NYUHSL Faculty Bibliography

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school:SOM

Department/Unit:Neurology

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23152

Multiple sclerosis. 2022.DOI: 10.1177/13524585221084577

Multiple Sclerosis Severity Score (MSSS) improves the accuracy of individualized prediction in MS

Kalincik, Tomas; Kister, Ilya; Bacon, Tamar E; Malpas, Charles B; Sharmin, Sifat; Horakova, Dana; Kubala-Havrdova, Eva; Patti, Francesco; Izquierdo, Guillermo; Eichau, Sara; Ozakbas, Serkan; Onofrj, Marco; Lugaresi, Alessandra; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Grammond, Pierre; Sola, Patrizia; Ferraro, Diana; Alroughani, Raed; Terzi, Murat; Boz, Cavit; Grand'Maison, Francois; Bergamaschi, Roberto; Gerlach, Oliver; Sa, Maria J; Kappos, Ludwig; Cartechini, Elisabetta; Lechner-Scott, Jeannette; van Pesch, Vincent; Shaygannejad, Vahid; Granella, Franco; Spitaleri, Daniele; Iuliano, Gerardo; Maimone, Davide; Prevost, Julie; Soysal, Aysun; Turkoglu, Recai; Ampapa, Radek; Butzkueven, Helmut; Cutter, Gary

BACKGROUND/UNASSIGNED:The MSBase prediction model of treatment response leverages multiple demographic and clinical characteristics to estimate hazards of relapses, confirmed disability accumulation (CDA), and confirmed disability improvement (CDI). The model did not include Multiple Sclerosis Severity Score (MSSS), a disease duration-adjusted ranked score of disability. OBJECTIVE/UNASSIGNED:To incorporate MSSS into the MSBase prediction model and compare model accuracy with and without MSSS. METHODS/UNASSIGNED:The associations between MSSS and relapse, CDA, and CDI were evaluated with marginal proportional hazards models adjusted for three principal components representative of patients' demographic and clinical characteristics. The model fit with and without MSSS was assessed with penalized r2 and Harrell C. RESULTS/UNASSIGNED:A total of 5866 MS patients were started on disease-modifying therapy during prospective follow-up (age 38.4â€‰Â±â€‰10.6â€‰years; 72% female; disease duration 8.5â€‰Â±â€‰7.7â€‰years). Including MSSS into the model improved the accuracy of individual prediction of relapses by 31%, of CDA by 23%, and of CDI by 24% (Harrell C) and increased the amount of variance explained for relapses by 49%, for CDI by 11%, and for CDA by 10% as compared with the original model. CONCLUSION/UNASSIGNED:Addition of a single, readily available metric, MSSS, to the comprehensive MSBase prediction model considerably improved the individual accuracy of prognostics in MS.

PMID: 35373638

ISSN: 1477-0970

CID: 5191742

Neurodiem

COVID and Multiple Sclerosis: What have we learned since the start of the pandemic?

Kister, Ilya

(Website)

CID: 5192292

Journal of neurosurgery. 2022:136(4):990-991.DOI: 10.3171/2021.1.JNS21227

Editorial. The future of stroke care is remote and now [Editorial]

Oermann, Eric K; Riina, Howard A

PMID: 34560649

ISSN: 1933-0693

CID: 5883382

Current opinion in neurology. 2022:35(2):181-188.DOI: 10.1097/WCO.0000000000001034

Sudden unexpected death in epilepsy

Friedman, Daniel

PURPOSE OF REVIEW/OBJECTIVE:Sudden unexpected death in epilepsy (SUDEP) is a major contributor to premature mortality in people with epilepsy. This review provides an update on recent findings on the epidemiology of SUDEP, clinical risk factors and potential mechanisms. RECENT FINDINGS/RESULTS:The overall risk rate of SUDEP is approximately 1 per 1000 patients per year in the general epilepsy population and that children and older adults have a similar incidence. Generalized convulsive seizures (GCS), perhaps through their effects on brainstem cardiopulmonary networks, can cause significant postictal respiratory and autonomic dysfunction though other mechanisms likely exist as well. Work in animal models of SUDEP has identified multiple neurotransmitter systems, which may be future targets for pharmacological intervention. There are also chronic functional and structural changes in autonomic function in patients who subsequently die from SUDEP suggesting that some SUDEP risk is dynamic. Modifiable risks for SUDEP include GCS seizure frequency, medication adherence and nighttime supervision. SUMMARY/CONCLUSIONS:Current knowledge of SUDEP risk factors has identified multiple targets for SUDEP prevention today as we await more specific therapeutic targets that are emerging from translational research studies.

PMID: 35102124

ISSN: 1473-6551

CID: 5182232

Cancer discovery. 2022:12(4):1022-1045.DOI: 10.1158/2159-8290.CD-20-1265

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Chang, Chewei Anderson; Jen, Jayu; Jiang, Shaowen; Sayad, Azin; Mer, Arvind Singh; Brown, Kevin R; Nixon, Allison M L; Dhabaria, Avantika; Tang, Kwan Ho; Venet, David; Sotiriou, Christos; Deng, Jiehui; Wong, Kwok-Kin; Adams, Sylvia; Meyn, Peter; Heguy, Adriana; Skok, Jane A; Tsirigos, Aristotelis; Ueberheide, Beatrix; Moffat, Jason; Singh, Abhyudai; Haibe-Kains, Benjamin; Khodadadi-Jamayran, Alireza; Neel, Benjamin G

Resistance to targeted therapies is an important clinical problem in HER2-positive (HER2+) breast cancer. "Drug-tolerant persisters" (DTPs), a sub-population of cancer cells that survive via reversible, non-genetic mechanisms, are implicated in resistance to tyrosine kinase inhibitors (TKIs) in other malignancies, but DTPs following HER2 TKI exposure have not been well characterized. We found that HER2 TKIs evoke DTPs with a luminal-like or a mesenchymal-like transcriptome. Lentiviral barcoding/single cell RNA-sequencing reveal that HER2+ breast cancer cells cycle stochastically through a "pre-DTP" state, characterized by a G0-like expression signature and enriched for diapause and/or senescence genes. Trajectory analysis/cell sorting show that pre-DTPs preferentially yield DTPs upon HER2 TKI exposure. Cells with similar transcriptomes are present in HER2+ breast tumors and are associated with poor TKI response. Finally, biochemical experiments indicate that luminal-like DTPs survive via estrogen receptor-dependent induction of SGK3, leading to rewiring of the PI3K/AKT/mTORC1 pathway to enable AKT-independent mTORC1 activation.

