Faculty Bibliography
Searched for:
school:SOM
Department/Unit:Otolaryngology
Total Results:
7768
Predictors of Morning Fatigue in Oncology Patients During Chemotherapy [Meeting Abstract]
ISI:000351633500178
ISSN: 1538-9847
CID: 1539052
Characterizing pain at diagnosis of head and neck cancer in an underserved population [Meeting Abstract]
ISI:000352748600003
ISSN: 1526-5900
CID: 1565302
Creating a Culture of Health for Older Adults Around the World: The Aging Research Interest Group Symposium [Meeting Abstract]
ISI:000351633500186
ISSN: 1538-9847
CID: 1593812
Adherence to Antiestrogen Oral Endocrine Therapy Among Older Women With Breast Cancer [Meeting Abstract]
ISI:000351633500189
ISSN: 1538-9847
CID: 1539492
Free online otolaryngology educational modules: a pilot study
IMPORTANCE: Otolaryngology residents need concise, easily accessible modules to expand educational opportunities between surgical cases. These modules should be inexpensive to create and improve learning outcomes. OBJECTIVE: The purpose of this pilot study was to assess whether otolaryngology residents at multiple institutions used online video modules to supplement their studying for the Otolaryngology Training Exam, whether the modules had any effect on their Otolaryngology Training Examination Scores, and to obtain survey feedback about the modules. DESIGN, SETTING, AND PARTICIPANTS: This randomized trial was conducted in 3 academic departments of otolaryngology in the United States among 37 residents enrolled in 3 otolaryngology residency programs. INTERVENTIONS: Residents were randomized into 2 groups, one with access to the educational modules and the other with no access. MAIN OUTCOMES AND MEASURES: Otolaryngology training examination scores were obtained from the year prior to the intervention (2012) and the year following module access (2013). Residents with access to the modules were also surveyed to assess use and obtain feedback about the modules. RESULTS: Otolaryngology training examination scores improved significantly from 2012 to 2013 among both residents who had access to the modules and those who did not in the sections of head and neck, laryngology, and sleep medicine. However, scores in the sections of pediatric otolaryngology (8% increase, P = .03), otology (7% increase, P = .02), and facial plastic surgery (10% increase, P = .02) improved from 2012 to 2013 only among residents with access to the modules. All respondents rated the videos as very helpful, with a rating of 4 of 5 on a Likert scale. CONCLUSIONS AND RELEVANCE: Online otolaryngology educational modules are an inexpensive way to expand resident learning opportunities. Despite the lack of quantifiable improvement in otolaryngology training examination scores in this study, use of online modules sends a message to otolaryngology residents that their education is a priority; self-study outside the hospital and clinics is necessary and expected; and that instructors are willing to try more nontraditional or progressive forms of education to increase resident knowledge.
PMID: 25695900
ISSN: 2168-619x
CID: 2541462
Bilateral cochlear implants with large asymmetries in electrode insertion depth: implications for the study of auditory plasticity
Abstract Conclusion: The human frequency-to-place map may be modified by experience, even in adult listeners. However, such plasticity has limitations. Knowledge of the extent and the limitations of human auditory plasticity can help optimize parameter settings in users of auditory prostheses. Objectives: To what extent can adults adapt to sharply different frequency-to-place maps across ears? This question was investigated in two bilateral cochlear implant users who had a full electrode insertion in one ear, a much shallower insertion in the other ear, and standard frequency-to-electrode maps in both ears. Methods: Three methods were used to assess adaptation to the frequency-to-electrode maps in each ear: (1) pitch matching of electrodes in opposite ears, (2) listener-driven selection of the most intelligible frequency-to-electrode map, and (3) speech perception tests. Based on these measurements, one subject was fitted with an alternative frequency-to-electrode map, which sought to compensate for her incomplete adaptation to the standard frequency-to-electrode map. Results: Both listeners showed remarkable ability to adapt, but such adaptation remained incomplete for the ear with the shallower electrode insertion, even after extended experience. The alternative frequency-to-electrode map that was tested resulted in substantial increases in speech perception for one subject in the short insertion ear.
