Faculty Bibliography

Although complications of transseptosphenoidal (TSS) pituitary surgery have been discussed in the literature, there has not been an analysis of complication rates related to clinical features and the nature of the tumor. A retrospective review of 366 TSS procedures (354 patients) for excision of pituitary adenomas evaluated the incidence and management of perioperative complications. The mortality rate was 0.82%. The most frequently encountered complications were transient diabetes insipidus (8.74%) and cerebrospinal fluid (CSF) rhinorrhea (4.10%). Other complications included exacerbation of visual acuity and visual field defects, hemorrhage, hydrocephalus, and meningitis. The factors evaluated were gender, age, tumor size, hormone secretory status, and any history of prior pituitary surgery.There was a significantly higher incidence of transient diabetes insipidus in patients with hormone-secreting tumors. Minor and total complication rates were significantly increased in microadenomas, hormone-secreting tumors, in female patients, and in patients less than 60 years of age reflecting the increased incidence of transient diabetes insipidus in young female patients with hormone-secreting tumors. Observed intraoperative CSF leaks predisposed to postoperative CSF rhinorrhea. There were no identifiable risk factors for major complications.

Endolymphatic system surgery for Meniere's disease, particularly endolymphatic shunting, remains controversial. In 1988, we presented our findings on the efficacy of the Denver Inner Ear Shunt in 100 patients. These data were accumulated in the short term. The purpose of this article is to review the long-term results of our endolymphatic shunt procedure, highlighting the population of Denver Inner Ear Shunt recipients. Results were analyzed according to both 1972 and 1985 AAO-HNS criteria. We seek corroboration or refutation of our preliminary conclusion that (a) endolymphatic shunt surgery has little efficacy and that (b) the Denver valve does not appear to offer any advantage in this regard.

OBJECTIVE: To determine if elective cosmetic septorhinoplasty impacts on nasal air flow resistance over the long-term. DESIGN: Case series. Mean postoperative follow-up period was 41.5 months (range, 16 to 77 months). PATIENTS: A consecutive sample of 200 patients having undergone cosmetic open septorhinoplasty by one of us (P.A.A.) before July 1992 were contacted by telephone; 50 agreed to participate, and 27 actually participated in the study. INTERVENTIONS: Open cosmetic septorhinoplasty performed by one of us (P.A.A.). MAIN OUTCOME MEASURES: Comparison of preoperative and postoperative nasal resistance values by headout body displacement plethysmography; correlation of preoperative and postoperative nasal valve anatomy with nasal resistance values; and correlation of postoperative nasal resistance values with subjective evaluation of nasal air flow as reported on a 10-point analogue scale. RESULTS: Of the 27 patients, 10 had normal preoperative nasal resistance values and 17 had elevated resistance values. Preoperative Normal Group: Four of the 10 patients' mean resistance values exceeded normal limits postoperatively. One of these four patients reported subjective nasal obstruction. Preoperative Abnormal Group: Of the 17 patients, surgery resulted in normal resistance values postoperatively in six, decreased but still above normal resistance values in eight, and no decrease in postoperative resistance values in three. CONCLUSIONS: (1) Patients with normal nasal resistance values may suffer long-term, asymptomatic increase in nasal resistance values after cosmetic open septorhinoplasty, often with no quantifiable change at the nasal valve. (2) Patients with elevated nasal resistance measurements generally improve with open septorhinoplasty. Patients with isolated septal deformities improve with septoplasty. Patients with upper lateral cartilage collapse improve with spreader grafts. The lasting objective improvement on the nasal valve using spreader grafts is reported herein for the first time. (3) Subjective estimations of nasal patency do not correlate well with objective measures of patency, namely nasal resistance measurements. (4) Cosmetic septorhinoplasty can alter nasal patency. Continued care must be exercised when manipulating the nasal framework for cosmetic purposes, as slight changes to the nasal valve may result in significant alterations in nasal air flow resistance

This study compares the internal fixation of mandibular fractures using either rigid 2.7 mm AO/ASIF plates or mini-plates. In the rigid plate group, 88 fractures were fixed with 88 plates. In the mini-plate group, 116 fractures were fixed with 170 plates. All the cases were consecutive and were treated in two South Wales hospitals during a 3-year period from 1988 to 1991. The aetiology of injury, timing of surgery, site of fracture, antibiotic policy and demographic features were evenly distributed between the two groups but there was a higher incidence of females in the mini-plate group. Both plating systems were successful in restoring functional occlusion. Rigid plates avoided the use of postoperative elastics better than mini-plates but the difference was not significant. There was a significantly higher incidence (P = 0.013) of infection in the mini-plate (12.9%) compared with the rigid plate (2.3%) group but 7.9% of the rigid group developed facial nerve weakness. A significantly higher proportion of mini-plates needed to be removed (P = 0.00019). A better treatment outcome for angle and comminuted fractures was noted with rigid plates

