Searched for: school:SOM
Department/Unit:Population Health
Literacy Promotion: An Essential Component of Primary Care Pediatric Practice: Technical Report
Klass, Perri; Mendelsohn, Alan L; Hutton, John S; Dunlap, Marny; Anderson, Ashaunta T; High, Pamela C; Navsaria, Dipesh; ,
Early literacy promotion in pediatric primary care supports parents and caregivers in reading with their children from birth, offering counseling in interactive, developmentally appropriate strategies and providing developmentally and culturally appropriate and appealing children's books. This technical report reviews the evidence that reading with young children supports language, cognitive, and social-emotional development. Promoting early literacy in pediatric primary care offers a strengths-based strategy to support families in creating positive childhood experiences, which strengthen early relational health. An increasing body of evidence, reviewed in this report, shows that clinic-based literacy promotion, provided with fidelity to an evidence-based model, has benefits for children, for parents and caregivers, and for pediatric physicians and advanced care providers as well. Reading with young children supports early brain development and the neural "reading network," and improves school readiness. High-quality literacy promotion is especially essential for children who face disparities and inequities because of social factors, systemic racism, and socioeconomic risk. All families benefit from high-quality and diverse books and from developmentally appropriate guidance supporting interactions around books and stories. Thus, literacy promotion can be a universal primary prevention strategy to strengthen families and support healthy development. Partnerships at community, local, and state levels offer opportunities for integration with other programs, services, and platforms. Literacy promotion in primary care pediatric practice, recognized by the American Academy of Pediatrics as an essential component since 2014, has become increasingly common. There are successful models for public funding at federal, state, county, and municipal levels, but sustainable funding, including payment to pediatric physicians and advanced care providers, remains a need so that the benefits of pediatric early literacy promotion and the joys of books and shared reading can truly be offered on a population level.
PMID: 39342415
ISSN: 1098-4275
CID: 5763352
Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
Giles, Ellie; Heifets, Abraham; Artia, Zoraima; Inde, Zintis; Liu, Zhongle; Zhang, Zhiguo; Wang, Zhenghe; Su, Zhengchen; Chung, Zara; Frangos, Zachary J.; Li, Yunlong; Yen, Yun; Sidorova, Yulia A.; Tse-Dinh, Yuk Ching; He, Yuan; Tang, Young; Li, Yong; Pérez-Pertejo, Yolanda; Gupta, Yogesh K.; Zhu, Yini; Sun, Ying; Li, Yihe; Chen, Yicheng; Aldhamen, Yasser Ali; Hu, Yanmei; Zhang, Yan Jessie; Zhang, Xu; Yuan, Xinrui; Wang, Xingyou; Qin, Xingping; Yu, Xinfang; Xu, Xin; Qi, Xin; Lu, Xin; Wu, Xiaoyang; Blanchet, Xavier; Foong, Wuen Ee; Bradshaw, William J.; Gerwick, William H.; Kerr, William G.; Hahn, William C.; Donaldson, William A.; Van Voorhis, Wesley C.; Zhang, Wenjun; Tang, Weiping; Li, Wei; Houry, Walid A.; Lowther, W. Todd; Clayton, W. Brent; Van Hung Le, Vuong; Ronchi, Virginia Paola; Woods, Virgil A.; Scoffone, Viola Camilla; Maltarollo, Vinicius Gonçalves; Dolce, Vincenza; Maranda, Vincent; Segers, Vincent F.M.; Namasivayam, Vigneshwaran; Gunasekharan, Vignesh; Robinson, Victoria L.; Banerji, Versha; Tandon, Vasudha; Thai, Van Chi; Pai, Vaibhav P.; Desai, Umesh R.; Baumann, Ulrich; Chou, Tsui Fen; Chou, Tristan; O"™Mara, Tracy A.; Banjo, Toshihiro; Su, Tong; Lan, Tong; Ogunwa, Tomisin Happy; Hermle, Tobias; Corson, Timothy W.; O"™Meara, Timothy R.; Kotzé, Timothy J.; Herdendorf, Timothy J.; Richardson, Timothy I.; Kampourakis, Thomas; Gillingwater, Thomas H.; Jayasinghe, Thilina D.; Teixeira, Thaiz Rodrigues; Ikegami, Tetsuro; Moreda, Teresa Lozano; Haikarainen, Teemu; Akopian, Tatos; Abaffy, Tatjana; Swart, Tarryn; Mehlman, Tamar; Teramoto, Tadahisa; Azeem, Syeda Maryam; Dallman, Sydney; Brady-Kalnay, Susann M.; Sarilla, Suryakala; Van Doren, Steven R.; Marx, Steven O.; Olson, Steven H.; Poirier, Steve; Waggoner, Stephen N.; Capuzzi, Stephen J.; Celano, Stephanie L.; Sainas, Stefano; Gustincich, Stefano; Espinoza, Stefano; Zahler, Stefan; Banerjee, Sourav; Xu, Sophia Q.; Park, Soonju; Byun, Soo Young; Chadni, Somaia Haque; Tsimbalyuk, Sofiya; Zhu, Siran; White, Simon