Searched for: school:SOM
Department/Unit:Plastic Surgery
Flow perfusion improves mineralization and maintains uniform cellular distribution in thick 3D scaffolds [Meeting Abstract]
Allori, AC; Sailon, AM; Lin, CD; Clark, E; Ricci, JL; Vasiliu, C; Smay, JE; Warren, SM
ISI:000253799600005
ISSN: 8756-3282
CID: 76442
Ultrasound detection of submerged dental implants through soft tissue in a porcine model
Culjat, Martin O; Choi, Mijin; Singh, Rahul S; Grundfest, Warren S; Brown, Elliott R; White, Shane N
STATEMENT OF PROBLEM: Current methods of measuring soft tissue thickness over potential dental implant sites and locating submerged implants may be imprecise or invasive. PURPOSE: The purpose of this study was to develop and demonstrate proof of the concept of a customized ultrasound imaging system in locating and measuring the depth of implants submerged beneath soft tissue. MATERIAL AND METHODS: A complete ultrasound system, including a customized soft tissue-matched transducer, transceiver, and digital signal processing algorithms, was created for the specific application of detecting dental implants anchored in bone beneath soft tissue. The system was used to locate implants placed in cancellous bone and measure overlying soft tissue depth in a porcine model. Ten measurements were made on each porcine model by manually moving the transducer laterally over the soft tissue surface. Data were analyzed with descriptive statistics. RESULTS: The mean signal-to-noise ratio, SNR (standard deviation), from the bone surfaces, was 19.1 (4.6) dB, and the mean SNR from the implant surfaces was 36.6 (2.2) dB, resulting in a mean difference of 17.5 dB, or x56.2, in average signal power between the bone and implant surfaces. Consequently, implants were easily and accurately (+/-0.2 mm) located beneath at least 5 mm of soft tissue. Likewise, soft tissue depths over bone and implants were accurately measured and were within the corresponding caliper tissue measurement error (+/-0.5 mm). CONCLUSIONS: The specialized ultrasound imaging system located and measured the depth of implants placed in bone submerged beneath soft tissue in a porcine model
PMID: 18319093
ISSN: 0022-3913
CID: 153408
Pediatric facial fractures: current national incidence, distribution, and health care resource use
Vyas, Raj M; Dickinson, Brian P; Wasson, Kristy L; Roostaeian, Jason; Bradley, James P
To date, reports on the incidence and distribution of pediatric facial fractures have been inconsistent and have originated only from institutional studies. The need for current national data exists. We examined the Kids' Inpatient Database and the Nationwide Inpatient Sample to obtain national information on facial fracture discharges from 1997 to 2003. Data showed that pediatric patients (age, 0-17 years) make up 14.7% of all facial fractures, with children aged 1 to 4 years comprising only 5.6% of the total and children 15 to 17 years old making up more than half the group. The male-to-female ratio was 2.5. Significantly lengthier hospitalizations were observed with female patients, Medicaid insurance, teaching hospitals, government hospitals, and metropolitan hospitals. Significantly higher charges were associated with patients aged 1 to 4 years, Medicaid insurance, Western US geography, teaching hospitals, metropolitan hospitals, and children's hospitals. During the 6-year period of this study, there was a trend toward (1) increased hospital charges (with stable costs), (2) more patients treated at teaching hospitals, and (3) a convergence in length of stay between hospitals with differing ownerships (with government hospitals having progressively shorter hospitalizations, whereas private for-profit hospitals have progressively lengthier hospitalizations). The incidence of facial fractures in children is small yet significant and has remained stable during the past few decades. Certain patient populations are prone to facial fractures, and various patient and hospital factors are associated with lengthier and more expensive hospitalizations. An understanding of disparities in resource use among various patient, hospital, and geographic settings is critical for physicians and policy makers.
