Searched for: school:SOM
Department/Unit:Population Health
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies
Shendre, Aditi; Wiener, Howard; Irvin, Marguerite R; Zhi, Degui; Limdi, Nita A; Overton, Edgar T; Wassel, Christina L; Divers, Jasmin; Rotter, Jerome I; Post, Wendy S; Shrestha, Sadeep
BACKGROUND:Local ancestry may contribute to the disproportionate burden of subclinical and clinical cardiovascular disease among admixed African Americans compared with other populations, suggesting a rationale for admixture mapping. METHODS AND RESULTS/RESULTS:gene (lipoma high mobility group protein I-C fusion partner-like 2) with hard and all coronary heart disease. CONCLUSIONS:We identified several novel LEA regions, in addition to previously identified genetic variations, associated with cCIMT and cardiovascular disease events among African Americans.
PMID: 28408707
ISSN: 1942-3268
CID: 4318602
Changes in self-reported general health, physical health, and mental health following the affordable care act's medicaid expansion [Meeting Abstract]
Winkelman, T N; Chang, V W
BACKGROUND: The adoption of Medicaid expansion in some states and not others provided a unique natural experiment to study the effects of Medicaid. Research stemming from this natural experiment suggests that Medicaid expansion increased health insurance coverage, improved access to care, and reduced cost-related barriers to prescription drugs among low income individuals. Findings with respect to health outcomes, however, have been more mixed. Therefore, we analyzed recently released national data from the Behavioral Risk Factor Surveillance System (BRFSS) to assess the relationship between Medicaid expansion and self-reported health measures among low-income individuals. METHODS: We used 2011-2015 BRFSS data, which provided 3 years of data prior to implementation of Medicaid expansion and 2 years of follow-up data in the majority of expansion states. Our study sample consisted of all individuals age 18-64 with household incomes below $15,000, targeting individuals who would have qualified for Medicaid coverage in expansion states. As in prior work, we excluded five states that had previously expanded Medicaid. Our outcomes were self-reported general health, poor physical health days, poor mental health days, and disability following Medicaid expansion. We used a difference-in-differences approach to estimate the effect of Medicaid expansion on our outcomes of interest. Our key independent variable was equal to 1 for individuals living in states where expansion was in effect during the month of their interview. Estimates were obtained with multivariable linear probability models and adjusted for age, race/ethnicity, sex, education, marital status, and children, as well as state-level and quarter year fixed effects. We used BRFSS sampling weights and estimated robust standard errors clustered at the state level to account for serial autocorrelation. RESULTS: In adjusted analyses of the influence of Medicaid expansion, we found that expansion was associated with a significant reduction in fair/poor self-rated health (2.5 percentage points [95% CI, -3.5 to -1.5]). While expansion was not associated with a statistically significant change in the number of poor physical health days (-0.20 days [95% CI, -0.68 to 0.28]), it was associated with a significant reduction in the number of poor mental health days (-0.52 days [95% CI, -0.99 to -0.04]). Change in disability prevalence did not vary between expansion and non-expansion states (P = 0.73). Adjusted linear time trends prior to expansion (2011 to 2013) for all outcomes were similar in expansion and non-expansion states (P > .05 for all comparisons). CONCLUSIONS: To our knowledge this is the first national study to report positives changes in self-reported general health following the ACA's Medicaid expansion provision, driven by changes in mental health. Whether these trends continue to improve will likely depend on whether policymakers choose to improve or repeal the ACA in the coming months
EMBASE:615581527
ISSN: 0884-8734
CID: 2553982
Improving data collection, documentation, and workflow in a dementia screening study
Read, Kevin B; LaPolla, Fred Willie Zametkin; Tolea, Magdalena I; Galvin, James E; Surkis, Alisa
BACKGROUND: A clinical study team performing three multicultural dementia screening studies identified the need to improve data management practices and facilitate data sharing. A collaboration was initiated with librarians as part of the National Library of Medicine (NLM) informationist supplement program. The librarians identified areas for improvement in the studies' data collection, entry, and processing workflows. CASE PRESENTATION: The librarians' role in this project was to meet needs expressed by the study team around improving data collection and processing workflows to increase study efficiency and ensure data quality. The librarians addressed the data collection, entry, and processing weaknesses through standardizing and renaming variables, creating an electronic data capture system using REDCap, and developing well-documented, reproducible data processing workflows. CONCLUSIONS: NLM informationist supplements provide librarians with valuable experience in collaborating with study teams to address their data needs. For this project, the librarians gained skills in project management, REDCap, and understanding of the challenges and specifics of a clinical research study. However, the time and effort required to provide targeted and intensive support for one study team was not scalable to the library's broader user community.