J.; Garavaglia, Silvia; Buroni, Silvia; Conticello, Silvestro G.; Shyng, Show Ling; Ashkar, Shireen R.; Maruta, Shinsaku; Chauhan, Shefali; Chu, Shaoyou; Zhou, Shan; Li, Shan; Seo, Seung Yong; Dzhumaev, Sergei; Ammendola, Serena; Radhakrishnan, Senthil K.; Landfear, Scott M.; Legare, Scott; Wazir, Sarah; Johannsen, Sandra; Geden, Sandra E.; Shelburne, Samuel A.; Phadke, Sameer; Hossain, Sakib; Katyal, Sachin; Cullinane, Ryan T.; Gorgoglione, Ruggiero; do Monte-Neto, Rubens Lima; Uribe, Ruben Vazquez; Reguera, Rosa Maria; McCarthy, Ronan R.; Viola, Ronald E.; Gierse, Robin Matthias; Solano, Roberto; Blumenthal, Robert M.; Bradley, Robert K.; Lake, Robert J.; Kelm, Robert J.; Hickey, Robert J.; Vandenberg, Robert J.; Blelloch, Robert; Batey, Robert A.; Kejriwal, Rishabh; Yan, Riqiang; Angell, Richard M.; Ebright, Richard H.; Moore, Richard G.; Taylor, Richard E.; Austin, Richard C.; Douville, Renée N.; Dame, Remus T.; Koppisetti, Rama K.; Mazitschek, Ralph; Tiwari, Rakesh Kumar; Singh, Rakesh K.; Verma, Rajkumar; Ramachandran, Rajesh; Harijan, Rajesh K.; Agrawal, Rajendra K.; Ferreira, Rafaela Salgado; Guido, Rafael V.C.; Rocha, Rafael Eduardo Oliveira; Balaña-Fouce, Rafael; Rowswell-Turner, Rachael B.; Lee, Pil H.; von Hundelshausen, Philipp; Ip, Philbert; Toogood, Peter; Ngoi, Peter; Jones, Peter L.; Agogo-Mawuli, Percy; Wu, Pengpeng; Liu, Pengda; Zhou, Pei; Moreira, Paulo Otávio Lourenço; Fish, Paul V.; Mellor, Paul; Martin-Malpartida, Pau; O"™Connell, Patrick; Chuong, Patrick; Sobrado, Pablo; Iglesias, Pablo; Bishop, Ozlem Tastan; Silvennoinen, Olli; Escaffre, Olivier; Kandror, Olga; Rabal, Obdulia; Khalaf, Noureddine Ben; Anastasio, Noelle C.; Gumede, Njabulo Joyfull; Mahmoodi, Niusha; Rouzbeh, Nirvan; Bharambe, Nikhil; Longo, Nicola; Horstmann, Nicola; Matovic, Nick; Schneider, Nicholas O.; Trinh, Nguyen Mai; Chan, Nei Li; Gandhi, Neha S.; Singh, Neeraj; Kootstra, Neeltje A.; Singh, Nathanael; Merrill, Nathan M.; Van Pelt, Natascha; Zelinskaya, Natalia; Stec, Natalia; Christodoulides, Myron; Hussain, Muhammad Saddam; De Luise, Monica; Maksimainen, Mirko M.; Giardini, Miriam A.; Al-Yozbaki, Minnatallah; Paige, Mikell; Jackson, Michael R.; Mowat, Michael; Levin, Michael; Rizzi, Menico; Bedi, Mel; O"™Mara, Megan L.; Skorodinsky, Maxim; Champion, Matthew M.; Alteen, Matthew G.; Soellner, Matthew B.; Serafim, Mateus Sá Magalhães; Mehedi, Masfique; Pasquali, Marzia; McDowell, Mary Ann; Maurice, Martin St; Safo, Martin K.; Giorgis, Marta; Cerna, Mark Vincent C.dela; Ashton, Mark R.; Hannink, Mark; Wilson, Mark A.; Tye, Mark A.; Mellado, Mario; Barghash, Marim M.; Valli, Marilia; Macias, Maria J.; Caroleo, Maria Cristina; Vleminckx, Margot; Lolli, Marco Lucio; Lolicato, Marco; Windisch, Marc P.; Lussier, Marc P.; Ben-Johny, Manu; Kilkenny, Mairi Louise; Nagai, Maira Harume; Fathallah, M. Dahmani; Randall, Lia M.; Whitesell, Luke; Iommarini, Luisa; Antonelli, Lorenzo; Walensky, Loren D.; Hedstrom, Lizbeth; Zhuo, Ling; Malkas, Linda H.; Chen, Lifeng; Puchades-Carrasco, Leonor; Wert-Lamas, Leon; Su, Leila; Byrne, Lee J.; Cowen, Leah E.; Haupt, Larisa M.; Lehtio, Lari; Pusztai, Lajos; Lee, Kyung Hyeon; Kim, Kyu Kwang; Rohde, Kyle H.; Sarosiek, Kristopher; Smith, Kristiana S.; Liu, Koting; Korotkov, Konstantin V.; Mostert, Konrad J.; Nagamori, Kiyo; Faller, Kiterie M.E.; Musta, Kirsikka; McManus, Kirk James; Sugamori, Kim S.; Ghilarducci, Kim; Pham, Kien; Machaca, Khaled; Parang, Keykavous; Hopkins, Kevin M.; Lobb, Kevin A.; Lai, Kent; Wentworth, Kelly L.; Wong, Keith S.; Ojo, Kayode K.; Gadar, Kavita; Martin, Katie R.; Cunningham, Kathryn A.; Molyneaux, Kathleen A.; Hansen, Kasper B.; Francisco, Karol R.; Sishtla, Kamakshi; Abrahão, Jônatas Santos; Sistla, Jyothi C.; Liao, Junzhuo; Kee, Jung Min; Wang, Jun; Bogomolovas, Julijus; Lescar, Julien; Cools, Julie; Milosavljevic, Julian; Oyarzabal, Julen; Lasarte, Juan José; Arias, Juan Antonio Sanchez; Rodriguez-Frade, José Miguel; Watkins, Joshua; Finkelstein, Joshua M.; Gruber, Joshua J.; Nasburg, Joshua Alexander; Maciag, Joseph J.; Rayman, Joseph B.; Costoya, Jose A.; Pederick, Jordan L.; So, Jonathan; Pascal, John M.; Tanner, John J.; Coles, John G.; Bruning, John Burt; Bruning, John B.; Stetefeld, Joerg; Reis, Joana; Lee, Jiyoun; Lin, Jiusheng; Zhao, Jinshi; Xu, Jingyi; Liao, Jiayu; Zhu, Jiaqi; Wang, Jianghai; Xu, Jiake; Lin, Jiabei; Zhou, Jia; Jossart, Jennifer N.; MacKeigan, Jeffrey P.; Dickhout, Jeffrey; Evans, Jay D.; Maynes, Jason T.; Mousa, Jarrod