PMID: 34911733

ISSN: 2159-8290

CID: 5085072

Journal of neurosurgical anesthesiology. 2022:34(2):209-220.DOI: 10.1097/ANA.0000000000000825

Perceptions Regarding the SARS-CoV-2 Pandemic's Impact on Neurocritical Care Delivery: Results From a Global Survey

Lele, Abhijit V; Wahlster, Sarah; Alunpipachathai, Bhunyawee; Awraris Gebrewold, Meron; Chou, Sherry H-Y; Crabtree, Gretchen; English, Shane; Der-Nigoghossian, Caroline; Gagnon, David J; Kim-Tenser, May; Karanjia, Navaz; Kirkman, Matthew A; Lamperti, Massimo; Livesay, Sarah L; Mejia-Mantilla, Jorge; Melmed, Kara; Prabhakar, Hemanshu; Tumino, Leandro; Venkatasubba Rao, Chethan P; Udy, Andrew A; Videtta, Walter; Moheet, Asma M; Hinson, H E; Olm-Shipman, Casey M; Da Silva, Ivan; Cervantes-Arslanian, Anna M; Carlson, Andrew P; Sivakumar, Sanjeev; Shah, Vishank A; Bonomo, Jordan B; Hatton, Kevin W; Kapinos, Gregory; Hughes, Christopher G; RodrÃguez-Vega, Gloria M; Mainali, Shraddha; Chang, Cherylee W J; Dissin, Jonathan; Wang, Jing; Mailloux, Patrick T; Dhar, Rajat; Naik, Bhiken I; Sarwal, Aarti; Muehlschlegel, Susanne; Nobleza, Christa O'Hana S; Shapshak, Angela Hays; Wyler, David A; Latorre, Julius Gene S; Varelas, Panayiotis N; Ansari, Safdar A; Krishnamoorthy, Vijay; Rao, Shyam S; Ivan Da Silva, Demetrios J Kutsogiannis; Akbari, Yama; Rosenblatt, Kathryn; Roberts, Debra E; Kim, Jennifer A; Batra, Ayush; Srinivasan, Vasisht; Williamson, Craig A; Cai, Xuemei; George, Pravin; Pizzi, Michael A; Luk, K H Kevin; Berger, Karen; Babi, Marc-Alain; Hirsch, Karen G; Lay, Cappi C; Fontaine, Gabriel V; Lewis, Ariane; Lamer-Rosen, Amanda B; Kalanuria, Atul; Khawaja, Ayaz M; Rabinstein, Alejandro A; Andrews, Charles M; Badjatia, Neeraj; McDonagh, David L; Rajajee, Venkatakrishna; Dombrowski, Keith E; Daniels, Justin D; O'Phelan, Kristine H; Birrer, Kara L; Davis, Nicole C; Marino, Kaylee K; Li, Fanny; Sharma, Archit; Tesoro, Eljim P; Sadan, Ofer; Mehta, Yatin B; Boone, Myles Dustin; Barthol, Colleen; LÃ³pez Delgado, Hubiel J; Maricela, GarcÃa Arellano; Mijangos-Mendez, Julio C; Lopez-Pulgarin, Jose A; Terrett, Luke A; Rigamonti, Andrea; Couillard, Philippe; ChassÃ©, MichaÃ«l; Al-Jehani, Hosam M; Cunto, Eleonora R; Villalobos, Luis M; Rocchetti, NicolÃ¡s S; Aparicio, Gabriela; Domeniconi, Gustavo G; Gemelli, Nicolas A; Badano, Mariana F; Costilla, Cesar M; Caporal, Paula; Camerlingo, SebastiÃ¡n; Balasini, Carina; LÃ³pez, Rossana G; Mario, Mauri; Ilutovich, Santiago A; Torresan, Gabriela V; Mazzola, Ana M; Daniela, E; Olmos, K; Maldonado, Roberto MÃ©rida; La Fuente Zerain, Gustavo; Paiva, Wellingson Silva; FalcÃ£o, AntÃ´nio Eiras; Rojas, SalomÃ³n; Franco, Gilberto Paulo Pereira; Azevedo, Renata A; Kurtz, Pedro; Balbo, Flor G; Carreno, Jose N; Rubiano, Andres M; Ciro, Juan Diego; Zulma Urbina, C; Pinto, Diego Barahona; GÃ³mez, Pedro CÃ©sar GutiÃ©rrez; Castillo, L; Ranero, Jorge Luis; Apodaca, Julio C; GÃ³mez Arriola, Natalia E; ReÃ¡tegui, RocÃo NÃ¡jar; Chumbe, Maria M; Rodriguez Tucto, Xandra Yanina; Davila Flores, Rafael E; Mora, Jacobo E; Al-Suwaidan, Faisal Abdulrahman; Abulhasan, Yasser B; Belay, Hanna Demissie; Kebede, Dawit K; Ewunetu, Mulugeta Biyadgie; Molla, Sisay; Tulu, Fitsum Alemu; Gebremariam, Senay A; Tibar, Houyam; Yimer, Fasika Tesfaneh; Farombi, Temitope Hannah; Xavier, Nshimiyimana Francios; Osman, Jama; Padayachy, Llewellyn C; Vander Laenen, Margot J; Breitenfeld, Tomislav; Takala, Riikka; Lasocki, Sigismond; Czorlich, Patrick; Poli, Sven; Neumann, Bernhard; Lochner, Piergiorgio; Menon, Sanjay; Wartenberg, Katja E; Wolf, Stefan; Etminan, Nima; Konczalla, Juergen; Schubert, Gerrit A; Wittstock, Matthias; BÃ¶sel, Julian; Robba, Chiara; De Cassai, Alessandro; Alampi, Daniela; Zugni, Nicola; Fuselli, Ennio; Bilotta, Federico; Stival, Eleonora; Castioni, Carlo Alberto; Tringali, Eleonora; Gelormini, Domenico; Dias, Celeste; Badenes, Rafael; Ramos-GÃ³mez, Luis A; Llompart-Pou, Juan A; Tena, Susana Altaba; Merlani, Paolo; van den Bergh, Walter M; Hoedemaekers, Cornelia W; Abdo, Wilson F; van der Jagt, Mathieu; Gorbachov, Sergii; Dinsmore, J E; Reddy, Ugan; Tattum, L; Aneman, Anders; Rhodes, Jonathan K J; Sopheak, Pak; Jian, Song; Chan, Matthew Tv; Nagayama, Masao; Suzuki, Hidenori; Luthra, Ankur; Zirpe, Kapil G; Pratheema, R; Sethuraman, Manikandan; Tripathy, Swagata; Mahajan, Charu; Deb, Kallol; Gupta, Devendra; Gupta, Nidhi; Kapoor, Indu; Tandon, Monica S; Singhal, Vasudha; Parakh, Anil; Moningi, Srilata; Garg, Mudit; Sandhu, Kavita; Ali, Zulfiqar; Sharma, Vivek Bharti; Kumar, Subodh; Kumar, Prashant; Aggarwal, Deepesh G; Shukla, Urvi B; Dixit, Subhal; Nafissi, Shahriar; Mokhtari, Majid; Shrestha, Gentle S; Puvanendiran, Shanmugam; Sakchinabut, Sarunkorn; Kaewwinud, Jeerawat; Thirapattaraphan, Porntip; Petsakul, Suttasinee; Nuchpramool, Pruchwilai; Nitikaroon, Phongsak; Thaksin, Niyutta; Vongsfak, Jirapong; Sarapuddin, Gemmalynn B; Van Bui, Tuan; Seppelt, Oceania Ian M; Bhonagiri, Deepak; Winearls, James R; Flower, Oliver J; Westerlund, Torgeir A; Van Oosterwyck, Wout

