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Department/Unit:Child and Adolescent Psychiatry

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11189


ECG signal enhancement using S-Transform

Ari, Samit; Das, Manab Kumar; Chacko, Anil
Electrocardiogram (ECG), which is a noninvasive technique, is used generally as a primary diagnostic tool for cardiovascular diseases. In real-time scenario, noises like channel noise, muscle artifacts, electrode motion and baseline wander are often embedded with ECG signals during acquisition and transmission. In this paper, an automatic ECG signal enhancement technique is proposed to remove noise components from time-frequency domain represented noisy ECG signal. Stockwell transform (S-Transform) is used in this work to represent the noisy ECG signal in time-frequency domain. Next, masking and filtering technique is applied to remove unwanted noise components from time-frequency domain. The proposed technique does not require any prior information like R-peak position or reference signal as auxiliary signal. This method is evaluated on ECG signals which are available in MIT-BIH Arrhythmia database. The experimental results demonstrate that the proposed method shows better signal to noise ratio (SNR) and lower root means square error (RMSE) compared to earlier reported wavelet transform with soft thresholding (WT-Soft) and wavelet transform with subband dependent threshold (WT-Subband) based technique. To quantify the significant difference among all methods, the performances of different ECG enhancement techniques at 1.25dB input SNR level are compared using analysis of variance (ANOVA) based statistical evaluation technique and it is seen that the proposed method yields superior performance compared to other methods. R-peak detection test is also conducted on enhanced ECG signal in addition to SNR and RMSE to evaluate the quality of biology-related information preserved in the enhanced ECG signal. The performance of R-peak detection for denoised ECG signals, in terms of sensitivity and positive predictivity using proposed enhancement method, is also better than WT-Soft, WT-Subband methods, and validates the superiority of the proposed method.
PMID: 23668340
ISSN: 0010-4825
CID: 786082

Adult attention-deficit hyperactivity disorder and obesity: epidemiological study

Cortese, Samuele; Faraone, Stephen V; Bernardi, Silvia; Wang, Shuai; Blanco, Carlos
BACKGROUND: A significant association between attention-deficit hyperactivity disorder (ADHD) and obesity has been reported. This study addresses unexplored aspects of this relationship. AIMS: To evaluate the association between adult obesity and: (a) persistent, remitted or lifetime ADHD; (b) number of childhood ADHD symptoms, controlling for socioeconomic status and mood, anxiety and substance use disorders. METHOD: Face-to-face psychiatric interviews in 34 653 US adults from the National Epidemiologic Study on Alcohol and Related Conditions. Obesity was defined as a body mass index >/=30. RESULTS: Persistent, lifetime or remitted ADHD were not associated with obesity after controlling for confounders. The number of childhood ADHD symptoms was significantly associated with adult obesity, even after adjustment, in women. CONCLUSIONS: Childhood ADHD symptoms are associated with obesity in women even after comorbid psychiatric disorders are accounted for. This provides a rationale for longitudinal studies assessing the impact of the treatment of childhood ADHD symptoms on obesity in women.
PMCID:3696877
PMID: 23661765
ISSN: 0007-1250
CID: 1154562

Response to Chronis-Tuscano et al. and Arns and Strehl [Letter]

Sonuga-Barke, Edmund; Brandeis, Daniel; Cortese, Samuele; Daley, David; Danckaerts, Marina; Dopfner, Manfred; Ferrin, Maite; Holtmann, Martin; Van der Oord, Saskia
PMID: 23820834
ISSN: 0002-953x
CID: 1154552

Socio-economic status, neighbourhood food environments and consumption of fruits and vegetables in New York City