J.; Chuah, Janelle; Gebauer, Jan M.; Voss, Jan Hendrik; Shorter, James; Ng, James; Granneman, James G.; Siqueira-Neto, Jair L.; Miner, Jaden; Kratz, Jadel Müller; Fries, Jacob; Ferreira, Jacob; Boorman, Jacob; Kwiatkowski, Jacek; Perry, J. Jefferson P.; Cakir, Isin; Lotsaris, Irina; Qureshi, Insaf Ahmed; Verhamme, Ingrid M.; Mungrue, Imran N.; Arozarena, Imanol; Corvo, Ileana; Caliandro, Ileana; Greig, Iain R.; Kim, Hyeong Jun; Zhou, Hui; Feng, Hui; Fan, Hua Ying; Jung, Hoyoung; Lieberman, Howard B.; Debonsi, Hosana Maria; Xu, Hongyang; Van Remmen, Holly; Tam, Heng Keat; Chaytow, Helena; Hoppe, Heinrich; Wulff, Heike; Shim, Heesung; Yuan, Haynes; Tilford, Hannah; Moore, Hannah P.; Zhou, Han; Jafar-Nejad, Hamed; Breton, Hairol E.; Li, Hai; Cildir, Gokhan; Lee, Gyeongeun; Rucinski, Gwennan; Alvarez, Guzmán; Caljon, Guy; Akk, Gustav; de Souza, Guilherme Eduardo; Veit, Guido; Popowicz, Grzegorz Maria; Bowman, Gregory R.; Stuchbury, Grant David; Conn, Graeme L.; Michlewski, Gracjan; Dahal, Gopal; Leuzzi, Giuseppe; Gasparre, Giuseppe; Fiermonte, Giuseppe; Girolimetti, Giulia; Roti, Giovanni; Cortopassi, Gino; De Keulenaer, Gilles; Colotti, Gianni; Parico, Gian Carlo G.; Prikler, Gergely; Lukacs, Gergely L.; Garcia, George A.; Greene, Geoffrey L.; Mayer, Gaétan; Eitzen, Gary; Dempsey, Garrett; Zhang, Gang; Lembo, Gaia; Bognár, Gabriella; Rodriguez, G. Marcela; Svensson, Fredrik; Bdira, Fredj Ben; Vizeacoumar, Frederick S.; Buckner, Frederick S.; Luh, Frank; Vizeacoumar, Franco J.; Borriello, Francesco; van den Akker, Focco; Ingoglia, Filippo; Wang, Feng; Leng, Fenfei; Xiang, Fei; Yu, Fang; Gavathiotis, Evripidis; Glukhov, Evgenia; Garcia-Cuesta, Eva M.; Jo, Eunji; Kroon, Erna Geessien; Fan, Erkang; Lisabeth, Erika Mathes; Cione, Erika; Thompson, Erik W.; Strauss, Erick; Rubin, Eric J.; Trakhtenberg, Ephraim F.; Petretto, Enrico; Mason, Emily R.; Christensen, Emily M.; Leung, Elisa; Mameli, Eleonora; Lama, Eleonora; Abraham, Elena Theres; Lenci, Elena; Aguilera, Elena; Silva, Elany Barbosa; Lynn, Edward G.; Hsiao, Edward C.; Gelardi, Edoardo Luigi Maria; Glubb, Dylan M.; Duncan, Dustin; Krishnamurthy, Durga; Zochodne, Douglas William; Shoue, Douglas A.; Dirksen, Dorian; Lee, Donghan; Ronning, Donald R.; Slotboom, Dirk J.; Chaudhuri, Dipayan; Zhang, Dingqiang; Alramadhani, Dina; Ortiz, Diana; Hu, Di; Welsbie, Derek S.; Coombe, Deirdre R.; Anderson, Deborah H.; Ferraris, Davide Maria; Riches, David W.H.; Krist, David T.; Shum, David; Siderovski, David P.; Moreira, David; Smith, David M.; Hosfield, David J.; Dowling, David J.; Drewry, David H.; Hildeman, David A.; Trader, Darci J.; Manor, Danny; Chen, Daniel; Lawrence, Daniel A.; Keedy, Daniel A.; Tumes, Damon J.; Luo, Dahai; Santiago, César; Paulino, Cristina; Arrigoni, Cristina; Myhr, Courtney; Wilson, Cornelia M.; Loy, Cody A.; Reglero, Clara; Alkan, Cigdem; Morisseau, Christophe; Muli, Christine S.; Zeina, Christina M.; Weber, Christian; Müller, Christa E.; Kemet, Chinyere Maat; Mantri, Chinmay Kumar; Peltier, Cheryl; Liu, Chen; Huimei, Chen; Dieck, Chelsea L.; Keller, Charles; Karan, Charles; Kahler, Charlene M.; Yang, Chao Yie; Huang, Chang; Chaton, Catherine T.; Partch, Carrie L.; Chapman, Carly J.; Bon, Carlotta; Ballatore, Carlo; Torner, Carles; Novina, Carl D.; Lempicki, Camille; Fraser, Cameron; Dickinson, Bryan C.; Mota, Bruno Eduardo Fernandes; Hammock, Bruce D.; Morten, Brianna C.; Dymock, Brian W.; Geisbrecht, Brian V.; Duggan, Brendan M.; Salas, Brenda P.Medellin; Pressly, Brandon; Agianian, Bogos; Gong, Bin; Balakrishnan, Bijina; Englinger, Bernhard; Kováts, Benjámin; Chua, Benjamin Soon Kai; Perry, Benjamin; Liou, Benjamin; Edelman, Benjamin L.; Bailey-Elkin, Ben A.; Ribeiro, Beatriz Murta Rezende Moraes; Diallo, Bakary N"™tji; O"™Dea, Austin; Colomba, Audrey; Apfel, Athena Marie; ElSheikh, Assmaa; Prince, Ashutosh; John, Ashley L.St; Paparella, Ashleigh S.; Haas, Arthur L.; Chatterjee, Arnab K.; Samantha, Ariela; Panganiban, Antonito T.; Pineda-Lucena, Antonio; Garmendia, Antonio E.; Del Rio Flores, Antonio; O"™Donoghue, Anthony J.; Virtanen, Anniina; Fiorillo, Annarita; Müller, Anna; Montanaro, Anna; Minakova, Anna; Porcelli, Anna Maria; Hirsch, Anna K.H.; D"™Antuono, Anna; Borowska, Anna; Motyl, Anna A.L.; Cathcart, Ann M.; Ojha, Anil K.; Taglialatela, Angelo; White, Andrew; Cuddihy, Andrew R.; Lam, Andrew; Reidenbach, Andrew G.; Freywald, Andrew; Berti, Andrew; Herr, Andrew B.; Stahl, Andreas; Trabocchi, Andrea; Foote, Andrea