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Predictors of Hospitalization in a Cohort of Children with Elevated Symptoms of Mania

Horwitz, Sarah McCue; Hoagwood, Kimberly Eaton; Guo, Fei; Arnold, L Eugene; Taylor, H Gerry; Young, Andrea S; Youngstrom, Eric A; Fristad, Mary A; Birmaher, Boris; Findling, Robert L
Describe hospitalization rates in children with elevated symptoms of mania and determine predictors of psychiatric hospitalizations during the 96 month follow-up. Eligible 6-12.9 year olds and their parents visiting 9 outpatient mental health clinics were invited to be screened with the Parent General Behavior Inventory 10-item Mania Scale. Of 605 children with elevated symptoms of mania eligible for follow-up, 538 (88.9%) had ≥ 1 of 16 possible follow-up interviews and are examined herein. Multivariate Cox regression indicated only four factors predicted hospitalizations: parental mental health problems (HR 1.80; 95% CI 1.21, 2.69); hospitalization prior to study entry (HR 3.03; 95% CI 1.80, 4.43); continuous outpatient mental health service use (HR 3.73; 95% CI 2.40, 5.50); and low parental assessment of how well treatment matched child's needs (HR 3.97; 95% CI 2.50, 6.31). Parental perspectives on mental health services should be gathered routinely, as they can signal treatment failures.
PMID: 32556647
ISSN: 1573-3289
CID: 4485242

Afraid and Awake: The Interaction Between Trauma and Sleep in Children and Adolescents

Fellman, Veronica; Heppell, Patrick J; Rao, Suchet
Traumatic experiences and sleep disturbances are both common in children and adolescents. Because of the reciprocal relationship between sleep complaints and trauma, a mental health evaluation should include not only an assessment of posttraumatic stress disorder and other trauma symptoms but also a specific evaluation of sleep-related complaints. Similarly, if a history of both trauma and sleep complaints is identified, an effective trauma-informed intervention, whether psychological, psychopharmacologic, or a combination of the two, should directly address sleep issues.
PMID: 33223064
ISSN: 1558-0490
CID: 4680152

Just Let Me Sleep in: Identifying and Treating Delayed Sleep Phase Disorder in Adolescents

Feder, Michael A; Baroni, Argelinda
Individuals with delayed sleep phase disorder (DSPD) are unable to naturally fall asleep and awake at conventional times; for this reason, DSPD is often mistaken for insomnia. However, unlike many patients with insomnia, those with DSPD struggle to get up at appropriate times. DSPD is associated with school refusal, academic difficulties, and lower employment rate. DSPD in youth has prevalence as high as 16%, and is often comorbid with other psychiatric disorders. Treatments include appropriate light exposure during the day, melatonin use, developing an evening routine that minimizes arousal-increasing activities, and gradually shifting sleep-wake times toward more functional ones.
PMID: 33223060
ISSN: 1558-0490
CID: 4680142

Pediatric Sleep Disorders: A Unique Opportunity for Child and Adolescent Psychiatry [Editorial]

Lunsford-Avery, Jessica R; Baroni, Argelinda
PMID: 33223071
ISSN: 1558-0490
CID: 4680162

When Night Falls Fast: Sleep and Suicidal Behavior Among Adolescents and Young Adults

Fernandes, Sara N; Zuckerman, Emily; Miranda, Regina; Baroni, Argelinda
Sleep disturbances have been linked to suicidal ideation and behaviors in adolescents. Specifically, insomnia and nightmares are associated with current suicide risk and predict future ideation. Associations between hypersomnia, sleep apnea, and suicide remain inconclusive. Potential biological mechanisms underlying these relationships include executive functioning deficits and hyperarousal. Related psychological factors may include thwarted belongingness, perceived burdensomeness, and negative appraisals. Assessing suicide risk in patients with sleep disturbances, and vice versa, is needed. Therapeutic interventions such as cognitive behavior therapy for insomnia and imagery rehearsal treatment, as well as pharmacologic treatments, show promise in treating sleep disorders and suicidal behavior.
PMID: 33223066
ISSN: 1558-0490
CID: 4676382