BACKGROUND:The SARS-CoV-2 (COVID-19) pandemic has impacted many facets of critical care delivery. METHODS:An electronic survey was distributed to explore the pandemic's perceived impact on neurocritical care delivery between June 2020 and March 2021. Variables were stratified by World Bank country income level, presence of a dedicated neurocritical care unit (NCCU) and experiencing a COVID-19 patient surge. RESULTS:Respondents from 253 hospitals (78.3% response rate) from 47 countries (45.5% low/middle income countries; 54.5% with a dedicated NCCU; 78.6% experienced a first surge) participated in the study. Independent of country income level, NCCU and surge status, participants reported reductions in NCCU admissions (67%), critical care drug shortages (69%), reduction in ancillary services (43%) and routine diagnostic testing (61%), and temporary cancellation of didactic teaching (44%) and clinical/basic science research (70%). Respondents from low/middle income countries were more likely to report lack of surge preparedness (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.8-5.8) and struggling to return to prepandemic standards of care (OR, 12.2; 95% CI, 4.4-34) compared with respondents from high-income countries. Respondents experiencing a surge were more likely to report conversion of NCCUs and general-mixed intensive care units (ICUs) to a COVID-ICU (OR 3.7; 95% CI, 1.9-7.3), conversion of non-ICU beds to ICU\ beds (OR, 3.4; 95% CI, 1.8-6.5), and deviations in critical care and pharmaceutical practices (OR, 4.2; 95% CI 2.1-8.2). Respondents from hospitals with a dedicated NCCU were less likely to report conversion to a COVID-ICU (OR, 0.5; 95% CI, 0.3-0.9) or conversion of non-ICU to ICU beds (OR, 0.5; 95% CI, 0.3-0.9). CONCLUSION/CONCLUSIONS:This study reports the perceived impact of the COVID-19 pandemic on global neurocritical care delivery, and highlights shortcomings of health care infrastructures and the importance of pandemic preparedness.

PMID: 34882104

ISSN: 1537-1921

CID: 5326642

Neuro-oncology. 2022:24(4):516-527.DOI: 10.1093/neuonc/noab252

EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults

Frappaz, Didier; Dhall, Girish; Murray, Matthew J; Goldman, Stuart; Faure Conter, Cecile; Allen, Jeffrey; Kortmann, Rolf Dieter; Haas-Kogen, Daphne; Morana, Giovanni; Finlay, Jonathan; Nicholson, James C; Bartels, Ute; Souweidane, Mark; Schönberger, Stefan; Vasiljevic, Alexandre; Robertson, Patricia; Albanese, Assunta; Alapetite, Claire; Czech, Thomas; Lau, Chin C; Wen, Patrick; Schiff, David; Shaw, Dennis; Calaminus, Gabriele; Bouffet, Eric

The incidence of intracranial germ cell tumors (iGCT) is much lower in European and North American (E&NA) than in Asian population. However, E&NA cooperative groups have simultaneously developed with success treatment strategies with specific attention paid to long-term sequelae. Neurological sequelae may be reduced by establishing a diagnosis with an endoscopic biopsy and/or cerebrospinal fluid (CSF) and/or serum analysis, deferring the need to perform a radical surgery. Depending on markers and/or histological characteristics, patients are treated as either germinoma or non-germinomatous germ cell tumors (NGGCT). Metastatic disease is defined by a positive CSF cytology and/or distant drops in craniospinal MRI. The combination of surgery and/or chemotherapy and radiation therapy is tailored according to grouping and staging. With more than 90% 5-year event-free survival (EFS), localized germinomas can be managed without aggressive surgery, and benefit from chemotherapy followed by whole ventricular irradiation with local boost. Bifocal germinomas are treated as non-metastatic entities. Metastatic germinomas may be cured with craniospinal irradiation. With a 5-year EFS over 70%, NGGCT benefit from chemotherapy followed by delayed surgery in case of residual disease, and some form of radiotherapy. Future strategies will aim at decreasing long-term side effects while preserving high cure rates.

