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Restless Legs Syndrome in Children and Adolescents

DelRosso, Lourdes M; Mogavero, Maria Paola; Baroni, Argelinda; Bruni, Oliviero; Ferri, Raffaele
Children with psychiatric comorbidities frequently are referred for evaluation of sleep complaints. Common sleep symptoms can include difficulty falling asleep, frequent nocturnal awakening, restless sleep, and symptoms of restless legs syndrome (RLS). The understanding of the sleep condition in relation to the psychiatric comorbidity often is a challenge to the physician and often sleep disorders remain undiagnosed, untreated, or undertreated. Restless legs syndrome has been associated with psychiatric comorbidities and with certain medications, such as antidepressants, antihistamines, and antipsychotics. This article reviews the presentation of RLS and restless sleep, the association with psychiatric comorbidities, and treatment options.
PMID: 33223058
ISSN: 1558-0490
CID: 4676362

Editors' Best of 2020 [Editorial]

Novins, Douglas K; Althoff, Robert R; Cortese, Samuele; Drury, Stacy S; Frazier, Jean A; Henderson, Schuyler W; McCauley, Elizabeth; Njoroge, Wanjikũ F M; White, Tonya J H
There is, in the content of the Journal, an embarrassment of riches, and picking a "best" seems to demand a certain qualification: is the "best" the most interesting, most surprising, most educational, most important, most provocative, most enjoyable? How to choose? We are hardly unbiased and can admit to a special affection for the ones that we and the authors worked hardest on, hammering version after version into shape. Acknowledging these biases, here are the 2020 articles that we think deserve your attention, or at least a second read.
PMID: 33353662
ISSN: 1527-5418
CID: 4731032

Afraid and Awake: The Interaction Between Trauma and Sleep in Children and Adolescents

Fellman, Veronica; Heppell, Patrick J; Rao, Suchet
Traumatic experiences and sleep disturbances are both common in children and adolescents. Because of the reciprocal relationship between sleep complaints and trauma, a mental health evaluation should include not only an assessment of posttraumatic stress disorder and other trauma symptoms but also a specific evaluation of sleep-related complaints. Similarly, if a history of both trauma and sleep complaints is identified, an effective trauma-informed intervention, whether psychological, psychopharmacologic, or a combination of the two, should directly address sleep issues.
PMID: 33223064
ISSN: 1558-0490
CID: 4680152

Differential utility of teacher and parent-teacher combined information in the assessment of Attention Deficit/Hyperactivity Disorder symptoms

Garcia-Rosales, Alexandra; Vitoratou, Silia; Faraone, Stephen V; Rudaizky, Daniel; Banaschewski, Tobias; Asherson, Philip; Sonuga-Barke, Edmund; Buitelaar, Jan; Oades, Robert D; Rothenberger, Aribert; Steinhausen, Hans-Christoph; Taylor, Eric; Chen, Wai
BACKGROUND:Consistent research findings indicate that parents and teachers observe genuinely different Attention Deficit/Hyperactivity Disorder (ADHD) behaviours in their respective settings. OBJECTIVE:To evaluate the utility of information provided by teacher informant assessments (INFAs) of ADHD symptoms, and the implications of aggregation algorithms in combing parents' information, i.e. using 'or-rule' (endorsement by either one informant) versus 'and-rule' (endorsement by both informants). METHOD/METHODS:Teacher ratings on Conners scales and clinical data from parental accounts on 1383 probands and their siblings from the IMAGE study were analysed. The psychometric properties of teacher and combined ratings using the item response theory model (IRT) are presented. Kappa coefficients, intraclass correlations and linear regression were employed. RESULTS:First, teacher endorsement of symptoms is located in a narrow part of the trait continuum close to the average levels. Symptoms exhibit comparable perception in the measurement of the trait(s) with similar discrimination ability and information (reliability). Second, the IRT properties of the 'or-rule' ratings are predominantly influenced by parent-INFAs; and the 'and-rule' ratings predominantly by teacher-INFAs ratings. Third, parent-teacher INFAs agreement was low, both for individual items (κ = 0.01-0.15) and for dimensional scores (r = 0.12-0.16). The 'or-rule' captured milder expressions of ADHD symptoms, whereas the 'and-rule' indexed greater severity of ADHD. CONCLUSIONS:Parent and teacher-INFAs provide different kinds of information, while both are useful. Teacher-INFA and the 'and-rule' provide a more accurate index of severity than an additive symptom count. Parent-INFA and the 'or-rule' are more sensitive for detecting cases with milder ADHD.
PMID: 32246275
ISSN: 1435-165x
CID: 4485972