Editors' Best of 2020 [Editorial]

Novins, Douglas K; Althoff, Robert R; Cortese, Samuele; Drury, Stacy S; Frazier, Jean A; Henderson, Schuyler W; McCauley, Elizabeth; Njoroge, Wanjikũ F M; White, Tonya J H
There is, in the content of the Journal, an embarrassment of riches, and picking a "best" seems to demand a certain qualification: is the "best" the most interesting, most surprising, most educational, most important, most provocative, most enjoyable? How to choose? We are hardly unbiased and can admit to a special affection for the ones that we and the authors worked hardest on, hammering version after version into shape. Acknowledging these biases, here are the 2020 articles that we think deserve your attention, or at least a second read.
PMID: 33353662
ISSN: 1527-5418
CID: 4731032

Risk and protective factors for mental disorders with onset in childhood/adolescence: an umbrella review of published meta-analyses of observational longitudinal studies

Marco, Solmi; Dragioti, Elena; Arango, Celso; Radua, Joaquim; Ostinelli, Edoardo; Kilic, Ozge; Yilmaz, Ugur Eser; Yalcinay-İnan, Merve; Soares, Fernanda Cunha; Mariano, Luca; Mosillo, Pierluca; Cortese, Samuele; Correll, Christoph U; Carvalho, Andre F; Shin, Jae Il; Fusar-Poli, Paolo
The patho-etiology of mental disorders with onset in childhood or adolescence other than autism spectrum disorder and attention-deficit/hyperactivity disorder remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases. Quality of MAs was measured with AMSTAR-2. Out of 6,851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8,884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium and antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.
PMID: 32931804
ISSN: 1873-7528
CID: 4592932

Differential utility of teacher and parent-teacher combined information in the assessment of Attention Deficit/Hyperactivity Disorder symptoms

Garcia-Rosales, Alexandra; Vitoratou, Silia; Faraone, Stephen V; Rudaizky, Daniel; Banaschewski, Tobias; Asherson, Philip; Sonuga-Barke, Edmund; Buitelaar, Jan; Oades, Robert D; Rothenberger, Aribert; Steinhausen, Hans-Christoph; Taylor, Eric; Chen, Wai
BACKGROUND:Consistent research findings indicate that parents and teachers observe genuinely different Attention Deficit/Hyperactivity Disorder (ADHD) behaviours in their respective settings. OBJECTIVE:To evaluate the utility of information provided by teacher informant assessments (INFAs) of ADHD symptoms, and the implications of aggregation algorithms in combing parents' information, i.e. using 'or-rule' (endorsement by either one informant) versus 'and-rule' (endorsement by both informants). METHOD/METHODS:Teacher ratings on Conners scales and clinical data from parental accounts on 1383 probands and their siblings from the IMAGE study were analysed. The psychometric properties of teacher and combined ratings using the item response theory model (IRT) are presented. Kappa coefficients, intraclass correlations and linear regression were employed. RESULTS:First, teacher endorsement of symptoms is located in a narrow part of the trait continuum close to the average levels. Symptoms exhibit comparable perception in the measurement of the trait(s) with similar discrimination ability and information (reliability). Second, the IRT properties of the 'or-rule' ratings are predominantly influenced by parent-INFAs; and the 'and-rule' ratings predominantly by teacher-INFAs ratings. Third, parent-teacher INFAs agreement was low, both for individual items (κ = 0.01-0.15) and for dimensional scores (r = 0.12-0.16). The 'or-rule' captured milder expressions of ADHD symptoms, whereas the 'and-rule' indexed greater severity of ADHD. CONCLUSIONS:Parent and teacher-INFAs provide different kinds of information, while both are useful. Teacher-INFA and the 'and-rule' provide a more accurate index of severity than an additive symptom count. Parent-INFA and the 'or-rule' are more sensitive for detecting cases with milder ADHD.
PMID: 32246275
ISSN: 1435-165x
CID: 4485972

To which world regions does the valence-dominance model of social perception apply?

