Searched for: school:SOM
Department/Unit:Plastic Surgery
Expression patterns of kinin-dependent genes in endometrial cancer
Orchel, Joanna; Witek, Lukasz; Kimsa, Malgorzata; Strzalka-Mrozik, Barbara; Kimsa, Magdalena; Olejek, Anita; Mazurek, Urszula
OBJECTIVE: The present study has focused on the identification of the differences between expression patterns of kinin-dependent genes in endometrial cancer with the use of real-time quantitative reverse transcription polymerase chain reaction and oligonucleotide microarray. MATERIALS AND METHODS: The study group consisted of 50 endometrium samples collected from women with endometrial cancer. Gene expression of kinin receptors BR1 and BR2 was evaluated with real-time quantitative reverse transcription polymerase chain reaction. The analysis of the expression profile of genes related to the kinin mitogenic signal transduction pathway was performed using HG-U133A oligonucleotide microarrays. RESULTS: The transcriptional activity of the B1 receptor for kinins increased in patients with grade 1 (G1) and grade 2 (G2) endometrial cancer when compared to the control group, whereas it decreased in patients with grade 3 (G3) endometrial cancer. The expression of the B2 receptor showed a growing trend reaching the peak in the G2, whereas G3 was characterized by a decrease in the gene transcriptional activity. Significant differential gene expression was recorded for GNB1, PRKAR1A, KRAS, MAP2K2, GNG5, MAPK1, ADCY9, GNG11, JUN, PRKCA, PRKACB, FOS, PLCB4, ADCY8, and GNG12. CONCLUSION: The expression changes in kinin-dependent genes might cause disturbance in the underlying biological processes, which could be important for the pathogenesis of endometrial cancer. This will eventually help to improve treatment strategies for patients with endometrial cancer in the future.
PMID: 22706224
ISSN: 1525-1438
CID: 2654862
Hemangioma update: pearls from 30 years of treatment
Zide, Barry M; Levine, Steven M
ABSTRACT: This manuscript is a compilation of clinical lessons learned from 30 years of treating hemangiomas. We review relevant clinical anatomy, the role of lasers and medications, timing of surgery, and operative judgment, as it pertains to the treatment of hemangiomas.
PMID: 21734553
ISSN: 0148-7043
CID: 169464
Effects of lidocaine plus epinephrine and prilocaine on autologous fat graft survival
Weichman, Katie E; Warren, Stephen M
PMID: 22777433
ISSN: 1049-2275
CID: 173030
Surgical treatment of malignant melanoma: practical guidelines
Levine, Steven M; Shapiro, Richard L
Melanoma is currently the fifth and sixth most common solid malignancy diagnosed in men and women, respectively. Although accounting for only 4% of cases of all cutaneous malignancies, melanoma accounts for more than 75% of all deaths from skin cancer. This article discusses epidemiology and risk factors, proper biopsy technique, advanced histologic evaluation of biopsy material, assessment of tumor thickness and staging, preoperative metastatic evaluation, excision margin, treatment of regional lymph nodes, treatment of recurrence, and some special clinical situations.
PMID: 22800553
ISSN: 0733-8635
CID: 173033
Litigation and legislation. Judgment day
Jerrold, Laurance
PMID: 22749000
ISSN: 1097-6752
CID: 1992242
Experience with 60 adult patients with facial paralysis secondary to tumor extirpation
Terzis, Julia K; Konofaos, Petros
BACKGROUND: : The aim of this study was to present the authors' experience with facial reanimation in adult patients following tumor extirpation and to analyze the functional outcomes. METHODS: : From 1978 to 2006, 60 adult patients underwent facial reanimation for facial paralysis following tumor extirpation. There was one patient with bilateral facial paralysis. Thus, evaluation was carried out in 61 hemifaces. Three independent assessors evaluated the preoperative and postoperative videos using the Terzis grading scale for eye closure, smile, depressor, and overall aesthetic and functional outcomes. Preoperative and postoperative electromyographic interpretations and the effect of demographic variables were also evaluated. RESULTS: : There was significant improvement regarding preoperative versus postoperative outcomes for overall aesthesis and function. Good and excellent results were observed in 72.14 percent of the hemifaces (n = 44). The difference between preoperative and postoperative electromyographic results was of statistical significance (p < 0.0001) for each target reinnervated. Better results were observed in younger patients (=35 years) (p = 0.023) and in early cases (p = 0.019). CONCLUSIONS: : The results of this present series illustrate that age and denervation time correlate with the final functional outcome. Cross-facial nerve grafts should ideally be used in patients with denervation time less than 6 months or more than 2 years combined with muscle transfers. In patients with a denervation time between 6 months and 2 years, the use of the babysitter procedure can yield a superior outcome. CLINICAL QUESTION/LEVEL OF EVIDENCE:: Therapeutic, IV.
