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105

Journal of gastrointestinal surgery. 2021:25(7):1885-1895.DOI: 10.1007/s11605-020-04551-4

SSAT State-of-the-Art Conference: Advancements in the Microbiome

Miller, Miquell O; Kashyap, Purna C; Becker, Sarah L; Thomas, Ryan M; Hodin, Richard A; Miller, George; Hundeyin, Mautin; Pushalkar, Smruti; Cohen, Deirdre; Saxena, Deepak; Shogan, Benjamin D; Morris-Stiff, Gareth J
The microbiome plays a major role in human physiology by influencing obesity, inducing inflammation, and impacting cancer therapies. During the 60th Annual Meeting of the Society of the Alimentary Tract (SSAT) at the State-of-the-Art Conference, experts in the field discussed the influence of the microbiome. This paper is a summary of the influence of the microbiome on obesity, inflammatory bowel disease, pancreatic cancer, cancer therapies, and gastrointestinal optimization. This review shows how the microbiome plays an important role in the development of diseases and surgical complications. Future studies are needed in targeting the gut microbiome to develop individualized therapies.
PMID: 32989690
ISSN: 1873-4626
CID: 4651692
Healthcare (Basel). 2021:9(6).DOI: 10.3390/healthcare9060679

Protective Measures against COVID-19: Dental Practice and Infection Control

Induri, Sri Nitya Reddy; Chun, Yunah Caroline; Chun, Joonmo Christopher; Fleisher, Kenneth E; Glickman, Robert S; Xu, Fangxi; Ioannidou, Efthimia; Li, Xin; Saxena, Deepak
The onset of the Coronavirus 2019 (COVID-19) pandemic has challenged the worldwide healthcare sector, including dentistry. The highly infectious nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and risk of transmission through aerosol generating procedures has profoundly impacted the delivery of dental care services globally. As dental practices with renewed infection control strategies and preventive measures are re-opening in the "new normal" period, it is the responsibility of healthcare professionals to constantly analyze new data and limit the spread of COVID-19 in dental care settings. In the light of new variants of SARS-CoV-2 rapidly emerging in different geographic locations, there is an urgent need to comply more than ever with the rigorous public health measures to mitigate COVID-19 transmission. The aim of this article is to provide dental clinicians with essential information regarding the spread of SARS-CoV-2 virus and protective measures against COVID-19 transmission in dental facilities. We complied and provided guidance and standard protocols recommended by credible national and international organizations. This review will serve as an aid to navigating through this unprecedented time with ease. Here we reviewed the available literature recommended for the best current practices that must be taken for a dental office to function safely and successfully.
PMCID:8230244
PMID: 34200036
ISSN: 2227-9032
CID: 4936982
Lancet. 2021:398(10308):1317-1343.DOI:

Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050 [Review]