To which world regions does the valence-dominance model of social perception apply?

Jones, Benedict C; DeBruine, Lisa M; Flake, Jessica K; Liuzza, Marco Tullio; Antfolk, Jan; Arinze, Nwadiogo C; Ndukaihe, Izuchukwu L G; Bloxsom, Nicholas G; Lewis, Savannah C; Foroni, Francesco; Willis, Megan L; Cubillas, Carmelo P; Vadillo, Miguel A; Turiegano, Enrique; Gilead, Michael; Simchon, Almog; Saribay, S Adil; Owsley, Nicholas C; Jang, Chaning; Mburu, Georgina; Calvillo, Dustin P; Wlodarczyk, Anna; Qi, Yue; Ariyabuddhiphongs, Kris; Jarukasemthawee, Somboon; Manley, Harry; Suavansri, Panita; Taephant, Nattasuda; Stolier, Ryan M; Evans, Thomas R; Bonick, Judson; Lindemans, Jan W; Ashworth, Logan F; Hahn, Amanda C; Chevallier, Coralie; Kapucu, Aycan; Karaaslan, Aslan; Leongómez, Juan David; Sánchez, Oscar R; Valderrama, Eugenio; Vásquez-Amézquita, Milena; Hajdu, Nandor; Aczel, Balazs; Szecsi, Peter; Andreychik, Michael; Musser, Erica D; Batres, Carlota; Hu, Chuan-Peng; Liu, Qing-Lan; Legate, Nicole; Vaughn, Leigh Ann; Barzykowski, Krystian; Golik, Karolina; Schmid, Irina; Stieger, Stefan; Artner, Richard; Mues, Chiel; Vanpaemel, Wolf; Jiang, Zhongqing; Wu, Qi; Marcu, Gabriela M; Stephen, Ian D; Lu, Jackson G; Philipp, Michael C; Arnal, Jack D; Hehman, Eric; Xie, Sally Y; Chopik, William J; Seehuus, Martin; Azouaghe, Soufian; Belhaj, Abdelkarim; Elouafa, Jamal; Wilson, John P; Kruse, Elliott; Papadatou-Pastou, Marietta; De La Rosa-Gómez, Anabel; Barba-Sánchez, Alan E; González-Santoyo, Isaac; Hsu, Tsuyueh; Kung, Chun-Chia; Wang, Hsiao-Hsin; Freeman, Jonathan B; Oh, Dong Won; Schei, Vidar; Sverdrup, Therese E; Levitan, Carmel A; Cook, Corey L; Chandel, Priyanka; Kujur, Pratibha; Parganiha, Arti; Parveen, Noorshama; Pati, Atanu Kumar; Pradhan, Sraddha; Singh, Margaret M; Pande, Babita; Bavolar, Jozef; Kačmár, Pavol; Zakharov, Ilya; Álvarez-Solas, Sara; Baskin, Ernest; Thirkettle, Martin; Schmidt, Kathleen; Christopherson, Cody D; Leonis, Trinity; Suchow, Jordan W; Olofsson, Jonas K; Jernsäther, Teodor; Lee, Ai-Suan; Beaudry, Jennifer L; Gogan, Taylor D; Oldmeadow, Julian A; Balas, Benjamin; Stevens, Laura M; Colloff, Melissa F; Flowe, Heather D; Gülgöz, Sami; Brandt, Mark J; Hoyer, Karlijn; Jaeger, Bastian; Ren, Dongning; Sleegers, Willem W A; Wissink, Joeri; Kaminski, Gwenaël; Floerke, Victoria A; Urry, Heather L; Chen, Sau-Chin; Pfuhl, Gerit; Vally, Zahir; Basnight-Brown, Dana M; Jzerman, Hans I; Sarda, Elisa; Neyroud, Lison; Badidi, Touhami; Van der Linden, Nicolas; Tan, Chrystalle B Y; Kovic, Vanja; Sampaio, Waldir; Ferreira, Paulo; Santos, Diana; Burin, Debora I; Gardiner, Gwendolyn; Protzko, John; Schild, Christoph; ÅšcigaÅ‚a, Karolina A; Zettler, Ingo; O'Mara Kunz, Erin M; Storage, Daniel; Wagemans, Fieke M