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Department/Unit:Child and Adolescent Psychiatry

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Accounting for Comorbidity in Etiologic Research

Khachadourian, Vahe; Janecka, Magdalena
INTRODUCTION/UNASSIGNED:Comorbidity between disorders is pervasive, and its relationship to the main conditions under investigation needs to be addressed for robust causal inference. However, many clinical etiologic studies still fail to capitalize on the theoretical advancements and improved recommendations regarding covariate adjustment in this context. Specifically, studies often lack explicit causal assumptions about the role of comorbidity in exposure-outcome relationships, potentially leading to inappropriate accounting for comorbid conditions and resulting in biased effect estimates. This study aims to explore common causal structures involving comorbidity and provide guidance for handling it in etiologic research. METHODS/UNASSIGNED:We use Directed Acyclic Graphs (DAGs) to depict six causal scenarios involving comorbidity as a confounder, mediator, collider, or consequence of the exposure or outcome, illustrated with real-world clinical examples. Simulations were conducted across 5,000 iterations for each scenario, assessing the impact of conditioning on comorbidity under four effect measures (risk difference, odds ratio, risk ratio, and mean difference). Bias was evaluated by comparing adjusted and unadjusted effect estimates to the true values. RESULTS/UNASSIGNED:The impact of conditioning on comorbidity varied by its causal role. Adjusting for comorbidity mitigated bias when it acted as a confounder but introduced bias when it was a mediator or collider. In instances where comorbidity was a consequence of either the exposure or outcome, the decision to adjust depended on the research objectives and could vary across effect measures. DISCUSSION/UNASSIGNED:Explicit causal assumptions are essential for selecting appropriate analytical strategies in etiologic research. This study provides practical guidance on analytical handling of the measures of comorbidity, highlighting the need for study design and analysis to align with research objectives. Future work should address more complex causal structures and other methodological challenges.
PMCID:12554262
PMID: 41146954
ISSN: 1179-1349
CID: 5961072

EJSO

Kefleyesus, Amaniel; Bakrin, Naoual; Kepenekian, Vahan; Gerbaud-Coulas, Chloe; Li, Anne; Vassal, Olivia; Eveno, Clarisse; Sgarbura, Olivia; Nelson, Gregg; Bouchard-Fortier, Antoine; Mack, Lloyd; Rivard, Justin; Fagotti, Anna; Kusamura, Shigeki; Robella, Manuela; Piso, Pompiliu; Acs, Miklos; Arias, Fernando; Rau, Beate; Lambert, Laura A.; Wadhwa, Anupama; Polanco, Patricio; Somashekhar, S. P.; Teixeira-Farinha, Hugo; Alyami, Mohammad; Glehen, Olivier; Hubner, Martin
ISI:001502083200001
ISSN: 0748-7983
CID: 5991962

Improved Access to Behavioral Health Care for Patients in a Large New York City Behavioral Health Clinic by the Transition to Telemedicine

Reliford, Aaron; Zhang, Emily; Liu, Anni; Lanina, Olga; Williams, Sharifa Z; Sanichar, Navin; Khan, Shabana; Dapkins, Isaac; Frankle, William Gordon
OBJECTIVE/UNASSIGNED:To examine the transition to telemental health within the behavioral health program of a large federally qualified health center, The Family Health Centers at NYU Langone, in the 3 months following the onset of the COVID-19 pandemic-specifically impacts on show rates and access to care. METHODS/UNASSIGNED:Demographic and clinical information for all scheduled visits was collected for two time periods: the telemental health period, March 16, 2020-July 16, 2020 (46,878 visits, 5,183 patients), and a comparison period, March 15, 2019-July 16, 2019 (47,335 visits, 5,190 patients). Data collected included modality, appointments scheduled/completed/cancelled/no-showed, age, gender, race, language, and diagnosis. Generalized estimating equations with a compound symmetry correlation structure and logit link were used for analysis. RESULTS/UNASSIGNED:= 0.01), which was eliminated by implementation of telemental health. CONCLUSIONS/UNASSIGNED:This study supports the use telemental health to increase access for all patients, including those from under-represented, lower socioeconomic status backgrounds.
PMCID:12040568
PMID: 40308563
ISSN: 2692-4366
CID: 5834012

Surveying barriers to training: a call for change for international neuropsychology trainees in the U.S

Nayar, Kritika; Lunia, Palak; Miao, Iris Yi; Choi, Elizabeth; Lalchandani, Rinku; Hong, Yue Doris; Tan, Alexander
INTRODUCTION/UNASSIGNED:By 2050, the U.S. population is projected to become increasingly heterogeneous, requiring a culturally competent neuropsychology workforce equipped to serve this evolving demographic. International graduate trainees bring valuable cultural and linguistic assets to the field of clinical neuropsychology but face significant structural barriers involving restrictive immigration policies. METHODS/UNASSIGNED: = 28) levels, alongside personal narratives from four international trainees. RESULTS/UNASSIGNED:Results reveal low international trainee enrollment - particularly at the postdoctoral level - and widespread immigration-related challenges, such as limited visa sponsorship and duration, unawareness of visa-related training restrictions, and discomfort among directors in supporting visa issues. Despite the potential benefits of STEM designation for clinical and counseling psychology programs to ease visa barriers, few programs have attempted and succeeded in this process. Personal narratives also highlighted the burdensome STEM conversion process, and the role of trainee-led efforts in overcoming bureaucratic hurdles. CONCLUSIONS/UNASSIGNED:To urgently address these issues, we advocate for systemic reforms including national-level STEM reclassification of psychology programs, extended visa durations, enhanced national pipelines and institutional support for visa sponsorship, and improved education on immigration policies. These efforts align with the Multicultural Orientation (MCO) model and AACN's Relevance 2050 goals by fostering a culturally and linguistically responsive workforce equipped to meet evolving mental health needs and to ensure the continued relevance of clinical neuropsychology.
PMID: 41025483
ISSN: 1744-411x
CID: 5978922