Micah, Angela E.; Cogswell, Ian E.; Cunningham, Brandon; Ezoe, Satoshi; Harle, Anton C.; Maddison, Emilie R.; McCracken, Darrah; Nomura, Shuhei; Simpson, Kyle E.; Stutzman, Hayley N.; Tsakalos, Golsum; Wallace, Lindsey E.; Zhao, Yingxi; Zende, Rahul R.; Abbafati, Cristiana; Abdelmasseh, Michael; Abedi, Aidin; Abegaz, Kedir Hussein; Abhilash, E. S.; Abolhassani, Hassan; Abrigo, Michael R. M.; Adhikari, Tara Ballav; Afzal, Saira; Ahinkorah, Bright Opoku; Ahmadi, Sepideh; Ahmed, Haroon; Ahmed, Muktar Beshir; Rashid, Tarik Ahmed; Ajami, Marjan; Aji, Budi; Akalu, Yonas; Akunna, Chisom Joyqueenet; Al Hamad, Hanadi; Alam, Khurshid; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Alemayehu, Yosef; Alhassan, Robert Kaba; Alinia, Cyrus; Aljunid, Syed Mohamed; Almustanyir, Sami Almustanyir; Alvis-Guzman, Nelson; Alvis-Zakzuk, Nelson J.; Amini, Saeed; Amini-Rarani, Mostafa; Amu, Hubert; Ancuceanu, Robert; Andrei, Catalina Liliana; Andrei, Tudorel; Angell, Blake; Anjomshoa, Mina; Antonio, Carl Abelardo T.; Antony, Catherine M.; Aqeel, Muhammad; Arabloo, Jalal; Arab-Zozani, Morteza; Aripov, Timur; Arrigo, Alessandro; Ashraf, Tahira; Atnafu, Desta Debalkie; Ausloos, Marcel; Avila-Burgos, Leticia; Awan, Asma Tahir; Ayano, Getinet; Ayanore, Martin Amogre; Azari, Samad; Azhar, Gulrez Shah; Babalola, Tesleem Kayode; Bahrami, Mohammad Amin; Baig, Atif Amin; Banach, Maciej; Barati, Nastaran; Barnighausen, Till Winfried; Barrow, Amadou; Basu, Sanjay; Baune, Bernhard T.; Bayati, Mohsen; Benzian, Habib; Berman, Adam E.; Bhagavathula, Akshaya Srikanth; Bhardwaj, Nikha; Bhardwaj, Pankaj; Bhaskar, Sonu; Bibi, Sadia; Bijani, Ali; Bodolica, Virginia; Bragazzi, Nicola Luigi; Braithwaite, Dejana; Breitborde, Nicholas J. K.; Breusov, Alexey V.; Briko, Nikolay Ivanovich; Busse, Reinhard; Cahuana-Hurtado, Lucero; Callander, Emily Joy; Camera, Luis Alberto; Castaneda-Orjuela, Carlos A.; Catala-Lopez, Ferran; Charan, Jaykaran; Chatterjee, Souranshu; Chattu, Soosanna Kumary; Chattu, Vijay Kumar; Chen, Simiao; Cicero, Arrigo Francesco Giuseppe; Dadras, Omid; Dahlawi, Saad M. A.; Dai, Xiaochen; Dalal, Koustuv; Dandona, Lalit; Dandona, Rakhi; Davitoiu, Dragos Virgil; De Neve, Jan-Walter; de Sa-Junior, Antonio Reis; Denova-Gutierrez, Edgar; Dhamnetiya, Deepak; Dharmaratne, Samath Dhamminda; Doshmangir, Leila; Dube, John; Ehsani-Chimeh, Elham; Zaki, Maysaa El Sayed; El Tantawi, Maha; Eskandarieh, Sharareh; Farzadfar, Farshad; Ferede, Tomas Y.; Fischer, Florian; Foigt, Nataliya A.; Freitas, Alberto; Friedman, Sara D.; Fukumoto, Takeshi; Fullman, Nancy; Gaal, Peter Andras; Gad, Mohamed M.; Garcia-Gordillo, M. A.; Garg, Tushar; Ghafourifard, Mansour; Ghashghaee, Ahmad; Gholamian, Asadollah; Gholamrezanezhad, Ali; Ghozali, Ghozali; Gilani, Syed Amir; Glavan, Ionela-Roxana; Glushkova, Ekaterina Vladimirovna; Goharinezhad, Salime; Golechha, Mahaveer; Goli, Srinivas; Guha, Avirup; Gupta, Veer Bala; Gupta, Vivek Kumar; Haakenstad, Annie; Haider, Mohammad Rifat; Hailu, Alemayehu; Hamidi, Samer; Hanif, Asif; Harapan, Harapan; Hartono, Risky Kusuma; Hasaballah, Ahmed I.; Hassan, Shoaib; Hassanein, Mohamed H.; Hayat, Khezar; Hegazy, Mohamed I.; Heidari, Golnaz; Hendrie, Delia; Heredia-Pi, Ileana; Herteliu, Claudiu; Hezam, Kamal; Holla, Ramesh; Hossain, Sheikh Jamal; Hosseinzadeh, Mehdi; Hostiuc, Sorin; Huda, Tanvir M.; Hwang, Bing-Fang; Iavicoli, Ivo; Idrisov, Bulat; Ilesanmi, Olayinka Stephen; Irvani, Seyed Sina Naghibi; Islam, Sheikh Mohammed Shariful; Ismail, Nahlah Elkudssiah; Isola, Gaetano; Jahani, Mohammad Ali; Jahanmehr, Nader; Jakovljevic, Mihajlo; Janodia, Manthan Dilipkumar; Javaheri, Tahereh; Jayapal, Sathish Kumar; Jayawardena, Ranil; Jazayeri, Seyed Behzad; Jha, Ravi Prakash; Jonas, Jost B.; Joo, Tamas; Joukar, Farahnaz; Jurisson, Mikk; Kaambwa, Billingsley; Kalhor, Rohollah; Kanchan, Tanuj; Kandel, Himal; Matin, Behzad Karami; Karimi, Salah Eddin; Kassahun, Getinet; Kayode, Gbenga A.; Karyani, Ali Kazemi; Keikavoosi-Arani, Leila; Khader, Yousef Saleh; Khajuria, Himanshu; Khalilov, Rovshan; Khammarnia, Mohammad; Khan, Junaid; Khubchandani, Jagdish; Kianipour, Neda; Kim, Gyu Ri; Kim, Yun