Talbot; Mattevi, Andrea; Ilari, Andrea; Chini, Andrea; Caporali, Andrea; Battistoni, Andrea; Matheeussen, An; Rangarajan, Amith Vikram; Patel, Amit K.; Caflisch, Amedeo; Bryant-Friedrich, Amanda; Garaeva, Alisa A.; Vrielink, Alice; Tomilov, Alexey; Degterev, Alexei; Gingras, Alexandre R.; Statsyuk, Alexander V.; Freiberg, Alexander N.; Kushnir, Alexander; Agoulnik, Alexander I.; de Sousa, Alessandra Mara; Sverzhinsky, Aleksandr; de Oliveira, Aldo Sena; Ciccia, Alberto; Smrcka, Alan V.; Toh, Alan Kie Leong; Shaqra, Ala M.; Mushtaq, Aisha; Ayachi, Aicha Gharbi; Ghosh, Agnidipta; Andricopulo, Adriano D.; Ferrando, Adolfo A.; Presser, Adam G.; Mysore, Venkatesh; Gupta, Tushita; Abramyan, Tigran M.; Schroedl, Stefan; Pemberton, Ryan P.; DeHaan, Nicholas; Young, Matthew A.; Goldenberg, Joshua M.; Sorenson, Jon M.; Warrington, Jeffrey M.; Cox, Bryan D.; Anderson, Brandon M.; Bergman, Bastiaan; Cann, Andrew B.; Lee, Andreia H.; Kenyon, Victor; Chern, Ting Rong; Williams, Tiffany; Van Grack, Tessa; O"™Brien, Terrence E.; Palazzo, Teresa; Hare, Stephanie; Contreras, Stephanie; Shek, Stefani; PrasadPrasad, Srimukh Veccham Krishna; Suterwala, Shabbir; de Oliveira, Saulo; Eckert, Sam; Gniewek, Pawel; Henriksen, Niel; Anthis, Nicholas J.; Ahmed, Mostafa; Mysinger, Michael; Ngo, Lien; Giesler, Kyle; Sarangapani, Krishna; Stafford, Kate; Ng, Ho Leung; van den Bedem, Henry; Truong, Ha; Friedland, Greg; Moharreri, Ehsan; Thayer, Desiree; Laggner, Christian; Butler, Brittany; Worley, Brad; Thomas, Bill; Samudio, Ben; Davtyan, Aram; O"™Sullivan, Ann Marie; Rosnik, Andreana; Stecula, Adrian; Morrison, Adrian; Ho, Gregory; Nguyen, Kong; Bernard, Denzil; Wallach, Izhar
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-54655-z, published online 02 April 2024 The original version of this Article contained errors. In the original version of this article, Ellie Giles was omitted from the Author list. Additionally, the following Affiliation information has been updated: 1. Affiliation 25 was incorrect. Affiliation 25 "˜Queensland University of Technology, Brisbane, USA."™ now reads, "˜Queensland University of Technology, Brisbane, Australia."™ 2. Marta Giorgis was incorrectly affiliated with the "˜University of Aberdeen, Aberdeen, UK."™ The correct Affiliation is listed below: "˜University of Turin, Turin, Italy."™ 3. Affiliations 52, 125 and 261 were duplicated. As a result, the correct Affiliation for Andrew B. Herr, Benjamin Liou, David A. Hildeman, Joseph J. Maciag, Ying Sun, Durga Krishnamurthy, and Stephen N. Waggoner is: "˜Cincinnati Children"™s Hospital Medical Center, Cincinnati, USA."™ Furthermore, an outdated version of Figure 1 was typeset. The original Figure 1 and accompanying legend appear below. (Figure presented.) Pairs of representative compounds extracted from AI patents (right) and corresponding prior patents (left) for clinical-stage programs (CDK792,93, A2Ar-antagonist94,95, MALT196,97, QPCTL98,99, USP1100,101, and 3CLpro102,103). The identical atoms between the chemical structures are highlighted in red. Lastly, The Acknowledgements section contained an error. "See Supplementary section S1." now reads, "See Supplementary section S2." The original Article has been corrected.
SCOPUS:85204723078
ISSN: 2045-2322
CID: 5714322
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, Izhar; Bernard, Denzil; Nguyen, Kong; Ho, Gregory; Morrison, Adrian; Stecula, Adrian; Rosnik, Andreana; O"™Sullivan, Ann Marie; Davtyan, Aram; Samudio, Ben; Thomas, Bill; Worley, Brad; Butler, Brittany; Laggner, Christian; Thayer, Desiree; Moharreri, Ehsan; Friedland, Greg; Truong, Ha; van den Bedem, Henry; Ng, Ho Leung; Stafford, Kate; Sarangapani, Krishna; Giesler, Kyle; Ngo, Lien; Mysinger, Michael; Ahmed, Mostafa; Anthis, Nicholas J.; Henriksen, Niel; Gniewek, Pawel; Eckert, Sam; de Oliveira, Saulo; Suterwala, Shabbir; PrasadPrasad, Srimukh Veccham Krishna; Shek, Stefani; Contreras, Stephanie; Hare, Stephanie; Palazzo, Teresa; O"™Brien, Terrence E.; Van Grack, Tessa; Williams, Tiffany; Chern, Ting Rong; Kenyon, Victor; Lee, Andreia H.; Cann, Andrew B.; Bergman, Bastiaan; Anderson, Brandon M.; Cox, Bryan D.; Warrington, Jeffrey M.; Sorenson, Jon M.; Goldenberg, Joshua M.; Young, Matthew A.; DeHaan, Nicholas; Pemberton, Ryan P.; Schroedl, Stefan; Abramyan, Tigran M.; Gupta, Tushita; Mysore, Venkatesh; Presser, Adam G.; Ferrando, Adolfo A.; Andricopulo, Adriano D.; Ghosh, Agnidipta; Ayachi, Aicha Gharbi; Mushtaq, Aisha; Shaqra, Ala M.; Toh, Alan Kie Leong; Smrcka, Alan V.; Ciccia, Alberto; de