A; Saunders, Blair; Sirota, Miroslav; Sloane, Guyan V; Lima, Tiago J S; Uittenhove, Kim; Vergauwe, Evie; Jaworska, Katarzyna; Stern, Julia; Ask, Karl; van Zyl, Casper J J; Körner, Anita; Weissgerber, Sophia C; Boudesseul, Jordane; Ruiz-Dodobara, Fernando; Ritchie, Kay L; Michalak, Nicholas M; Blake, Khandis R; White, David; Gordon-Finlayson, Alasdair R; Anne, Michele; Janssen, Steve M J; Lee, Kean Mun; Nielsen, Tonje K; Tamnes, Christian K; Zickfeld, Janis H; Rosa, Anna Dalla; Vianello, Michelangelo; Kocsor, Ferenc; Kozma, Luca; Putz, Ádám; Tressoldi, Patrizio; Irrazabal, Natalia; Chatard, Armand; Lins, Samuel; Pinto, Isabel R; Lutz, Johannes; Adamkovic, Matus; Babincak, Peter; Baník, Gabriel; Ropovik, Ivan; Coetzee, Vinet; Dixson, Barnaby J W; Ribeiro, Gianni; Peters, Kim; Steffens, Niklas K; Tan, Kok Wei; Thorstenson, Christopher A; Fernandez, Ana Maria; Hsu, Rafael M C S; Valentova, Jaroslava V; Varella, Marco A C; Corral-Frías, Nadia S; Frías-Armenta, Martha; Hatami, Javad; Monajem, Arash; Sharifian, MohammadHasan; Frohlich, Brooke; Lin, Hause; Inzlicht, Michael; Alaei, Ravin; Rule, Nicholas O; Lamm, Claus; Pronizius, Ekaterina; Voracek, Martin; Olsen, Jerome; Giolla, Erik Mac; Akgoz, Aysegul; ÖzdoÄŸru, Asil A; Crawford, Matthew T; Bennett-Day, Brooke; Koehn, Monica A; Okan, Ceylan; Gill, Tripat; Miller, Jeremy K; Dunham, Yarrow; Yang, Xin; Alper, Sinan; Borras-Guevara, Martha Lucia; Cai, Sun Jun; Tiantian, Dong; Danvers, Alexander F; Feinberg, David R; Armstrong, Marie M; Gilboa-Schechtman, Eva; McCarthy, Randy J; Muñoz-Reyes, Jose Antonio; Polo, Pablo; Shiramazu, Victor K M; Yan, Wen-Jing; Carvalho, Lilian; Forscher, Patrick S; Chartier, Christopher R; Coles, Nicholas A
Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .
PMID: 33398150
ISSN: 2397-3374
CID: 4738672

Risk and protective factors for mental disorders with onset in childhood/adolescence: an umbrella review of published meta-analyses of observational longitudinal studies

Marco, Solmi; Dragioti, Elena; Arango, Celso; Radua, Joaquim; Ostinelli, Edoardo; Kilic, Ozge; Yilmaz, Ugur Eser; Yalcinay-İnan, Merve; Soares, Fernanda Cunha; Mariano, Luca; Mosillo, Pierluca; Cortese, Samuele; Correll, Christoph U; Carvalho, Andre F; Shin, Jae Il; Fusar-Poli, Paolo
The patho-etiology of mental disorders with onset in childhood or adolescence other than autism spectrum disorder and attention-deficit/hyperactivity disorder remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases. Quality of MAs was measured with AMSTAR-2. Out of 6,851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8,884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium and antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.
PMID: 32931804
ISSN: 1873-7528
CID: 4592932