PMCID:8972311

PMID: 34724065

ISSN: 1523-5866

CID: 5219272

Nature genetics. 2022:54(4):412-436.DOI: 10.1038/s41588-022-01024-z

New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, CÃƒÂ©line; KÃƒÂ¼ÃƒÂ§ÃƒÂ¼kali, Fahri; Jansen, Iris E; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A; Boland, Anne; Damotte, Vincent; van der Lee, Sven J; Costa, Marcos R; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; AlarcÃƒÂ³n-MartÃƒÂn, Emilio; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; ÃƒÂlvarez, Victoria; Armstrong, Nicola J; Tsolaki, Anthoula; AntÃƒÂºnez, Carmen; Appollonio, Ildebrando; Arcaro, Marina; Archetti, Silvana; Pastor, Alfonso Arias; Arosio, Beatrice; Athanasiu, Lavinia; Bailly, Henri; Banaj, Nerisa; Baquero, Miquel; Barral, Sandra; Beiser, Alexa; Pastor, Ana BelÃƒÂ©n; Below, Jennifer E; Benchek, Penelope; Benussi, Luisa; Berr, Claudine; Besse, CÃƒÂ©line; Bessi, Valentina; Binetti, Giuliano; Bizarro, Alessandra; Blesa, Rafael; Boada, MercÃƒÂ¨; Boerwinkle, Eric; Borroni, Barbara; Boschi, Silvia; BossÃƒÂ¹, Paola; BrÃƒÂ¥then, Geir; Bressler, Jan; Bresner, Catherine; Brodaty, Henry; Brookes, Keeley J; Brusco, Luis Ignacio; Buiza-Rueda, Dolores; BÃƒÂ»rger, Katharina; Burholt, Vanessa; Bush, William S; Calero, Miguel; Cantwell, Laura B; Chene, GeneviÃƒÂ¨ve; Chung, Jaeyoon; Cuccaro, Michael L; Carracedo, ÃƒÂngel; Cecchetti, Roberta; Cervera-Carles, Laura; Charbonnier, Camille; Chen, Hung-Hsin; Chillotti, Caterina; Ciccone, Simona; Claassen, Jurgen A H R; Clark, Christopher; Conti, Elisa; Corma-GÃƒÂ³mez, AnaÃƒÂ¯s; Costantini, Emanuele; Custodero, Carlo; Daian, Delphine; Dalmasso, Maria Carolina; Daniele, Antonio; Dardiotis, Efthimios; Dartigues, Jean-FranÃƒÂ§ois; de Deyn, Peter Paul; de Paiva Lopes, Katia; de Witte, Lot D; Debette, StÃƒÂ©phanie; Deckert, JÃƒÂ¼rgen; Del Ser, Teodoro; Denning, Nicola; DeStefano, Anita; Dichgans, Martin; Diehl-Schmid, Janine; Diez-Fairen, MÃƒÂ³nica; Rossi, Paolo Dionigi; Djurovic, Srdjan; Duron, Emmanuelle; DÃƒÂ¼zel, Emrah; Dufouil, Carole; Eiriksdottir, Gudny; Engelborghs, Sebastiaan; Escott-Price, Valentina; Espinosa, Ana; Ewers, Michael; Faber, Kelley M; Fabrizio, Tagliavini; Nielsen, Sune Fallgaard; Fardo, David W; Farotti, Lucia; Fenoglio, Chiara; Fernández-Fuertes, Marta; Ferrari, Raffaele; Ferreira, Catarina B; Ferri, Evelyn; Fin, Bertrand; Fischer, Peter; Fladby, Tormod; FlieÃƒÅ¸bach, Klaus; Fongang, Bernard; Fornage, Myriam; Fortea, Juan; Foroud, Tatiana M; Fostinelli, Silvia; Fox, Nick C; Franco-MacÃƒÂas, Emlio; Bullido, María J; Frank-GarcÃƒÂa, Ana; Froelich, Lutz; Fulton-Howard, Brian; Galimberti, Daniela; GarcÃƒÂa-Alberca, Jose Maria; GarcÃƒÂa-González, Pablo; Garcia-Madrona, Sebastian; Garcia-Ribas, Guillermo; Ghidoni, Roberta; Giegling, Ina; Giorgio, Giaccone; Goate, Alison M; Goldhardt, Oliver; Gomez-Fonseca, Duber; González-PÃƒÂ©rez, Antonio; Graff, Caroline; Grande, Giulia; Green, Emma; Grimmer, Timo; GrÃƒÂ¼nblatt, Edna; Grunin, Michelle; Gudnason, Vilmundur; Guetta-Baranes, Tamar; Haapasalo, Annakaisa; Hadjigeorgiou, Georgios; Haines, Jonathan L; Hamilton-Nelson, Kara L; Hampel, Harald; Hanon, Olivier; Hardy, John; Hartmann, Annette M; Hausner, Lucrezia; Harwood, Janet; Heilmann-Heimbach, Stefanie; Helisalmi, Seppo; Heneka, Michael T; Hernández, Isabel; Herrmann, Martin J; Hoffmann, Per; Holmes, Clive; Holstege, Henne; Vilas, Raquel Huerto; Hulsman, Marc; Humphrey, Jack; Biessels, Geert Jan; Jian, Xueqiu; Johansson, Charlotte; Jun, Gyungah R; Kastumata, Yuriko; Kauwe, John; Kehoe, Patrick G; Kilander, Lena; StÃƒÂ¥hlbom, Anne Kinhult; Kivipelto, Miia; Koivisto, Anne; Kornhuber, Johannes; Kosmidis, Mary H; Kukull, Walter A; Kuksa, Pavel P; Kunkle, Brian W; Kuzma, Amanda B; Lage, Carmen; Laukka, Erika J; Launer, Lenore; Lauria, Alessandra; Lee, Chien-Yueh; Lehtisalo, Jenni; Lerch, Ondrej; LleÃƒÂ³, Alberto; Longstreth, William; Lopez, Oscar; de Munain, Adolfo Lopez; Love, Seth; LÃƒÂ¶wemark, Malin; Luckcuck, Lauren; Lunetta, Kathryn L; Ma, Yiyi; MacÃƒÂas, Juan; MacLeod, Catherine A; Maier, Wolfgang; Mangialasche, Francesca; Spallazzi, Marco; MarquiÃƒÂ©, Marta; Marshall, Rachel; Martin, Eden R; Montes, Angel MartÃƒÂn; RodrÃƒÂguez, Carmen MartÃƒÂnez; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Medina, Miguel; Meggy, Alun; Mehrabian, Shima; Mendoza, Silvia; MenÃƒÂ©ndez-González, Manuel; Mir, Pablo; Moebus, Susanne; Mol, Merel; Molina-Porcel, Laura; Montrreal, Laura; Morelli, Laura; Moreno, Fermin; Morgan, Kevin; Mosley, Thomas; NÃƒÂ¶then, Markus M; Muchnik, Carolina; Mukherjee, Shubhabrata; Nacmias, Benedetta; Ngandu, Tiia; Nicolas, Gael; Nordestgaard, BÃƒÂ¸rge G; Olaso, Robert; Orellana, Adelina; Orsini, Michela; Ortega, Gemma; Padovani, Alessandro; Paolo, Caffarra; Papenberg, Goran; Parnetti, Lucilla; Pasquier, Florence; Pastor, Pau; Peloso, Gina; PÃƒÂ©rez-CordÃƒÂ³n, Alba; PÃƒÂ©rez-Tur, Jordi; Pericard, Pierre; Peters, Oliver; Pijnenburg, Yolande A L; Pineda, Juan A; PiÃƒÂ±ol-Ripoll, Gerard; Pisanu, Claudia; Polak, Thomas; Popp, Julius; Posthuma, Danielle; Priller, Josef; Puerta, Raquel; Quenez, Olivier; Quintela, InÃƒÂ©s; Thomassen, Jesper Qvist; Rábano, Alberto; Rainero, Innocenzo; Rajabli, Farid; Ramakers, Inez; Real, Luis M; Reinders, Marcel J T; Reitz, Christiane; Reyes-Dumeyer, Dolly; Ridge, Perry; Riedel-Heller, Steffi; Riederer, Peter; Roberto, Natalia; Rodriguez-Rodriguez, Eloy; Rongve, Arvid; Allende, Irene Rosas; Rosende-Roca, MaitÃƒÂ©e; Royo, Jose Luis; Rubino, Elisa; Rujescu, Dan; Sáez, María Eugenia; Sakka, Paraskevi; Saltvedt, Ingvild; Sanabria, ÃƒÂngela; Sánchez-Arjona, María