Faculty Bibliography
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Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. 2026:61(5):706-710.DOI: 10.3760/cma.j.cn112144-20260119-00032
[Twenty-one year follow-up of comprehensive treatments for immature permanent teeth after trauma: a case report]
PMID: 42056039
ISSN: 1002-0098
CID: 6041442
Synergistic Activity of Eugenol, Cinnamaldehyde, and Carvacrol in Combination with Different Antibacterial Agents Against Multidrug-Resistant Gram-Negative Clinical Isolates
PMCID:13113955
PMID: 42041354
ISSN: 2079-6382
CID: 6041422
Mobile Imaging-Based Machine Learning for Dental Caries, Sealants, and Fluorosis: Protocol for a Cross-Sectional Model Development and Validation Study
BACKGROUND:Assessing dental caries, sealants, and fluorosis is essential for public health surveillance, providing critical data to evaluate national prevention programs. Standard methods performed by dental professionals are often limited by affordability, accessibility, and scalability for both population-level and individualized assessments. Mobile health (mHealth) approaches to concurrently detect caries, sealants, and fluorosis have remained largely unexplored, especially at the population level. OBJECTIVE:This study leverages mHealth technologies that integrate computer vision using machine learning and deep learning with images captured by smartphone cameras and low-cost intraoral cameras. The primary objective is to develop and validate models for detecting caries lesions, identifying sealants, and quantifying fluorosis severity from standardized dental images, using standardized visual clinical examinations as the reference standard. METHODS:The proposed study population will include approximately 1000 adolescents in Colorado, United States, living in communities with naturally elevated fluoride levels in the public water system. Participants will undergo standardized clinical dental examinations and imaging using intraoral cameras and smartphones. Supervised learning models will incorporate reference chart-based color correction, radiomic spatial and textural features, and neural network classifiers. The reference standard will be standardized visual clinical examinations performed by trained and calibrated dental professionals. Two models will be developed and evaluated: one to detect caries lesions and sealants and another to assess fluorosis severity. Model performance will be evaluated against clinical assessments by dental professionals using stratified cross-validation and multiclass performance metrics while minimizing bias and accounting for confounders common to human examiners. RESULTS:A standardized dental examination, an intraoral imaging protocol, and a smartphone imaging protocol are used to assess all 8 permanent molars for caries and sealants, as well as the 6 upper anterior teeth for fluorosis severity. Pilot studies were conducted to test study logistics and calibrate 3 examiners in person, supplemented by debriefings, mobile app training, and a web-based calibration module. The study was funded in September 2022 with supplemental funding awarded in June 2024. The study launched in May 2024, and as of January 2026, data have been collected from approximately 300 participants. CONCLUSIONS:The integration of computer vision and mobile device imaging will enable affordable, scalable, population-level assessments for detecting caries and sealants and quantifying fluorosis severity among adolescents. mHealth technologies have been increasingly incorporated into dentistry for both clinical decision support and at-home use. This protocol will further help establish a structured methodological framework for acquiring, processing, and analyzing mobile imaging data for dental health surveillance and epidemiological studies. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)/UNASSIGNED:DERR1-10.2196/91239.
PMCID:13077280
PMID: 41911013
ISSN: 1929-0748
CID: 6041142
Eponyms in Dentistry - Endodontics [Historical Article]
This paper explores the historical evolution of dentistry through the lens of eponyms, focusing particularly on endodontics. From the era of extractions to the introduction of restorations by Pierre Fauchard and the development of prosthodontics and root preservation in the 19th century, dentistry has advanced in parallel with scientific breakthroughs in microbiology and technology. These innovations enabled the understanding and treatment of pulpal disease and the creation of effective root canal techniques. We highlight 31 key eponyms-32 individuals whose contributions to instruments, methods, materials, or classifications shaped modern endodontics and whose legacies remain embedded in practice.