PMCID:5370608
PMID: 28377680
ISSN: 1558-9439
CID: 2536732
A Case of Rectal Ureaplasma Infection and Implications for Testing in Young Men Who Have Sex with Men: The P18 Cohort Study
Abbott, Collette E; Greene, Richard E; Kapadia, Farzana; Halkitis, Perry N
Ureaplasma is a significant cause of nongonococcal urethritis. This is a case of rectal Ureaplasma found on culture in a young man who has sex with men not previously reported in the literature. Nucleic acid amplification tests are now standard of care for sexually transmitted infection testing, but they do not test for Ureaplasma and, therefore, may be missing important infections. Ureaplasma could have important implications in urethritis and rectal HIV transmission among men who have sex with men engaging in condomless anal intercourse. Further study of Ureaplasma's role as a rectal pathogen may be warranted.
PMCID:5374866
PMID: 28027001
ISSN: 2325-8306
CID: 2383552
Pilot RCT of a technology-assisted weight management intervention within primary care at the VA Newyork Harbor healthcare system [Meeting Abstract]
Viglione, C M; Amarnani, S; Bouwman, D; Lazar, K; Fang, Y; Sherman, S; Kalet, A; Tenner, C; Jay, M
BACKGROUND: Obesity is under-treated and primary care teams find it difficult to provide effective lifestyle-based weight management counseling. Further, only 10% of eligible patients attendMOVE!, theVAweight management and health promotion program. We developed an intervention called Goals for Eating and Moving (GEM) to improve counseling within primary care (PC) and increase attendance in intensive weight management programs such as MOVE!. METHODS: Veterans with a Body Mass Index of greater than or equal to 30 or between 25 and 29.99 with at least one comorbidity were recruited by phone and randomized toGEMor "Enhanced Usual Care" (EUC). GEMutilizes the Patient Aligned Care Teams (PACTs) within the VA to deliver 5As counseling (Assess, Advise, Agree, Assist and Arrange) to promote modest weight loss and behavior change. Participants use a goal-setting tool to generate tailored materials, which facilitates in-person and phone counseling with health coaches. Coaches support PACTcounseling during regular PC visits and encourage participants to join VA weight management services. Veterans in GEM received the intervention and Veterans in EUC met with a coach to receive the VA "healthy living messages" pamphlet. At baseline and 3 months, participants had weight measurements and completed surveys. We used the Paffenbarger Physical Activity Questionnaire and a 17-item screener to derive fruit and vegetable intake, energy from fat, and dietary fiber. Vegetable intake (leafy greens/salad) and sugar-sweetened beverage were measured as individual items. We performed per-protocol analyses (Wilcoxon Rank sums test and Spearman Correlation) to assess the relationship between GEM and different variables. RESULTS: Thirty-one Veterans (mean age = 53.48, 63% male, mean BMI = 31.72) enrolled and 25 returned at 3-months (1 dropped out and 5 were lost-tofollow up). Those in GEM lost significantly more weight at 3-months (-1.59 kg, SD = 1.76) than those in EUC (-0.63 kg, SD = 3.42, p = 0.03). There were no statistically significant differences in diet and physical activity. For Veterans that received GEM, higher number of phone coaching sessions was correlated with weight loss (Spearman Correlation -0.58, p = 0.09). CONCLUSIONS: This early analysis indicates that GEM promotes small but significant (p = 0.03) weight loss at 3-months and identified the need for high patient retention and engagement, since the number of health coaching calls may correlate with weight loss. Based on this we have refined protocols for phone coaching to ensure that scheduling and reminder calls are patientcentered. This pilot study informed the development of a multi-site cluster- RCT of GEM to begin in June 2017 (NIH # 1R01 DK111928-01)