Bernal; Sanchez-Garcia, Florentino; Juan, Pascual Sánchez; Sánchez-Valle, Raquel; Sando, Sigrid B; Sarnowski, ChloÃƒÂ©; Satizabal, Claudia L; Scamosci, Michela; Scarmeas, Nikolaos; Scarpini, Elio; Scheltens, Philip; Scherbaum, Norbert; Scherer, Martin; Schmid, Matthias; Schneider, Anja; Schott, Jonathan M; SelbÃƒÂ¦k, Geir; Seripa, Davide; Serrano, Manuel; Sha, Jin; Shadrin, Alexey A; Skrobot, Olivia; Slifer, Susan; Snijders, Gijsje J L; Soininen, Hilkka; Solfrizzi, Vincenzo; Solomon, Alina; Song, Yeunjoo; Sorbi, Sandro; Sotolongo-Grau, Oscar; Spalletta, Gianfranco; Spottke, Annika; Squassina, Alessio; Stordal, Eystein; Tartan, Juan Pablo; Tárraga, LluÃƒÂs; TesÃƒÂ, Niccolo; Thalamuthu, Anbupalam; Thomas, Tegos; Tosto, Giuseppe; Traykov, Latchezar; Tremolizzo, Lucio; TybjÃƒÂ¦rg-Hansen, Anne; Uitterlinden, Andre; Ullgren, Abbe; Ulstein, Ingun; Valero, Sergi; Valladares, Otto; Broeckhoven, Christine Van; Vance, Jeffery; Vardarajan, Badri N; van der Lugt, Aad; Dongen, Jasper Van; van Rooij, Jeroen; van Swieten, John; Vandenberghe, Rik; Verhey, Frans; Vidal, Jean-Sébastien; Vogelgsang, Jonathan; Vyhnalek, Martin; Wagner, Michael; Wallon, David; Wang, Li-San; Wang, Ruiqi; Weinhold, Leonie; Wiltfang, Jens; Windle, Gill; Woods, Bob; Yannakoulia, Mary; Zare, Habil; Zhao, Yi; Zhang, Xiaoling; Zhu, Congcong; Zulaica, Miren; Farrer, Lindsay A; Psaty, Bruce M; Ghanbari, Mohsen; Raj, Towfique; Sachdev, Perminder; Mather, Karen; Jessen, Frank; Ikram, M Arfan; de MendonÃƒÂ§a, Alexandre; Hort, Jakub; Tsolaki, Magda; Pericak-Vance, Margaret A; Amouyel, Philippe; Williams, Julie; Frikke-Schmidt, Ruth; Clarimon, Jordi; Deleuze, Jean-FranÃƒÂ§ois; Rossi, Giacomina; Seshadri, Sudha; Andreassen, Ole A; Ingelsson, Martin; Hiltunen, Mikko; Sleegers, Kristel; Schellenberg, Gerard D; van Duijn, Cornelia M; Sims, Rebecca; van der Flier, Wiesje M; Ruiz, AgustÃƒÂn; Ramirez, Alfredo; Lambert, Jean-Charles; Laczo, Jan; Matoska, Vaclav; Serpente, Maria; Assogna, Francesca; Piras, Fabrizio; Piras, Federica; Ciullo, Valentina; Shofany, Jacob; Ferrarese, Carlo; Andreoni, Simona; Sala, Gessica; Zoia, Chiara Paola; Zompo, Maria Del; Benussi, Alberto; Bastiani, Patrizia; Takalo, Mari; Natunen, Teemu; Laatikainen, Tiina; Tuomilehto, Jaakko; Antikainen, Riitta; Strandberg, Timo; Lindström, Jaana; Peltonen, Markku; Abraham, Richard; Al-Chalabi, Ammar; Bass, Nicholas J; Brayne, Carol; Brown, Kristelle S; Collinge, John; Craig, David; Deloukas, Pangiotis; Fox, Nick; Gerrish, Amy; Gill, Michael; Gwilliam, Rhian; Harold, Denise; Hollingworth, Paul; Johnston, Jarret A; Jones, Lesley; Lawlor, Brian; Livingston, Gill; Lovestone, Simon; Lupton, Michelle; Lynch, Aoibhinn; Mann, David; McGuinness, Bernadette; McQuillin, Andrew; O'Donovan, Michael C; Owen, Michael J; Passmore, Peter; Powell, John F; Proitsi, Petra; Rossor, Martin; Shaw, Christopher E; Smith, A David; Gurling, Hugh; Todd, Stephen; Mummery, Catherine; Ryan, Nathalie; Lacidogna, Giordano; Adarmes-Gómez, Ad; Mauleón, Ana; Pancho, Ana; Gailhajenet, Anna; Lafuente, Asunción; Macias-García, D; MartÃn, Elvira; PelejÃ , Esther; Carrillo, F; MerlÃn, Isabel Sastre; Garrote-Espina, L; Vargas, Liliana; Carrion-Claro, M; MarÃn, M; Labrador, Ma; Buendia, Mar; Alonso, María Dolores; Guitart, Marina; Moreno, Mariona; Ibarria, Marta; PeriñÃ¡n, Mt; Aguilera, Nuria; Gómez-Garre, P; Cañabate, Pilar; Escuela, R; Pineda-SÃ¡nchez, R; Vigo-Ortega, R; Jesús, S; Preckler, Silvia; Rodrigo-Herrero, Silvia; Diego, Susana; Vacca, Alessandro; Roveta, Fausto; Salvadori, Nicola; Chipi, Elena; Boecker, Henning; Laske, Christoph; Perneczky, Robert; Anastasiou, Costas; Janowitz, Daniel; Malik, Rainer; Anastasiou, Anna; Parveen, Kayenat; Lage, Carmen; López-García, Sara; Antonell, Anna; Mihova, Kalina Yonkova; Belezhanska, Diyana; Weber, Heike; Kochen, Silvia; Solis, Patricia; Medel, Nancy; Lisso, Julieta; Sevillano, Zulma; Politis, Daniel G; Cores, Valeria; Cuesta, Carolina; Ortiz, Cecilia; Bacha, Juan Ignacio; Rios, Mario; Saenz, Aldo; Abalos, Mariana Sanchez; Kohler, Eduardo; Palacio, Dana Lis; Etchepareborda, Ignacio; Kohler, Matias; Novack, Gisela; Prestia, Federico Ariel; Galeano, Pablo; Castaño, Eduardo M; Germani, Sandra; Toso, Carlos Reyes; Rojo, Matias; Ingino, Carlos; Mangone, Carlos; Rubinsztein, David C; Teipel, Stefan; Fievet, Nathalie; Deramerourt, Vincent; Forsell, Charlotte; Thonberg, HÃ¥kan; Bjerke, Maria; Roeck, Ellen De; Martínez-Larrad, María Teresa; Olivar, Natividad; Aguilera, Nuria; Cano, Amanda; Cañabate, Pilar; Macias, Juan; Maroñas, Olalla; Nuñez-Llaves, Raúl; Olivé, ClÃ udia; PelejÃ¡, Ester; Adarmes-Gómez, Astrid D; Alonso, María Dolores; Amer-Ferrer, Guillermo; Antequera, Martirio; Burguera, Juan Andrés; Carrillo, FÃ¡tima; Carrión-Claro, Mario; Casajeros, María José; Martinez de Pancorbo, Marian; Escuela, RocÃo; Garrote-Espina, Lorena; Gómez-Garre, Pilar; Hevilla, Saray; Jesús, Silvia; Espinosa, Miguel Angel Labrador; Legaz, Agustina; López-García, Sara; Macias-García, Daniel; Manzanares, Salvadora; MarÃn, Marta; MarÃn-Muñoz, Juan; MarÃn, Tamara; Martínez, Begoña; Martínez, Victoriana; Martínez-Lage Ãlvarez, Pablo; Iriarte, Maite Mendioroz; PeriñÃ¡n-Tocino, María Teresa; Pineda-SÃ¡nchez, RocÃo; Real de Asúa, Diego; Rodrigo, Silvia; Sastre, Isabel; Vicente, Maria Pilar; Vigo-Ortega, Rosario; Vivancos, Liliana; Epelbaum, Jacques; Hannequin, Didier; Campion, Dominique; Deramecourt, Vincent; Tzourio, Christophe; Brice, Alexis; Dubois, Bruno; Williams, Amy; Thomas, Charlene; Davies, Chloe; Nash, William; Dowzell, Kimberley; Morales, Atahualpa