Faculty Bibliography

Introduction: Squamous cell carcinoma (SCC) is the most common form of cancer in the head and neck. Variants of this exist, including Basaloid Squamous Cell Carcinoma (BSCC) and Spindle Cell Carcinomas (SpCC). BSCC was first described by Wain et al in 1986 and is described as being a rare, aggressive, high grade variant of SCC that shows predilection for the tongue, larynx and hypopharynx.1 BSCC of the head and neck has also been associated with poorer clinical outcomes compared with conventional SCC.2 Spindle Cell Carcinomas account for 3% of head and neck SCCs and are derived from conventional SCCs. The objective of this study was to compare clinicopathologic features and postoperative course of variant SCCs to confirm reported propensity for aggressiveness. Materials & Methods: A retrospective chart review of patients with SCC at Bellevue Hospital Center and NYU Langone Medical Center by the Department of Oral & Maxillofacial Surgery from June 2006 until 2012 were retrospectively reviewed and classified based on histologic criteria. Classifications were confirmed by at least 2 pathologists and included BSCC and SpCC. Clinical information, including clinicopathologic and clinical course. Results: All cases of SCC since June 2006 were reviewed. Seven of the reviewed cases were SCC variants, six cases of BSCC and 1 case of SpCC. The age of the patients ranged from 30-68 with a mean age of 56. The majority of patients were causcasian males with history significant for tobacco and alcohol use. BSCC was most often found in the floor of the mouth with invasion into the mandible with other locations in the tongue, tonsil and buccal vestibule. In the case of the patient with SpCC, invasion included the maxilla, pterygopalatine fossa and orbit. TNM staging in BSCC varied from T1N0- T4N2. The TNM staging in SpCC was T4N1M1. Selective neck dissections were performed on 3 patients with BSCC and the patient with SpCC. Surgical margins were positive in 2 cases of BSCC as well as in the patient with SpCC. Perineural invasion was noted in 5 BSCC cases and the SpCC case. Three BSCC patients received chemotherapy as well as the patient with SpCC, while all patients underwent radiation therapy. One patient with BSCC had metastasis while the patient with SpCC had metastasis to the left globe and ultimately died. Conclusions: Most patients with variant SCCs were white males in their late 50s with a significant history of exposure to tobacco and alcohol. Of the total seven cases of BSCC and SpCC 43% had positive margins and 85% exhibited perineural invasion. Surgical treatment included neck dissection, wide resection with reconstruction and postoperative radiation and, in some cases, chemotherapy. BSCC and SpCC can be devastating and aggressive tumors and correct diagnosis is key. The importance of close follow up of these patients, and any patient with a history of SCC, was demonstrated by 28% of the patients presenting with recurrence within two years of diagnosis. Identifying the specific histologic cell type can determine aggressiveness of the tumor as well as help to guide treatment. Results of this study are consistent with previous studies showing rarity, however, significant difference in aggressiveness, recurrence, and death were not observed as compared to other SCC cases treated at our institution

Low-velocity gunshot wounds to the mandible are complex injuries that can be aesthetically and functionally devastating. Despite advances in plating systems and surgical techniques, repair of such injuries remains a challenging endeavor. Traditionally, external fixation has resulted in longer treatment times and the need for revision surgery. Rigid fixation has many proponents because of shorter postoperative treatment times and fewer complications. We report a case of a low-velocity gunshot injury to the mandible with comminution and a full-thickness soft tissue wound treated definitively with maxillomandibular fixation and an external fixation device.