PMID: 41926371
ISSN: 1089-6287
CID: 6041212
In Vitro Single-Cell Transcriptomic Profiling of Cultured Stem Cells From Apical Papilla and Dental Pulp Stem Cells: Unveiling Cellular Heterogeneity
INTRODUCTION/BACKGROUND:Dental-derived mesenchymal stem cells show considerable variability in their differentiation potential due to the use of nonspecific surface markers and technical limitations in isolation protocols. This study aimed to employ single-cell RNA sequencing to compare the cellular composition of cultured stem cells from apical papilla (SCAPs) and dental pulp (DPSCs), with the goal of detecting subpopulations underlying their divergent regenerative behaviour and identifying markers that can facilitate future isolation and functional targeting. METHOD/METHODS:SCAP and DPSC tissues were obtained from 3 human donors and cultured to passage 2. Single-cell suspensions were sequenced to generate gene expression profiles. Dimensionality reduction and clustering were performed using the Seurat package and visualised using uniform manifold approximation and projection. Cluster-specific differential gene expression was computed as log2 fold change, followed by gene set enrichment analysis. Pseudotime trajectory analysis was used to map lineage progression based on transcriptional gene expression. RESULTS:Transcriptomic analysis identified 12 distinct clusters shared across DPSC and SCAP cultures. While both cell types contributed comparably to overall biological processes, key differences emerged within specific clusters. Clusters 3, 4, 5, 6, and 9 expressed high levels of proliferative markers (MKI67, TOP2A, and TYMS), suggesting active proliferating populations. Cluster 9 was notable for the coexpression of pericyte-associated markers (NOTCH3, PDGFRB) alongside canonical mesenchymal stromal cell markers (MCAM, THY1, DCN), identifying a previously uncharacterised progenitor-like subset. NOTCH3 and PDGFRB were also present in a more mature fibroblast-enriched population in cluster 7, dominated by collagen-related genes. IGFBP3 and IGFBP5 were selectively enriched in SCAP-derived clusters 7 and 9, whereas IGFBP4, 6, and 7 were expressed across both DPSC and SCAP populations. Clusters 10 and 11, primarily derived from DPSCs, were enriched in stress-response, heat shock, and apoptotic genes, which may reflect culture-induced adaptations. Pseudotime trajectory inference positioned cluster 9 at a putative progenitor-like node; however, this represents a hypothesis-generating model based on transcriptional similarity in cultured cells rather than validated lineage relationships. CONCLUSION/CONCLUSIONS:and functional in vitro and in vivo validation are needed to establish their regenerative potential and translational relevance.
PMCID:13157157
PMID: 42090950
ISSN: 1875-595x
CID: 6041392
Cancer pain: current practice and emerging targets
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. Recent advances in cancer neuroscience have provided novel insights into the neurobiology of cancer pain. The emerging picture of cancer pain is a disorder of aberrant crosstalk between the tumour, the sensory innervation that the tumour creates and the immune cells that these nerves attract. Precision approaches to disrupt this aberrant pain signalling cascade are guided by newly recognized molecular mechanisms. Here, we review the current practice of cancer pain management and the emerging future of personalized, mechanism-driven pain therapy in oncology.
PMID: 41933501
ISSN: 1476-5381
CID: 6041272
Eponyms in Dentistry - Restorative Dentistry [Historical Article]
This article, the seventh in an eight-part special issue on dental eponyms, focuses on 18 key eponyms in restorative dentistry contributed by 19 innovative dentists, scientists, and engineers. Eponyms serve as historical reminders of the legacy of individuals whose innovations have shaped clinical practice. In this paper, we explore contributions ranging from the Toffelmire matrix systems to Hollanbeck carvers and Morrison adjustable chairs. This paper underscores the importance of remembering the foundational figures in dentistry. In doing so, it reinforces the value of historical continuity and honors the lasting impact of those who advanced the field of restorative care.
PMID: 41926374
ISSN: 1089-6287
CID: 6041242
Eponyms in Dentistry - Anatomy and Histology [Historical Article]
This article, the second in a series of eight, highlights the lives and original works of 21 scientists whose names are preserved in 20 enduring eponyms still found in dental anatomy and histology textbooks. Though frequently referenced in education, the historical context and the original publications behind these terms are often overlooked. By revisiting their biographies and citing the original sources where each eponym was first described, this work offers a long-overdue acknowledgment of their lasting contributions to dental science.
PMID: 41926369
ISSN: 1089-6287
CID: 6041192
Investigating the analytical robustness of the social and behavioural sciences
The same dataset can be analysed in different justifiable ways to answer the same research question, potentially challenging the robustness of empirical science1-3. In this crowd initiative, we investigated the degree to which research findings in the social and behavioural sciences are contingent on analysts' choices. We examined a stratified random sample of 100 studies published between 2009 and 2018, in which, for one claim per study, at least five reanalysts independently reanalysed the original data. The statistical appropriateness of the reanalyses was assessed in peer evaluations, and the robustness indicators were inspected along a range of research characteristics and study designs. We found that 34% of the independent reanalyses yielded the same result (within a tolerance region of ±0.05 Cohen's d) as the original report; with a four times broader tolerance region, this indicator increased to 57%. Of the reanalyses conducted, 74% reached the same conclusion as the original investigation, 24% yielded no effects or inconclusive results and 2% reported the opposite effect. This exploratory study indicates that the common single-path analyses in social and behavioural research should not be simply assumed to be robust to alternative analyses4. Therefore, we recommend the development and use of practices to explore and communicate this neglected source of uncertainty.
PMID: 41922703
ISSN: 1476-4687
CID: 6041172
Eponyms in Dentistry - Oral Surgery [Historical Article]
The development of oral and maxillofacial surgery advanced rapidly following the introduction of general anesthesia in 1846, evolving from simple tooth extractions to complex procedures involving the jaws and facial skeleton. Initially driven by general surgeons in Europe and later refined by specialists in the U.S. and elsewhere, this progress is reflected in enduring surgical eponyms. This paper highlights 23 pioneers associated with 21 foundational eponyms-procedures, instruments, and classifications-that remain central to oral surgical practice. These eponyms honor the innovators whose work shaped the field and continue to connect modern surgery to its historical roots.
PMID: 41926370
ISSN: 1089-6287
CID: 6041202