Jin; Kisa, Adnan; Kisa, Sezer; Kohler, Stefan; Kosen, Soewarta; Koteeswaran, Rajasekaran; Laxminarayana, Sindhura Lakshmi Koulmane; Koyanagi, Ai; Krishan, Kewal; Kumar, G. Anil; Kusuma, Dian; Lamnisos, Demetris; Lansingh, Van Charles; Larsson, Anders O.; Lasrado, Savita; Le, Long Khanh Dao; Lee, Shaun Wen Huey; Lee, Yeong Yeh; Lim, Stephen S.; Lobo, Stany W.; Lozano, Rafael; Abd El Razek, Hassan Magdy; Abd El Razek, Muhammed Magdy; Mahdavi, Mokhtar Mahdavi; Majeed, Azeem; Makki, Alaa; Maleki, Afshin; Malekzadeh, Reza; Manda, Ana Laura; Mansour-Ghanaei, Fariborz; Mansournia, Mohammad Ali; Arnedo, Carlos Alberto Marrugo; Martinez-Valle, Adolfo; Masoumi, Seyedeh Zahra; Maude, Richard James; Mckee, Martin; Medina-Solis, Carlo Eduardo; Menezes, Ritesh G.; Meretoja, Atte; Meretoja, Tuomo J.; Mesregah, Mohamed Kamal; Mestrovic, Tomislav; Kostova, Neda Milevska; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Mohajer, Bahram; Mohamed, Teroj Abdulrahman; Mohammadi, Mokhtar; Mohammadian-Hafshejani, Abdollah; Mohammed, Shafiu; Moitra, Modhurima; Mokdad, Ali H.; Molokhia, Mariam; Moni, Mohammad Ali; Moradi, Yousef; Morze, Jakub; Mousavi, Seyyed Meysam; Mpundu-Kaambwa, Christine; Muriithi, Moses K.; Muthupandian, Saravanan; Nagarajan, Ahamarshan Jayaraman; Naimzada, Mukhammad David; Nangia, Vinay; Naqvi, Atta Abbas; Narayana, Aparna Ichalangod; Nascimento, Bruno Ramos; Naveed, Muhammad; Nayak, Biswa Prakash; Nazari, Javad; Ndejjo, Rawlance; Negoi, Ionut; Kandel, Sandhya Neupane; Trang Huyen Nguyen; Nonvignon, Justice; Noubiap, Jean Jacques; Nwatah, Vincent Ebuka; Oancea, Bogdan; Ojelabi, Foluke Adetola Ogunyemi; Olagunju, Andrew T.; Olakunde, Babayemi Oluwaseun; Olgiati, Stefano; Olusanya, Jacob Olusegun; Onwujekwe, Obinna E.; Otoiu, Adrian; Otstavnov, Nikita; Otstavnov, Stanislav S.; Owolabi, Mayowa O.; Padubidri, Jagadish Rao; Palladino, Raffaele; Panda-Jonas, Songhomitra; Park, Eun-Cheol; Kan, Fatemeh Pashazadeh; Pawar, Shrikant; Toroudi, Hamidreza Pazoki; Pereira, David M.; Perianayagam, Arokiasamy; Pesudovs, Konrad; Piccinelli, Cristiano; Postma, Maarten J.; Prada, Sergio I.; Rabiee, Mohammad; Rabiee, Navid; Rahim, Fakher; Rahimi-Movaghar, Vafa; Rahman, Mohammad Hifz Ur; Rahman, Mosiur; Rahmani, Amir Masoud; Ram, Usha; Ranabhat, Chhabi Lal; Ranasinghe, Priyanga; Rao, Chythra R.; Rathi, Priya; Rawaf, David Laith; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Reiner, Robert C., Jr.; Renzaho, Andre M. N.; Reshmi, Bhageerathy; Riaz, Mavra A.; Ripon, Rezaul Karim; Saad, Anas M.; Sahraian, Mohammad Ali; Sahu, Maitreyi; Salama, Joseph S.; Salehi, Sana; Samy, Abdallah M.; Sanabria, Juan; Sanmarchi, Francesco; Santos, Joao Vasco; Santric-Milicevic, Milena M.; Sathian, Brijesh; Savic, Miloje; Saxena, Deepak; Sayyah, Mehdi; Schwendicke, Falk; Senthilkumaran, Subramanian; Sepanlou, Sadaf G.; Seylani, Allen; Shahabi, Saeed; Shaikh, Masood Ali; Sheikh, Aziz; Shetty, Adithi; Shetty, Pavanchand H.; Shibuya, Kenji; Shrime, Mark G.; Shuja, Kanwar Hamza; Singh, Jasvinder A.; Skryabin, Valentin Yurievich; Skryabina, Anna Aleksandrovna; Soltani, Shahin; Soofi, Moslem; Spurlock, Emma Elizabeth; Stefan, Simona Catalina; Szerencses, Viktoria; Szocska, Miklos; Tabares-Seisdedos, Rafael; Taddele, Biruk Wogayehu; Tefera, Yonas Getaye; Thavamani, Aravind; Tobe-Gai, Ruoyan; Topor-Madry, Roman; Tovani-Palone, Marcos Roberto; Bach Xuan Tran; Car, Lorainne Tudor; Ullah, Anayat; Ullah, Saif; Umar, Nasir; Undurraga, Eduardo A.; Valdez, Pascual R.; Vasankari, Tommi Juhani; Villafane, Jorge Hugo; Violante, Francesco S.; Vlassov, Vasily; Bay Vo; Vollmer, Sebastian; Theo Vos; Giang Thu Vu; Linh Gia Vu; Wamai, Richard G.; Werdecker, Andrea; Woldekidan, Mesfin Agachew; Wubishet, Befikadu Legesse; Xu, Gelin; Yaya, Sanni; Yazdi-Feyzabadi, Vahid; Yigit, Vahit; Yip, Paul; Yirdaw, Birhanu Wubale; Yonemoto, Naohiro; Younis, Mustafa Z.; Yu, Chuanhua; Yunusa, Ismaeel; Moghadam, Telma Zahirian; Zandian, Hamed; Zastrozhin, Mikhail Sergeevich; Zastrozhina, Anasthasia; Zhang, Zhi-Jiang; Ziapour, Arash; Zuniga, Yves Miel H.; Hay, Simon I.; Murray, Christopher J. L.; Dieleman, Joseph L.
ISI:000705490300019
ISSN: 0140-6736
CID: 5071652
Frontiers in pediatrics. 2021:9.DOI:

Vaping, SARS-CoV-2, and Multisystem Inflammatory Syndrome: A Perfect Storm [Review]

Brar, Esha; Saxena, Anish; Dukler, Claudia; Xu, Fangxi; Saxena, Deepak; Cheema Brar, Preneet; Guo, Yuqi; Li, Xin
ISI:000654002300001
ISSN: 2296-2360
CID: 4892412
Frontiers in oral health. 2021:2.DOI: 10.3389/froh.2021.729144

Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients

Xu, Fangxi; Aboseria, Eman; Janal, Malvin N; Pushalkar, Smruti; Bederoff, Maria V; Vasconcelos, Rebeca; Sapru, Sakshi; Paul, Bidisha; Queiroz, Erica; Makwana, Shreya; Solarewicz, Julia; Guo, Yuqi; Aguallo, Deanna; Gomez, Claudia; Shelly, Donna; Aphinyanaphongs, Yindalon; Gordon, Terry; Corby, Patricia M; Kamer, Angela R; Li, Xin; Saxena, Deepak
PMCID:8757783
PMID: 35048050
ISSN: 2673-4842
CID: 5131632
Lancet. 2021:398(10311):1593-1618.DOI:

Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019

Ward, Joseph L.; Azzopardi, Peter S.; Francis, Kate Louise; Santelli, John S.; Skirbekk, Vegard; Sawyer, Susan M.; Kassebaum, Nicholas J.; Mokdad, Ali H.; Hay, Simon I.; Abd-Allah, Foad; Abdoli, Amir; Abdollahi, Mohammad; Abedi, Aidin; Abolhassani, Hassan; Abreu, Lucas Guimaraes; Abrigo, Michael R. M.; Abu-Gharbieh, Eman; Abushouk, Abdelrahman I.; Adebayo, Oladimeji M.; Adekanmbi, Victor; Adham, Davoud; Advani, Shailesh M.; Afshari, Khashayar; Agrawal, Anurag; Ahmad, Tauseef; Ahmadi, Keivan; Ahmed, Anwar E.; Aji, Budi; Akombi-Inyang, Blessing; Alahdab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Alcalde-Rabanal, Jacqueline Elizabeth; Alemu, Biresaw Wassihun; Al-Hajj, Samar; Alhassan, Robert Kaba; Ali, Saqib; Alicandro, Gianfranco; Alijanzadeh, Mehran; Aljunid, Syed Mohamed; Almasi-Hashiani, Amir; Almasri, Nihad A.; Al-Mekhlafi, Hesham M.; Alonso, Jordi; Al-Raddadi, Rajaa M.; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Amare, Azmeraw T.; Amini, Saeed; Aminorroaya, Arya; Amit, Arianna Maever L.; Amugsi, Dickson A.; Ancuceanu, Robert; Anderlini, Deanna; Andrei, Catalina Liliana; Androudi, Sofia; Ansari, Fereshteh; Ansari, Iman; Antonio, Carl Abelardo T.; Anvari, Davood; Anwer, Razique; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arab-Zozani, Morteza; Arnlov, Johan; Asaad, Malke; Asadi-Aliabadi, Mehran; Asadi-Pooya, Ali A.; Atout, Maha Moh\d Wahbi; Ausloos, Marcel; Avenyo, Elvis Korku; Avila-Burgos, Leticia; Quintanilla, Beatriz Paulina Ayala; Ayano, Getinet; Aynalem, Yared Asmare; Azari, Samad; Azene, Zelalem Nigussie; Bakhshaei, Mohammad Hossein; Bakkannavar, Shankar M.; Banach, Maciej; Banik, Palash Chandra; Barboza, Miguel A.; Barker-Collo, Suzanne Lyn; Baernighausen, Till Winfried; Basu, Sanjay; Baune, Bernhard T.; Bayati, Mohsen; Bedi, Neeraj; Beghi, Ettore; Bekuma, Tariku Tesfaye; Bell, Arielle Wilder; Bell, Michelle L.; Benjet, Corina; Bensenor, Isabela M.; Berhe, Abadi Kidanemariam; Berhe, Kidanemaryam; Berman, Adam E.; Bhagavathula, Akshaya Srikanth; Bhardwaj, Nikha; Bhardwaj, Pankaj; Bhattacharyya, Krittika; Bhattarai, Suraj; Bhutta, Zulfiqar A.; Bijani, Ali; Bikbov, Boris; Biondi, Antonio; Birhanu, Tesega Tesega Mengistu; Biswas, Raaj Kishore; Bohlouli, Somayeh; Bolla, Srinivasa Rao; Boloor, Archith; Borschmann, Rohan; Boufous, Soufiane; Bragazzi, Nicola Luigi; Braithwaite, Dejana; Breitborde, Nicholas J. K.; Brenner, Hermann; Britton, Gabrielle B.; Burns, Richard A.; Nagaraja, Sharath Burugina; Butt, Zahid A.; dos Santos, Florentino Luciano Caetano; Camera, Luis Alberto; Campos-Nonato, Ismael R.; Campuzano Rincon, Julio Cesar; Cardenas, Rosario; Carreras, Giulia; Carrero, Juan J.; Carvalho, Felix; Castaldelli-Maia, Joao Mauricio; Castaneda-Orjuela, Carlos A.; Castelpietra, Giulio; Catala-Lopez, Ferran; Cerin, Ester; Chandan, Joht Singh; Chang, Hsing-Yi; Chang, Jung-Chen; Charan, Jaykaran; Chattu, Vijay Kumar; Chaturvedi, Sarika; Choi, Jee-Young Jasmine; Chowdhury, Mohiuddin Ahsanul Kabir; Christopher, Devasahayam J.; Dinh-Toi Chu; Chung, Michael T.; Chung, Sheng-Chia; Cicuttini, Flavia M.; Constantin, Traian Vasile; Costa, Vera Marisa; Dahlawi, Saad M. A.; Dai, Haijiang; Dai, Xiaochen; Damiani, Giovanni; Dandona, Lalit; Dandona, Rakhi; Daneshpajouhnejad, Parnaz; Darwesh, Aso Mohammad; Alberto Davila-Cervantes, Claudio; Davletov, Kairat; De la Hoz, Fernando Pio; De Leo, Diego; Dervenis, Nikolaos; Desai, Rupak; Desalew, Assefa; Deuba, Keshab; Dharmaratne, Samath Dhamminda; Dhungana, Govinda Prasad; Dianatinasab, Mostafa; da Silva, Diana Dias; Diaz, Daniel; Didarloo, Alireza; Djalalinia, Shirin; Dorostkar, Fariba; Doshi, Chirag P.; Doshmangir, Leila; Doyle, Kerrie E.; Duraes, Andre Rodrigues; Kalan, Mohammad Ebrahimi; Ebtehaj, Sanam; Edvardsson, David; El