorogood, Nancy; Humphreys, Suzanne P; Noonan, Vanessa K; Ho, Chester; Bakal, Jeffrey A; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Pedro, Karlo; Fehlings, Michael; Alvi, Mohammed; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Fehlings, Michael; Pedro, Karlo; Alvi, Mohammed; Dionne, Antoine; Richard-Denis, Andréane; Brouillard, Émile; Lassassy, Ismail; Bourassa-Moreau, Etienne; Khoueir, Paul; Wang, Zhi; Mac-Thiong, Jean-Marc; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Nathens, Avery B; Yuan, Eva Y; He, Yingshi; Mathieu, Francois; Sklar, Michael C; Wilson, Jefferson R; Witiw, Christopher D; Badhiwala, Jetan; Sharma, Ojasvi; Levett, Jordan J; Weber, Michael H; Barbosa, Ramon Guerra; Lages, Gustavo; Alencar, Johmeson; Sadiqi, Said; Hakbijl-van der Wind, Aline J; Egberts, Sylvia; Stolwijk, Janneke; Osterthun, Rutger; van Diemen, Tijn; Oner, F Cumhur; Post, Marcel W M; ,; Hong, Heather A; Parsons, Jessica; Xu, Jijie; Walden, Kristen; Fallah, Nader; Cheng, Christiana L; Attabib, Najmedden; Christie, Sean D; Craven, Cathy B; Fehlings, Michael; Fourney, Daryl R; Kainth, Hardeep S; Kwon, Brian K; Linassi, Gary A; Moganathas, Saranjan; Paquet, Jerome; Mac-Thiong, Jean-Marc; Townson, Andrea F; Urquhart, Jennifer; Tsai, Eve; Whelan, Alex J; Noonan, Vanessa K; ,; Ye, Vincent C; Malhotra, Armaan K; Shakil, Husain; Essa, Ahmad; Witiw, Christopher D; Bond, Michael; Beresford, Aidan; Noonan, Vanessa K; Rotem-Kohavi, Naama; Dvorak, Marcel F; Kwon, Brian K; Liu, Guiping; Sutherland, Jason M; Karthikeyan, Vishwathsen; Lozano, Christopher; Malhotra, Armaan; Shakil, Husain; Wilson, Jefferson; Witiw, Christopher; Badhiwala, Jetan; Chenevert, Alexandre; Lanoue, Charlotte; Couture, Jérôme; Bédard, Sonia; Gammel, Juliette; Silvestre, Jason; Rivas, Gabrielle; Lawrence, James; Ravinsky, Robert; Dermott, Jennifer A; Jaakkimainen, Liisa; To, Teresa; Bouchard, Maryse; Howard, Andrew W; Lebel, David E; Ostertag, Curtis A; Whittaker, Tara; Nicholls, Fred H; Dukkipati, Siril Teja; Driscoll, Mark; Lu, Daisy A; Sahraoui, Oussama; Danino, Alain; Wang, Zhi; Sahi, Gurjovan; Du, Jin Tong; Abbas, Aazad; Hanna, Sager; Berrington, Neil; Almojuela, Alysa; Johnson, Michael; Lewis, Stephen; Goytan, Michael; Toor, Jay; Du, Jin Tong; Lung, Tiffany; Nahanni, Celina; Cadieux, Chloe; Dandal, Gavin; Anderson, Nicola; Lewis, Stephen; Nielsen, Christopher; Massicote, Eric; Rampersaud, Raja; Skaik, Khaled; Phan, Philippe; Belanger, Genevieve; Kingwell, Stephen; Stratton, Alexandra; Coyle, Matthew; Wai, Eugene; Olijnyk, Leonardo; Kaiser, Paul; Brunette-Clément, Tristan; Shedid, Daniel; Yuh, Sung-Joo; Barbosa, Ramon Guerra; Lages, Gustavo; Pimenta, Newton; Murray, Sean A; Driscoll, Mark; Lung, Tiffany; Cadieux, Chloe; Du, Jin Tong; Lazarus, Jed; Nahanni, Celina; Nielsen, Christopher; Rampersaud, Raja; Yoo, Arim; Gandhi, Pranjan; Rajapaksege, Nathasha; Hart, Shannon L; Shi, Victoria; Pahuta, Markian; Guha, Daipayan; Lu, Daisy A; Wang, Zhi; Al-Shakfa, M Fidaa; Shen, Jesse; Mulhall, Drew; Kow, Chien Yew; Masson, Anand Oliveira; Veilleux, Catherine; du Plessis, Stephan; Casha, Steve; Thomas, Ken; Yang, Michael; Valošek, Jan; Bouthillier, Maxime; Cohen-Adad, Julien; ,; Li, Ling Jing; Dukkipati, Siril Teja; Driscoll, Mark; Ludwig, Taryn; Mina, Mina; Gibbon, Stephanie; Bello, Oluwakanyinsola; Anderson, Sarah J; Willetts, Lian; Lewkonia, Peter; Deprato, Andy; Chalmers, Kieran; Tice, Andrew; Romeo, Jessica; Carsen, Sasha; Smit, Kevin; Hadi, Ayesha; Kim, Dorothy J; Doria, Andrea S; Khalvati, Farzad; Chen, Chaojun; Dermott, Jennifer A; Lebel, David E; Dufresne, Justin; Aubert, Benjamin; Imbeault, Rachelle; Roy-Beaudry, Marjolaine; Cresson, Thierry; Parent, Stefan; Liu, Taylor; Tice, Andrew; Romeo, Jessica; Smit, Kevin
PMID: 41386990
ISSN: 1488-2310
CID: 5978112
BMC nephrology. 2025:27(1).DOI: 10.1186/s12882-025-04659-2

