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Review of Cardiovascular Effects of ADHD Medications [Review]

Levin, Charles J.; Goodman, David W.; Adler, Lenard A.
The prevalence of attention-deficit/hyperactivity disorder (ADHD) among adults is approximately 4.4%, and more than 1.5 million Americans are prescribed stimulants for the treatment of ADHD. Stimulants (such as methylphenidate and amphetamine compounds), along with the nonstimulant atomoxetine, are widely prescribed for ADHD, and more Americans are continuing to use these medications throughout their adult lives. Given the action of these drugs on the cardiovascular system, health care professionals have asked whether chronic use of these substances substantively increase the risk for cardiovascular disease (CVD). A comprehensive body of research suggests that this may not be the case. All adult patients should be monitored for changes in blood pressure and pulse during treatment with ADHD medications; furthermore, people at risk for CVD or with existing CVD should be evaluated at baseline in conjunction with appropriate medical personnel, and ongoing treatment should be collaborative with such medical colleagues.
ISI:000458412200004
ISSN: 0048-5713
CID: 3694502

Emotional Dysregulation in Adult ADHD

Adler, Lenard A.; Silverstein, Michael J.
Adult attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder that persists into adulthood in about one-half of all patients. Although the current Diagnostic and Statistical Manual of Mental Disorders, fifth edition diagnostic formulation limits ADHD symptoms to those of inattention and hyperactivity-impulsivity, there has been a substantial amount of research supporting symptoms of emotional dysregulation (ED) as being either a part of the ADHD syndrome or co-traveling symptoms. This article reviews the description of emotional dysregulation, how emotional dysregulation fits in the diagnostic schemata of ADHD, methods of assessment of emotional dysregulation, and treatment of emotional dysregulation.
ISI:000458412200003
ISSN: 0048-5713
CID: 3694512

Adult ADHD [Editorial]

Adler, Lenard A.
ISI:000458412200002
ISSN: 0048-5713
CID: 3694522

Adult ADHD: Psychosocial Treatment Components and Efficacy Status

Gallagher, Richard; Feder, Michael A.
Psychosocial treatments for attention-deficit/hyperactivity dis- order (ADHD) in adults and emerging adults have developed to address core symptoms of ADHD (hyperactivity, impulsivity, and inattention) and associated functional impairments. These psychosocial treatments have been developed to enhance the effect of medication treatments. Evidence-based psychosocial treatments teach patients skills in organization, time management, and planning by using a cognitive-behavioral framework. The latest version of these programs also teaches mindfulness skills, so patients learn to think critically before acting impulsively. Cognitive components to address maladaptive thoughts found in ADHD and associated patterns found in comorbid anxiety and depression facilitate mental health. Research indicates that these skill-based programs lead to significant changes including reductions in core symptoms, improved executive functioning, and reduced functional impairments. This article reviews the findings from meta-analyses and details treatment targets and treatment components contained in efficacious interventions.
ISI:000458412200006
ISSN: 0048-5713
CID: 3694492

Groupwise 3D Nonlinear Registration of OCT Image Series for Analyzing Dynamic Lamina Cribrosa Changes [Meeting Abstract]

Hong, Sungmin; Ravier, Mathilde; Ishikawa, Hiroshi; Girot, Charly; Tauber, Jenna; Wollstein, Gadi; Schuman, Joel S.; Fishbaugh, James; Gerig, Guido
ISI:000442912505005
ISSN: 0146-0404
CID: 3333512

A Mixed Methods Study of the Stages of Implementation for an Evidence-Based Trauma Intervention in Schools

Nadeem, Erum; Saldana, Lisa; Chapman, Jason; Schaper, Holle
A mixed methods study was conducted to examine the implementation process of 26 urban school-based mental health clinics that took part in a training and implementation support program for an evidence-based school trauma intervention. Implementation process was observed using the Stages of Implementation Completion (SIC) measure. Qualitative interviews were conducted with clinic leaders in order to gain insight into clinic processes related to the SIC. Results showed that almost all of the clinics engaged in some activities related to pre-implementation (engagement, feasibility, and readiness), but only 31% of the sites formally started delivering the program to youth. Completing more pre-implementation activities, particularly those related to readiness, predicted program start-up. Qualitative analysis comparing those that implemented the program to those that did not revealed critical differences in decision-making processes, leadership strategies, and the presence of local champions for the program. This study documented the patterns of clinic behavior that occurs as part of large-scale training efforts, suggests some unique challenges that occur in schools, and highlights the importance of engaging in particular implementation activities (i.e., readiness planning, stakeholder consensus and planning meetings) as part of program start-up. Findings indicate that pre-implementation and readiness-related consultation should be employed as part of broad-scale implementation and training efforts.
PMCID:6020145
PMID: 29937254
ISSN: 1878-1888
CID: 3161532

Social Services and Behavioral Emergencies: Trauma-Informed Evaluation, Diagnosis, and Disposition