Statement of Problem: The microvascular free fibula flap is widely used to reconstruct complex craniomaxillofacial defects following ablative surgery. Since its popularization for mandibular bony reconstruction in 1989, many permutations of the fibula flap have been applied to composite head and neck defects. Several authors describe endosseous implantation of the fibula post operatively or at the time of surgery to aid in dental reconstruction, but this can leave a patient partially edentulous for up to 1 year after initial surgery. Many patients are lost to follow up and do not go on to complete dental rehabilitation. This may contribute to suboptimal nutritional status, poor cosmetic outcomes, and decreased patient satisfaction. We will discuss how these problems can be circumvented by single stage surgery that incorporates dental implants and a prosthesis to allow for complete jaw reconstruction. Methods: A retrospective chart review at NYU Langone Medical Center and Bellevue Hospital Center was completed to identify patients undergoing extirpative surgery of the maxilla or mandible with immediate reconstruction with a free fibula flap, dental implants, and dental prosthesis from 2011-2012. A total of 5 patients were treated for ameloblastoma (n=3), intraosseus hemangioma (n=1), and odontogenic myxoma (n=1) of the maxilla (n=1) and mandible (n=4). Virtual surgical planning was implemented in all cases. During the computer assisted design phase, a virtual dental construct of an implant supported prosthesis was applied to the planned resection site and the fibula flap was designed to support the desired prosthesis. The cutting jigs for the jaw and fibula were manufactured according to plan as well as the implant borne dental prosthesis. In addition to osteotomy cutting slots, the fibular jig had implant drill guides to aid in correct placement. The prosthesis was secured to the fibular implants with custom abutments and then placed into temporary maxillomandibular fixation with the native dentition prior to plate osteosynthesis of the fibula. Post operative physical examination and computed tomography was used to evaluate occlusion and flap position. Results: All patients were reconstructed successfully with this method without any flap or implant failures. Longest follow up time was 12 months with a mean of 6 months. A total of 23 implants were planned and placed with no implant failures. 1 implant was not used due to suboptimal position in relation to the prosthesis. All patients required post operative guiding elastics with all patients achieving a reproducible desired occlusion by 2 (Figure psented) weeks. All patients tolerated a soft diet by postoperative week 3 without the need for supplemental enteral or parenteral feeding. All patients reported satisfaction in their reconstruction. The mean operative time was 8 hours. One patient needed revision surgery for a mobile locking screw in the plate hardware. Conclusion: The fibula flap continues to be the workhorse of jaw reconstruction, and with proper patient selection and pre-operative planning, it can be used to successfully reconstruct complex maxillofacial defects from bone to teeth in a single operation. In our experience, computer assisted design and virtual planning is essential in achieving the above described results while maintaining appropriate operative times

BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST), the composite primary endpoint of stroke, myocardial infarction, or death during the periprocedural period or ipsilateral stroke thereafter did not differ between carotid artery stenting and carotid endarterectomy for symptomatic or asymptomatic carotid stenosis. A secondary aim of this randomised trial was to compare the composite endpoint of restenosis or occlusion. METHODS: Patients with stenosis of the carotid artery who were asymptomatic or had had a transient ischaemic attack, amaurosis fugax, or a minor stroke were eligible for CREST and were enrolled at 117 clinical centres in the USA and Canada between Dec 21, 2000, and July 18, 2008. In this secondary analysis, the main endpoint was a composite of restenosis or occlusion at 2 years. Restenosis and occlusion were assessed by duplex ultrasonography at 1, 6, 12, 24, and 48 months and were defined as a reduction in diameter of the target artery of at least 70%, diagnosed by a peak systolic velocity of at least 3.0 m/s. Studies were done in CREST-certified laboratories and interpreted at the Ultrasound Core Laboratory (University of Washington). The frequency of restenosis was calculated by Kaplan-Meier survival estimates and was compared during a 2-year follow-up period. We used proportional hazards models to assess the association between baseline characteristics and risk of restenosis. Analyses were per protocol. CREST is registered with ClinicalTrials.gov, number NCT00004732. FINDINGS: 2191 patients received their assigned treatment within 30 days of randomisation and had eligible ultrasonography (1086 who had carotid artery stenting, 1105 who had carotid endarterectomy). In 2 years, 58 patients who underwent carotid artery stenting (Kaplan-Meier rate 6.0%) and 62 who had carotid endarterectomy (6.3%) had restenosis or occlusion (hazard ratio [HR] 0.90, 95% CI 0.63-1.29; p=0.58). Female sex (1.79, 1.25-2.56), diabetes (2.31, 1.61-3.31), and dyslipidaemia (2.07, 1.01-4.26) were independent predictors of restenosis or occlusion after the two procedures. Smoking predicted an increased rate of restenosis after carotid endarterectomy (2.26, 1.34-3.77) but not after carotid artery stenting (0.77, 0.41-1.42). INTERPRETATION: Restenosis and occlusion were infrequent and rates were similar up to 2 years after carotid endarterectomy and carotid artery stenting. Subsets of patients could benefit from early and frequent monitoring after revascularisation. FUNDING: National Institute of Neurological Disorders and Stroke and Abbott Vascular Solutions.

