Faculty Bibliography

Objective: Evaluate the efficacy and tolerability of triple-bead mixed amphetamine salts (MAS) in ADHD. Method: Adults with ADHD Rating Scale IV (ADHD-RS-IV) total scores ≥32 were randomized to 6 weeks of triple-bead MAS (25, 50, or 75 mg) or placebo. The primary endpoint was ADHD-RS-IV total score change from baseline at end of study (EOS). Results: Least squares mean (95% confidence interval [CI]) treatment differences for ADHD-RS-IV total score changes from baseline to EOS significantly favored triple-bead MAS (all doses combined: -10.6 [-13.2, -8.0]; p < .0001); there were no significant differences between triple-bead MAS dosages. The most frequently reported TEAEs with triple-bead MAS (all doses combined) included insomnia, decreased appetite, and dry mouth. Mean ± SD pulse and systolic blood pressure increases at EOS were 3.5 ± 10.33 bpm and 0.3 ± 10.48 mmHg with triple-bead MAS (all doses combined). Conclusion: Triple-bead MAS significantly reduced adult ADHD symptoms; the safety profile was consistent with previous triple-bead MAS studies.

The ecological approach is a framework for studying the behavior of animals in their environments. My version of an ecological approach focuses on learning in the context of development. I argue that the most important thing animals learn is behavioral flexibility. They must acquire the ability to flexibly guide their behavior from moment to moment in the midst of developmental changes in their bodies, brains, skills, and environments. They must select, modify, and create behaviors appropriate to the current situation. In essence, animals must learn how to learn. I describe the central concepts and empirical strategies for studying learning in development and use examples of infants coping with novel tasks to give a flavor of what researchers know and still must discover about the functions and processes of learning (to learn) in (not and) development.

BACKGROUND: A mature medical professional identity (PI) is a fundamental outcome of medical education (Irby and Hamstra, 2016) and medical schools across the country are developing approaches to support professional identity formation (PIF) in students. Reflective capacity, not just in the moment but as a broad skill, is key to core professional competency and may underlie PIF (Wald, 2015). Yet the relationship between reflective capacity and PIF is not well understood. Do these two concepts assess the same developmental capacity? Is reflective capacity a prerequisite for professional identity development? This pilot study is an initial attempt to explore this issue and to examine the relationship between written reflective capacity and professional identity development.
METHOD(S): As part of a professionalism curriculum medical students complete the Professional Identity Essay (PIE) at three time points: upon entrance to the school, after basic science courses, and after clinical rotations. The PIE (Bebeau and Lewis 2004), based on Kegan's developmental model (1982), requires responses to 9 prompts which elicit conceptions of the professional role. It is scored on a 5-point scale reflecting Kegan's 5 stages, with transitional stages captured by half-points. For this study, we randomly selected 20 PIE protocols from the 100 completed by the Class of 2020 after their basic science curriculum. These were scored by three raters (VM, AK, LA). Interrater reliability was established by reaching 100% agreement within one half stage on the PIE. The same raters scored the PIE protocols with the Reflection Evaluation for Learners' Enhanced Competencies Tool (REFLECT), following the scoring criteria (Wald 2010, Wald 2012). For both the PIE and REFLECT we averaged the three raters into a single score. A Pearson two-tailed correlation was then computed between the two scales.
RESULT(S): Completed scores on both measures were available for 19 of the 20 PIES. The range of PIE scores was 2.5-4, as would be expected of students at this point in their careers (Kalet 2018). REFLECT scores ranged 2-4. There was a statistically significant moderate positive correlation between the PIE and REFLECT (r=.628, p=.004), with REFLECT scores explaining 39% of the variance of PIE scores.
CONCLUSION(S): The correlation between PIE scores and REFLECT ratings suggests that the PIE captures and reflects some elements of learners' reflective capacity. However there remains a large component of the PIE score not explained by reflective capacity, which suggests that the PIE, as a standalone measure of PIF, demonstrates qualities beyond reflective capacity. Further investigation is warranted in order to tease out the interplay between these two concepts. Understanding the relationship between PIF and reflective capacity can inform educators in promoting a more nuanced and sophisticated PI development in students