Castillo; Bernardo-Harrington, Mateus; Turton, James; Lord, Jenny; Brown, Kristelle; Vardy, Emma; Fisher, Elizabeth; Warren, Jason D; Rossor, Martin; Ryan, Natalie S; Guerreiro, Rita; Uphill, James; Bass, Nick; Heun, Reinhard; Kölsch, Heike; SchÃ¼rmann, Britta; Lacour, André; Herold, Christine; Johnston, Janet A; Passmore, Peter; Powell, John; Patel, Yogen; Hodges, Angela; Becker, Tim; Warden, Donald; Wilcock, Gordon; Clarke, Robert; Deloukas, Panagiotis; Ben-Shlomo, Yoav; Hooper, Nigel M; Pickering-Brown, Stuart; Sussams, Rebecca; Warner, Nick; Bayer, Anthony; Heuser, Isabella; Drichel, Dmitriy; Klopp, Norman; Mayhaus, Manuel; Riemenschneider, Matthias; Pinchler, Sabrina; Feulner, Thomas; Gu, Wei; van den Bussche, Hendrik; HÃ¼ll, Michael; Frölich, Lutz; Wichmann, H-Erich; Jöckel, Karl-Heinz; O'Donovan, Michael; Owen, Michael; Bahrami, Shahram; Bosnes, Ingunn; Selnes, Per; Bergh, Sverre; Palotie, Aarno; Daly, Mark; Jacob, Howard; Matakidou, Athena; Runz, Heiko; John, Sally; Plenge, Robert; McCarthy, Mark; Hunkapiller, Julie; Ehm, Meg; Waterworth, Dawn; Fox, Caroline; Malarstig, Anders; Klinger, Kathy; Call, Kathy; Behrens, Tim; Loerch, Patrick; MÃ¤kelÃ¤, Tomi; Kaprio, Jaakko; Virolainen, Petri; Pulkki, Kari; Kilpi, Terhi; Perola, Markus; Partanen, Jukka; PitkÃ¤ranta, Anne; Kaarteenaho, Riitta; Vainio, Seppo; Turpeinen, Miia; Serpi, Raisa; Laitinen, Tarja; MÃ¤kelÃ¤, Johanna; Kosma, Veli-Matti; Kujala, Urho; Tuovila, Outi; Hendolin, Minna; Pakkanen, Raimo; Waring, Jeff; Riley-Gillis, Bridget; Liu, Jimmy; Biswas, Shameek; Diogo, Dorothee; Marshall, Catherine; Hu, Xinli; Gossel, Matthias; Graham, Robert; Cummings, Beryl; Ripatti, Samuli; Schleutker, Johanna; Arvas, Mikko; Carpén, Olli; Hinttala, Reetta; Kettunen, Johannes; Mannermaa, Arto; Laukkanen, Jari; Julkunen, Valtteri; Remes, Anne; KÃ¤lviÃ¤inen, Reetta; Peltola, Jukka; Tienari, Pentti; Rinne, Juha; Ziemann, Adam; Waring, Jeffrey; Esmaeeli, Sahar; Smaoui, Nizar; Lehtonen, Anne; Eaton, Susan; LahdenperÃ¤, Sanni; van Adelsberg, Janet; Michon, John; Kerchner, Geoff; Bowers, Natalie; Teng, Edmond; Eicher, John; Mehta, Vinay; Gormley, Padhraig; Linden, Kari; Whelan, Christopher; Xu, Fanli; Pulford, David; FÃ¤rkkilÃ¤, Martti; Pikkarainen, Sampsa; Jussila, Airi; Blomster, Timo; Kiviniemi, Mikko; Voutilainen, Markku; Georgantas, Bob; Heap, Graham; Rahimov, Fedik; Usiskin, Keith; Lu, Tim; Oh, Danny; Kalpala, Kirsi; Miller, Melissa; McCarthy, Linda; Eklund, Kari; PalomÃ¤ki, Antti; IsomÃ¤ki, Pia; PirilÃ¤, Laura; Kaipiainen-SeppÃ¤nen, Oili; Huhtakangas, Johanna; Lertratanakul, Apinya; Hochfeld, Marla; Bing, Nan; Gordillo, Jorge Esparza; Mars, Nina; Pelkonen, Margit; Kauppi, Paula; Kankaanranta, Hannu; Harju, Terttu; Close, David; Greenberg, Steven; Chen, Hubert; Betts, Jo; Ghosh, Soumitra; Salomaa, Veikko; Niiranen, Teemu; Juonala, Markus; MetsÃ¤rinne, Kaj; KÃ¤hönen, Mika; Junttila, Juhani; Laakso, Markku; PihlajamÃ¤ki, Jussi; Sinisalo, Juha; Taskinen, Marja-Riitta; Tuomi, Tiinamaija; Challis, Ben; Peterson, Andrew; Chu, Audrey; Parkkinen, Jaakko; Muslin, Anthony; Joensuu, Heikki; Meretoja, Tuomo; Aaltonen, Lauri; Mattson, Johanna; Auranen, Annika; Karihtala, Peeter; Kauppila, Saila; Auvinen, PÃ¤ivi; Elenius, Klaus; Popovic, Relja; Schutzman, Jennifer; Loboda, Andrey; Chhibber, Aparna; Lehtonen, Heli; McDonough, Stefan; Crohns, Marika; Kulkarni, Diptee; Kaarniranta, Kai; Turunen, Joni A; Ollila, Terhi; Seitsonen, Sanna; Uusitalo, Hannu; Aaltonen, Vesa; Uusitalo-JÃ¤rvinen, Hannele; LuodonpÃ¤Ã¤, Marja; Hautala, Nina; Loomis, Stephanie; Strauss, Erich; Chen, Hao; Podgornaia, Anna; Hoffman, Joshua; Tasanen, Kaisa; Huilaja, Laura; Hannula-Jouppi, Katariina; Salmi, Teea; Peltonen, Sirkku; Koulu, Leena; Harvima, Ilkka; Wu, Ying; Choy, David; Pussinen, Pirkko; Salminen, Aino; Salo, Tuula; Rice, David; Nieminen, Pekka; Palotie, Ulla; Siponen, Maria; Suominen, Liisa; MÃ¤ntylÃ¤, PÃ¤ivi; Gursoy, Ulvi; Anttonen, Vuokko; SipilÃ¤, Kirsi; Davis, Justin Wade; Quarless, Danjuma; Petrovski, Slavé; Wigmore, Eleonor; Chen, Chia-Yen; Bronson, Paola; Tsai, Ellen; Huang, Yunfeng; Maranville, Joseph; Shaikho, Elmutaz; Mohammed, Elhaj; Wadhawan, Samir; Kvikstad, Erika; Caliskan, Minal; Chang, Diana; Bhangale, Tushar; Pendergrass, Sarah; Holzinger, Emily; Chen, Xing; Hedman, Ã…sa; King, Karen S; Wang, Clarence; Xu, Ethan; Auge, Franck; Chatelain, Clement; Rajpal, Deepak; Liu, Dongyu; Call, Katherine; Xia, Tai-He; Brauer, Matt; Kurki, Mitja; Karjalainen, Juha; Havulinna, Aki; Jalanko, Anu; Palta, Priit; Della Briotta Parolo, Pietro; Zhou, Wei; LemmelÃ¤, Susanna; Rivas, Manuel; Harju, Jarmo; Lehisto, Arto; Ganna, Andrea; Llorens, Vincent; Laivuori, Hannele; RÃ¼eger, Sina; Niemi, Mari E; Tukiainen, Taru; Reeve, Mary Pat; Heyne, Henrike; Palin, Kimmo; Garcia-Tabuenca, Javier; Siirtola, Harri; Kiiskinen, Tuomo; Lee, Jiwoo; Tsuo, Kristin; Elliott, Amanda; Kristiansson, Kati; HyvÃ¤rinen, Kati; Ritari, Jarmo; Koskinen, Miika; PylkÃ¤s, Katri; Kalaoja, Marita; Karjalainen, Minna; Mantere, Tuomo; Kangasniemi, Eeva; Heikkinen, Sami; Laakkonen, Eija; Sipeky, Csilla; Heron, Samuel; Karlsson, Antti; Jambulingam, Dhanaprakash; Rathinakannan, Venkat Subramaniam; Kajanne, Risto; Aavikko, Mervi; Jiménez, Manuel GonzÃ¡lez; Della Briotta Parola, Pietro; Lehistö, Arto; Kanai, Masahiro; Kaunisto, Mari; KilpelÃ¤inen, Elina; SipilÃ¤, Timo P; Brein, Georg; Awaisa, Ghazal; Shcherban, Anastasia; Donner, Kati; Loukola, Anu; Laiho, PÃ¤ivi; Sistonen, Tuuli; Kaiharju, Essi; Laukkanen, Markku; JÃ¤rvensivu, Elina; LÃ¤hteenmÃ¤ki, Sini; MÃ¤nnikkö, Lotta; Wong, Regis; Mattsson, Hannele; Hiekkalinna, Tero; Paajanen, Teemu; PÃ¤rn, Kalle; Gracia-Tabuenca, Javier; Abner, Erin; Adams, Perrie