EMBASE:615581752
ISSN: 0884-8734
CID: 2553892
Food insecurity in veterans recruited for a pilot weight management study for veterans in primary care: An exploratory analysis [Meeting Abstract]
Viglione, C M; Rahman, N; Sanon, O; Chowdhury, A; Fang, Y; Sherman, S; Kalet, A; Dognin, J; Jay, M
BACKGROUND: Food insecurity (FI) occurs when individuals or households have limited or uncertain access to adequate food. People with FI may find it particularly difficult to eat a balanced diet and manage weight. Individuals who report FI are 1.4 times more likely to have obesity. U.S. Veterans have a greater prevalence of FI compared with the general population (24% vs. 19%). As part of a pilot randomized controlled trial to test the impact of an obesity intervention for Veterans, we explored the prevalence of FI in our sample and assessed the impact of FI on weight outcomes. METHODS: Veterans with a Body Mass Index of greater than or equal to 30 or between 25 and 29.99 with at least one comorbidity were recruited by phone for a pilot study. Participants randomized to the intervention received a technology-assisted health coaching session and follow-up coaching calls; control participants received a VA "healthy living messages" pamphlet. At baseline and 3 months, participants had weight measurements and completed surveys. To measure FI, we used a 6-item Household Food Security Scale (FI = 2 or more affirmative responses). We assessed the impact of FI on variables independent of arm assignment in participants who returned for a 3-month measurement visit (Wilcoxon rank sum tests and Fisher's Exact Test). We also analyzed the role of FI as a moderator between arm and study variables using ANOVA. RESULTS: Out of 31 Veterans who enrolled in the study (Mean age = 53.48, 63% male, mean BMI = 31.72), 10 demonstrated FI at baseline and 25 participants completed 3 month measurements. Independent of the intervention, those with FI (n = 10) lost .01 kg of weight and those without FI (n = 15) lost 1.69 kg at 3-months but the difference was not significant (p = 0.2). Similarly, 0/10 Veterans with FI achieved 2.5% weight loss, compared to 4/15 of those without FI (p = 0.12). Those with FI in the control group gained weight when compared to those without FI (1.04 kg, SD = 1.41 vs. -1.75, SD = 3.96) and those with FI in the intervention lost the same amount of weight as those without FI (-1.59 kg, SD = 0.83, vs. -1.59, SD = 2.27; p = 0.24 for the interaction (not significant)). CONCLUSIONS: FI in Veterans enrolled in a weight management study is high. Participants with FI in the control arm may have gained weight when compared to non-FI participants, while intervention arm participants with FI lost similar amounts of weight to those without FI. This suggests that the intervention may reduce the negative impact of FI. While this pilot study was not powered to show a significant difference, we have amended health coaching protocols to better address FI in our intervention (e.g. screening for FI and linking participants with Supplemental Nutrition Assistance Program (SNAP) benefits and similar resources) hoping to maximize its effectiveness
EMBASE:615580916
ISSN: 0884-8734
CID: 2554252
Serum perfluoroalkyl substances in children exposed to the world trade center disaster
Trasande, Leonardo; Koshy, Tony T; Gilbert, Joseph; Burdine, Lauren K; Attina, Teresa M; Ghassabian, Akhgar; Honda, Masato; Marmor, Michael; Chu, Dinh Binh; Han, Xiaoxia; Shao, Yongzhao; Kannan, Kurunthachalam