PMID: 18362709
ISSN: 1049-2275
CID: 410412
Medial sphenoid ridge meningiomas: classification, microsurgical anatomy, operative nuances, and long-term surgical outcome in 35 consecutive patients
Russell, Stephen M; Benjamin, Vallo
OBJECTIVE: On the basis of contemporary multiplanar imaging, microsurgical observations, and long-term follow-up in 60 consecutive patients with sphenoid ridge meningiomas, we propose a modification to Cushing's classification of these tumors. This article will concentrate on patients from this series with global medial sphenoid ridge tumors. METHODS: Data were collected prospectively for 35 patients with global meningiomas arising from the medial portion of the sphenoid ridge that were surgically treated between 1982 and 2002. RESULTS: All patients were followed for the entire length of this study (mean, 12.8 yr). The tumor size ranged from 2 to 8 cm (mean, 4.5 cm). Of the 24 patients with purely intradural tumors, four (17%) had Simpson Grade I and 19 had Simpson Grade II resections; 23 (96%) had gross total resections. Of the 11 patients with tumors extending extradurally (i.e., cavernous sinus), one (9%) patient had a Simpson Grade II resection, whereas nine (82%) had Simpson Grade III resections, with the latter being all visible tumor removed except that in the cavernous sinus. One (9%) of these 11 patients had a gross total resection, and 9 (82%) had radical resections, with the latter defined as total removal of all intradural tumor. The overall morbidity rate was 18%. There was no surgical mortality or symptomatic cerebral infarction. CONCLUSION: An accurate classification of global medial sphenoid meningiomas is mandatory to gain insight into their clinical behavior and for understanding the long-term efficacy and safety of available treatment options. Primary medial sphenoid ridge tumors consistently involve the unilateral arteries of the anterior cerebral circulation, and therefore, the resection of tumor from around these arteries is the most important operative nuance for their safe excision
PMID: 18424966
ISSN: 1524-4040
CID: 79385
Oropharyngeal kaposi sarcoma in related persons negative for human immunodeficiency virus
Sikora, Andrew G; Shnayder, Yelizaveta; Yee, Herman; DeLacure, Mark D
OBJECTIVES: Kaposi sarcoma (KS) is a vascular tumor that can affect the mucosa of the upper aerodigestive tract. Although KS is the most common malignancy in patients with acquired immunodeficiency syndrome, it is rare in immunocompetent persons. We describe an unusual presentation of KS in 2 related individuals and describe our attempts to determine whether oropharyngeal KS is associated with human herpesvirus 8 (HHV-8). METHODS: All relevant clinical and surgical information, including information on tumor histopathologic and human immunodeficiency virus (HIV) serologic tests, was abstracted from the patient charts and electronic databases. HHV-8 immunohistochemistry was performed on paraffin-fixed specimens. RESULTS: Both patient 1 and patient 2 (the nephew of patient 1) were referred for workup of a tonsillar mass that was pathologically confirmed to be KS. In each case, HIV serologic testing was negative, and a screening immunologic workup, including a quantitative natural killer cell count, a B- and T-lymphocyte count, and immunoglobulin analysis, also yielded findings that were within normal limits. Immunohistochemistry performed on 1 pathological specimen showed positive staining for the presence of HHV-8, the etiologic agent of KS. CONCLUSIONS: The presence of oropharyngeal KS in 2 related HIV-negative individuals supports a role for genetic factors in susceptibility to KS, a common exposure to an infectious agent such as HHV-8, or both. Whereas most KS cases in industrialized countries are associated with immunodeficiency, clinical and laboratory data do not suggest that either of the patients described in this report are immunodeficient. Their susceptibility to KS may be secondary to a subtle inherited defect in host resistance to HHV-8, or another unknown factor
PMID: 18444476
ISSN: 0003-4894
CID: 79149
Quantifying augmentation gluteoplasty outcomes: a comparison of three instruments used to measure gluteal projection
Raposo-Amaral, Cassio Eduardo; Ferreira, Daniel Miranda; Warren, Stephen M; Magna, Luis Alberto; Ferreira, Lydia Massako
BACKGROUND: Gluteal augmentation is increasingly common. However, few studies have quantitatively reported postoperative gluteal projection. This study compared three different standardized instruments (i.e., radiographic, sonographic, and anthropometric) for quantifying gluteal projection after lumbar-hip dermal fat rotational flap to identify a simple, cost-efficient valid instrument. METHODS: A total of 10 women ages 35 to 68 years (mean, 47.3 years) with skin flaccidity and gluteal ptosis underwent bilateral lumbar-hip dermal fat rotation flap gluteal augmentation (20 procedures). Gluteal projection was measured 1 week preoperatively and 8 months postoperatively using computerized axial tomography (CAT) scan, ultrasound, and anthropometry. RESULTS: The CAT scan measured 1.40 cm of projection on the left (p < 0.001) and 1.43 cm on the right (p = 0.001). Ultrasound measured 2.16 cm of projection on the left (p < 0.001) and 1.88 cm on the right (p = 0.001). Anthropometry measured 1.75 cm of projection on the left (p < 0.01) and 1.35 cm on the right (p < 0.05). Repeated measures analysis of variance (ANOVA) comparing the CAT scan, ultrasound, and anthropometry demonstrated statistically similar results on the left (p = 0.43) and right (p = 0.62). CONCLUSIONS: All three instruments were sufficiently sensitive to measure a statistically significant increase in postoperative gluteal projection. Moreover, all three instruments were statistically similar in accuracy of measurement. Therefore, the authors conclude that ultrasound or anthropometry are satisfactory, inexpensive instruments for accurately quantifying postoperative gluteal projection
PMID: 18030413
ISSN: 0364-216x
CID: 94243
High dose radiation impairs hypoxia responsiveness and vascular recovery in vitro and in vivo [Meeting Abstract]
Nguyen, PD; Lerman, OZ; Chang, CC; Thanik, VD; Warren, SM; Saadeh, PB; Levine, JP
ISI:000253761000057
ISSN: 1067-1927
CID: 76409
Topical therapy for diabetic wounds using lineage-negative progenitor cells [Meeting Abstract]
Lin, CD; Macklin, JE; Lerman, OZ; Tepper, OT; Saadeh, PB; Levine, JP; Warren, SM
ISI:000253761000071
ISSN: 1067-1927
CID: 76410
Non possum sequi tibi! Where am I going if I cannot follow you? [Letter]
Lerman, Oren Z
PMID: 18317177
ISSN: 1529-4242
CID: 128928
RNA interference of p53 improves diabetic wound healing [Meeting Abstract]
Chang, CC; Thanik, VD; Branson, BR; Gupta, SM; Levine, JP; Warren, SM; Saadeh, PB
ISI:000253761000165
ISSN: 1067-1927
CID: 76412