Sleep-Related Problems and Pediatric Anxiety Disorders

Crowe, Katherine; Spiro-Levitt, Carolyn
Sleep-related problems are highly prevalent among childhood and adolescent anxiety disorders. The objective of this review was to summarize the relevant clinical research literature as it pertains to the nature of the association between sleep-related problems and youth anxiety, developmental factors relevant to this association, and intervention efforts to target comorbid sleep challenges and anxiety. Limitations of the literature and future directions are discussed.
PMID: 33223063
ISSN: 1558-0490
CID: 4676372

Unpacking Racial/Ethnic Differences in the Associations between Neighborhood Disadvantage and Academic Achievement: Mediation of Future Orientation and Moderation of Parental Support

Xiao, Yunyu; Romanelli, Meghan; Vélez-Grau, Carolina; Lindsey, Michael A
Despite the extensive literature on the deleterious effects of perceived neighborhood disadvantage on academic achievement, there is a dearth of information on racial/ethnic differences in the underlying roles of future orientation and parental support that may mediate or moderate this association. Using data from 3618 students in grades 6-9 (50% female, Meanage = 12.9 [1.3], 6.99% Black, 10.39% Hispanic/Latino, 82.61% White) in two communities in North Carolina during 2009-2014 who completed the School Success Profile, a self-report social environmental assessment, this study conducted multiple group analyses across three racial/ethnic groups (Black, Hispanic/Latino, White), revealing that perceived neighborhood disadvantage was associated with lower future orientation, which in turn was related to poorer academic achievement. The mediating effects were stronger among Black youth compared to White and Hispanic/Latino adolescents. Adolescents with high parental support were minimally affected by perceived neighborhood disadvantage. The findings identify nuanced racial/ethnic disparities in perceived neighborhood influences on academic achievement and raise important intervention targets to promote academic achievement among disadvantaged subgroups.
PMID: 32964380
ISSN: 1573-6601
CID: 5030882

Staff Perceptions and Implementation Fidelity of an Autism Spectrum Disorder Care Pathway on a Child/Adolescent General Psychiatric Inpatient Service

Donnelly, Lauren J; Cervantes, Paige E; Okparaeke, Eugene; Stein, Cheryl R; Filton, Beryl; Kuriakose, Sarah; Havens, Jennifer; Horwitz, Sarah M
While youth with autism spectrum disorder (ASD) are psychiatrically hospitalized at high rates, general psychiatric settings are not designed to meet their unique needs. Previous evaluations of an ASD-Care Pathway (ASD-CP) on a general psychiatric unit revealed sustained reductions in crisis interventions (intramuscular medication use, holds/restraints; Cervantes et al. in J Autism Dev Disord 49(8):3173-3180, https://doi.org/10.1007/s10803-019-04029-6, 2019; Kuriakose et al. in J Autism Dev Disord 48(12):4082-4089, https://doi.org/10.1007/s10803-018-3666-y, 2018). The current study investigated staff perceptions of the ASD-CP (N = 30), and examined rates of ASD-CP implementation fidelity in relation to patient outcomes (N = 28). Staff identified visual communication aids and reward strategies as most helpful. The number of days of reward identification early in the inpatient stay was associated with fewer crisis interventions later in a patient's stay.
PMID: 32394312
ISSN: 1573-3432
CID: 4438022

Processing speed and brain volume in individuals at clinical high-risk for psychosis with comorbid eating disorders: A brief report [Letter]

Sarac, Cansu; Bilgrami, Zarina R; Haas, Shalaila S; Herrera, Shaynna N; Myers, Jonathan J; Nelson, Barnaby; Malaspina, Dolores; Corcoran, Cheryl M
PMID: 32928620
ISSN: 1573-2509
CID: 4592742