Searched for: school:SOM
Department/Unit:Child and Adolescent Psychiatry
In vivo 7Tesla imaging of the dentate granule cell layer in schizophrenia
Kirov, Ivan I; Hardy, Caitlin J; Matsuda, Kant; Messinger, Julie; Cankurtaran, Ceylan Z; Warren, Melina; Wiggins, Graham C; Perry, Nissa N; Babb, James S; Goetz, Raymond R; George, Ajax; Malaspina, Dolores; Gonen, Oded
PURPOSE: The hippocampus is central to the pathophysiology of schizophrenia. Histology shows abnormalities in the dentate granule cell layer (DGCL), but its small size (~100mum thickness) has precluded in vivo human studies. We used ultra high field magnetic resonance imaging (MRI) to compare DGCL morphology of schizophrenic patients to matched controls. METHOD: Bilateral hippocampi of 16 schizophrenia patients (10 male) 40.7+/-10.6years old (mean+/-standard deviation) were imaged at 7Tesla MRI with heavily T2()-weighted gradient-echo sequence at 232mum in-plane resolution (0.08muL image voxels). Fifteen matched controls (8 male, 35.6+/-9.4years old) and one ex vivo post mortem hippocampus (that also underwent histopathology) were scanned with same protocol. Three blinded neuroradiologists rated each DGCL on a qualitative scale of 1 to 6 (from "not discernible" to "easily visible, appearing dark gray or black") and mean left and right DGCL scores were compared using a non-parametric Mann-Whitney test. RESULTS: MRI identification of the DGCL was validated with histopathology. Mean right and left DGCL ratings in patients (3.2+/-1.0 and 3.5+/-1.2) were not statistically different from those of controls (3.9+/-1.1 and 3.8+/-0.8), but patients had a trend for lower right DGCL score (p=0.07), which was significantly associated with patient diagnosis (p=0.05). The optimal 48% sensitivity and 80% specificity for schizophrenia were achieved with a DGCL rating of =2. CONCLUSION: Decreased contrast in the right DGCL in schizophrenia was predictive of schizophrenia diagnosis. Better utility of this metric as a schizophrenia biomarker may be achieved in future studies of patients with homogeneous disease subtypes and progression rates.
PMCID:3709603
PMID: 23664589
ISSN: 1573-2509
CID: 381292
Lisdexamfetamine dimesylate in adults with attention-deficit/ hyperactivity disorder who report clinically significant impairment in executive function: results from a randomized, double-blind, placebo-controlled study
Adler, Lenard A; Dirks, Bryan; Deas, Patrick F; Raychaudhuri, Aparna; Dauphin, Matthew R; Lasser, Robert A; Weisler, Richard H
OBJECTIVE: Behavioral rating scales that assess impairments in executive function commonly associated with attention-deficit/hyperactivity disorder (ADHD) may offer advantages over neuropsychological testing. The primary objective of this study was to evaluate the efficacy of lisdexamfetamine dimesylate for executive function deficits in adults with ADHD and clinically significant executive function impairment using self-reported Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A) assessments. METHOD: This randomized double-blind study, conducted between May 2010 and November 2010, screened at least 1 participant at 35 of 39 registered US clinical research sites. Adults (aged 18-55 years) with a primary ADHD diagnosis (meeting full DSM-IV-TR criteria) and executive function deficits (assessed by baseline BRIEF-A Global Executive Composite [GEC] T-scores of at least 65) were randomized to treatment with optimized lisdexamfetamine dimesylate (30 mg/d, 50 mg/d, or 70 mg/d; n = 80) or placebo (n = 81) during a 10-week double-blind treatment period. Outcome measures included the BRIEF-A scales (GEC, index, and clinical subscales). RESULTS: At week 10 or at early termination, lisdexamfetamine dimesylate was associated with significantly greater reductions from baseline in mean BRIEF-A GEC T-scores than placebo (effect size, 0.74; P < .0001) and significantly greater reductions from baseline in mean T-scores for both BRIEF-A index scales (Behavioral Regulation Index and Metacognition Index) and all 9 clinical subscales (P = .0056 for all). At week 10 or at early termination, mean T-scores for BRIEF-A indexes and clinical subscales were below levels of clinically significant executive function deficits (ie, < 65) with lisdexamfetamine dimesylate treatment. The mean (SD) GEC T-score was 57.2 (14.11) for the lisdexamfetamine dimesylate group and 68.3 (17.12) for the placebo group. The safety profile of lisdexamfetamine dimesylate was consistent with other long-acting psychostimulants. CONCLUSION: Among adults with ADHD and clinically significant executive function deficits, lisdexamfetamine dimesylate was associated with significant improvements in self-reported executive function ratings. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01101022.
PMID: 23945447
ISSN: 0160-6689
CID: 495102
Maintenance of Response After Open-Label Treatment with Atomoxetine Hydrochloride in International European and Non-European Adult Outpatients with Attention-Deficit/Hyperactivity Disorder: A Placebo-Controlled, Randomised Withdrawal Study
Upadhyaya, Himanshu; Antoni Ramos-Quiroga, J.; Adler, Lenard A.; Williams, David; Tanaka, Yoko; Lane, Jeannine R.; Escobar, Rodrigo; Trzepacz, Paula; Camporeale, Angelo; Allen, Albert J.