Patient monitoring in a pragmatic, multicenter trial of incremental hemodialysis: early experience from the TwoPlus randomized controlled trial

Gautam, Samir C; Awad, Alaa S; Niyyar, Vandana Dua; Flythe, Jennifer E; Abdel-Rahman, Emaad M; Raimann, Jochen G; Woldemichael, Jobira A; Sheikh, Hiba I; Gaurav, Raman; Kotanko, Peter; Yang, Xiwei; Gencerliler, Nihan; Divers, Jasmin; Murea, Mariana
PMID: 41366335
ISSN: 1471-2369
CID: 5977312
JACC: Heart failure. 2025.DOI: 10.1016/j.jchf.2025.102776

Rising Exception Requests in the Current Heart Allocation System

Flattery, Erin; Patel, Suhani S; Golob, Stephanie; Massie, Allan B; Phillips, Katherine; Ali, Syed Zain; Singh, Arushi; Wayda, Brian; Rao, Shaline; Leacche, Marzia; Goldberg, Randal; Reyentovich, Alex; Moazami, Nader; Alam, Amit H
BACKGROUND:Despite the goal of the 2018 revision to the heart allocation policy to reduce reliance on exception requests through improved granularity in status criteria, there has been a dramatic rise in exception requests. OBJECTIVES/OBJECTIVE:This study evaluated trends in exception use over the first 6 years of the updated policy, assessing associated clinical factors, temporal changes, and impact on waitlist outcomes. METHODS:This retrospective transplant registry analysis included all adult isolated heart transplant candidates from October 18, 2018, to September 30, 2024. Candidates were stratified by exception use, listing era, and region. Exception use was compared using Wilcoxon rank-sum and chi-squared tests, with multilevel logistic regression assessing independent associations. Trends over time and across UNOS (United Network for Organ Sharing) regions were evaluated, and a competing risks framework examined time to transplant and waitlist mortality. RESULTS:Among 26,330 candidates, 38.6% used exception requests, with a statistically significant increase over time, particularly in higher priority statuses. Exception use was more common among Black, non-Hispanic candidates, and candidates with blood type O, and less likely for patients with blood type A (P < 0.001). Additionally, pretransplant isolated durable left ventricular assist devices were less common in candidates who requested exceptions (19.0% vs 31.6%; P < 0.001). Overall, 39.9% of exception candidates were listed at status 1 or 2 compared to 29% of nonexception candidates, and 69.2% of exception candidates were removed from the waitlist at status 1 or 2 compared with 37% of nonexception candidates. CONCLUSIONS:The rising use of exceptions underscores ongoing limitations in allocation criteria, and disparities suggesting inequities in access to higher listing status. Policy refinements are needed to ensure a balance between medical urgency and equitable allocation.
PMID: 41329111
ISSN: 2213-1787
CID: 5974852
Open forum infectious diseases. 2025:12(12).DOI: 10.1093/ofid/ofaf677