Tantawi, Maha; Elgendy, Islam Y.; El-Jaafary, Shaimaa I.; Elsharkawy, Aisha; Eshrati, Babak; Eskandarieh, Sharareh; Esmaeilnejad, Saman; Esmaeilzadeh, Firooz; Esteghamati, Sadaf; Faro, Andre; Farzadfar, Farshad; Fattahi, Nazir; Feigin, Valery L.; Ferede, Tomas Y.; Fereshtehnejad, Seyed-Mohammad; Fernandes, Eduarda; Ferrara, Pietro; Filip, Irina; Fischer, Florian; Fisher, James L.; Foigt, Nataliya A.; Folayan, Morenike Oluwatoyin; Fomenkov, Artem Alekseevich; Foroutan, Masoud; Fukumoto, Takeshi; Gad, Mohamed M.; Gaidhane, Abhay Motiramji; Gallus, Silvano; Gebre, Teshome; Gebremedhin, Ketema Bizuwork; Gebremeskel, Gebreamlak Gebremedhn; Gebremeskel, Leake; Gebreslassie, Assefa Ayalew; Gesesew, Hailay Abrha; Ghadiri, Keyghobad; Ghafourifard, Mansour; Ghamari, Farhad; Ghashghaee, Ahmad; Gilani, Syed Amir; Gnedovskaya, Elena V.; Godinho, Myron Anthony; Golechha, Mahaveer; Goli, Srinivas; Gona, Philimon N.; Gopalani, Sameer Vali; Gorini, Giuseppe; Grivna, Michal; Gubari, Mohammed Ibrahim Mohialdeen; Gugnani, Harish Chander; Guimaraes, Rafael Alves; Guo, Yuming; Gupta, Rajeev; Haagsma, Juanita A.; Hafezi-Nejad, Nima; Haile, Teklehaimanot Gereziher; Haj-Mirzaian, Arvin; Haj-Mirzaian, Arya; Hall, Brian J.; Hamadeh, Randah R.; Abdullah, Kanaan Hamagharib; Hamidi, Samer; Handiso, Demelash Woldeyohannes; Hanif, Asif; Hankey, Graeme J.; Haririan, Hamidreza; Maria Haro, Josep; Hasaballah, Ahmed I.; Hashi, Abdiwahab; Hassan, Amr; Hassanipour, Soheil; Hassankhani, Hadi; Hayat, Khezar; Heidari-Soureshjani, Reza; Herteliu, Claudiu; Heydarpour, Fatemeh; Ho, Hung Chak; Hole, Michael K.; Holla, Ramesh; Hoogar, Praveen; Hosseini, Mostafa; Hosseinzadeh, Mehdi; Hostiuc, Mihaela; Hostiuc, Sorin; Househ, Mowafa; Hsairi, Mohamed; Huda, Tanvir M.; Humayun, Ayesha; Hussain, Rabia; Hwang, Bing-Fang; Iavicoli, Ivo; Ibitoye, Segun Emmanuel; Ilesanmi, Olayinka Stephen; Ilic, Irena M.; Ilic, Milena D.; Inbaraj, Leeberk Raja; Intarut, Nirun; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Islam, M. Mofizul; Islam, Sheikh Mohammed Shariful; Iso, Hiroyasu; Ivers, Rebecca Q.; Jahani, Mohammad Ali; Jakovljevic, Mihajlo; Jalali, Amir; Janodia, Manthan Dilipkumar; Javaheri, Tahereh; Jeemon, Panniyammakal; Jenabi, Ensiyeh; Jha, Ravi Prakash; Jha, Vivekanand; Ji, John S.; Jonas, Jost B.; Jones, Kelly M.; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Juliusson, Petur B.; Jurisson, Mikk; Kabir, Ali; Kabir, Zubair; Kalankesh, Leila R.; Kalhor, Rohollah; Kamyari, Naser; Kanchan, Tanuj; Karch, Andre; Karimi, Salah Eddin; Kaur, Supreet; Kayode, Gbenga A.; Keiyoro, Peter Njenga; Khalid, Nauman; Khammarnia, Mohammad; Khan, Maseer; Khan, Md Nuruzzaman; Khatab, Khaled; Khater, Mona M.; Khatib, Mahalaqua Nazli; Khayamzadeh, Maryam; Khazaie, Habibolah; Khoja, Abdullah T.; Kieling, Christian; Kim, Young-Eun; Kim, Yun Jin; Kimokoti, Ruth W.; Kisa, Adnan; Kisa, Sezer; Kivimaki, Mika; Koolivand, Ali; Kosen, Soewarta; Koyanagi, Ai; Krishan, Kewal; Kugbey, Nuworza; Kumar, G. Anil; Kumar, Manasi; Kumar, Nithin; Kurmi, Om P.; Kusuma, Dian; La Vecchia, Carlo; Lacey, Ben; Lal, Dharmesh Kumar; Lalloo, Ratilal; Lan, Qing; Landires, Ivan; Lansingh, Van Charles; Larsson, Anders O.; Lasrado, Savita; Lassi, Zohra S.; Lauriola, Paolo; Lee, Paul H.; Lee, Shaun Wen Huey; Leigh, James; Leonardi, Matilde; Leung, Janni; Levi, Miriam; Lewycka, Sonia; Li, Bingyu; Li, Ming-Chieh; Li, Shanshan; Lim, Lee-Ling; Lim, Stephen S.; Liu, Xuefeng; Lorkowski, Stefan; Lotufo, Paulo A.; Lunevicius, Raimundas; Maddison, Ralph; Mahasha, Phetole Walter; Mahdavi, Mokhtar Mahdavi; Mahmoudi, Morteza; Majeed, Azeem; Maleki, Afshin; Malekzadeh, Reza; Malta, Deborah Carvalho; Mamun, Abdullah A.; Mansouri, Borhan; Mansournia, Mohammad Ali; Martinez, Gabriel; Martinez-Raga, Jose; Martins-Melo, Francisco Rogerlandio; Mason-Jones, Amanda J.; Masoumi, Seyedeh Zahra; Mathur, Manu Raj; Maulik, Pallab K.; McGrath, John J.; Mehndiratta, Man Mohan; Mehri, Fereshteh; Memiah, Peter T. N.; Mendoza, Walter; Menezes, Ritesh G.; Mengesha, Endalkachew Worku; Meretoja, Atte; Meretoja, Tuomo J.; Mestrovic, Tomislav; Miazgowski, Bartosz; Miazgowski, Tomasz; Michalek, Irmina Maria; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Mirzaei, Hamed; Mirzaei, Maryam; Moazen, Babak; Mohammad, Dara K.; Mohammadi, Shadieh; Mohammadian-Hafshejani, Abdollah; Mohammadifard, Noushin; Mohammadpourhodki, Reza; Mohammed, Shafiu; Monasta, Lorenzo; Moradi, Ghobad; Moradi-Lakeh, Maziar; Moradzadeh, Rahmatollah; Moraga, Paula; Morrison, Shane Douglas; Mosapour, Abbas; Khaneghah, Amin Mousavi; Mueller, Ulrich Otto; Muriithi, Moses K.; Murray, Christopher