M; Aguirre, Alyssa; Albert, Marilyn S; Albin, Roger L; Allen, Mariet; Alvarez, Lisa; Apostolova, Liana G; Arnold, Steven E; Asthana, Sanjay; Atwood, Craig S; Ayres, Gayle; Baldwin, Clinton T; Barber, Robert C; Barnes, Lisa L; Barral, Sandra; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Below, Jennifer E; Benchek, Penelope; Benitez, Bruno A; Bennett, David; Bertelson, John; Margaret, Flanagan E; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Brewer, James; Burke, James R; Burns, Jeffrey M; Bush, Will S; Buxbaum, Joseph D; Cairns, Nigel J; Cao, Chuanhai; Carlson, Christopher S; Carlsson, Cynthia M; Carney, Regina M; Carrasquillo, Minerva M; Chasse, Scott; Chesselet, Marie-Francoise; Chesi, Alessandra; Chin, Nathaniel A; Chui, Helena C; Chung, Jaeyoon; Craft, Suzanne; Crane, Paul K; Cribbs, David H; Crocco, Elizabeth A; Cruchaga, Carlos; Cuccaro, Michael L; Cullum, Munro; Darby, Eveleen; Davis, Barbara; De Jager, Philip L; DeCarli, Charles; DeToledo, John; Dick, Malcolm; Dickson, Dennis W; Dombroski, Beth A; Doody, Rachelle S; Duara, Ranjan; Ertekin-Taner, NilÃ¼fer; Evans, Denis A; Fairchild, Thomas J; Fallon, Kenneth B; Farlow, Martin R; Farrell, John J; Fernandez-Hernandez, Victoria; Ferris, Steven; Frosch, Matthew P; Fulton-Howard, Brian; Galasko, Douglas R; Gamboa, Adriana; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Grabowski, Thomas J; Graff-Radford, Neill R; Grant, Struan F A; Green, Robert C; Growdon, John H; Haines, Jonathan L; Hakonarson, Hakon; Hall, James; Hamilton, Ronald L; Harari, Oscar; Harrell, Lindy E; Haut, Jacob; Head, Elizabeth; Henderson, Victor W; Hernandez, Michelle; Hohman, Timothy; Honig, Lawrence S; Huebinger, Ryan M; Huentelman, Matthew J; Hulette, Christine M; Hyman, Bradley T; Hynan, Linda S; Ibanez, Laura; Jarvik, Gail P; Jayadev, Suman; Jin, Lee-Way; Johnson, Kim; Johnson, Leigh; Kamboh, M Ilyas; Karydas, Anna M; Katz, Mindy J; Kaye, Jeffrey A; Keene, C Dirk; Khaleeq, Aisha; Kim, Ronald; Knebl, Janice; Kowall, Neil W; Kramer, Joel H; Kuksa, Pavel P; LaFerla, Frank M; Lah, James J; Larson, Eric B; Lee, Chien-Yueh; Lee, Edward B; Lerner, Alan; Leung, Yuk Yee; Leverenz, James B; Levey, Allan I; Li, Mingyao; Lieberman, Andrew P; Lipton, Richard B; Logue, Mark; Lyketsos, Constantine G; Malamon, John; Mains, Douglas; Marson, Daniel C; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; Massman, Paul; Masurkar, Arjun; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McDonough, Stefan; McKee, Ann C; Mesulam, Marsel; Mez, Jesse; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Monuki, Edwin S; Morris, John C; Myers, Amanda J; Nguyen, Trung; O'Bryant, Sid; Olichney, John M; Ory, Marcia; Palmer, Raymond; Parisi, Joseph E; Paulson, Henry L; Pavlik, Valory; Paydarfar, David; Perez, Victoria; Peskind, Elaine; Petersen, Ronald C; Phillips-Cremins, Jennifer E; Pierce, Aimee; Polk, Marsha; Poon, Wayne W; Potter, Huntington; Qu, Liming; Quiceno, Mary; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reisch, Joan S; Ringman, John M; Roberson, Erik D; Rodriguear, Monica; Rogaeva, Ekaterina; Rosen, Howard J; Rosenberg, Roger N; Royall, Donald R; Sager, Mark A; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Slifer, Susan H; Small, Scott; Smith, Amanda G; Smith, Janet P; Song, Yeunjoo E; Sonnen, Joshua A; Spina, Salvatore; George-Hyslop, Peter St; Stern, Robert A; Stevens, Alan B; Strittmatter, Stephen M; Sultzer, David; Swerdlow, Russell H; Tanzi, Rudolph E; Tilson, Jeffrey L; Trojanowski, John Q; Troncoso, Juan C; Tsuang, Debby W; Valladares, Otto; Van Deerlin, Vivianna M; van Eldik, Linda J; Vassar, Robert; Vinters, Harry V; Vonsattel, Jean-Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Whitehead, Patrice L; Wijsman, Ellen M; Wilhelmsen, Kirk C; Williams, Benjamin; Williamson, Jennifer; Wilms, Henrik; Wingo, Thomas S; Wisniewski, Thomas; Woltjer, Randall L; Woon, Martin; Wright, Clinton B; Wu, Chuang-Kuo; Younkin, Steven G; Yu, Chang-En; Yu, Lei; Zhang, Yuanchao; Zhao, Yi; Zhu, Xiongwei; Adams, Hieab; Akinyemi, Rufus O; Ali, Muhammad; Armstrong, Nicola; Aparicio, Hugo J; Bahadori, Maryam; Becker, James T; Breteler, Monique; Chasman, Daniel; Chauhan, Ganesh; Comic, Hata; Cox, Simon; Cupples, Adrienne L; Davies, Gail; DeCarli, Charles S; Duperron, Marie-Gabrielle; Dupuis, Josée; Evans, Tavia; Fan, Frank; Fitzpatrick, Annette; Fohner, Alison E; Ganguli, Mary; Geerlings, Mirjam; Glatt, Stephen J; Gonzalez, Hector M; Goss, Monica; Grabe, Hans; Habes, Mohamad; Heckbert, Susan R; Hofer, Edith; Hong, Elliot; Hughes, Timothy; Kautz, Tiffany F; Knol, Maria; Kremen, William; Lacaze, Paul; Lahti, Jari; Grand, Quentin Le; Litkowski, Elizabeth; Li, Shuo; Liu, Dan; Liu, Xuan; Loitfelder, Marisa; Manning, Alisa; Maillard, Pauline; Marioni, Riccardo; Mazoyer, Bernard; van Lent, Debora Melo; Mei, Hao; Mishra, Aniket; Nyquist, Paul; O'Connell, Jeffrey; Patel, Yash; Paus, Tomas; Pausova, Zdenka; Raikkonen-Talvitie, Katri; Riaz, Moeen; Rich, Stephen; Rotter, Jerome; Romero, Jose; Roshchupkin, Gena; Saba, Yasaman; Sargurupremraj, Murali; Schmidt, Helena; Schmidt, Reinhold; Shulman, Joshua M; Smith, Jennifer; Sekhar, Hema; Rajula, Reddy; Shin, Jean; Simino, Jeannette; Sliz, Eeva; Teumer, Alexander; Thomas, Alvin; Tin, Adrienne; Tucker-Drob, Elliot; Vojinovic, Dina; Wang, Yanbing; Weinstein, Galit; Williams, Dylan; Wittfeld, Katharina; Yanek, Lisa; Yang, Yunju