Oliveira, Aldo Sena; Sverzhinsky, Aleksandr; de Sousa, Alessandra Mara; Agoulnik, Alexander I.; Kushnir, Alexander; Freiberg, Alexander N.; Statsyuk, Alexander V.; Gingras, Alexandre R.; Degterev, Alexei; Tomilov, Alexey; Vrielink, Alice; Garaeva, Alisa A.; Bryant-Friedrich, Amanda; Caflisch, Amedeo; Patel, Amit K.; Rangarajan, Amith Vikram; Matheeussen, An; Battistoni, Andrea; Caporali, Andrea; Chini, Andrea; Ilari, Andrea; Mattevi, Andrea; Foote, Andrea Talbot; Trabocchi, Andrea; Stahl, Andreas; Herr, Andrew B.; Berti, Andrew; Freywald, Andrew; Reidenbach, Andrew G.; Lam, Andrew; Cuddihy, Andrew R.; White, Andrew; Taglialatela, Angelo; Ojha, Anil K.; Cathcart, Ann M.; Motyl, Anna A.L.; Borowska, Anna; D"™Antuono, Anna; Hirsch, Anna K.H.; Porcelli, Anna Maria; Minakova, Anna; Montanaro, Anna; Müller, Anna; Fiorillo, Annarita; Virtanen, Anniina; O"™Donoghue, Anthony J.; Del Rio Flores, Antonio; Garmendia, Antonio E.; Pineda-Lucena, Antonio; Panganiban, Antonito T.; Samantha, Ariela; Chatterjee, Arnab K.; Haas, Arthur L.; Paparella, Ashleigh S.; John, Ashley L.St; Prince, Ashutosh; ElSheikh, Assmaa; Apfel, Athena Marie; Colomba, Audrey; O"™Dea, Austin; Diallo, Bakary N"™tji; Ribeiro, Beatriz Murta Rezende Moraes; Bailey-Elkin, Ben A.; Edelman, Benjamin L.; Liou, Benjamin; Perry, Benjamin; Chua, Benjamin Soon Kai; Kováts, Benjámin; Englinger, Bernhard; Balakrishnan, Bijina; Gong, Bin; Agianian, Bogos; Pressly, Brandon; Salas, Brenda P.Medellin; Duggan, Brendan M.; Geisbrecht, Brian V.; Dymock, Brian W.; Morten, Brianna C.; Hammock, Bruce D.; Mota, Bruno Eduardo Fernandes; Dickinson, Bryan C.; Fraser, Cameron; Lempicki, Camille; Novina, Carl D.; Torner, Carles; Ballatore, Carlo; Bon, Carlotta; Chapman, Carly J.; Partch, Carrie L.; Chaton, Catherine T.; Huang, Chang; Yang, Chao Yie; Kahler, Charlene M.; Karan, Charles; Keller, Charles; Dieck, Chelsea L.; Huimei, Chen; Liu, Chen; Peltier, Cheryl; Mantri, Chinmay Kumar; Kemet, Chinyere Maat; Müller, Christa E.; Weber, Christian; Zeina, Christina M.; Muli, Christine S.; Morisseau, Christophe; Alkan, Cigdem; Reglero, Clara; Loy, Cody A.; Wilson, Cornelia M.; Myhr, Courtney; Arrigoni, Cristina; Paulino, Cristina; Santiago, César; Luo, Dahai; Tumes, Damon J.; Keedy, Daniel A.; Lawrence, Daniel A.; Chen, Daniel; Manor, Danny; Trader, Darci J.; Hildeman, David A.; Drewry, David H.; Dowling, David J.; Hosfield, David J.; Smith, David M.; Moreira, David; Siderovski, David P.; Shum, David; Krist, David T.; Riches, David W.H.; Ferraris, Davide Maria; Anderson, Deborah H.; Coombe, Deirdre R.; Welsbie, Derek S.; Hu, Di; Ortiz, Diana; Alramadhani, Dina; Zhang, Dingqiang; Chaudhuri, Dipayan; Slotboom, Dirk J.; Ronning, Donald R.; Lee, Donghan; Dirksen, Dorian; Shoue, Douglas A.; Zochodne, Douglas William; Krishnamurthy, Durga; Duncan, Dustin; Glubb, Dylan M.; Gelardi, Edoardo Luigi Maria; Hsiao, Edward C.; Lynn, Edward G.; Silva, Elany Barbosa; Aguilera, Elena; Lenci, Elena; Abraham, Elena Theres; Lama, Eleonora; Mameli, Eleonora; Leung, Elisa; Christensen, Emily M.; Mason, Emily R.; Petretto, Enrico; Trakhtenberg, Ephraim F.; Rubin, Eric J.; Strauss, Erick; Thompson, Erik W.; Cione, Erika; Lisabeth, Erika Mathes; Fan, Erkang; Kroon, Erna Geessien; Jo, Eunji; Garcia-Cuesta, Eva M.; Glukhov, Evgenia; Gavathiotis, Evripidis; Yu, Fang; Xiang, Fei; Leng, Fenfei; Wang, Feng; Ingoglia, Filippo; van den Akker, Focco; Borriello, Francesco; Vizeacoumar, Franco J.; Luh, Frank; Buckner, Frederick S.; Vizeacoumar, Frederick S.; Bdira, Fredj Ben; Svensson, Fredrik; Rodriguez, G. Marcela; Bognár, Gabriella; Lembo, Gaia; Zhang, Gang; Dempsey, Garrett; Eitzen, Gary; Mayer, Gaétan; Greene, Geoffrey L.; Garcia, George A.; Lukacs, Gergely L.; Prikler, Gergely; Parico, Gian Carlo G.; Colotti, Gianni; De Keulenaer, Gilles; Cortopassi, Gino; Roti, Giovanni; Girolimetti, Giulia; Fiermonte, Giuseppe; Gasparre, Giuseppe; Leuzzi, Giuseppe; Dahal, Gopal; Michlewski, Gracjan; Conn, Graeme L.; Stuchbury, Grant David; Bowman, Gregory R.; Popowicz, Grzegorz Maria; Veit, Guido; de Souza, Guilherme Eduardo; Akk, Gustav; Caljon, Guy; Alvarez, Guzmán; Rucinski, Gwennan; Lee, Gyeongeun; Cildir, Gokhan; Li, Hai; Breton, Hairol E.; Jafar-Nejad, Hamed; Zhou, Han; Moore, Hannah P.; Tilford, Hannah; Yuan, Haynes; Shim, Heesung; Wulff, Heike; Hoppe, Heinrich; Chaytow, Helena; Tam, Heng Keat; Van Remmen, Holly; Xu, Hongyang; Debonsi, Hosana Maria; Lieberman, Howard B.; Jung, Hoyoung; Fan, Hua Ying; Feng, Hui; Zhou, Hui; Kim, Hyeong