Amplifying Our Voices: Fostering Advocacy in Infectious Diseases Fellowship

Paras, Molly L; Stead, Wendy; Bisono-Garcia, Bismarck; Pottinger, Paul S; Aziz, Rabita; Aziz, Mariam; Balba, Gayle P; Blackburn, Brian G; Butt, Saira; Chow, Brian; Graber, Christopher J; Muñoz-Gomez, Sigridh; Pellegrino, Rachael A; Schultz, Sara; Shnekendorf, Rachel; Jezek, Amanda; Martin, Arlene; Luther, Vera P; ,
Advocacy has long been at the core of the infectious diseases (ID) field, with clinicians and researchers advocating to ensure patients can access the care they need on an individual and global scale. The Infectious Diseases Society of America Training Program Directors' (PD) Committee met in 2024 and discussed ways that advocacy is and should be incorporated into fellowship training, as well as highlighted the role PDs play in advocating for their trainees. Policies with a negative impact on ID clinical care, public health, and research underscore the importance of mobilizing the field of ID to advocate for the patients and communities we serve, as well as for ourselves. This paper presents ideas generated at this meeting and is meant to serve as a reference for ID PDs, as well as the wider ID community, as a call to action for teaching and participating in advocacy work.
PMCID:12662047
PMID: 41322240
ISSN: 2328-8957
CID: 5974582
Medical mycology case reports. 2025:50.DOI: 10.1016/j.mmcr.2025.100751

Application of plasma cell-free metagenomic next-generation sequencing for the identification of Aspergillus fumigatus donor-derived infections among solid organ transplant recipients [Case Report]

Mah, Jordan K; Hogan, John I; Kothadia, Sonya; Keenan, Jeffrey E; Berger, Johnathan; Carugati, Manuela
A cluster of Aspergillus fumigatus donor-derived infections (DDI) was rapidly diagnosed using plasma metagenomic next-generation sequencing (mNGS) among solid organ transplant recipients. The heart recipient, experiencing marginal hemodynamics, underwent an endomyocardial biopsy, which was concerning for a fungal infection on histopathology. Plasma mNGS was performed, identifying A. fumigatus two days prior to conventional diagnostics. This timely diagnosis enabled prompt nephrectomies in the kidney recipients, who survived. This report represents the first published use of mNGS in the diagnosis of Aspergillus fumigatus DDI, highlighting the utility of this novel, underutilized assay for early diagnosis of donor-derived infections.
PMCID:12663023
PMID: 41324077
ISSN: 2211-7539
CID: 5974682
Prostglandins & other lipid mediators. 2025.DOI: 10.1016/j.prostaglandins.2025.107046

Lipocalin Prostaglandin D₂ Synthase (L-PGDS) Deficiency Disrupts Heme Catabolism and Iron Homeostasis in Mice

Stevenson, Matthew; Chen, Bryan; Srivastava, Ankita; Hall, Chris; Ragolia, Louis
Efficient recycling of red blood cells (RBCs) requires not only heme cleavage but also stabilization of reactive intermediates generated during iron liberation. Lipocalin Prostaglandin D₂ Synthase (L-PGDS, β-trace protein), best known for prostaglandin synthesis, possesses structural and biochemical features consistent with a buffering role in heme catabolism. Here, we show that L-PGDS knockout mice exhibit elevated plasma, increased total splenic iron, reduced total hepatic iron, decreased plasma free heme/hemin, and modest RBC enlargement, consistent with disrupted iron release. Transcript-protein mismatches in key iron regulators, including NRF2 and FPN, further suggest redox imbalance and impaired iron sensing. Despite normal Hmox1 expression, these mice display widespread evidence of inefficient porphyrin clearance. Combined with prior findings that L-PGDS binds ferric biliverdin and is upregulated during heme overload, our results support a model in which L-PGDS buffers porphyrin intermediates to facilitate their safe processing and clearance. This study identifies L-PGDS as a putative auxiliary factor in heme catabolism, with implications for iron recycling, erythropoiesis, and systemic iron homeostasis. All data in this report are from male mice.
PMID: 41274340
ISSN: 1098-8823
CID: 5976242
Blood cancer journal. 2025:15(1).DOI: 10.1038/s41408-025-01424-4

Site-specific prognosis and temporal trends in extranodal marginal zone lymphoma patients in the United States [Letter]

Munir, Malak; Vaughn, John L; Rimmalapudi, Sravani; Epperla, Narendranath
PMCID:12638744
PMID: 41271637
ISSN: 2044-5385
CID: 5976202