ISI:000325712500004
ISSN: 0213-6163
CID: 612162
Landmark legislative trends in juvenile justice: an update and primer for child and adolescent psychiatrists [Editorial]
Bath, Eraka; Sidhu, Shawn; Stepanyan, Sofia T
PMID: 23800478
ISSN: 1527-5418
CID: 2313512
Adult attention-deficit hyperactivity disorder and obesity: epidemiological study
Cortese, Samuele; Faraone, Stephen V; Bernardi, Silvia; Wang, Shuai; Blanco, Carlos
BACKGROUND: A significant association between attention-deficit hyperactivity disorder (ADHD) and obesity has been reported. This study addresses unexplored aspects of this relationship. AIMS: To evaluate the association between adult obesity and: (a) persistent, remitted or lifetime ADHD; (b) number of childhood ADHD symptoms, controlling for socioeconomic status and mood, anxiety and substance use disorders. METHOD: Face-to-face psychiatric interviews in 34 653 US adults from the National Epidemiologic Study on Alcohol and Related Conditions. Obesity was defined as a body mass index >/=30. RESULTS: Persistent, lifetime or remitted ADHD were not associated with obesity after controlling for confounders. The number of childhood ADHD symptoms was significantly associated with adult obesity, even after adjustment, in women. CONCLUSIONS: Childhood ADHD symptoms are associated with obesity in women even after comorbid psychiatric disorders are accounted for. This provides a rationale for longitudinal studies assessing the impact of the treatment of childhood ADHD symptoms on obesity in women.
PMCID:3696877
PMID: 23661765
ISSN: 0007-1250
CID: 1154562
Response to Chronis-Tuscano et al. and Arns and Strehl [Letter]
Sonuga-Barke, Edmund; Brandeis, Daniel; Cortese, Samuele; Daley, David; Danckaerts, Marina; Dopfner, Manfred; Ferrin, Maite; Holtmann, Martin; Van der Oord, Saskia
PMID: 23820834
ISSN: 0002-953x
CID: 1154552
Ledge and wedge: younger and older adults' perception of action possibilities
Comalli, David; Franchak, John; Char, Angela; Adolph, Karen
The current study investigated whether younger (college-age) and older adults (60+ years) differ in their ability to perceive safe and unsafe motor actions. Participants decided whether to walk through openings varying in width in two penalty conditions: In the doorway condition, if participants attempted to squeeze through impossibly narrow openings, the penalty for error was entrapment. In the ledge condition, if participants attempted to inch along impossibly narrow ledges, the penalty for error was falling. Results showed that across the lifespan, people consider falling to be a more severe penalty than getting stuck: Both younger and older adults made more conservative decisions when the penalty for error was falling, and older women were especially leery of falling. In both age groups, abilities and decisions were based on dynamic properties of the body, such as compressed body size in the doorway condition and balance in the ledge condition. Findings indicate that failure to perceive possibilities for action is unlikely to be the cause of the increased prevalence of falling in older adults.
PMCID:3756555
PMID: 23660744
ISSN: 1432-1106
CID: 1651632
Pediatric disinhibited eating: Toward a research domain criteria framework
Tanofsky-Kraff, Marian; Engel, Scott; Yanovski, Jack A; Pine, Daniel S; Nelson, Eric E
PMCID:3695480
PMID: 23658090
ISSN: 0276-3478
CID: 363322
Role reversals [Letter]
Henderson, Schuyler W
ORIGINAL:0010467
ISSN: 0890-8567
CID: 1901642
Socio-economic status, neighbourhood food environments and consumption of fruits and vegetables in New York City
Jack, Darby; Neckerman, Kathryn; Schwartz-Soicher, Ofira; Lovasi, Gina S; Quinn, James; Richards, Catherine; Bader, Michael; Weiss, Christopher; Konty, Kevin; Arno, Peter; Viola, Deborah; Kerker, Bonnie; Rundle, Andrew
OBJECTIVE: Recommendations for fruit and vegetable consumption are largely unmet. Lower socio-economic status (SES), neighbourhood poverty and poor access to retail outlets selling healthy foods are thought to predict lower consumption. The objective of the present study was to assess the interrelationships between these risk factors as predictors of fruit and vegetable consumption. DESIGN: Cross-sectional multilevel analyses of data on fruit and vegetable consumption, socio-demographic characteristics, neighbourhood poverty and access to healthy retail food outlets. SETTING: Survey data from the 2002 and 2004 New York City Community Health Survey, linked by residential zip code to neighbourhood data. SUBJECTS: Adult survey respondents (n 15 634). RESULTS: Overall 9.9 % of respondents reported eating >/=5 servings of fruits or vegetables in the day prior to the survey. The odds of eating >/=5 servings increased with higher income among women and with higher educational attainment among men and women. Compared with women having less than a high-school education, the OR was 1.12 (95 % CI 0.82, 1.55) for high-school graduates, 1.95 (95 % CI 1.43, 2.66) for those with some college education and 2.13 (95 % CI 1.56, 2.91) for college graduates. The association between education and fruit and vegetable consumption was significantly stronger for women living in lower- v. higher-poverty zip codes (P for interaction < 0.05). The density of healthy food outlets did not predict consumption of fruits or vegetables. CONCLUSIONS: Higher SES is associated with higher consumption of produce, an association that, in women, is stronger for those residing in lower-poverty neighbourhoods.
PMCID:3696996
PMID: 23388104
ISSN: 1368-9800
CID: 279232