Searched for: Department/Unit:Otolaryngology
Minimally invasive trigeminal ablation in patients with refractory trigeminal neuralgia who are ineligible for intracranial intervention
Tajali, Yasser; Ward, Max; Abraham, Mickey; Hillen, Machteld; Mahmoud, Omar; Herschman, Yehuda; Mammis, Antonios; Paskhover, Boris
We describe the use of minimally invasive trigeminal ablation, an endoscopic ablative technique to treat trigeminal neuralgia in patients who are traditionally poor surgical candidates. We present 4 patients who presented with refractory unilateral trigeminal neuralgia. Three of the patients had previously failed stereotactic radiosurgery and three of them have multiple sclerosis. Due either to lack of neurovascular compression, minimally invasive trigeminal ablation was offered. Intraoperatively, an incision is made along the buccal mucosa or mid-brow and the tissue is endoscopically dissected in a plane towards the symptomatic nerve. Once isolated, the epineurium is partially ablated with thermocautery and the tissue surrounding the nerve is decompressed. All patients reported resolution of their pain post-operatively and were pain free at last follow up. Two patients had mild hypesthesia over the ablated nerve territory. Minimally invasive trigeminal ablation is a safe and effective technique for symptomatic control of trigeminal neuralgia. The efficacy, low risk, and relative ease of the procedure makes it ideal for use in patients who are refractory to medical management and have no neurovascular compression, are unable to tolerate traditional surgery or have failed other therapies.
PMID: 31537461
ISSN: 1532-2653
CID: 4611492
The Educational Quality of Neurosurgical Resources on YouTube
Ward, Max; Ward, Brittany; Abraham, Mickey; Nicheporuck, Alexis; Elkattawy, Omar; Herschman, Yehuda; Mammis, Antonios; Liu, James K; Paskhover, Boris
BACKGROUND:YouTube has rapidly become one of the most widely accessed educational platforms of our time. Over 1 billion hours of YouTube content are viewed every day, including neurosurgical videos. To date, there has never been a qualitative analysis of neurosurgical content on YouTube. METHODS:By evaluating the search interest of neurosurgical terms via Google Trends, we selected 8 search terms to assess on YouTube. For each term, we selected the top 20 videos, 10 when sorting by view count and 10 when sorting by relevance. Using the DISCERN criteria, we evaluated 131 unique YouTube videos to assess bias and overall educational quality. In addition, we categorized each video based on its intended utility and the credentials of the video's commentator. The number of views, average DISCERN scores, and bias scores were compared between search terms and between video categories. RESULTS:There were 131 unique and 29 duplicate videos. The videos received 143,538,363 combined views (1,104,141 average). The average video age was 4.6 years (range, 66 days to 12.5 years). The term "brain surgery" received the most total views (62,339,885), with an average DISCERN score of 1.65 overall and 2 for bias. The average DISCERN score was 2.02 overall and 2.39 for bias. There were 45 advertisements for either hospitals, physicians, or companies, totaling 18,052,873 views and averaging a DISCERN score of 2.04. CONCLUSIONS:YouTube is a frequently viewed but biased source for neurosurgical information. Advertisements are frequently disguised as educational material, and few videos provide references or sources for their information.
PMID: 31276855
ISSN: 1878-8769
CID: 4611482
The neural basis of motion sickness
Cohen, Bernard; Dai, Mingjia; Yakushin, Sergei B; Cho, Catherine
Although motion of the head and body has been suspected or known as the provocative cause for the production of motion sickness for centuries, it is only within the last 20 yr that the source of the signal generating motion sickness and its neural basis has been firmly established. Here, we briefly review the source of the conflicts that cause the body to generate the autonomic signs and symptoms that constitute motion sickness and provide a summary of the experimental data that have led to an understanding of how motion sickness is generated and can be controlled. Activity and structures that produce motion sickness include vestibular input through the semicircular canals, the otolith organs, and the velocity storage integrator in the vestibular nuclei. Velocity storage is produced through activity of vestibular-only (VO) neurons under control of neural structures in the nodulus of the vestibulo-cerebellum. Separate groups of nodular neurons sense orientation to gravity, roll/tilt, and translation, which provide strong inhibitory control of the VO neurons. Additionally, there are acetylcholinergic projections from the nodulus to the stomach, which along with other serotonergic inputs from the vestibular nuclei, could induce nausea and vomiting. Major inhibition is produced by the GABAB receptors, which modulate and suppress activity in the velocity storage integrator. Ingestion of the GABAB agonist baclofen causes suppression of motion sickness. Hopefully, a better understanding of the source of sensory conflict will lead to better ways to avoid and treat the autonomic signs and symptoms that constitute the syndrome.