OBJECTIVE:To review the classification of fungal sinusitis as well as discuss current approaches to diagnosis and management. DATA SOURCES: A MEDLINE literature search was performed using the index terms sinus infection, fungal, diagnosis, radiology, microbiology, and treatment. The search was restricted to the English language and human subjects. With one exception the references were restricted to the last 10 years. Clinical data from studies performed at our institution were also included. RESULTS: Fungal sinusitis can be divided into four primary categories: (1) acute/fulminant (invasive), (2) chronic/indolent (invasive), (3) fungus ball, and (4) allergic fungal sinusitis. Each subtype has unique immunologic, pathologic, and clinical features. Allergic fungal sinusitis is the most recently described and most common form. The treatment and prognosis of fungal sinusitis varies significantly among the four different categories. CONCLUSION: Recent advances in endoscopy and computed tomography have enhanced the understanding of fungal sinusitis; however, they remain diseases surrounded by controversy. New insights into the etiology and pathogenesis of these diseases along with advances in diagnosis and treatment will lead to improved medical therapy

BACKGROUND: Parathyroid (PTH) cyst is a rare lesion. Only about 200 cases have been reported to date. The diagnosis of a PTH cyst is difficult, particularly in its differentiation from thyroid cyst. It has clinical significance because PTH cysts can mimic a thyroid mass and can be associated with hyperparathyroidism. METHODS: This presentation illustrates an additional case of a PTH cyst. The importance of fine-needle aspiration (FNA) in the diagnosis of PTH cyst and its management are discussed. RESULTS: Fine-needle aspiration of clear fluid containing an elevated PTH hormone level proved to be diagnostic in the patient. Recurrence of the cyst after FNA required surgical resection. The current concepts of etiology and treatment are summarized. CONCLUSIONS: PTH cyst should be in the differential diagnosis in any patient initially seen with an anterior cystic neck mass. Radiologic imaging and FNA can accurately diagnose PTH cysts. Surgical excision may be needed for recurrent cysts after aspiration

The articulator positions of a subject with a cochlear implant were measured with an electromagnetic midsagittal articulometer (EMMA) system with and without auditory feedback available to the subject via his implant. Acoustic analysis of sibilant productions included specific measures of their spectral properties as well as the F3 formant amplitude. More general postural characteristics of the utterances, such as speech rate and sound level, were measured as well. Because of the mechanical and aerodynamic interdependence of the articulators, the postural variables must be considered before attributing speech improvement to the selective correction of a phonemic target with the use of auditory feedback. The tongue blade position was related to the shape and central tendency of the /integral of/ spectra; however, changes in the spectral contrast between /s/ and /integral of/ were not related to changes in the more general postural variables of rate and sound level. These findings suggest that the cochlear implant is providing this subject with important auditory cues that he can use to monitor his speech and maintain the phonemic contrast between /s/ and /integral of/

We have previously shown that inhibitory afferents regulate dendrite size in the gerbil lateral superior olive (LSO) during the first 3 postnatal weeks. To determine how rapidly this effect occurs, we performed unilateral cochlear ablations at one week postnatal, and LSO neurons were filled with biocytin-containing whole cell electrodes in the acute brain slice preparation. The manipulation leads to excitatory denervation in the ipsilateral LSO, and inhibitory denervation in the contralateral LSO. Filled neurons were analyzed with a computer-based morphometric system at 1 to 6 days after the manipulation. For all contralateral neurons examined there was a significant increase in the total number of dendritic branches and the total dendritic length, as compared to control neurons. A time-course analysis of the change in branch points showed that inhibition exerted its effect with a latency of 2-3 days. Excitatory denervation led to a significant reduction in soma size, although dendrites neither shrank nor expanded. Since cochlea removal was performed 5 days before sound-evoked activity began, the hypertrophy of the contralateral LSO neurons indicates that trophic modulation may be attributed to spontaneous inhibitory synaptic transmission

We previously demonstrated that inhibitory synaptic transmission influences dendrite development in vivo. We now report an analogous finding in an organotypic culture of a glycinergic projection nucleus, the medial nucleus of the trapezoid body (MNTB), and its postsynaptic target, the lateral superior olive (LSO) of gerbils. Cultures were generated at 6-7 days postnatal and grown in serum containing medium with or without the glycine receptor antagonist, strychnine (SN), at 2 microM. LSO neurons were then labeled with biocytin, and the dendritic arbors were analyzed morphometrically. Compared to neurons form age-matched in vivo tissue, the neurons cultured in control media were somewhat atrophic, including decreases in dendritic branching and length. Incubation in strychnine led to a dramatic increase in dendritic branching and total dendritic length. Control neurons averaged 6.3 branches compared to 18 branches/neuron in SN-treated cultures. There was a similar increase in primary dendrites and total dendritic length. The physical elimination of MNTB cells did not mimic SN treatment, presumably because glycinergic LSO neurons generated intrinsic connections. In fact, the LSO soma area was significantly greater following MNTB removal, suggesting that these afferents provide a second signal to postsynaptic neurons. These results suggest that spontaneous glycinergic transmission regulates the growth of postsynaptic processes