Jones, Benedict C; DeBruine, Lisa M; Flake, Jessica K; Liuzza, Marco Tullio; Antfolk, Jan; Arinze, Nwadiogo C; Ndukaihe, Izuchukwu L G; Bloxsom, Nicholas G; Lewis, Savannah C; Foroni, Francesco; Willis, Megan L; Cubillas, Carmelo P; Vadillo, Miguel A; Turiegano, Enrique; Gilead, Michael; Simchon, Almog; Saribay, S Adil; Owsley, Nicholas C; Jang, Chaning; Mburu, Georgina; Calvillo, Dustin P; Wlodarczyk, Anna; Qi, Yue; Ariyabuddhiphongs, Kris; Jarukasemthawee, Somboon; Manley, Harry; Suavansri, Panita; Taephant, Nattasuda; Stolier, Ryan M; Evans, Thomas R; Bonick, Judson; Lindemans, Jan W; Ashworth, Logan F; Hahn, Amanda C; Chevallier, Coralie; Kapucu, Aycan; Karaaslan, Aslan; Leongómez, Juan David; Sánchez, Oscar R; Valderrama, Eugenio; Vásquez-Amézquita, Milena; Hajdu, Nandor; Aczel, Balazs; Szecsi, Peter; Andreychik, Michael; Musser, Erica D; Batres, Carlota; Hu, Chuan-Peng; Liu, Qing-Lan; Legate, Nicole; Vaughn, Leigh Ann; Barzykowski, Krystian; Golik, Karolina; Schmid, Irina; Stieger, Stefan; Artner, Richard; Mues, Chiel; Vanpaemel, Wolf; Jiang, Zhongqing; Wu, Qi; Marcu, Gabriela M; Stephen, Ian D; Lu, Jackson G; Philipp, Michael C; Arnal, Jack D; Hehman, Eric; Xie, Sally Y; Chopik, William J; Seehuus, Martin; Azouaghe, Soufian; Belhaj, Abdelkarim; Elouafa, Jamal; Wilson, John P; Kruse, Elliott; Papadatou-Pastou, Marietta; De La Rosa-Gómez, Anabel; Barba-Sánchez, Alan E; González-Santoyo, Isaac; Hsu, Tsuyueh; Kung, Chun-Chia; Wang, Hsiao-Hsin; Freeman, Jonathan B; Oh, Dong Won; Schei, Vidar; Sverdrup, Therese E; Levitan, Carmel A; Cook, Corey L; Chandel, Priyanka; Kujur, Pratibha; Parganiha, Arti; Parveen, Noorshama; Pati, Atanu Kumar; Pradhan, Sraddha; Singh, Margaret M; Pande, Babita; Bavolar, Jozef; Kačmár, Pavol; Zakharov, Ilya; Álvarez-Solas, Sara; Baskin, Ernest; Thirkettle, Martin; Schmidt, Kathleen; Christopherson, Cody D; Leonis, Trinity; Suchow, Jordan W; Olofsson, Jonas K; Jernsäther, Teodor; Lee, Ai-Suan; Beaudry, Jennifer L; Gogan, Taylor D; Oldmeadow, Julian A; Balas, Benjamin; Stevens, Laura M; Colloff, Melissa F; Flowe, Heather D; Gülgöz, Sami; Brandt, Mark J; Hoyer, Karlijn; Jaeger, Bastian; Ren, Dongning; Sleegers, Willem W A; Wissink, Joeri; Kaminski, Gwenaël; Floerke, Victoria A; Urry, Heather L; Chen, Sau-Chin; Pfuhl, Gerit; Vally, Zahir; Basnight-Brown, Dana M; Jzerman, Hans I; Sarda, Elisa; Neyroud, Lison; Badidi, Touhami; Van der Linden, Nicolas; Tan, Chrystalle B Y; Kovic, Vanja; Sampaio, Waldir; Ferreira, Paulo; Santos, Diana; Burin, Debora I; Gardiner, Gwendolyn; Protzko, John; Schild, Christoph; ÅšcigaÅ‚a, Karolina A; Zettler, Ingo; O'Mara Kunz, Erin M; Storage, Daniel; Wagemans, Fieke M A; Saunders, Blair; Sirota, Miroslav; Sloane, Guyan V; Lima, Tiago J S; Uittenhove, Kim; Vergauwe, Evie; Jaworska, Katarzyna; Stern, Julia; Ask, Karl; van Zyl, Casper J J; Körner, Anita; Weissgerber, Sophia C; Boudesseul, Jordane; Ruiz-Dodobara, Fernando; Ritchie, Kay L; Michalak, Nicholas M; Blake, Khandis R; White, David; Gordon-Finlayson, Alasdair R; Anne, Michele; Janssen, Steve M J; Lee, Kean Mun; Nielsen, Tonje K; Tamnes, Christian K; Zickfeld, Janis H; Rosa, Anna Dalla; Vianello, Michelangelo; Kocsor, Ferenc; Kozma, Luca; Putz, Ádám; Tressoldi, Patrizio; Irrazabal, Natalia; Chatard, Armand; Lins, Samuel; Pinto, Isabel R; Lutz, Johannes; Adamkovic, Matus; Babincak, Peter; Baník, Gabriel; Ropovik, Ivan; Coetzee, Vinet; Dixson, Barnaby J W; Ribeiro, Gianni; Peters, Kim; Steffens, Niklas K; Tan, Kok Wei; Thorstenson, Christopher A; Fernandez, Ana Maria; Hsu, Rafael M C S; Valentova, Jaroslava V; Varella, Marco A C; Corral-Frías, Nadia S; Frías-Armenta, Martha; Hatami, Javad; Monajem, Arash; Sharifian, MohammadHasan; Frohlich, Brooke; Lin, Hause; Inzlicht, Michael; Alaei, Ravin; Rule, Nicholas O; Lamm, Claus; Pronizius, Ekaterina; Voracek, Martin; Olsen, Jerome; Giolla, Erik Mac; Akgoz, Aysegul; ÖzdoÄŸru, Asil A; Crawford, Matthew T; Bennett-Day, Brooke; Koehn, Monica A; Okan, Ceylan; Gill, Tripat; Miller, Jeremy K; Dunham, Yarrow; Yang, Xin; Alper, Sinan; Borras-Guevara, Martha Lucia; Cai, Sun Jun; Tiantian, Dong; Danvers, Alexander F; Feinberg, David R; Armstrong, Marie M; Gilboa-Schechtman, Eva; McCarthy, Randy J; Muñoz-Reyes, Jose Antonio; Polo, Pablo; Shiramazu, Victor K M; Yan, Wen-Jing; Carvalho, Lilian; Forscher, Patrick S; Chartier, Christopher R; Coles, Nicholas A
Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .
PMID: 33398150
ISSN: 2397-3374
CID: 4738672