Jack, Darby; Neckerman, Kathryn; Schwartz-Soicher, Ofira; Lovasi, Gina S; Quinn, James; Richards, Catherine; Bader, Michael; Weiss, Christopher; Konty, Kevin; Arno, Peter; Viola, Deborah; Kerker, Bonnie; Rundle, Andrew
OBJECTIVE: Recommendations for fruit and vegetable consumption are largely unmet. Lower socio-economic status (SES), neighbourhood poverty and poor access to retail outlets selling healthy foods are thought to predict lower consumption. The objective of the present study was to assess the interrelationships between these risk factors as predictors of fruit and vegetable consumption. DESIGN: Cross-sectional multilevel analyses of data on fruit and vegetable consumption, socio-demographic characteristics, neighbourhood poverty and access to healthy retail food outlets. SETTING: Survey data from the 2002 and 2004 New York City Community Health Survey, linked by residential zip code to neighbourhood data. SUBJECTS: Adult survey respondents (n 15 634). RESULTS: Overall 9.9 % of respondents reported eating >/=5 servings of fruits or vegetables in the day prior to the survey. The odds of eating >/=5 servings increased with higher income among women and with higher educational attainment among men and women. Compared with women having less than a high-school education, the OR was 1.12 (95 % CI 0.82, 1.55) for high-school graduates, 1.95 (95 % CI 1.43, 2.66) for those with some college education and 2.13 (95 % CI 1.56, 2.91) for college graduates. The association between education and fruit and vegetable consumption was significantly stronger for women living in lower- v. higher-poverty zip codes (P for interaction < 0.05). The density of healthy food outlets did not predict consumption of fruits or vegetables. CONCLUSIONS: Higher SES is associated with higher consumption of produce, an association that, in women, is stronger for those residing in lower-poverty neighbourhoods.
PMCID:3696996
PMID: 23388104
ISSN: 1368-9800
CID: 279232

Play, attention, and learning: how do play and timing shape the development of attention and influence classroom learning?

Hedges, James H; Adolph, Karen E; Amso, Dima; Bavelier, Daphne; Fiez, Julie A; Krubitzer, Leah; McAuley, J Devin; Newcombe, Nora S; Fitzpatrick, Susan M; Ghajar, Jamshid
The behavioral and neurobiological connections between play and the development of critical cognitive functions, such as attention, remain largely unknown. We do not yet know how these connections relate to the formation of specific abilities, such as spatial ability, and to learning in formal environments, such as in the classroom. Insights into these issues would be beneficial not only for understanding play, attention, and learning individually, but also for the development of more efficacious systems for learning and for the treatment of neurodevelopmental disorders. Different operational definitions of play can incorporate or exclude varying types of behavior, emphasize varying developmental time points, and motivate different research questions. Relevant questions to be explored in this area include, How do particular kinds of play relate to the development of particular kinds of abilities later in life? How does play vary across societies and species in the context of evolution? Does play facilitate a shift from reactive to predictive timing, and is its connection to timing unique or particularly significant? This report will outline important research steps that need to be taken in order to address these and other questions about play, human activity, and cognitive functions.
PMCID:3842829
PMID: 23763338
ISSN: 1749-6632
CID: 1651622

Ledge and wedge: younger and older adults' perception of action possibilities

Comalli, David; Franchak, John; Char, Angela; Adolph, Karen
The current study investigated whether younger (college-age) and older adults (60+ years) differ in their ability to perceive safe and unsafe motor actions. Participants decided whether to walk through openings varying in width in two penalty conditions: In the doorway condition, if participants attempted to squeeze through impossibly narrow openings, the penalty for error was entrapment. In the ledge condition, if participants attempted to inch along impossibly narrow ledges, the penalty for error was falling. Results showed that across the lifespan, people consider falling to be a more severe penalty than getting stuck: Both younger and older adults made more conservative decisions when the penalty for error was falling, and older women were especially leery of falling. In both age groups, abilities and decisions were based on dynamic properties of the body, such as compressed body size in the doorway condition and balance in the ledge condition. Findings indicate that failure to perceive possibilities for action is unlikely to be the cause of the increased prevalence of falling in older adults.
PMCID:3756555
PMID: 23660744
ISSN: 1432-1106
CID: 1651632