Heppell, Patrick J; Rao, Suchet
The emergency department's role in a psychiatric crisis is to assess for safety, provide crisis interventions, reach a diagnosis, make decisions about disposition and treatment, and provide linkage to the next level of care within the hospital or in the community. The evaluation of children and adolescents involved in the child welfare system brings numerous additional challenges to this already-complex environment, including familial and systemic issues and an almost ubiquitous history of trauma. This article endeavors to increase understanding of child welfare-related issues and provides insight toward using a more trauma-informed and comprehensive approach that incorporates all these factors.
PMID: 29933794
ISSN: 1558-0490
CID: 3158412

Training, Education, and Curriculum Development for the Pediatric Psychiatry Emergency Service

Egolf, Amy; Hoffman, Pamela; Mroczkowski, Megan M; Prager, Laura M; Tyson, John W; Donise, Kathleen
Pediatric psychiatric emergency care is delivered in different settings with vastly different resources around the country. Training programs lack guidance on developing optimal curricula for this highly variable but crucial setting. A model curriculum for child and adolescent psychiatry trainees may be helpful to provide such guidance; its components include recommendations for assessing baseline knowledge, identifying and teaching core subject content, encouraging development of essential skills, and building in supervision for learners. Future directions include further study in current pediatric emergency psychiatry education and expanding the scope of curricula to include different learners and delivery models.
PMID: 29933798
ISSN: 1558-0490
CID: 5849072

Emotion regulation and spillover of interpersonal stressors to postsession insight among depressed and suicidal adolescents

Bounoua, Nadia; Abbott, Caroline; Zisk, Abigail; Herres, Joanna; Diamond, Guy; Kobak, Roger
OBJECTIVE:Little is known about the extent to which previous weeks' stressful events spill over and influence adolescents' abilities to derive insight from treatment sessions. Even less is known about factors that moderate clients' vulnerabilities to these spillover effects. The current study examined the spillover of negative interpersonal events to postsession insight and the role of difficulties in emotion regulation in this spillover effect. METHOD:Participants were 129 adolescents with moderate to severe depressive symptoms and suicidal ideation (Mage = 14.96, 83% female, 56% African American/Black) participating in a comparative efficacy trial of Attachment-Based Family Therapy (ABFT) and Family-Enhanced Nondirective Supportive Therapy (FE-NST). A within-subject mediation model tested presession negative affect as a mediator of spillover of past week's events on postsession insight. We then examined baseline difficulties in emotion regulation (DERS) as a between-subjects moderator of the mediation model. RESULTS:Negative affect partially mediated (44%) the spillover of the past week's negative events on adolescents' ratings of postsession insight (p = .03, 95% confidence interval, CI [-.09., -.002]). Baseline DERS increased adolescents' vulnerabilities to spillover effects (p = .01, 95% CI [-.28, -.03]). Negative interpersonal events from the past week influence presession negative affect and spill over to adolescents' abilities to gain insight from their treatment sessions. Adolescents who began treatment with greater DERS were particularly vulnerable to these spillover effects. Findings indicate the need for therapists to adapt sessions to individual differences in depressed and suicidal adolescents' exposure to negative interpersonal events preceding treatment and in their vulnerabilities to spillover and emotion dysregulation. (PsycINFO Database Record
PMID: 29939053
ISSN: 1939-2117
CID: 4519382

Prenatal exposure to disaster-related traumatic stress and developmental trajectories of temperament in early childhood: Superstorm Sandy pregnancy study

Zhang, Wei; Rajendran, Khushmand; Ham, Jacob; Finik, Jackie; Buthmann, Jessica; Davey, Kei; Pehme, Patricia M; Dana, Kathryn; Pritchett, Alexandra; Laws, Holly; Nomura, Yoko
BACKGROUND:Little is known about the impact of prenatal maternal stress (PNMS) on the developmental trajectory of temperament and few studies have been able to incorporate a natural disaster as a quasi-experimental stressor. The current study investigated PNMS related to Superstorm Sandy ('Sandy'), a hurricane that struck the New York metropolitan area in October 2012, in terms of objective exposure during pregnancy, subjective stress reaction as assessed by maternal symptoms of post-traumatic stress, and their impact on the developmental changes in temperament during early childhood. METHOD:A subsample of 318 mother-child dyads was drawn from the Stress in Pregnancy Study. Temperament was measured at 6, 12, 18, and 24 months of age. RESULTS:Objective exposure was associated with greater High-Intensity Pleasure, Approach, Perceptual Sensitivity and Fearfulness, but lower Cuddliness and Duration of Orientation at 6 months. Objective exposure and its interaction with subjective stress reaction predicted developmental changes in temperament. In particular, objective exposure was linked to greater increases in Activity Level but decreases in High-Intensity Pleasure, Approach, and Fearfulness. The combination of objective exposure and subjective stress reaction was also associated with greater increases in Activity Level. LIMITATIONS:Temperament was measured solely via maternal report. Trimester-specific effects of Sandy on temperament were not examined. CONCLUSION:This is the first study to examine the effects of prenatal maternal exposure to a natural disaster on trajectories of early childhood temperament. Findings suggest that both objective stress exposure and subjective stress reaction in-utero predict developmental trajectories of temperament in early childhood.
PMCID:5963732
PMID: 29614461
ISSN: 1573-2517
CID: 5401252