Staff Perceptions and Implementation Fidelity of an Autism Spectrum Disorder Care Pathway on a Child/Adolescent General Psychiatric Inpatient Service

Donnelly, Lauren J; Cervantes, Paige E; Okparaeke, Eugene; Stein, Cheryl R; Filton, Beryl; Kuriakose, Sarah; Havens, Jennifer; Horwitz, Sarah M
While youth with autism spectrum disorder (ASD) are psychiatrically hospitalized at high rates, general psychiatric settings are not designed to meet their unique needs. Previous evaluations of an ASD-Care Pathway (ASD-CP) on a general psychiatric unit revealed sustained reductions in crisis interventions (intramuscular medication use, holds/restraints; Cervantes et al. in J Autism Dev Disord 49(8):3173-3180, https://doi.org/10.1007/s10803-019-04029-6, 2019; Kuriakose et al. in J Autism Dev Disord 48(12):4082-4089, https://doi.org/10.1007/s10803-018-3666-y, 2018). The current study investigated staff perceptions of the ASD-CP (N = 30), and examined rates of ASD-CP implementation fidelity in relation to patient outcomes (N = 28). Staff identified visual communication aids and reward strategies as most helpful. The number of days of reward identification early in the inpatient stay was associated with fewer crisis interventions later in a patient's stay.
PMID: 32394312
ISSN: 1573-3432
CID: 4438022