The World Trade Center (WTC) disaster released large amounts of various chemical substances into the environment, including perfluoroalkyl substances (PFASs). Yet, no studies have examined exposures in children living or attending schools near the disaster site. We measured serum PFASs in WTC Health Registry (WTCHR) respondents who were =8 years of age on September 11, 2001 and a sociodemographically-matched comparison group. We also examined the relationship of PFASs levels with dust cloud exposure; home dust exposure, and with traumatic exposure, the latter to take into account differences related to possible mental health consequences and associated behavioral problems. Serum samples, collected between 2014 and 2016, were analyzed from 123 WTCHR participants and from 185 participants in the comparison group. In the WTCHR group, median perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) levels were 1.81ng/mL and 3.72ng/mL, respectively. Controlling for sex, caloric intake, race/ethnicity, and date of birth, significant increases among WTCHR participants compared with the matched comparison group were detected for perfluorohexanesulfonate (0.23ng/mL increase or 0.24log unit increase, p=0.006); PFOS (0.86ng/mL increase or 0.16log unit increase, p=0.011); PFOA (0.35ng/mL increase or 0.18log unit increase, p<0.001); perfluorononanoic acid (0.12ng/mL increase or 0.17log unit increase, p=0.003); perfluorodecanoic acid (0.06ng/mL increase or 0.42log unit increase, p<0.001); and perfluoroundecanoic acid (0.03ng/mL increase or 0.32log unit increase, p=0.019). Stronger associations were identified for home dust exposures and traumatic exposures than dust cloud. These findings highlight the importance of conducting longitudinal studies in this population to assess possible cardiometabolic and renal consequences related to these exposures.
PMCID:5328959
PMID: 28104511
ISSN: 1096-0953
CID: 2414042
High-risk community and primary care providers knowledge about and barriers to low-dose computed topography lung cancer screening
Simmons, Vani N; Gray, Jhanelle E; Schabath, Matthew B; Wilson, Lauren E; Quinn, Gwendolyn P
INTRODUCTION: Until recently, there has not been a valid and reliable screening test for lung cancer. As compared to chest X-ray, low-dose computed tomography (LDCT) lung cancer screening has demonstrated greater sensitivity resulting in lung cancer diagnosis at an earlier stage, thereby reducing lung cancer mortality among high-risk individuals by 20%. In the current study, we sought to examine knowledge and attitudes about LDCT screening for lung cancer among an ethnically and racially diverse sample of high risk (HR) community members and primary care providers (PCP). METHODS: Eligible individuals participated in a focus group using semi-structured interview guides. Focus groups were conducted with PCPs (by telephone) and HRs (in-person). Sessions were audio-taped and transcribed verbatim. The constant comparison method and content analysis were used to analyze results. RESULTS: The majority of PCPs had limited knowledge of lung cancer CT screening. PCPs cited barriers to recommendation including, cost/insurance barriers and the potential for false positives. PCPs perceived the main benefit to be early detection of lung cancer. The majority of HRs had never heard of lung LDCT screening and had never had a healthcare provider recommend it to them. Perceived barriers included fear of results (bad news) and financial costs. The main perceived benefit was early detection. CONCLUSION: Lack of knowledge about LDCT was a key a barrier across both the PCP and HR. RESPONDENTS: Understanding the barriers to lung screening across diverse community populations is necessary to improve screening rates and shared decision-making.