Beyond average outcomes: A latent profile analysis of diverse developmental trajectories in preterm and early term-born children from the Adolescent Brain Cognitive Development study

Menu, Iris; Ji, Lanxin; Bhatia, Tanya; Duffy, Mark; Hendrix, Cassandra L; Thomason, Moriah E
Preterm birth poses a major public health challenge, with significant and heterogeneous developmental impacts. Latent profile analysis was applied to the National Institutes of Health Toolbox performance of 1891 healthy prematurely born children from the Adolescent Brain and Cognitive Development study (970 boys, 921 girls; 10.00 ± 0.61 years; 1.3% Asian, 13.7% Black, 17.5% Hispanic, 57.0% White, 10.4% Other). Three distinct neurocognitive profiles emerged: consistently performing above the norm (19.7%), mixed scores (41.0%), and consistently performing below the norm (39.3%). These profiles were associated with lasting cognitive, neural, behavioral, and academic differences. These findings underscore the importance of recognizing diverse developmental trajectories in prematurely born children, advocating for personalized diagnosis and intervention to enhance care strategies and long-term outcomes for this heterogeneous population.
PMID: 39136075
ISSN: 1467-8624
CID: 5726802

Characteristics of Hospitalized Patients Referred for Complementary and Integrative Health Services at a Large Metropolitan Academic Medical Center

Millon, Emma M; Shang, Andrea; DeMarco, Kathleen A
BACKGROUND/UNASSIGNED:Complementary and integrative health (CIH) services enhance physiological and psychological wellbeing, while potentially reducing medical costs. Despite these benefits, use of inpatient CIH services remains poorly characterized, impeding efforts to develop equitable and effective healthcare. OBJECTIVE/UNASSIGNED:This retrospective case-control study examined characteristics of patients likely to receive CIH referrals and consults. METHOD/UNASSIGNED:Electronic health records were analyzed from patients hospitalized at a large metropolitan academic medical center from September 2022 to February 2024. RESULTS/UNASSIGNED:values <0.001). Among those referred, 72% received at least one CIH consult, with lower odds of completing a consult for male patients. CONCLUSION/UNASSIGNED:Disparities underscore the need for equitable CIH services access in healthcare systems. Future research will test how to broaden services to male patients, those with non-English language preference, and less medical complexity, to ensure greater benefit from holistic healthcare.
PMCID:12541185
PMID: 41132820
ISSN: 2753-6130
CID: 5957302

A Case of Hypothermia Associated With the Use of Multiple Antipsychotics in a Patient With Late-Onset Schizophrenia [Letter]

Eloma-Ata, Amanda; Wafy, Fatma; Parikh, Amir; Tusher, Alan
ISI:001437276500012
ISSN: 0271-0749
CID: 5935952

Helping Children Heal: Counseling Interventions for Divorce-Related Family Disruption

Schmidt, Christopher D.; Misurell, Justin R.; Feder, Michael A.; Peffer, Avery; Grigg, Jenai
ISI:001537305900001
ISSN: 1066-4807
CID: 5908652

JOURNAL OF SOCIAL WORK

Kant, Jessica D.; Bono, Madeline H.; Boskey, Elizabeth R.
ISI:001432025800001
ISSN: 1468-0173
CID: 5822982

"We cannot live like Canadian": Yazidi refugees' perspectives on mental health, coping strategies and barriers to care

Bobyn, Jacqueline; Abraham, Bethel; Kain, Nicole; Williams, Kimberly; Coakley, Annalee; Watterson, Rita
BACKGROUND/UNASSIGNED:The Yazidi people are a Kurdish religious minority group who have been persecuted by the Islamic State of Iraq and Syria (ISIS). The complexity of the trauma the Yazidi people endured, and a limited understanding of their illness belief models have created challenges to providing culturally sensitive psychiatric care. The purpose of this study was to use focus group methodology to understand Yazidi refugees' experiences, to provide culturally informed mental health care. METHODS/UNASSIGNED:Two in-person focus groups were held in Calgary, Alberta with Yazidi refugee women from Iraq and Syria (N = 6, N = 7) to assess perspectives on mental health, preferred coping strategies and perceived barriers to care. Participants were selected using purposive sampling. Focus group design and facilitation were done in partnership with Yazidi cultural brokers and interpreters. Focus groups were conducted in English and interpreted in Kurmanji. The focus groups were recorded, coded, and subjected to qualitative content thematic analyses. The analysis was guided by an interpretivist epistemology and informed by pragmatism, to situate participants' perspectives within their social context while generating culturally informed insights for psychiatric care in Canada. RESULTS/UNASSIGNED:Experiences with psychiatric symptoms (e.g. grief and loss, somatization, depression, trauma) were identified. Family reunification and community support were emphasized as preferred coping methods. Perceived unrealistic expectations of refugees post-migration, social isolation and language difficulties were acknowledged as barriers to care. CONCLUSION/UNASSIGNED:Providing appropriate psychiatric care to Yazidi refugee women requires a culturally informed approach. Findings in this study support the need for culturally sensitive mental health interventions in refugee populations post migration.
PMCID:12583056
PMID: 41195346
ISSN: 1664-0640
CID: 5965352