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ÃŽÂµ4 allele.

PMCID:9005347

PMID: 35379992

ISSN: 1546-1718

CID: 5213092

Clinical neuropsychologist. 2022:36(3):699-720.DOI: 10.1080/13854046.2020.1794044

Recurrent intracerebral hemorrhages due to central nervous system vasculitis: A neuropsychological case report [Case Report]

Resch, Zachary J; Ovsiew, Gabriel P; Soble, Jason R

OBJECTIVE:Primary angiitis of the central nervous system (PACNS) is a rare and devastating form of vasculitis that destroys the vessels of the brain and spinal cord, resulting in progressive and debilitating neurologic symptoms. The objective of the present study was to detail the diagnostic process of a case of a patient with PACNS who suffered from six intracerebral hemorrhages (ICHs). METHOD/METHODS:The patient was an African American woman with a history of recurrent ICHs of unclear etiology who received serial neuropsychological evaluations over the course of a 5-year period. Two comprehensive neuropsychological evaluations are included, as well as an overview of her clinical course, including differential diagnostic considerations and treatment planning. RESULTS:Neuropsychological assessment revealed marked deficits in visuospatial abilities and processing speed associated with her underlying neuropathology. Integrated review of her medical records indicated a probable diagnosis of PACNS as the likely etiology of her recurrent ICHs. CONCLUSIONS:This study demonstrates the importance of differential diagnosis of low base-rate conditions, functional neuroanatomy and neurobehavioral phenomenology, serial assessment, and cognitive reserve in clinical neuropsychological practice.

PMID: 32715901

ISSN: 1744-4144

CID: 5592712

Psycho-oncology. 2022:31(4):622-630.DOI: 10.1002/pon.5847

African-centered coping, resilience, and psychological distress in Black prostate cancer patients

Martin, Chloé M; Schofield, Elizabeth; Napolitano, Stephanie; Avildsen, Isabelle K; Emanu, Jessica C; Tutino, Rebecca; Roth, Andrew J; Nelson, Christian J

OBJECTIVE:Blacks have the highest incidence and mortality rates for prostate cancer (PCa) in the U.S. Black PCa patients (PCaP) also report high psychological distress. Identifying culturally specific coping strategies that lower distress among Black PCaP could help improve psychological interventions for this group. African-centered coping (strategies unique to the structure of Black personality and the African-centered worldview) have been identified. We hypothesized that these coping strategies and resilience would be associated with lower psychological distress (anxiety and depression) in Black PCaP. METHODS:Black PCaP (N = 95) completed a survey assessing African-centered coping strategies, resilience, anxiety, and depression. Multiple regression was employed to examine African-centered coping strategies and resilience as predictors of psychological distress. RESULTS:Participants were aged M = 67 ± 9 years and 52% had late-stage PCa. Twenty percent met criteria for clinically significant anxiety, and 17% for depression. African-centered coping strategies were not associated with lower anxiety or depression, while resilience was associated with decreased anxiety (r = -0.45, p < 0.001) and depression (r = -0.54, p < 0.001). Mediation analyses did not support an indirect association among African-centered coping strategies, resilience, and anxiety and depression. CONCLUSIONS:Contrary to hypotheses, African-centered coping strategies were not associated with psychological distress. However, as predicted, greater resilience was associated with lower anxiety and depression. These findings support the relevancy of resilience in Blacks' psychological adjustment to PCa. It might be worthwhile to explore African-centered coping strategies that help Black PCaP cope with distress.

PMCID:9881393

PMID: 34751457

ISSN: 1099-1611

CID: 5783362