J. L.; Muthupandian, Saravanan; Naderi, Mehdi; Nagarajan, Ahamarshan Jayaraman; Naghavi, Mohsen; Naimzada, Mukhammad David; Nangia, Vinay; Nayak, Vinod C.; Nazari, Javad; Ndejjo, Rawlance; Negoi, Ionut; Negoi, Ruxandra Irina; Netsere, Henok Biresaw; Nguefack-Tsague, Georges; Diep Ngoc Nguyen; Huong Lan Thi Nguyen; Nie, Jing; Ningrum, Dina Nur Anggraini; Nnaji, Chukwudi A.; Nomura, Shuhei; Noubiap, Jean Jacques; Nowak, Christoph; Nunez-Samudio, Virginia; Ogbo, Felix Akpojene; Oghenetega, Onome Bright; Oh, In-Hwan; Oladnabi, Morteza; Olagunju, Andrew T.; Olusanya, Bolajoko Olubukunola; Olusanya, Jacob Olusegun; Bali, Ahmed Omar; Omer, Muktar Omer; Onwujekwe, Obinna E.; Ortiz, Alberto; Otoiu, Adrian; Otstavnov, Nikita; Otstavnov, Stanislav S.; Overland, Simon; Owolabi, Mayowa O.; Mahesh, P. A.; Padubidri, Jagadish Rao; Pakshir, Keyvan; Palladino, Raffaele; Pana, Adrian; Panda-Jonas, Songhomitra; Pandey, Anamika; Able Panelo, Carlo Irwin; Park, Eun-Kee; Patten, Scott B.; Peden, Amy E.; Filipino Pepito, Veincent Christian; Peprah, Emmanuel K.; Pereira, Jeevan; Pesudovs, Konrad; Hai Quang Pham; Phillips, Michael R.; Piradov, Michael A.; Pirsaheb, Meghdad; Postma, Maarten J.; Pottoo, Faheem Hyder; Pourjafar, Hadi; Pourshams, Akram; Prada, Sergio I.; Pupillo, Elisabetta; Syed, Zahiruddin Quazi; Rabiee, Mohammad Hasan; Rabiee, Navid; Radfar, Amir; Rafiee, Ata; Raggi, Alberto; Rahim, Fakher; Rahimi-Movaghar, Vafa; Rahman, Mohammad Hifz Ur; Rahman, Muhammad Aziz; Ramezanzadeh, Kiana; Ranabhat, Chhabi Lal; Rao, Sowmya J.; Rashedi, Vahid; Rastogi, Prateek; Rathi, Priya; Rawaf, David Laith; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Renzaho, Andre M. N.; Rezaei, Negar; Rezaei, Nima; Rezai, Mohammad Sadegh; Riahi, Seyed Mohammad; Rickard, Jennifer; Roever, Leonardo; Ronfani, Luca; Roth, Gregory A.; Rubagotti, Enrico; Rumisha, Susan Fred; Rwegerera, Godfrey M.; Sabour, Siamak; Sachdev, Perminder S.; Saddik, Basema; Sadeghi, Ehsan; Moghaddam, Sahar Saeedi; Sagar, Rajesh; Sahebkar, Amirhossein; Sahraian, Mohammad Ali; Sajadi, S. Mohammad; Salem, Marwa Rashad; Salimzadeh, Hamideh; Samy, Abdallah M.; Sanabria, Juan; Santric-Milicevic, Milena M.; Saraswathy, Sivan Yegnanarayana Iyer; Sarrafzadegan, Nizal; Sarveazad, Arash; Sathish, Thirunavukkarasu; Sattin, Davide; Saxena, Deepak; Saxena, Sonia; Schiavolin, Silvia; Schwebel, David C.; Schwendicke, Falk; Senthilkumaran, Subramanian; Sepanlou, Sadaf G.; Sha, Feng; Shafaat, Omid; Shahabi, Saeed; Shaheen, Amira A.; Shaikh, Masood Ali; Shakiba, Saeed; Shamsi, Mohammad Bagher; Shannawaz, Mohammed; Sharafi, Kiomars; Sheikh, Aziz; Sheikhbahaei, Sara; Shetty, B. Suresh Kumar; Shi, Peilin; Shigematsu, Mika; Shin, Jae Il; Shiri, Rahman; Shuval, Kerem; Siabani, Soraya; Sigfusdottir, Inga Dora; Sigurvinsdottir, Rannveig; Santos Silva, Diego Augusto; Silva, Joao Pedro; Simonetti, Biagio; Singh, Jasvinder A.; Singh, Virendra; Sinke, Abiy H.; Skryabin, Valentin Yurievich; Slater, Helen; Smith, Emma U. R.; Sobhiyeh, Mohammad Reza; Sobngwi, Eugene; Soheili, Amin; Somefun, Oluwaseyi Dolapo; Sorrie, Muluken Bekele; Soyiri, Ireneous N.; Sreeramareddy, Chandrashekhar T.; Stein, Dan J.; Stokes, Mark A.; Sudaryanto, Agus; Sultan, Iyad; Tabares-Seisdedos, Rafael; Tabuchi, Takahiro; Tadakamadla, Santosh Kumar; Taherkhani, Amir; Tamiru, Animut Tagele; Tareque, Md Ismail; Thankappan, Kavumpurathu Raman; Thapar, Rekha; Thomas, Nihal; Titova, Mariya Vladimirovna; Tonelli, Marcello; Tovani-Palone, Marcos Roberto; Bach Xuan Tran; Travillian, Ravensara S.; Tsai, Alexander C.; Tsatsakis, Aristidis; Car, Lorainne Tudor; Uddin, Riaz; Unim, Brigid; Unnikrishnan, Bhaskaran; Upadhyay, Era; Vacante, Marco; Tahbaz, Sahel Valadan; Valdez, Pascual R.; Varughese, Santosh; Vasankari, Tommi Juhani; Venketasubramanian, Narayanaswamy; Villeneuve, Paul J.; Violante, Francesco S.; Vlassov, Vasily; Vos, Theo; Giang Thu Vu; Waheed, Yasir; Wamai, Richard G.; Wang, Yafeng; Wang, Yanzhong; Wang, Yuan-Pang; Westerman, Ronny; Wickramasinghe, Nuwan Darshana; Wu, Ai-Min; Wu, Chenkai; Jabbari, Seyed Hossein Yahyazadeh; Yamagishi, Kazumasa; Yano, Yuichiro; Yaya, Sanni; Yazdi-Feyzabadi, Vahid; Yeshitila, Yordanos Gizachew; Yip, Paul; Yonemoto, Naohiro; Yoon, Seok-Jun; Younis, Mustafa Z.; Yousefinezhadi, Taraneh; Yu, Chuanhua; Yu, Yong; Yuce, Deniz; Zaidi, Syed Saoud; Bin Zaman, Sojib; Zamani, Mohammad; Zamanian, Maryam; Zarafshan, Hadi; Zarei, Ahmad; Zastrozhin, Mikhail Sergeevich; Zhang, Yunquan; Zhang, Zhi-Jiang; Zhao, Xiu-Ju George; Zhu, Cong; Patton, George C.; Viner, Russell M.
ISI:000713316000024
ISSN: 0140-6736
CID: 5071782
PLoS one. 2021:16(3).DOI: 10.1371/journal.pone.0242396