Jun; Greig, Iain R.; Caliandro, Ileana; Corvo, Ileana; Arozarena, Imanol; Mungrue, Imran N.; Verhamme, Ingrid M.; Qureshi, Insaf Ahmed; Lotsaris, Irina; Cakir, Isin; Perry, J. Jefferson P.; Kwiatkowski, Jacek; Boorman, Jacob; Ferreira, Jacob; Fries, Jacob; Kratz, Jadel Müller; Miner, Jaden; Siqueira-Neto, Jair L.; Granneman, James G.; Ng, James; Shorter, James; Voss, Jan Hendrik; Gebauer, Jan M.; Chuah, Janelle; Mousa, Jarrod J.; Maynes, Jason T.; Evans, Jay D.; Dickhout, Jeffrey; MacKeigan, Jeffrey P.; Jossart, Jennifer N.; Zhou, Jia; Lin, Jiabei; Xu, Jiake; Wang, Jianghai; Zhu, Jiaqi; Liao, Jiayu; Xu, Jingyi; Zhao, Jinshi; Lin, Jiusheng; Lee, Jiyoun; Reis, Joana; Stetefeld, Joerg; Bruning, John B.; , ; Coles, John G.; Tanner, John J.; Pascal, John M.; So, Jonathan; Pederick, Jordan L.; Costoya, Jose A.; Rayman, Joseph B.; Maciag, Joseph J.; Nasburg, Joshua Alexander; Gruber, Joshua J.; Finkelstein, Joshua M.; Watkins, Joshua; Rodriguez-Frade, José Miguel; Arias, Juan Antonio Sanchez; Lasarte, Juan José; Oyarzabal, Julen; Milosavljevic, Julian; Cools, Julie; Lescar, Julien; Bogomolovas, Julijus; Wang, Jun; Kee, Jung Min; Kee, Jung Min; Liao, Junzhuo; Sistla, Jyothi C.; Abrahão, Jônatas Santos; Sishtla, Kamakshi; Francisco, Karol R.; Hansen, Kasper B.; Molyneaux, Kathleen A.; Cunningham, Kathryn A.; Martin, Katie R.; Gadar, Kavita; Ojo, Kayode K.; Wong, Keith S.; Wentworth, Kelly L.; Lai, Kent; Lobb, Kevin A.; Hopkins, Kevin M.; Parang, Keykavous; Machaca, Khaled; Pham, Kien; Ghilarducci, Kim; Sugamori, Kim S.; McManus, Kirk James; Musta, Kirsikka; Faller, Kiterie M.E.; Nagamori, Kiyo; Mostert, Konrad J.; Korotkov, Konstantin V.; Liu, Koting; Smith, Kristiana S.; Sarosiek, Kristopher; Rohde, Kyle H.; Kim, Kyu Kwang; Lee, Kyung Hyeon; Pusztai, Lajos; Lehtio, Lari; Haupt, Larisa M.; Cowen, Leah E.; Byrne, Lee J.; Su, Leila; Wert-Lamas, Leon; Puchades-Carrasco, Leonor; Chen, Lifeng; Malkas, Linda H.; Zhuo, Ling; , ; Hedstrom, Lizbeth; Walensky, Loren D.; Antonelli, Lorenzo; Iommarini, Luisa; Whitesell, Luke; Randall, Lia M.; Fathallah, M. Dahmani; Nagai, Maira Harume; Kilkenny, Mairi Louise; Ben-Johny, Manu; Lussier, Marc P.; Windisch, Marc P.; Lolicato, Marco; Lolli, Marco Lucio; Vleminckx, Margot; Caroleo, Maria Cristina; Macias, Maria J.; Valli, Marilia; Barghash, Marim M.; Mellado, Mario; Tye, Mark A.; Wilson, Mark A.; Hannink, Mark; Ashton, Mark R.; Cerna, Mark Vincent C.dela; Giorgis, Marta; Safo, Martin K.; Maurice, Martin St; McDowell, Mary Ann; Pasquali, Marzia; Mehedi, Masfique; Serafim, Mateus Sá Magalhães; Soellner, Matthew B.; Alteen, Matthew G.; Champion, Matthew M.; Skorodinsky, Maxim; O"™Mara, Megan L.; Bedi, Mel; Rizzi, Menico; Levin, Michael; Mowat, Michael; Jackson, Michael R.; Paige, Mikell; Al-Yozbaki, Minnatallah; Giardini, Miriam A.; Maksimainen, Mirko M.; De Luise, Monica; Hussain, Muhammad Saddam; Christodoulides, Myron; Stec, Natalia; Zelinskaya, Natalia; Van Pelt, Natascha; Merrill, Nathan M.; Singh, Nathanael; Kootstra, Neeltje A.; Singh, Neeraj; Gandhi, Neha S.; Chan, Nei Li; Trinh, Nguyen Mai; Schneider, Nicholas O.; Matovic, Nick; Horstmann, Nicola; Longo, Nicola; Bharambe, Nikhil; Rouzbeh, Nirvan; Mahmoodi, Niusha; Gumede, Njabulo Joyfull; Anastasio, Noelle C.; Khalaf, Noureddine Ben; Rabal, Obdulia; Kandror, Olga; Escaffre, Olivier; Silvennoinen, Olli; Bishop, Ozlem Tastan; Iglesias, Pablo; Sobrado, Pablo; Chuong, Patrick; O"™Connell, Patrick; Martin-Malpartida, Pau; Mellor, Paul; Fish, Paul V.; Moreira, Paulo Otávio Lourenço; Zhou, Pei; , ; Liu, Pengda; Wu, Pengpeng; Agogo-Mawuli, Percy; Jones, Peter L.; Ngoi, Peter; Toogood, Peter; Ip, Philbert; von Hundelshausen, Philipp; Lee, Pil H.; Rowswell-Turner, Rachael B.; Balaña-Fouce, Rafael; Rocha, Rafael Eduardo Oliveira; Guido, Rafael V.C.; Ferreira, Rafaela Salgado; Agrawal, Rajendra K.; Harijan, Rajesh K.; Ramachandran, Rajesh; Verma, Rajkumar; Singh, Rakesh K.; Tiwari, Rakesh Kumar; Mazitschek, Ralph; Koppisetti, Rama K.; Dame, Remus T.; Douville, Renée N.; Austin, Richard C.; Taylor, Richard E.; Moore, Richard G.; Ebright, Richard H.; Angell, Richard M.; Yan, Riqiang; Kejriwal, Rishabh; Batey, Robert A.; Blelloch, Robert; Vandenberg, Robert J.; Hickey, Robert J.; Kelm, Robert J.; Lake, Robert J.; Bradley, Robert K.; Blumenthal, Robert M.; Solano, Roberto; Gierse, Robin Matthias; Viola, Ronald E.; McCarthy, Ronan R.; Reguera, Rosa Maria; Uribe, Ruben Vazquez; do Monte-Neto, Rubens Lima; Gorgoglione, Ruggiero; Cullinane, Ryan