PMID: 28285693
ISSN: 1872-8332
CID: 2586782
Using practice facilitation in primary care settings to reduce risk factors for cardiovascular disease: Physicians' burnout analysis [Meeting Abstract]
Blechter, B; Jiang, N; Goldfeld, K; Siman, N; Berry, C; Shelley, D
BACKGROUND: National surveys indicate high rates of burnout, particularly among primary care physicians. Despite concerns about the impact of burnout on health outcomes, this relationship is not well studied. HealthyHearts NYC, funded through the EvidenceNOW initiative of the Agency for Healthcare Research and Quality is evaluating the effectiveness of practice facilitation to improve adoption of Million Hearts' evidence-based ABCS guidelines (Aspirin, Blood pressure control (BP), Cholesterol management, and Smoking cessation) in small-to-medium size primary care practices. This study examined the association between site characteristics and physicians' burnout, as well as the relationship with the ABCS outcomes. METHODS: We present data on 99 small practices working with the NYCDOHMH Primary Care Information Project, and 8 Federally Qualified Health Centers (FQHC) from the Community Health Care Association of New York State. Each provider from participating practice sites completed a survey that included a validated question assessing burnout that used a 5-point scale ranging from 1- no symptoms of burnout to 5- completely burned out. For sites with multiple providers, we calculated a site burnout score by extracting the maximum score within each site. The burnout level was dichotomously coded as 1- burned out, and 0- not burned out. Each site completed a practice survey to report site characteristics, including the number of providers (1 vs. 2 or more), Patient Centered Medical Home (PCMH) status (recognized vs. not recognized), average number of patient visits per week, and total number of support staff. We used logistic regression analysis to assess the association of practice site characteristics and burnout. We also calculated a composite measure for patients with multiple CVD risk factors to capture the extent to which targets are met across three of the outcome measures (ABC). We used ttests to assess the difference in ABCS and composite measures by burnout status. RESULTS: Overall, 19% of physicians reported burnout. A significant difference was detected for all ABCS measures by the sites' burnout status. Sites reporting burnout had higher rates of meeting aspirin, smoking, and composite measure targets, but lower rates of meeting BP and cholesterol target measures and were more likely to have achieved PCMH recognition. FQHCs reported higher rates of burnout compared with small practices. CONCLUSIONS: The overall rates of burnout were lower than reported in previous surveys. Lower burnout rates among small independent practices compared with FQHCs may be related to small practice providers' greater level autonomy. We will present additional data exploring organizational factors that may explain variation in burnout across these different practice settings. Finally, previous research has similarly found inconsistent associations between quality and burnout. Further studies are required to determine whether healthier workplaces also result in higher quality care
EMBASE:615582060
ISSN: 0884-8734
CID: 2553782
Other Ways of Knowing
Hajizadeh, Negin; Basile, Melissa J; Kozikowski, Andrzej; Akerman, Meredith; Liberman, Tara; McGinn, Thomas; Diefenbach, Michael A
BACKGROUND:Patients with advanced-stage chronic obstructive pulmonary disease (COPD) may suffer severe respiratory exacerbations and need to decide between accepting life-sustaining treatments versus foregoing these treatments (choosing comfort care only). We designed the InformedTogether decision aid to inform this decision and describe results of a pilot study to assess usability focusing on participants' trust in the content of the decision aid, acceptability, recommendations for improvement, and emotional reactions to this emotionally laden decision. METHODS:Study participants ( N = 26) comprising clinicians, patients, and surrogates viewed the decision aid, completed usability tasks, and participated in interviews and focus groups assessing comprehension, trust, perception of bias, and perceived acceptability of InformedTogether. Mixed methods were used to analyze results. RESULTS:Almost all participants understood the gist (general meaning) of InformedTogether. However, many lower literacy participants had difficulty answering the more detailed questions related to comprehension, especially when interpreting icon arrays, and many were not aware that they had misunderstood the information. Qualitative analysis showed a range of emotional reactions to the information. Participants with low verbatim comprehension frequently referenced lived experiences when answering knowledge questions, which we termed "alternative knowledge." CONCLUSIONS:We found a range of emotional reactions to the information and frequent use of alternative knowledge frameworks for deriving meaning from the data. These observations led to insights into the impact of lived experiences on the uptake of biomedical information presented in decision aids. Communicating prognostic information could potentially be improved by eliciting alternative knowledge as a starting point to build communication, in particular for low literacy patients. Decision aids designed to facilitate shared decision making should elicit this knowledge and help clinicians tailor information accordingly.
PMCID:5373937
PMID: 28061041
ISSN: 1552-681x
CID: 3085262