Microbial population shift and metabolic characterization of silver diamine fluoride treatment failure on dental caries

Paul, Bidisha; Sierra, Maria A; Xu, Fangxi; Crystal, Yasmi O; Li, Xin; Saxena, Deepak; Ruff, Ryan Richard
The objective of this pilot study was to describe the microbial profiles present in the plaque and saliva of children who continued to develop new carious lesions following treatment with silver diamine fluoride ("nonresponders") compared to caries active, caries-free, and children immediately receiving SDF treatment for untreated caries in order to identify potential microbial differences that may relate to a re-incidence of caries. Saliva and plaque samples from infected and contralateral sites were obtained from twenty children who were either caries free, had active carious lesions, were caries active and received SDF treatment immediately before sampling, or had previously received SDF treatment and developed new caries. In total, 8,057,899 Illumina-generated sequence reads from 60 samples were obtained. Reads were processed using the Quantitative Insights Into Microbial Ecology pipeline. Group differences were assessed using Analysis of Variance Models and Tukey Honest Significant Differences. To identify significant taxa between treatment groups, Linear discriminant analysis Effect Size (LefSe) and Analysis of Differential Abundance Taking Sample Variation Into Account were used. Differential abundant analysis indicated that members of the Lachnospiraceae family were significantly enriched in non-responders and the genus Tannerella and species Granulicatella adiances were also highly abundant in this group. LefSe analysis between non-responders and SDF-treated groups revealed that genera Leptotrichia and Granulicatella were enriched in non-responders. We observed the highest abundance of phosphotransferase system and lowest abundance of lipopolysaccharide synthesis in non-responders. The microbiome in dental biofilms is responsible for initiation and progression of dental caries. SDF has been shown to be effective in arresting the progression carious lesions, in part due to its antimicrobial properties. Findings suggest that the differential abundance of select microbiota and specific pathway functioning in individuals that present with recurrent decay after SDF treatment may contribute to a potential failure of silver diamine fluoride to arrest dental caries. However, the short duration of sample collection following SDF application and the small sample size emphasize the need for further data and additional analysis.
PMID: 33720954
ISSN: 1932-6203
CID: 4817462
Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 2021:13(1).DOI: 10.1002/dad2.12172

Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

Kamer, Angela R; Pushalkar, Smruti; Gulivindala, Deepthi; Butler, Tracy; Li, Yi; Annam, Kumar Raghava Chowdary; Glodzik, Lidia; Ballman, Karla V; Corby, Patricia M; Blennow, Kaj; Zetterberg, Henrik; Saxena, Deepak; de Leon, Mony J
Introduction/UNASSIGNED:Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. Methods/UNASSIGNED:A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect-size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups. Results/UNASSIGNED: = 0.02 and 0.01) but not with P-tau. Discussion/UNASSIGNED:We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau. Further modeling is needed to establish the direct link between oral bacteria and Aβ.
PMCID:8040436
PMID: 33869725
ISSN: 2352-8729
CID: 4894752
Epilepsia. 2020:61(12):2619-2628.DOI: 10.1111/epi.16744

Cross talk between drug-resistant epilepsy and the gut microbiome

Holmes, Manisha; Flaminio, Zia; Vardhan, Mridula; Xu, Fangxi; Li, Xin; Devinsky, Orrin; Saxena, Deepak
One-third of epilepsy patients have drug-resistant epilepsy (DRE), which is often complicated by polydrug toxicity and psychiatric and cognitive comorbidities. Advances in understanding the microbiome and gut-brain-axis are likely to shed light on epilepsy pathogenesis, anti-seizure medication (ASM) resistance, and potential therapeutic targets. Gut dysbiosis is associated with inflammation, blood-brain barrier disruption, and altered neuromodulators. High-throughput and metagenomic sequencing has advanced the characterization of microbial species and functional pathways. DRE patients show altered gut microbiome composition compared to drug-sensitive patients and healthy controls. The ketogenic and modified Atkins diets can reduce seizures in some patients with DRE. These low-carbohydrate dietary therapies alter the taxonomic and functional composition of the gut microbiome, and composition varies between diet responders and nonresponders. Murine models suggest that specific phyla are necessary to confer efficacy from the diet, and antibiotic treatment may eliminate efficacy. The impact of diet might involve alterations in microbiota, promotion of select microbial interactions, and variance in brain neurotransmitter levels that then influence seizures. Understanding the mechanics of how diet manipulates seizures may suggest novel therapies. Most ASMs act on neuronal transmission via effects on ion channels and neurotransmitters. However, ASMs may also assert their effects via the gut microbiota. In animal models, the microbiota composition (eg, abundance of certain phyla) can vary with ASM active drug metabolites. Given the developing understanding of the gut microbiome in DRE, probiotics are another potential therapy. Probiotics alter the microbiota composition, and small studies suggest that these supplements can reduce seizures in some patients. DRE has enormous consequences to patients and society, and the gut microbiome holds promise as a potential therapeutic target. However, the exact mechanism and recognition of which patients are likely to be responders remain elusive. Further studies are warranted.
PMID: 33140419
ISSN: 1528-1167
CID: 4655972
Genes. 2020:11(10).DOI: 10.3390/genes11101188

Identification of Differentially Methylated Regions Associated with a Knockout of SUV39H1 in Prostate Cancer Cells

Yan, Wenbo; Guo, Yuqi; Xu, Fangxi; Saxena, Deepak; Li, Xin
Epigenetic alterations, such as histone methylations, affect the pathogenesis of tumors including prostate cancer (PCa). Previously, we reported that metformin reduced SUV39H1, a histone methyltransferase of H3 Lys9, to inhibit the migration of PCa cells. Since histone methylation is functionally linked to DNA methylation, we speculate that the knockout of the SUV39H1 gene will affect the genomic DNA methylation profile to regulate PCa cell migration and invasion. The genome-wide DNA methylation level is lower in SUV39H1 knockout (KO) cells than wild-type (WT) ones. However, the methylation levels in functional regions of CpG Islands (CGI), 5' untranslated region (UTR5), and exon regions are higher in KO cells than WT cells. Analysis of differentially methylated regions (DMRs) identified 1241 DMR genes that have differential methylation on CG sites when comparing the KO and WT samples. Gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes Pathways analysis showed that knockout of SUV39H1 affects gene sets and pathways that are heavily involved in cell shapes, cell recognition, adhesion, motility, and migration. Our study suggests that SUV39H1 plays an important role in PCa migration via the epigenetic regulation of methylation on CG sites, and is a novel and legitimate target to inhibit PCa cell migration.
PMID: 33066102
ISSN: 2073-4425
CID: 4642782