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Assessment of Valve Hemodynamics Following Transcatheter Versus Surgical Aortic Valve Replacement in Women With Small Aortic Annulus

Fadel, Elie,Diep, Calvin; Calin, Eliza,Masson, Jean-Bernard; Potvin, Jeannot,Gobeil, Jean-François; Noiseux, Nicolas,Kalavrouziotis, Dimitri; Mohammadi, Siamak,Stevens, Louis-Mathieu; Forcillo, Jessica,
ORIGINAL:7248946
ISSN: 3049-4826
CID: 6073793

DEVELOPMENT OF A HIGH-FIDELITY SIMULATOR TO PREDICT THE RISK OF CORONARY OCCLUSION IN HIGH-RISK VALVE-IN-VALVE PROCEDURES

Calin,E.; Perrin,N.; Ibrahim,R.; Bonan,R.; Tardif,J.; Modine,T.; Granada,J.; Ben Ali,W.
ORIGINAL:7248947
ISSN: 0828-282x
CID: 6073794

Calin, Eliza,Cartier, Andréanne; Nguyen, Olivier,St-Louis, Roxanne; Kalavrouziotis, Dimitri,Noiseux, Nicolas; Pacheco, Christine,Stevens, Louis-Mathieu; Mohammadi, Siamak,Forcillo, Jessica
ORIGINAL:7248945
ISSN: 3049-4826
CID: 6073792

Racism-based traumatic stress symptoms and risk for suicidal thoughts and behaviors among Black and Latine adolescents

Polanco-Roman, Lillian; Galán, Chardée A; Willis, Henry A; Santana, Adrelys Mateo; Satinsky, Emily N; Howard, Lorraine Y; Zhou, Elayne
OBJECTIVE:The present study examined the role of racism-based traumatic stress (RBTS) symptoms (i.e., traumatic stress reactions in direct response to experiences of racial discrimination) and suicide-related risk in a national sample of U.S. Black and Latine adolescents. METHOD/METHODS:= 1.64). Logistic regression analyses were used to test the association between RBTS symptoms and past-year suicidal ideation, plans, and attempts, accounting for conventional and racism-based potentially traumatic exposures (PTEs) and posttraumatic stress disorder symptoms. RESULTS:= .73. CONCLUSION/CONCLUSIONS:RBTS symptoms may be relevant in identifying suicide-related risk, particularly suicide attempts, among Black and Latine adolescents. While these findings provide insights into the relationship between RBTS and suicide-related risk, the cross-sectional design limits causal inference, and the use of a convenience sample may limit generalizability to the broader Black and Latine populations. Tailored interventions that address the nuanced effects of racial trauma on suicide risk are needed among youth of color. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
PMID: 40193482
ISSN: 1942-969x
CID: 6073798

Treating Gout to Target: Protecting the Heart From the First Flare to Long-Term Control [Editorial]

Keenan, Robert T; Cheng, Tang-Kai; Wei, James Cheng-Chung
PMID: 42141714
ISSN: 1756-185x
CID: 6073728

Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause

Carbonneau, Stephen; Mysliwiec, Vincent; Doyle, Audra Lisa; Stratton, Matthew; Dweck, Alyssa; Tartar, Jaime; Alesi, Michaela; Mason, Laura; Komorowski, James; VanDusseldorp, Trisha A
OBJECTIVE:To evaluate a GABAergic, melatonergic, and glutamatergic supplement for enhancing sleep quality in perimenopausal and postmenopausal women with low vasomotor symptom (VMS) burden. METHODS:A randomized, double-blind, placebo-controlled, decentralized trial (NCT07375095) was performed in healthy perimenopausal and postmenopausal women with moderate-to-severe sleep disturbance (patient-reported outcome measure information system sleep disturbance [PROMIS SD] SF 8b T-score ≥60) and minimal VMS (≤5 hot flashes and ≤2 night sweats/wk). Participants were randomized to a neurotransmitter-modulating supplement (NMS; L-theanine, gamma-aminobutyric acid, magnesium, S-adenosyl methionine, propyl gallate) or placebo for three weeks. Primary outcomes were changes in PROMIS SD and sleep-related impairment T-scores and responder rates. Secondary outcomes included diary-based total sleep time, sleep efficiency, and visual analog ratings of sleepiness and daytime functioning. RESULTS:Of 128 randomized participants, 127 completed the trial (NMS, n = 65; placebo, n = 62). Baseline characteristics and VMS frequency were similar between groups (3.0 ± 4.0 hot flashes and 1.9 ± 1.7 night sweats/wk). At week 3, NMS significantly improved PROMIS SD T-score (LS mean difference: -11.1 [95% CI, -13.6 to -8.6]; P = 0.0012) and responder rate (90.9% vs. 45.2%; P < 0.001) versus placebo. PROMIS sleep-related impairment T-score (-4.8 [95% CI, -7.3 to -2.3]; P < 0.001) and responder rate (50.8% vs. 32.2%; P = 0.047) also improved. All primary endpoints reached significance by week 2. NMS increased total sleep time by 40.9 minutes versus a 14.9-minute decrease with placebo (P < 0.001), and sleep efficiency improved by 7.4% versus 3.4% (P = 0.021). No between-group differences in adverse events were observed. CONCLUSION/CONCLUSIONS:In perimenopausal and postmenopausal women with disrupted sleep but minimal VMS, a NMS significantly improved sleep quality and duration.
PMID: 42742055
ISSN: 1530-0374
CID: 6073788