BACKGROUND:: The vascular anatomy of the supraclavicular artery island (SAI) flap has been investigated using both cadaveric anatomic dissections and angiographic studies. Accurate preoperative evaluation and localization of its vascular pedicle confirms its location, course, anatomic variation, and improves flap success. The objective of this report is to demonstrate the utility of multislice computed tomography (CT) angiography for confirming the presence of the vascular pedicle of the SAI flap when planning head and neck reconstruction. METHODS:: Patients were studied using 64-multislice CT angiography to localize the supraclavicular artery, including its origin and destination. Axial images, multiplanar reconstructions, and 3D volume-rendered images were analyzed on a Philips workstation. Radiologic image findings and clinical experience will be described. RESULTS:: SAI CT angiography was successfully performed in 15 patients (30 shoulders) ranging from ages 22 to 81 years. Accurate identification of the main vascular pedicle was achieved in 14/15 patients. Location, course, pedicle length, and anatomic variations were reported for 23 of 30 arteries. Mean vessel diameter was found to be 1.49 mm (range, 0.8-2.0 mm) on the right and 1.51 mm (range, 1.0-2.1 mm) on the left. The mean length of the artery was 38.3 mm on the right (range, 26.6-59.6 mm) and 38.4 mm on the left (range, 24.3-67.0 mm). In all patients, the supraclavicular artery originated off the transverse cervical artery-a branch of the thyrocervical trunk. Positioning of the patient's upper extremities at the side was helpful in the identification of the supraclavicular artery and its distribution. Contrast injection site should be contralateral to the side needed for the flap if sidedness is of importance, secondary to contrast bolus artifact. CONCLUSIONS:: Preoperative evaluation of the SAI flap with multislice computed tomography angiography is feasible in patients. A radiologic study protocol has been developed which improves ability to detect this vessel. This technique provides a noninvasive approach to the identification of the vascular anatomy and is easily standardized/reproducible. The identification of the vascular pedicle and its anatomy can be a benefit to the surgical team during preoperative design of the SAI flap; however, clinical experience confirming these radiologic findings will be needed to optimize surgical outcome.

PURPOSE: Failures of implant-abutment connections have been observed clinically, especially in single-tooth replacements. This study sought to evaluate the reliability and failure modes of implant-supported anterior crowns restored with different implant systems. MATERIALS AND METHODS: Forty-two Ti-6Al-4V dental implants (~4 mm diameter) were used for single anterior crown replacement and divided into two groups according to tested system: (NB) Replace Select system, Nobel Biocare (n = 21); and (IL) Internal connection system, Intra-Lock International (n = 21). Proprietary abutments were screwed to the implants and anatomically correct maxillary central incisor metal crowns were cemented and subjected to step-stress-accelerated life testing in water. Use-level probability Weibull curves and reliability for a mission of 50,000 cycles at 200 N (95% 2-sided confidence intervals) were calculated. Polarized-light and scanning electron microscopes were used for failure analyses. RESULTS: The Beta values for NB and IL (2.09 and 2.05, respectively) indicated that fatigue accelerated the failure of both groups. The calculated reliability for the NB system (0.81) was lower than for the IL system (0.96), but no significant difference was observed between groups. Screw and abutment fracture was the chief failure mode in group NB, while screw fracture was most representative in specimens of group IL. CONCLUSIONS: Reliability of implant-supported maxillary central incisor crowns was not significantly different between NB and IL abutments. Failure modes differed between implant systems