PMCID:4386730
PMID: 25719506
ISSN: 0001-6489
CID: 1474002
In Silico Analysis of RET Variants in Medullary Thyroid Cancer: From the Computer to the Bedside
OBJECTIVE: The American Thyroid Association (ATA) medullary thyroid cancer (MTC) guidelines group RET variants, in the setting of familial medullary thyroid cancer and multiple endocrine neoplasia type 2, into 4 classes of severity based on epidemiological data. The aim of this study was to determine if genotype correlates with phenotype in RET missense mutations. STUDY DESIGN: In silico mutational tolerance prediction. SETTING: Academic research hospital. SUBJECTS AND METHODS: We analyzed all RET variants currently listed in the ATA guidelines for the management of MTC using 2 computer-based (in silico) mutation tolerance prediction approaches: PolyPhen-2 HumVar and PolyPhen-2 HumDiv. Our analysis also included 27 different RET single-nucleotide polymorphisms resulting in missense variants. RESULTS: There was a statistically significant difference in the overall HumDiv score between ATA groups A and B (P = .025) and a statistically significant different HumVar score between benign polymorphisms and ATA group A (P = .023). Overall, RET variants associated with a less aggressive clinical phenotype generally had a lower Hum Div/Var score. CONCLUSIONS: Polyphen-2 Hum Div/Var may provide additional clinical data to help distinguish benign from MEN2/familial medullary thyroid carcinoma-causing RET variants as well as less aggressive phenotypes (ATA A) from more aggressive ones (ATA B-C). In silico genetic analyses, with proper validation, may predict the phenotypic severity of RET variants, providing clinicians with a tool to aid clinical decision making in cases in which the RET variant is currently unknown or little epidemiological data are available.
PMID: 25733075
ISSN: 0194-5998
CID: 1480442
Does cochleostomy location influence electrode trajectory and intracochlear trauma?
OBJECTIVES/HYPOTHESIS: Trauma to intracochlear structures during cochlear implant insertion is associated with poorer hearing outcomes. One way surgeons can influence insertion trauma is by choosing the surgical approach. We seek to compare cochleostomy (CO), peri-round window (PRW), and round window (RW) approaches using a fresh frozen temporal bone model. STUDY DESIGN: Experiments using fresh frozen temporal bones. METHODS: Cochlear implant insertions using the three aforementioned approaches were performed on 15 fresh frozen human temporal bones using a Cochlear 422 electrode. Insertions were evaluated by examining fluoroscopic recordings of histologic sections. RESULTS: Five cochlear implant insertions were performed using each of the three aforementioned approaches. Fluoroscopic examination revealed that none of the CO or PRW insertions contacted the modiolus during insertion, whereas three of five RW insertions did. RW insertions were less linear during insertion when compared to CO and PRW insertions (P < .05). CO insertions had significantly larger angular depth of insertion (487 degrees ) when compared to PRW (413 degrees ) and RW (375 degrees ) (P < .05). Histologic examination revealed one RW insertion resulted in osseous spiral lamina fracture, whereas the remaining insertions had no evidence of trauma. In the damaged specimen, the inserted electrode was observed to rest in the scala vestibuli, whereas the remaining electrodes rested in the scala tympani. CONCLUSIONS: Due to variability in RW anatomy, a CO or PRW window surgical approach appears to minimize the risk for insertion trauma. However, with favorable anatomy, a Cochlear 422 electrode can be inserted with any of the three approaches. LEVEL OF EVIDENCE: NA Laryngoscope, 125:966-971, 2015.
PMID: 25345671
ISSN: 1531-4995
CID: 1522942
A roadmap for discovery and translation in lymphoma [Letter]
PMCID:4375113
PMID: 25814490
ISSN: 1528-0020
CID: 1518992
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study
OBJECTIVE:To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. METHODS:CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with relapsing-remitting multiple sclerosis (RRMS); subcutaneous glatiramer acetate 20 mg once daily was included as an active reference comparator. The number and volume of T2-hyperintense, T1-hypointense, and gadolinium-enhancing (Gd+) lesions, as well as whole brain volume and MTR, were assessed in 681 patients (MRI cohort). RESULTS:DMF BID and TID produced significant and consistent reductions vs placebo in the number of new or enlarging T2-hyperintense lesions and new nonenhancing T1-hypointense lesions after 1 and 2 years of treatment and in the number of Gd+ lesions at week 24, year 1, and year 2. Lesion volumes were also significantly reduced. Reductions in brain atrophy and MTR changes with DMF relative to placebo did not reach statistical significance. CONCLUSIONS:The robust effects on MRI active lesion counts and total lesion volume in patients with RRMS demonstrate the ability of DMF to exert beneficial effects on inflammatory lesion activity in multiple sclerosis, and support DMF therapy as a valuable new treatment option in RRMS. CLASSIFICATION OF EVIDENCE/METHODS:This study provides Class I evidence of reduction in brain lesion number and volume, as assessed by MRI, over 2 years of delayed-release DMF treatment.
PMCID:4371413
PMID: 25681448
ISSN: 1526-632x
CID: 5348212