T.; Katyal, Sachin; Hossain, Sakib; Phadke, Sameer; Shelburne, Samuel A.; Geden, Sandra E.; Johannsen, Sandra; Wazir, Sarah; Legare, Scott; Landfear, Scott M.; Radhakrishnan, Senthil K.; Ammendola, Serena; Dzhumaev, Sergei; Seo, Seung Yong; Li, Shan; Zhou, Shan; Chu, Shaoyou; Chauhan, Shefali; Maruta, Shinsaku; Ashkar, Shireen R.; Shyng, Show Ling; Conticello, Silvestro G.; Buroni, Silvia; Garavaglia, Silvia; White, Simon J.; Zhu, Siran; Tsimbalyuk, Sofiya; Chadni, Somaia Haque; Byun, Soo Young; Park, Soonju; Xu, Sophia Q.; Banerjee, Sourav; Zahler, Stefan; Espinoza, Stefano; Gustincich, Stefano; Sainas, Stefano; Celano, Stephanie L.; Capuzzi, Stephen J.; Waggoner, Stephen N.; Poirier, Steve; Olson, Steven H.; Marx, Steven O.; Van Doren, Steven R.; Sarilla, Suryakala; Brady-Kalnay, Susann M.; Dallman, Sydney; Azeem, Syeda Maryam; Teramoto, Tadahisa; Mehlman, Tamar; Swart, Tarryn; Abaffy, Tatjana; Akopian, Tatos; Haikarainen, Teemu; Moreda, Teresa Lozano; Ikegami, Tetsuro; Teixeira, Thaiz Rodrigues; Jayasinghe, Thilina D.; Gillingwater, Thomas H.; Kampourakis, Thomas; Richardson, Timothy I.; Herdendorf, Timothy J.; Kotzé, Timothy J.; O"™Meara, Timothy R.; Corson, Timothy W.; Hermle, Tobias; Ogunwa, Tomisin Happy; Lan, Tong; Su, Tong; Banjo, Toshihiro; O"™Mara, Tracy A.; Chou, Tristan; Chou, Tsui Fen; Baumann, Ulrich; Desai, Umesh R.; Pai, Vaibhav P.; Thai, Van Chi; Tandon, Vasudha; Banerji, Versha; Robinson, Victoria L.; Gunasekharan, Vignesh; Namasivayam, Vigneshwaran; Segers, Vincent F.M.; Maranda, Vincent; Dolce, Vincenza; Maltarollo, Vinicius Gonçalves; Scoffone, Viola Camilla; Woods, Virgil A.; Ronchi, Virginia Paola; Van Hung Le, Vuong; Clayton, W. Brent; Lowther, W. Todd; Houry, Walid A.; Li, Wei; Tang, Weiping; Zhang, Wenjun; Van Voorhis, Wesley C.; Donaldson, William A.; Hahn, William C.; Kerr, William G.; Gerwick, William H.; Bradshaw, William J.; Foong, Wuen Ee; Blanchet, Xavier; Wu, Xiaoyang; Lu, Xin; Qi, Xin; Xu, Xin; Yu, Xinfang; Qin, Xingping; Wang, Xingyou; Yuan, Xinrui; Zhang, Xu; Zhang, Yan Jessie; Hu, Yanmei; Aldhamen, Yasser Ali; Chen, Yicheng; Li, Yihe; Sun, Ying; Zhu, Yini; Gupta, Yogesh K.; Pérez-Pertejo, Yolanda; Li, Yong; Tang, Young; He, Yuan; Tse-Dinh, Yuk Ching; Sidorova, Yulia A.; Yen, Yun; Li, Yunlong; Frangos, Zachary J.; Chung, Zara; Su, Zhengchen; Wang, Zhenghe; Zhang, Zhiguo; Liu, Zhongle; Inde, Zintis; Artia, Zoraima; Heifets, Abraham
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery.
SCOPUS:85191821387
ISSN: 2045-2322
CID: 5658952
Model-based estimation of individual-level social determinants of health and its applications in All of Us
Kim, Bo Young; Anthopolos, Rebecca; Do, Hyungrok; Zhong, Judy
OBJECTIVES/OBJECTIVE:We introduce a widely applicable model-based approach for estimating individual-level Social Determinants of Health (SDoH) and evaluate its effectiveness using the All of Us Research Program. MATERIALS AND METHODS/METHODS:Our approach utilizes aggregated SDoH datasets to estimate individual-level SDoH, demonstrated with examples of no high school diploma (NOHSDP) and no health insurance (UNINSUR) variables. Models are estimated using American Community Survey data and applied to derive individual-level estimates for All of Us participants. We assess concordance between model-based SDoH estimates and self-reported SDoHs in All of Us and examine associations with undiagnosed hypertension and diabetes. RESULTS:Compared to self-reported SDoHs, the area under the curve for NOHSDP is 0.727 (95% CI, 0.724-0.730) and for UNINSUR is 0.730 (95% CI, 0.727-0.733) among the 329 074 All of Us participants, both significantly higher than aggregated SDoHs. The association between model-based NOHSDP and undiagnosed hypertension is concordant with those estimated using self-reported NOHSDP, with a correlation coefficient of 0.649. Similarly, the association between model-based NOHSDP and undiagnosed diabetes is concordant with those estimated using self-reported NOHSDP, with a correlation coefficient of 0.900. DISCUSSION AND CONCLUSION/CONCLUSIONS:The model-based SDoH estimation method offers a scalable and easily standardized approach for estimating individual-level SDoHs. Using the All of Us dataset, we demonstrate reasonable concordance between model-based SDoH estimates and self-reported SDoHs, along with consistent associations with health outcomes. Our findings also underscore the critical role of geographic contexts in SDoH estimation and in evaluating the association between SDoHs and health outcomes.