Introduction/UNASSIGNED:The present study investigates the association of lifetime interpersonal violence (IPV) exposure, related posttraumatic stress disorder (IPV-PTSD), and appraisal of the degree of threat posed by facial avatars. Methods/UNASSIGNED:We recorded self-rated responses and high-density electroencephalography (HD-EEG) among women, 16 of whom with lifetime IPV-PTSD and 14 with no PTSD, during a face-evaluation task that displayed male face avatars varying in their degree of threat as rated along dimensions of dominance and trustworthiness. Results/UNASSIGNED:The study found a significant association between lifetime IPV exposure, under-estimation of dominance, and over-estimation of trustworthiness. Characterization of EEG microstates supported that lifetime IPV-PTSD modulates emotional appraisal, specifically in encoding and decoding processing associated with N170 and LPP evoked potentials. EEG source localization demonstrated an overactivation of the limbic system, in particular the parahippocampal gyrus, in response to non-threatening avatars. Additionally, dysfunctional involvement of attention-related processing anterior prefrontal cortex (aPFC) was found in response to relatively trustworthy avatars in IPV-PTSD individuals compared with non-PTSD controls. Discussion/UNASSIGNED:This study showed that IPV exposure and related PTSD modulate individuals' evaluation of facial characteristics suggesting threat. Atypical processing of these avatar characteristics was marked by group differences in brain regions linked to facial processing, emotion regulation, and memory.

Background: COVID-19 prevention and mitigation efforts were abrupt and challenging for most countries with the protracted lockdown straining socioeconomic activities. Marginalized groups and individuals are particularly vulnerable to adverse effects of the pandemic such as human rights abuses and violations which can lead to psychological distress. In this review, we focus on mental distress and disturbances that have emanated due to human rights restrictions and violations amidst the pandemic. We underscore how mental health is both directly impacted by the force of pandemic and by prevention and mitigation structures put in place to combat the disease. Methods: We conducted a review of relevant studies examining human rights violations in COVID-19 response, with a focus on vulnerable populations, and its association with mental health and psychological well-being. We searched PubMed and Embase databases for studies between December 2019 to July 2020. Three reviewers evaluated the eligibility criteria and extracted data. Results: Twenty-four studies were included in the systematic inquiry reporting on distress due to human rights violations. Unanimously, the studies found vulnerable populations to be at a high risk for mental distress. Limited mobility rights disproportionately harmed psychiatric patients, low-income individuals, and minorities who were at higher risk for self-harm and worsening mental health. Healthcare workers suffered negative mental health consequences due to stigma and lack of personal protective equipment and stigma. Other vulnerable groups such as the elderly, children, and refugees also experienced negative consequences. Conclusions: This review emphasizes the need to uphold human rights and address long term mental health needs of populations that have suffered disproportionately during the pandemic. Countries can embed a proactive psychosocial response to medical management as well as in existing prevention strategies. International human rights guidelines are useful in this direction but an emphasis should be placed on strengthening rights informed psychosocial response with specific strategies to enhance mental health in the long-term. We underscore that various fundamental human rights are interdependent and therefore undermining one leads to a poor impact on the others. We strongly recommend global efforts toward focusing both on minimizing fatalities, protecting human rights, and promoting long term mental well-being.

Environmental adversity increases child susceptibility to disrupted developmental outcomes, but the mechanisms by which adversity can shape development remain unclear. A translational cross-species approach was used to examine stress-mediated pathways by which poverty-related adversity can influence infant social development. Findings from a longitudinal sample of low-income mother-infant dyads indicated that infant cortisol (CORT) on its own did not mediate relations between early-life scarcity-adversity exposure and later infant behavior in a mother-child interaction task. However, maternal CORT through infant CORT served as a mediating pathway, even when controlling for parenting behavior. Findings using a rodent "scarcity-adversity" model indicated that pharmacologically blocking pup corticosterone (CORT, rodent equivalent to cortisol) in the presence of a stressed mother causally prevented social transmission of scarcity-adversity effects on pup social behavior. Furthermore, pharmacologically increasing pup CORT without the mother present was not sufficient to disrupt pup social behavior. Integration of our cross-species results suggests that elevated infant CORT may be necessary, but without elevated caregiver CORT, may not be sufficient in mediating the effects of environmental adversity on development. These findings underscore the importance of considering infant stress physiology in relation to the broader social context, including caregiver stress physiology, in research and interventional efforts.