OBJECTIVES: To evaluate the reliability and failure modes of regular and horizontal mismatched platforms for implant-abutment connection varying the implant diameter. MATERIAL AND METHODS: Regular (REG, n = 21, 4.0-mm-diameter implant) and horizontal mismatched (HM, n = 21, 4.6-mm-diameter implant) platform Ti-6Al-4V implants were restored with proprietary identical Ti-6Al-4V abutments and metal crowns (cobalt-chrome, Wirobond((R)) 280, BEGO, Bremen, Germany) cemented. Mechanical testing comprised step-stress accelerated-life testing, where crowns were distributed in three loading profiles for fatigue in water, producing timely and clinically relevant fractures. The probability of failure vs. cycles (95% two-sided confidence intervals) was calculated and plotted using a powerlaw relationship for damage accumulation, Weibull modulus (95% two-sided confidence intervals) and then the reliability for a mission of 50,000 cycles at 125 N load (95% two-sided confidence interval) were calculated. Fractography was performed in the scanning electron microscope. RESULTS: The beta-value for group REG (beta = 1.37) indicated that fatigue was a factor accelerating the failure, whereas load alone dictated the failure for group HM (beta = 0.71). The Weibull parameter contour plot showed no significantly different Weibull modulus for REG (10.24) compared to HM (10.20) and characteristic strength of 162.6 and 166.8 N, respectively (P > 0.91). The calculated reliability for a mission of 50,000 cycles at 125 N load was not significantly different (0.71 for REG and 0.73 for HM). Abutment screw failure was the chief failure mode. CONCLUSIONS: Reliability was not significantly different between groups and failure modes were similar

BACKGROUND: Mandible subcondylar fractures may be treated via a traditional visible access incision; however, with the advances in surgical endoscopy surgeons are transitioning to a minimally invasive approach in an effort to reduce surgical morbidity and external facial scarring. We sought to design a clinically applicable teaching tool in a large animal model that would allow the operator to gain experience treating mandible subcondylar fractures via an endoscopic approach. METHODS: A large animal model was developed using the Churra sheep. Subcondylar fractures were created, reduced, and internally plated in ten specimens via an extraoral, two-port endoscopic approach. Animals were monitored for surgical success during the intraoperative and immediate postoperative periods. RESULTS: Mandibles were reduced and fixated successfully in each of the animals. Operative time was reduced from 70 to 40 min as the surgeons became more familiar with the surgical procedure. Each of the ten Churra sheep used in the study tolerated the surgeries without postoperative complications. CONCLUSIONS: Capitalizing on a mandibular anatomy similar to humans, the Churra sheep successfully demonstrated utility for the extraoral, endoscopic approach in treating mandibular condyle fractures. This model offers surgeons the opportunity to gain surgical endoscopic experience before treating clinical patients.

BACKGROUND: Larger thoracic defects require stable yet flexible reconstruction to prevent flail chest and debilitating respiratory impairment. We present the use of locking rib-spanning plates as a chest salvage procedure. METHODS: A 30-year-old male presented with a massive desmoid tumor in the posterolateral aspect of the chest wall. The mass measured 22 by 14 by 6 cm and involved the posterior third through seventh ribs. The patient underwent wide excision and reconstruction in layers with a porcine dermal substitute for the pleura, locking rib-spanning plates for structural support, and coverage with ipsilateral latissimus dorsi. RESULTS: The patient tolerated the procedure without complication. He was extubated on postoperative day zero and has had an uneventful course. CONCLUSION: Chest wall reconstruction with rib-spanning plates is an alternative method of reconstruction for large chest wall defects. This method limits the foreign body burden while providing rigid structural support. This technique also makes chest wall reconstruction possible in situations that might previously have been treated with pneumonectomy.

Keloids present a formidable clinical challenge. Surgical excision in conjunction with radiation therapy may decrease the chance of keloid recurrence. Split-thickness skin grafts, however, are more prone to failure in the setting of radiation. In this report, we present a patient with a recurrent auricular keloid who underwent excision and immediate Integra (Integra LifeSciences, Plainsboro, NJ) application, followed by high-dose rate brachytherapy and interval split-thickness skin graft placement. A 23-year-old woman with a history of a recurrent auricular keloid after previous surgical excision, corticosteroid injection, and radiation underwent reexcision of her keloid. Integra was used to cover the resultant exposed auricular perichondrium. The patient then received high-dose rate brachytherapy (1500 cGy) on postoperative days 1 and 2, followed by definitive split-thickness skin graft placement 3 weeks after her initial surgery. The patient recovered from all interventions without complication. There was no evidence of keloid formation 27 months after the interval split-thickness skin graft placement at either the auricular recipient or thigh donor sites. We report the first case of a 2-stage reconstruction of a recurrent auricular keloid (composed of keloid excision and placement of Integra in conjunction with high-dose rate brachytherapy, followed by interval split-thickness skin grafting), resulting in an acceptable cosmetic result without evidence of recurrence at long-term follow-up.