PMID: 30699041
ISSN: 1522-1598
CID: 4590632
Tracheostomy Care Education for the Nonsurgical First Responder: A Needs-Based Assessment and Quality Improvement Initiative
Mehta, Kinneri; Schwartz, Marissa; Falcone, Todd E; Kavanagh, Katherine R
Objectives/UNASSIGNED:To perform a needs-based assessment for tracheostomy care education for nonsurgical first responders in the hospital setting and to implement and assess the efficacy of a targeted tracheostomy educational program. Methods/UNASSIGNED:A prospective observational study conducted between October 2017 and May 2018 including emergency medicine (EM) residents, internal medicine (IM) residents, and intensive care unit (ICU) advanced practice providers at 2 tertiary hospitals. Needs-based assessments were conducted, leading to specialty specific curricula. One-hour educational sessions included didactics and case-based simulation. A pre- and posttest objective knowledge quiz and self-assessment were administered, and a posttest was repeated at 6 months. Results/UNASSIGNED:< .05) in mean objective knowledge score was seen across all groups between pre- and postintervention assessments with relative but not significant improvement at 6 months. There were significant increases in comfort level from pre- to postintervention. At 6-month follow-up, comfort level remained significantly increased for the majority of questions for the EM group and for select questions for IM and ICU advanced practice provider groups. Discussion/UNASSIGNED:Nonsurgeons are often first responders to critical airway situations yet receive limited formal education regarding tracheostomy. We demonstrated improvement in knowledge and comfort after a targeted educational module for tracheostomy care and management. Implications for Practice/UNASSIGNED:Although tracheostomy care is multidisciplinary, specialty-specific education may provide a more relevant foundation on which to build skills. Prompt and effective management of tracheostomy emergencies by first responders may improve patient safety and reduce mortality.
PMCID:6684148
PMID: 31428724
ISSN: 2473-974x
CID: 4567942
ALTIS: A new algorithm for adaptive long-term SNR estimation in multi-talker babble
Soleymani, Roozbeh; Selesnick, Ivan W; Landsberger, David M
We introduce a real-time capable algorithm which estimates the long-term signal to noise ratio (SNR) of the speech in multi-talker babble noise. In real-time applications, long-term SNR is calculated over a sufficiently long moving frame of the noisy speech ending at the current time. The algorithm performs the real-time long-term SNR estimation by averaging "speech-likeness" values of multiple consecutive short-frames of the noisy speech which collectively form a long-frame with an adaptive length. The algorithm is calibrated to be insensitive to short-term fluctuations and transient changes in speech or noise level. However, it quickly responds to non-transient changes in long-term SNR by adjusting the duration of the long-frame on which the long-term SNR is measured. This ability is obtained by employing an event detector and adaptive frame duration. The event detector identifies non-transient changes of the long-term SNR and optimizes the duration of the long-frame accordingly. The algorithm was trained and tested for randomly generated speech samples corrupted with multi-talker babble. In addition to its ability to provide an adaptive long-term SNR estimation in a dynamic noisy situation, the evaluation results show that the algorithm outperforms the existing overall SNR estimation methods in multi-talker babble over a wide range of number of talkers and SNRs. The relatively low computational cost and the ability to update the estimated long-term SNR several times per second make this algorithm capable of operating in real-time speech processing applications.