PMID: 22743955
ISSN: 1529-4242
CID: 171130
Exploring the role of peer density in the self-reported oral health outcomes of older adults: A kernel density based approach
Widener, Michael J; Metcalf, Sara S; Northridge, Mary E; Chakraborty, Bibhas; Marshall, Stephen M; Lamster, Ira B
Previous research has documented that oral health is inextricably linked with overall health and is an important component of successful aging. Additionally, peer social interactions are known to improve older adults' general well-being by increasing social opportunities and knowledge of local resources. This study examines the relationship between peer density of participants aged 50 and older in the ElderSmile program and self-reported oral health in northern Manhattan. Results from logistic regression models found that higher peer kernel density estimation values are associated with better self-reported oral health. This reinforces the need for place-based health interventions, and provides new evidence of the importance of peer communities for older adults.
PMCID:3372621
PMID: 22542440
ISSN: 1353-8292
CID: 170466
Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces
Coelho, Paulo G; Giro, Gabriela; Teixeira, Hellen S; Marin, Charles; Witek, Lukas; Thompson, Van P; Tovar, Nick; Silva, Nelson R F A
This study investigated the effect of an Argon-based atmospheric pressure plasma (APP) surface treatment operated chairside at atmospheric pressure conditions applied immediately prior to dental implant placement in a canine model. Surfaces investigated comprised: rough titanium surface (Ti) and rough titanium surface + Argon-based APP (Ti-Plasma). Surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and chemistry by X-ray photoelectron spectroscopy (XPS). Six adult beagles dogs received two plateau-root form implants (n = 1 each surface) in each radii, providing implants that remained 1 and 3 weeks in vivo. Histometric parameters assessed were bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed by Kruskall-Wallis (95% level of significance) and Dunn's post-hoc test. The XPS analysis showed peaks of Ti, C, and O for the Ti and Ti- Plasma surfaces. Both surfaces presented carbon primarily as hydrocarbon (C-C, C-H) with lower levels of oxidized carbon forms. The Ti-Plasma presented large increase in the Ti (+11%) and O (+16%) elements for the Ti- Plasma group along with a decrease of 23% in surface-adsorbed C content. At 1 week no difference was found in histometric parameters between groups. At 3 weeks significantly higher BIC (>300%) and mean BAFO (>30%) were observed for Ti-Plasma treated surfaces. From a morphologic standpoint, improved interaction between connective tissue was observed at 1 week, likely leading to more uniform and higher bone formation at 3 weeks for the Ti-Plasma treated implants was observed.
PMID: 22492543
ISSN: 1549-3296
CID: 461942
Sagittal split osteotomy in a previously distracted mandible
Greig, Aina V H; Kapadia, Hitesh; Grayson, Barry H; McCarthy, Joseph G
PMID: 22743941
ISSN: 1529-4242
CID: 171129
Hispanic ethnicity and fatal fall risk: do age, gender, and community modify the relationship?
Landy, David C; Mintzer, Michael J; Silva, Amanda K; Dearwater, Stephen R; Schulman, Carl I
BACKGROUND: Hispanic ethnicity is associated with a reduced risk of fatal falls in the elderly despite lower socioeconomic standing. The factors responsible for this "Hispanic paradox" are unknown. We hypothesized that age and gender would modify this relationship and that the association would be accentuated in a community with prominent Hispanic culture. MATERIALS AND METHODS: The number of fatal falls in a 3-year period in the United States (US) and in Miami-Dade County, Florida (MDC) were obtained through the CDC's WISQARS database and the Florida Office of Vital Statistics. US Census Bureau data were used to define the total at-risk populations by age group and gender. Age group- and gender-specific ratios of the risk of fatal fall in Hispanic to white non-Hispanic individuals were calculated. RESULTS: In the US and MDC, Hispanic ethnicity was associated with a reduced risk of fatal fall across all age and gender subgroups. In the US, the risk reduction associated with Hispanic ethnicity grew from 11% and 23% in 65- to 74-year-old men and women, respectively, to 43% for both men and women over 84-years-old. This relationship was stronger in MDC than nationally in five of the six age and gender subgroups examined. CONCLUSIONS: Older individuals, women, and residents of communities with prominent Hispanic culture have the greatest reduction in fatal fall risk associated with Hispanic ethnicity.
PMID: 21529828
ISSN: 1095-8673
CID: 2699002