Spatial Transcriptomic Signatures of Cardiac Sarcoidosis

Foong, YH; Singh, A; Malik, M; Zhou, F; Liu, C; Willett, D; Golombeck, D; Zuluaga, T; Le, H; Caplan, AS; Durán, JGB; Fishman, GI; Aizer, A; Reyentovich, A; Peyster, E; Goldberg, RI; Vanguri, R
ORIGINAL:7248934
ISSN: 3050-6611
CID: 6073700

Endoscopic tunneled stricturotomy versus surgical conversion to Roux-en-Y gastric bypass for the management of stenosis after sleeve gastrectomy

Walradt, Trent; Szvarca, Daniel; Thompson, Christopher C
BACKGROUND AND AIMS:Stenosis after laparoscopic sleeve gastrectomy (LSG) is common. Endoscopic balloon dilation is first-line therapy but often requires multiple sessions and may fail. Surgical conversion to Roux-en-Y gastric bypass is effective but invasive. Endoscopic tunneled stricturotomy offers a less-invasive alternative. We compared clinical success, adverse events, and length of stay between endoscopic and surgical treatments for post-LSG stenosis. METHODS:This retrospective, matched cohort study included patients treated with endoscopic stricturotomy (ENDO) group or Roux-en-Y gastric bypass conversion (SURG) group, matched 1:1 by age, sex, body mass index, time from LSG, and previous treatments. The Fisher exact and t tests were used. RESULTS:In 24 patients (12/group), the rate of adverse events was lower in ENDO (0% vs 41.7%, P = .04). Length of stay was shorter in ENDO (1.21 vs 2.57 days, P = .03). Clinical success was 83.3% (ENDO) versus 100% (SURG) (P = .48). CONCLUSIONS:Endoscopic stricturotomy is a safe, effective alternative for refractory post-LSG stenosis.
PMID: 40819677
ISSN: 1097-6779
CID: 6073667

Percutaneous needle decompression for endoscopic iatrogenic pneumoperitoneum: assessment of safety and efficacy in real world practice

Walradt, Trent; Szvarca, Daniel; Melendez Torres, Jonathan; Thompson, Christopher C
PMID: 41986133
ISSN: 1468-3288
CID: 6073672

Validation of the American Society for Gastrointestinal Endoscopy's Complexity Grading System for Endoscopic Procedures

Walradt, Trent J; Szvarca, Daniel P; Jacobson, Brian C
INTRODUCTION/BACKGROUND:We sought to perform the first validation of the American Society for Gastrointestinal Endoscopy complexity grades for esophagogastroduodenoscopy (EGD), colonoscopy, endoscopic retrograde cholangiopancreatography (ERCP), and endoscopic ultrasound (EUS). METHODS:We used Pearson correlation coefficients to measure the correlation between complexity grades and both work relative value units and malpractice relative value units (RVUs) obtained from the Centers for Medicare and Medicaid Services. RESULTS:There was moderate to strong positive correlation between complexity grades and both work relative value unit and malpractice RVU for a range of EGD, colonoscopy, and EUS procedures. This was not observed for ERCP procedures, with many RVU values remaining low for even the most complex ERCP cases. DISCUSSION/CONCLUSIONS:The American Society for Gastrointestinal Endoscopy's endoscopic complexity grading system for EGD, colonoscopy, and EUS seems to correlate reasonably well with other recognized metrics of complexity and risk. The complexity levels for ERCP may be valid, but there is poor correlation with how these procedures are valued by Medicare.
PMCID:13102412
PMID: 41733267
ISSN: 2155-384x
CID: 6073671