PMID: 39003521
ISSN: 1527-974x
CID: 5731702
Prenatal Stress and Maternal Role in Neurodevelopment
Thomason, Moriah E; Hendrix, Cassandra L
This review summarizes recent findings on stress-related programming of brain development in utero, with an emphasis on situating findings within the mothers' broader psychosocial experiences. Meta-analyses of observational studies on prenatal stress exposure indicate the direction and size of effects on child neurodevelopment are heterogeneous across studies. Inspired by lifespan and topological frameworks of adversity, we conceptualize individual variation in mothers' lived experience during and prior to pregnancy as a key determinant of these heterogeneous effects across populations. We structure our review to discuss experiential categories that may uniquely shape the psychological and biological influence of stress on pregnant mothers and their developing children, including current socioeconomic resources, exposure to chronic and traumatic stressors, culture and historical trauma, and the contours of prenatal stress itself. We conclude by identifying next steps that hold potential to meaningfully advance the field of fetal programming.
PMCID:11694802
PMID: 39759868
ISSN: 2640-7922
CID: 5770732
Adolescent Blood Pressure and Early Age Stroke
Fishman, Boris; Vinograd, Adi; Tsur, Avishai M; Bardugo, Aya; Bendor, Cole D; Libruder, Carmit; Zucker, Inbar; Lutski, Miri; Ram, Amit; Hershkovitz, Yael; Orr, Omri; Furer, Ariel; Perelman, Maxim; Chodick, Gabriel; Yaniv, Gal; Tanne, David; Derazne, Estela; Tzur, Dorit; Afek, Arnon; Coresh, Josef; Grossman, Ehud; Twig, Gilad
BACKGROUND:Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardiovascular outcomes. METHODS:This nationwide, population-based, retrospective cohort study included all Israeli adolescents 16-19 years of age who were medically evaluated before compulsory military service from 1985 to 2013, including routine blood pressure measurements. The primary outcome was the first occurrence of a stroke (ischemic or hemorrhagic) at a young age (≤52 years), as documented in the Israeli National Stroke Registry. Cox proportional hazard models were stratified by sex and adjusted for birth year, sociodemographic variables, and adolescent body mass index. RESULTS:The cohort comprised 1,897,048 adolescents (42.4% women). During 11,355,476 person-years of follow-up, there were 1470 first stroke events at a young age. In men, an adolescent diastolic blood pressure value of ≥80 mmHg, compared with the reference group (diastolic blood pressure value of <70 mmHg), was associated with an increased risk of stroke (adjusted hazard ratio 1.28; 95% confidence interval [CI], 1.04 to 1.58), while a diastolic blood pressure value of 70-79 mmHg was not associated with an increased risk of stroke (adjusted hazard ratio 1.11; 95% CI 0.90 to 1.34). Among women, an adolescent diastolic blood pressure value of ≥80 mmHg, compared with the reference group (diastolic blood pressure value of <70 mmHg) was associated with an increased risk of stroke at a young age (adjusted hazard ratio 1.38; 95% CI 1.03 to 1.88), as was a diastolic blood pressure value of 70-79 mmHg (adjusted hazard ratio 1.41; 95% CI 1.09 to 1.81). Elevated adolescent systolic blood pressure values (≥120 mmHg) were not associated with an increased risk of stroke. CONCLUSIONS:Diastolic blood pressure values of ≥80 mmHg in adolescence were associated with an increased risk of stroke at a young age in both men and women. No similar association was observed for elevated systolic blood pressure.
PMID: 39550723
ISSN: 2766-5526
CID: 5757902
Differences in Breastfeeding Initiation and Duration by Migration History in the Hispanic Community Health Study/Study of Latinos
Stanhope, Kaitlyn K; Perreira, Krista M; Isasi, Carmen R; LeCroy, Madison N; Daviglus, Martha L; Gonzalez, Franklyn; Gallo, Linda C; Poelinz, Clarisa Medina; Suglia, Shakira F
PMID: 39355966
ISSN: 1556-8342
CID: 5762102
Staging schema for early diagnosis of prediabetes
Bergman, Michael; Abdul-Ghani, Muhammad; Chan, Juliana; Schmidt, Maria Inês; Ha, Joon; Kim, Sang Soo; Sherman, Arthur S; Jagannathan, Ram; Tuomilehto, Jaakko
PMID: 39522533
ISSN: 2213-8595
CID: 5752412
Pregnancy restructures the brain to prepare for childbirth and parenthood
McCormack, Clare; Thomason, Moriah
PMID: 39639143
ISSN: 1476-4687
CID: 5770712
Readability Assessment of Patient Education Materials on Uro-oncological Diseases Using Automated Measures
Rodler, Severin; Maruccia, Serena; Abreu, Andre; Murphy, Declan; Canes, David; Loeb, Stacy; Malik, Rena D; Bagrodia, Aditya; Cacciamani, Giovanni E
BACKGROUND AND OBJECTIVE/OBJECTIVE:Readability of patient education materials is of utmost importance to ensure understandability and dissemination of health care information in uro-oncology. We aimed to investigate the readability of the official patient education materials of the European Association of Urology (EAU) and American Urology Association (AUA). METHODS:Patient education materials for prostate, bladder, kidney, testicular, penile, and urethral cancers were retrieved from the respective organizations. Readability was assessed via the WebFX online tool for Flesch Kincaid Reading Ease Score (FRES) and for reading grade levels by Flesch Kincaid Grade Level (FKGL), Gunning Fog Score (GFS), Smog Index (SI), Coleman Liau Index (CLI), and Automated Readability Index (ARI). Layperson readability was defined as a FRES of ≥70 and with the other readability indexes <7 according to European Union recommendations. This study assessed only objective readability and no other metrics such as understandability. KEY FINDINGS AND LIMITATIONS/UNASSIGNED:Most patient education materials failed to meet the recommended threshold for laypersons. The mean readability for EAU patient education material was as follows: FRES 50.9 (standard error [SE]: 3.0), and FKGL, GFS, SI, CLI, and ARI all with scores ≥7. The mean readability for AUA patient material was as follows: FRES 64.0 (SE: 1.4), with all of FKGL, GFS, SI, and ARI scoring ≥7 readability. Only 13 out of 70 (18.6%) patient education materials' paragraphs met the readability requirements. The mean readability for bladder cancer patient education materials was the lowest, with a FRES of 36.7 (SE: 4.1). CONCLUSIONS AND CLINICAL IMPLICATIONS/CONCLUSIONS:Patient education materials from leading urological associations reveal readability levels beyond the recommended thresholds for laypersons and may not be understood easily by patients. There is a future need for more patient-friendly reading materials. PATIENT SUMMARY/RESULTS:This study checked whether health information about different cancers was easy to read. Most of it was too hard for patients to understand.
PMID: 39048402
ISSN: 2405-4569
CID: 5738652