Neutrality in the field: alpha-function and the dreaming dyad in psychoanalytic process

Schwartz, Henry P
Analysts have interpreted the concept of neutrality in a variety of ways, beginning with Strachey's use of that word to translate Freud's (1915) term, Indifferenz. In this paper, neutrality is linked to Freud's notions of free association and evenly suspended attention. A history of psychoanalytic attempts to clarify the concept are presented, with special attention to issues of ambiguity and the patient's role in the determination of neutrality. Neutrality is further elaborated in relation to the bipersonal field as described by the Barangers and contemporary field theorists. Understood in terms of the field, neutrality becomes a transpersonal concept, here conceived in terms of alpha-function and a dreaming dyad. Two clinical examples cast in the light of a Bionian perspective are discussed to suggest an alternative understanding of analytic impasses and their relation to alpha-function and neutrality.
PMID: 23824648
ISSN: 0033-2828
CID: 425402

Sleep duration and risk for hypertension in women: results from the nurses' health study

Gangwisch, James E; Feskanich, Diane; Malaspina, Dolores; Shen, Sa; Forman, John P
BACKGROUND: Acute sleep restriction has been shown to increase blood pressure and sympathetic nervous system activity. METHODS: We investigated the relationships between sleep duration and hypertension among women whose sleep durations were self-reported in 1986 (n = 82,130) and 2000 (n = 71,658) in the Nurses' Health Study I (NHS-I) and in 2001 (n = 84,674) in the Nurses' Health Study II (NHS-II). RESULTS: After controlling for multiple risk factors in logistic regression models, the prevalence of hypertension was significantly higher among women in all 3 groups who slept
PMCID:3731821
PMID: 23564028
ISSN: 0895-7061
CID: 427302

Role reversals [Letter]

Henderson, Schuyler W
ORIGINAL:0010467
ISSN: 0890-8567
CID: 1901642

In vivo 7Tesla imaging of the dentate granule cell layer in schizophrenia

Kirov, Ivan I; Hardy, Caitlin J; Matsuda, Kant; Messinger, Julie; Cankurtaran, Ceylan Z; Warren, Melina; Wiggins, Graham C; Perry, Nissa N; Babb, James S; Goetz, Raymond R; George, Ajax; Malaspina, Dolores; Gonen, Oded
PURPOSE: The hippocampus is central to the pathophysiology of schizophrenia. Histology shows abnormalities in the dentate granule cell layer (DGCL), but its small size (~100mum thickness) has precluded in vivo human studies. We used ultra high field magnetic resonance imaging (MRI) to compare DGCL morphology of schizophrenic patients to matched controls. METHOD: Bilateral hippocampi of 16 schizophrenia patients (10 male) 40.7+/-10.6years old (mean+/-standard deviation) were imaged at 7Tesla MRI with heavily T2()-weighted gradient-echo sequence at 232mum in-plane resolution (0.08muL image voxels). Fifteen matched controls (8 male, 35.6+/-9.4years old) and one ex vivo post mortem hippocampus (that also underwent histopathology) were scanned with same protocol. Three blinded neuroradiologists rated each DGCL on a qualitative scale of 1 to 6 (from "not discernible" to "easily visible, appearing dark gray or black") and mean left and right DGCL scores were compared using a non-parametric Mann-Whitney test. RESULTS: MRI identification of the DGCL was validated with histopathology. Mean right and left DGCL ratings in patients (3.2+/-1.0 and 3.5+/-1.2) were not statistically different from those of controls (3.9+/-1.1 and 3.8+/-0.8), but patients had a trend for lower right DGCL score (p=0.07), which was significantly associated with patient diagnosis (p=0.05). The optimal 48% sensitivity and 80% specificity for schizophrenia were achieved with a DGCL rating of
PMCID:3709603
PMID: 23664589
ISSN: 1573-2509
CID: 381292