Faculty Bibliography

There is a paucity of data related to sports injuries, concussions, and computerized neurocognitive testing (CNT) among very young athletes playing sports in recreational settings. The purpose of this study was to report baseline CNT results among male and female children, ages 5-11, playing sports in Hillsborough County, Florida using ImPACT Pediatric, which is specifically designed for this population. Data were collected from 2016 to 2017. The results show that 657 baseline tests were conducted and t-tests and linear regression were used to assess mean significant differences in composite scores with sex and age. Results showed that females scored better on visual memory and in general as age increased, baseline scores improved. The results can be used to build further studies on the use of CNT in recreational settings and their role in concussion treatment, management, and interventions.

Background: The anaesthetic dose causing neurotoxicity in animals has been evaluated, but the relationship between duration of volatile anaesthetic (VA) exposure and neurodevelopment in children remains unclear. Methods: Data were obtained from the Western Australian Pregnancy Cohort (Raine) Study, with language (Clinical Evaluation of Language Fundamentals: Receptive [CELF-R] and Expressive [CELF-E] and Total [CELF-T]) and cognition (Coloured Progressive Matrices [CPM]) assessed at age 10 yr. Medical records were reviewed, and children divided into quartiles based on total VA exposure duration before age three yr. The association between test score and exposure duration quartile was evaluated using linear regression, adjusting for patient characteristics and comorbidity. Results: Of 1622 children with available test scores, 148 had documented VA exposure and were split into the following quartiles: 25 to 35 to 60 min. Compared with unexposed children, CELF-T scores for children in the first and second quartiles did not differ, but those in the third and fourth quartiles had significantly lower scores ([3 rd quartile - Unexposed] -5.3; 95% confidence interval [CI], (-10.2 - -0.4), [4 th quartile - Unexposed] -6.2; 95% CI, (-11.6 - -0.9). CELF-E showed similar findings, but significant differences were not found in CELF-R or CPM for any quartile. Conclusions: Children with VA exposures 35 min had lower total and expressive language scores. It remains unclear if this is a dose-response relationship, or if children requiring longer exposures for longer surgeries have other clinical reasons for lower scores.

CONTEXT:Cardiovascular outcomes in mild thyroid dysfunction (treatment controversial) and moderate or severe dysfunction (treatment standard) remain uncertain. OBJECTIVE:To examine cross-sectional and prospective associations of thyroid function with cardiovascular risk factors and events. DESIGN:In the Atherosclerosis Risk in Communities Study, we measured concentrations of thyrotropin, free thyroxine, and total triiodothyronine (T3) in stored serum samples originally collected in 1990-1992. We used multivariable linear regression to assess cross-sectional associations of thyroid function with cardiovascular risk factors and Cox regression to assess prospective associations with cardiovascular events. Follow-up occurred through 31 December 2014. SETTING:General community. PARTICIPANTS:Black and white men and women from the United States, without prior myocardial infarction (MI), stroke, or heart failure. MAIN OUTCOMES AND MEASURES:Cross-sectional outcomes were blood pressure, glycemic markers, and blood lipids. Prospective outcomes were adjudicated fatal and nonfatal MI and stroke. RESULTS:Among 11,359 participants (57 ± 6 years, 58% women), thyroid function was more strongly associated with blood lipids than blood pressure or glycemic measures. Mean adjusted differences in low-density lipoprotein cholesterol were +15.1 (95% confidence interval: 10.5 to 19.7) and +3.2 (0.0 to 6.4) mg/dL in those with moderate/severe and mild chemical hypothyroidism, relative to euthyroidism; an opposite pattern was seen in hyperthyroidism. Similar differences were seen in triglycerides and non-high-density lipoprotein cholesterol. With a 22.5-year median follow-up, 1102 MIs and 838 strokes occurred, with similar outcomes among baseline thyroid function groups and by T3 concentrations. CONCLUSIONS:Hypothyroidism is associated with hyperlipidemia, but the magnitude is small in mild chemical hypothyroidism, and cardiovascular outcomes are similar between thyroid function groups.

We study the problem of identifying unreliable and adversarial workers in crowdsourcing systems where workers (or users) provide labels for tasks (or items). Most existing studies assume that worker responses follow specific probabilistic models; however, recent evidence shows the presence of workers adopting non-random or even malicious strategies. To account for such workers, we suppose that workers comprise a mixture of honest and adversarial workers. Honest workers may be reliable or unreliable, and they provide labels according to an unknown but explicit probabilistic model. Adversaries adopt labeling strategies different from those of honest workers, whether probabilistic or not. We propose two reputation algorithms to identify unreliable honest workers and adversarial workers from only their responses. Our algorithms assume that honest workers are in the majority, and they classify workers with outlier label patterns as adversaries. Theoretically, we show that our algorithms successfully identify unreliable honest workers, workers adopting deterministic strategies, and worst-case sophisticated adversaries who can adopt arbitrary labeling strategies to degrade the accuracy of the inferred task labels. Empirically, we show that filtering out outliers using our algorithms can significantly improve the accuracy of several state-of-the-art label aggregation algorithms in real-world crowdsourcing datasets.

By mid-2018, federal policy will require chain restaurants with more than 20 U.S. locations to include calorie information on their menus. Despite high expectations that this policy would encourage healthier eating, most studies of local policies to mandate calorie labels have demonstrated little impact on consumer choice. In this article, the authors adapt Burton and Kees's (2012) conceptual framework for eating behavior change to better understand the limited impact of these policies thus far. Using two surveys of fast-food consumers in Philadelphia, the authors estimate the percentage who might reasonably be expected to respond to calorie labels given the requirements of the Burton and Kees model. They find that as few as 8% of fast-food consumers meet all the model's requirements and, therefore, would be expected to change their eating behavior as a result of calorie information. The authors use the model and findings to consider how calorie-labeling policy could be improved for greater impact.