PMCID:7405887
PMID: 32773961
ISSN: 0885-2308
CID: 4563372
NONINVASIVE PERFUSION IMAGING BIOMARKER OF MALIGNANT GENOTYPE IN ISOCITRATE DEHYDROGENASE MUTANT GLIOMAS [Meeting Abstract]
Mureb, Monica; Jain, Rajan; Poisson, Laila; Littig, Ingrid Aguiar; Neto, Lucidio Nunes; Wu, Chih-Chin; Ng, Victor; Patel, Sohil; Patel, Seema; Serrano, Jonathan; Kurz, Sylvia; Cahill, Daniel; Bendszus, Martin; von Deimling, Andreas; Placantonakis, Dimitris; Golfinos, John; Kickingereder, Philipp; Snuderl, Matija; Chi, Andrew
ISI:000509478703153
ISSN: 1522-8517
CID: 4530372
Orbital Trauma
Lozada, Kirkland N; Cleveland, Patrick W; Smith, Jesse E
The orbit is contained within a complex bony architecture with overlying soft tissue that involves many important anatomical structures. Orbital trauma is a frequent cause of damage to these structures. The authors review the literature on reconstructive techniques focusing on fractures of the orbital rim, orbital roof, orbital floor, medial orbital wall, and naso-orbito-ethmoid complex. A thorough literature review was conducted using PubMed analyzing articles relevant to the subject matter. Various search terms were used to identify articles regarding orbital trauma presentation, diagnosis, management, as well as postoperative complications. Articles were examined by all authors and pertinent information was gleaned for the purpose of generating this review. Orbital trauma can result in a wide variety of complications in form and function. Not all orbital fractures require operative repair. However, bony disruption can cause enophthalmos, hypophthalmos, telecanthus, epiphora, cerebrospinal fluid leaks, orbital hematoma, and even blindness to name a few. Timing of operative repair as well as reconstructive method is dictated by the patient's individual presentation. Successful fracture management requires a detailed understanding of the anatomy and pathophysiology to ensure restoration of the patients' preoperative state. Orbital trauma encompasses a wide variety of mechanisms of injury and resulting fracture patterns. A variety of surgical approaches to the orbit exist as has been discussed allowing the surgeon access to all area of interest. Regardless of the fracture complexity, the principles of atraumatic technique, anatomic reduction, and stable fixation apply in all cases.
PMCID:6486387
PMID: 31037047
ISSN: 1535-2188
CID: 4520452
A PHASE 0 PHARMACODYNAMIC AND PHARMACOKINETIC STUDY OF EVEROLIMUS IN VESTIBULAR SCHWANNOMA (VS) AND MENINGIOMA PATIENTS [Meeting Abstract]
Karajannis, Matthias; Goldberg, Judith; Roland, J. Thomas; Sen, Chandranath; Placantonakis, Dimitris; Golfinos, John; Allen, Jeffrey; Dunbar, Erin; Plotkin, Scott; Akshintala, Srivandana; Schneider, Robert; Deng, Jingjing; Neubert, Thomas A.; Giancotti, Filippo; Zagzag, David; Blakeley, Jaishri O.
ISI:000509478700053
ISSN: 1522-8517
CID: 4511792
A PHASE 0 PHARMACODYNAMIC AND PHARMACOKINETIC STUDY OF EVEROLIMUS IN VESTIBULAR SCHWANNOMA (VS) AND MENINGIOMA PATIENTS [Meeting Abstract]
Karajannis, Matthias; Wang, Shiyang; Goldberg, Judith; Roland, Thomas; Sen, Chandranath; Placantonakis, Dimitris; Golfinos, John; Allen, Jeffrey; Dunbar, Erin; Plotkin, Scott; Akshintala, Srivandana; Schneider, Robert; Deng, Jingjing; Neubert, Thomas; Giancotti, Filippo; Blakeley, Jaishri
ISI:000473243700215
ISSN: 1522-8517
CID: 4511782
Vocal Fold Motion Recovery in Patients With Iatrogenic Unilateral Immobility: Cervical Versus Thoracic Injury
Tracy, Lauren F; Kwak, Paul E; Bayan, Semirra L; Van Stan, Jarrad H; Burns, James A
OBJECTIVES:/UNASSIGNED:Prognostic information about the return of vocal fold mobility in patients with iatrogenic unilateral vocal fold immobility (UVFI) can help with informed decisions about temporary and permanent treatment options. Although many variables can influence the likelihood of recovery, clinical experience suggests that cervical versus thoracic injury is a determining factor. The purpose of this study was to compare recovery rates from UVFI between cervical and thoracic injuries. METHODS:/UNASSIGNED:analyses. RESULTS:/UNASSIGNED:Overall, 15% of patients recovered vocal fold mobility at a median of 4.1 months. Patients with cervical injury (65 of 329 [20%]) were significantly more likely to recover mobility than patients with thoracic injury (11 of 173 [6.4%]) (odds ratio, 3.63). The cervical cohort contained more women (68% vs 31%) and was younger (mean age, 60.4 ± 13.8 vs 64.1 ± 16.1 years; Cohen's D = 0.25). CONCLUSIONS:/UNASSIGNED:Patients with cervical injuries resulting in UVFI are 4 times more likely to recover mobility than patients with thoracic injuries. This information can be valuable in counseling patients with UVFI and may affect clinical decision making.
PMID: 30345793
ISSN: 1943-572x
CID: 4505142