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134


RECOVERY OF BENZO(A)PYRENE (BP) METABOLITES AND DIMETHYLNITROSAMINE (DMN) IN RAT SALIVA [Meeting Abstract]

GUTTENPLAN, JB; BONOMO, R; FLIESSBACH, JH
ISI:A1980JP67100492
ISSN: 0197-016x
CID: 154621

Effects of enzyme inducers on dimethylnitrosamine demethylase activity and capacity of isolated microsomes to activate dimethylnitrosamine to a mutagen

Chapter by: Guttenplan, Joseph; Garro, AJ; Hutterer, F
in: Prevention and detection of cancer : proceedings of the Third International Symposium on Detection and Prevention of Cancer, New York, April 26 to May 1, 1976 by Nieburgs, Herbert E (Ed)
New York : M. Dekker, 1977-1980
pp. 139-153
ISBN: 9780824766825
CID: 3830532

Detection of trace amounts of dimethylnitrosamine in a modified Salmonella/microsome assay

Guttenplan, J B
PMID: 377068
ISSN: 0027-5107
CID: 156628

Near quantitative production of molecular nitrogen from metabolism of dimethylnitrosamine

Milstein, S; Guttenplan, J B
PMID: 572222
ISSN: 0006-291x
CID: 156629

EFFECTS OF BILE-ACIDS ON MICROSOMAL METABOLISM OF, AND MUTAGENESIS BY BENZO(A)PYRENE [Meeting Abstract]

UNGER, J; GUTTENPLAN, JB
ISI:A1979GR64900527
ISSN: 0197-016x
CID: 154628

RECOVERY OF BENZO(A)PYRENE, 3-METHYLCHOLANTHRENE AND THEIR METABOLITES IN RAT SALIVA AFTER IP INJECTION [Meeting Abstract]

SNYDER, W; GUTTENPLAN, JB
ISI:A1979GL65502281
ISSN: 0014-9446
CID: 154635

Effects of bile acids on microsomal metabolism of, and mutagenesis by benzo(a)pyrene

Unger, J.; Guttenplan, J. B.
SCOPUS:0018407059
ISSN: 0022-3263
CID: 2819652

Comutagenic effects exerted by N-nitroso compounds

Guttenplan, J B
Mutagenesis induced by dimethylnitrosamine (DMN) and N-methyl-N-nitrosourea (NMU) in Salmonella typhimurium TA100 and TA1530 is characterized by biphasic dose and time response curves. At low doses or short incubation times mutagenic response is minimal, but increases rapidly when an apparent threshold dose or threshold incubation time is exceeded. Bacteria pretreated with subthreshold doses of DMN or NMU were many times more sensitive to the mutagenic effects of methylating and ethylating N-nitroso compounds than were untreated bacteria. The growth phase of the bacteria had little effect on the percentage enhancement of mutagenesis caused by pretreatment with NMU although exponentially growing cells were more sensitive to mutagenesis induced by NMU or diethylnitrosamine. Mutagenesis induced by methylmethanesulfonate and N-propyl-N'-nitro-N-nitrosoguanidine was not significantly enhanced by pretreatment of bacteria with NMU or NEU suggesting that the former mutagens act by different mechanisms than NMU or NEU.
PMID: 370583
ISSN: 0027-5107
CID: 156630

KINETICS, DECOMPOSITION PRODUCTS AND FACTORS AFFECTING THE MUTAGENIC ACTIVITY OF N-METHYL-N-NITROSOUREA [Meeting Abstract]

MILSTEIN, S; GUTTENPLAN, JB
ISI:A1979JD11000050
ISSN: 0192-2521
CID: 154626

Mechanisms of inhibition by ascorbate of microbial mutagenesis induced by N-nitroso compounds

Guttenplan, J B
Mutagenesis induced by N-methyl-N-nitrosoguanidine (MNNG) and dimethylnitrosamine (DMN) in Salmonella TA 1530 was inhibited by ascorbate. Inhibition of MNNG-induced mutagenesis resulted from a reaction between ascorbate and MNNG that led to consumption of MNNG. The rate of this reaction was considerably enhanced by catalytic amounts of Cu(II) and Fe(III). No direct reaction between DMN and ascorbate was detectable, but relatively high concentrations of Cu(II) enchanced inhibition of DMN-induced mutagenesis by ascorbate. Added protein reduced the effectiveness of Cu(II) as a catalyst of the reaction between ascorbate and MNNG, which suggested that the microsomal protein necessary to activate DMN, may reduce the concentration of free Cu(II) and thereby lower its catalytic efficiency. Mutagenesis by N-methyl-N-nitrosourea was not inhibited by ascorbate.
PMID: 350382
ISSN: 0008-5472
CID: 156631