Faculty Bibliography

Informationists at NYU Health Sciences Libraries (NYUHSL) successfully applied for a NLM supplement to a translational research grant obtained by PIs in the NYU School of Medicine Department of Otolaryngology titled, "Clinical Management of Cochlear Implant Patients with Contralateral Hearing Aids". The grant involves development of evidence-based guidelines for post-implant management of patients with bimodal cochlear implants. The PIs are also seeking to acquire new data sets to merge with grant-generated data. In light of the shifting data requirements, and the potential introduction of additional datasets, informationists will evaluate and restructure the data model and data entry tool. Report queries will be refined for the new data model and options for a query tool appropriate for users unfamiliar with query languages will be assessed and implemented. The services offered through this supplement represent the deepest and most detailed data management support offered by NYUHSL to date. The components of the supplement are being analyzed as a pilot of a broader offering of these data management services

BACKGROUND:Flap necrosis following facial rhytidectomy constitutes a vexing and grievous complication to the patient and the surgeon. Treatment modalities that can expedite wound healing and re-epithelialization rates are highly desired. OBJECTIVES/OBJECTIVE:To assess wound healing and re-epithelialization rates of open wounds following postrhytidectomy flap necrosis treated with commercially available charged polystyrene microspheres (Polyheal-1, Polyheal Ltd, Israel). METHODS:Flap necrosis following rhytidectomy with open wounds in three female patients were treated using dressings soaked with Polyheal-1. Wound closure rates were documented. RESULTS:The wounds demonstrated both accelerated granulation tissue formation and rapid re-epithelialization rates. No complications or side effects were encountered. CONCLUSIONS:Charged polystyrene microspheres may offer a new and efficacious way to treat open wounds due to flap necrosis following facial rhytidectomy. Further research with larger patient numbers is still needed to verify these findings.

Propagation measurements at 28 GHz were conducted in outdoor urban environments in New York City using four different transmitter locations and 83 receiver locations with distances of up to 500 m. A 400 mega-chip per second channel sounder with steerable 24.5 dBi horn antennas at the transmitter and receiver was used to measure the angular distributions of received multipath power over a wide range of propagation distances and urban settings. Measurements were also made to study the small-scale fading of closely-spaced power delay profiles recorded at half-wavelength (5.35 mm) increments along a small-scale linear track (10 wavelengths, or 107 mm) at two different receiver locations. Our measurements indicate that power levels for small-scale fading do not significantly fluctuate from the mean power level at a fixed angle of arrival. We propose here a new lobe modeling technique that can be used to create a statistical channel model for lobe path loss and shadow fading, and we provide many model statistics as a function of transmitter-receiver separation distance. Our work shows that New York City is a multipath-rich environment when using highly directional steerable horn antennas, and that an average of 2.5 signal lobes exists at any receiver location, where each lobe has an average total angle spread of 40.3 degrees and an RMS angle spread of 7.8 degrees. This work aims to create a 28 GHz statistical spatial channel model for future 5G cellular networks.

Allergic fungal sinusitis (AFS), also referred to as allergic fungal rhinosinusitis (AFRS), is a noninvasive, eosinophilic form of recurrent chronic allergic hypertrophic rhinosinusitis. AFS has distinct clinical, histopathological, and prognostic findings that differentiate it from other forms of sinusitis. The core pathogenesis and optimum treatment strategies remain debated. Concerns surround the use of immunotherapy for AFS because allergen-specific immunoglobulin G (IgG) induced by immunotherapy could theoretically incite a Gell and Coombs type III (complex mediated) reaction. Type I hypersensitivity is established by high serum levels of allergen-specific IgE to various fungal antigens and positive Bipolaris skin test results. Type III hypersensitivity is established by an IgG-mediated process defined by the presence of allergen-specific IgG that forms complexes with fungal antigen inducing an immunologic inflammatory response. These reveal the multiple immunologic pathways through which AFS can impact host responses. Recent literature establishing benefits of fungal immunotherapy and no evidence of type III-mediated reactions, severe local reactions, or delayed reactions, indicate that application of AFS desensitization is a reasonable therapeutic strategy for this difficult to manage entity. Our review should encourage further clinical acceptance of AFS desensitization because the existing literature on this subject shows benefits of fungal immunotherapy and no evidence of type III-mediated reactions, severe local reactions, or delayed reactions.