Searched for: school:SOM
Department/Unit:Population Health
Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure
Caraher, Erin J; Kwon, Sophia; Haider, Syed H; Crowley, George; Lee, Audrey; Ebrahim, Minah; Zhang, Liqun; Chen, Lung-Chi; Gordon, Terry; Liu, Mengling; Prezant, David J; Schmidt, Ann Marie; Nolan, Anna
World Trade Center-particulate matter(WTC-PM) exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI). The receptor for advanced glycation end-products (RAGE) is most highly expressed in the lung, mediates metabolic risk, and single-nucleotide polymorphisms at the AGER-locus predict forced expiratory volume(FEV). Our objectives were to test the hypotheses that RAGE is a biomarker of WTC-LI in the FDNY-cohort and that loss of RAGE in a murine model would protect against acute PM-induced lung disease. We know from previous work that early intense exposure at the time of the WTC collapse was most predictive of WTC-LI therefore we utilized a murine model of intense acute PM-exposure to determine if loss of RAGE is protective and to identify signaling/cytokine intermediates. This study builds on a continuing effort to identify serum biomarkers that predict the development of WTC-LI. A case-cohort design was used to analyze a focused cohort of male never-smokers with normal pre-9/11 lung function. Odds of developing WTC-LI increased by 1.2, 1.8 and 1.0 in firefighters with soluble RAGE (sRAGE)>/=97pg/mL, CRP>/=2.4mg/L, and MMP-9=397ng/mL, respectively, assessed in a multivariate logistic regression model (ROCAUC of 0.72). Wild type(WT) and RAGE-deficient(Ager-/-) mice were exposed to PM or PBS-control by oropharyngeal aspiration. Lung function, airway hyperreactivity, bronchoalveolar lavage, histology, transcription factors and plasma/BAL cytokines were quantified. WT-PM mice had decreased FEV and compliance, and increased airway resistance and methacholine reactivity after 24-hours. Decreased IFN-gamma and increased LPA were observed in WT-PM mice; similar findings have been reported for firefighters who eventually develop WTC-LI. In the murine model, lack of RAGE was protective from loss of lung function and airway hyperreactivity and was associated with modulation of MAP kinases. We conclude that in a multivariate adjusted model increased sRAGE is associated with WTC-LI. In our murine model, absence of RAGE mitigated acute deleterious effects of PM and may be a biologically plausible mediator of PM-related lung disease.
PMCID:5604982
PMID: 28926576
ISSN: 1932-6203
CID: 2706992
Vascular Access Placement Order and Outcomes in Hemodialysis Patients: A Longitudinal Study
Murea, Mariana; Brown, W Mark; Divers, Jasmin; Moossavi, Shahriar; Robinson, Todd W; Bagwell, Benjamin; Burkart, John M; Freedman, Barry I
BACKGROUND:Arteriovenous accesses (AVA) in patients performing hemodialysis (HD) are labeled "permanent" for AV fistulas (AVF) or grafts (AVG) and "temporary" for tunneled central venous catheters (TCVC). Durability and outcomes of permanent vascular accesses based on the sequence in which they were placed or used receives little attention. This study analyzed longitudinal transitions between TCVC-based and AVA-based HD outcomes according to the order of placement. METHODS:All 391 patients initiating chronic HD via a TCVC between 2012 and 2013 at 12 outpatient academic dialysis units were included in this study. Chronological distributions of HD vascular accesses were recorded over a mean (SD) of 2.8 (0.9) years and sequentially grouped into periods for TCVC-delivered and AVA-delivered (AVF or AVG) HD. Primary AVA failure and cumulative access survival were evaluated based on access placement sequence and type, adjusting for age. RESULTS:In total, 92.3% (361/391) of patients underwent 497 AVA placement surgeries. Analyzing the initial 3 surgeries, primary AVF failure rates increased with each successive fistula placement (p = 0.008). Among the 82.9% (324/391) of TCVC patients successfully converted to an AVA, 30.9% returned to a TCVC, followed by a 58.0% conversion rate to another AVA. Annual per-patient vascular access transition rates were 2.02 (0.09) HD periods using a TCVC and 0.54 (0.03) HD periods using an AVA. Comparing the first AVA used with the second, cumulative access survivals were 701.0 (370.0) vs. 426.5 (275.0) days, respectively. Excluding those never converting to an AVF or AVG, 169 (52.2%) subsequently converted from a TCVC to a permanent access and received HD via AVA for ≥80% of treatments. CONCLUSIONS:HD vascular access outcomes differ based on the sequence of placement. In spite of frequent AVA placements, only half of patients effectively achieved a "permanent" vascular access and used an AVA for the majority of HD treatments.
PMID: 28930719
ISSN: 1421-9670
CID: 4318632
Acceptability and Feasibility of Using a Novel Geospatial Method to Measure Neighborhood Contexts and Mobility Among Transgender Women in New York City
Goedel, William C; Reisner, Sari L; Janssen, Aron C; Poteat, Tonia C; Regan, Seann D; Kreski, Noah T; Confident, Gladyne; Duncan, Dustin T
Purpose: To date, no studies utilizing global positioning system (GPS) technologies to measure mobility and environmental exposures have been conducted among a sample of transgender women despite the potential salient role neighborhood contexts may play in the health of this population. As such, the purpose of this study was to assess the acceptability and feasibility of a weeklong GPS protocol among a sample of transgender women in New York City. Methods: A sample of 14 transgender women residing in the New York City metropolitan area were recruited through community based methods to wear and charge a GPS device for 7 days to measure daily mobility. The acceptability of these methods was assessed using a pre- and postprotocol survey and their feasibility was measured using objective data derived from the GPS device. Pre- and postprotocol survey measures were compared using McNemar's test. Results: Participants reported high ratings of preprotocol acceptability, as well as few concerns regarding safety, appearance, and losing the device, all of which were maintained after completing the protocol. All 14 devices that were distributed were returned. In addition, all 14 participants had GPS data for at least 1 h on 1 day, and nine participants (64.3%) had at least 8 h of GPS data on all days. Conclusion: The findings of this pilot study demonstrate that the GPS methods are both acceptable and feasible among this sample of transgender women. GPS devices may be used in research among transgender women to understand neighborhood determinants of HIV and other STIs.
PMCID:5627666
PMID: 29082330
ISSN: 2380-193x
CID: 2765112
Acceptability of Ecological Momentary Assessment Among Young Men Who Have Sex with Men
Duncan, Dustin T; Kapadia, Farzana; Kirchner, Thomas R; Goedel, William C; Brady, William J; Halkitis, Perry N
The study evaluated the acceptability of text message- and voice-based ecological momentary assessment (EMA) methods among a sample (n=74) of young men who have sex with men (MSM). We assessed the acceptability of text message- and voice-based EMA methods. Almost all participants (96%) reported that they would be willing to accept texts on their smartphone to answer questions about their current mood, surroundings, or feelings. A large majority (89%) also reported being willing to accept phone calls to answer these questions. This work suggests that different EMA methods are acceptable for use among young MSM.
PMCID:6034697
PMID: 29988981
ISSN: 1936-1653
CID: 3191592
Health literacy and child health outcomes: Parental health literacy and medication errors
Chapter by: Yin, H. Shonna
in: Health literacy and child health outcomes: Promoting effective health communication strategies to improve quality of care by Connelly, Rosina Avila [Ed]; Turner, Teri [Ed]
Cham, Switzerland: Springer International Publishing AG; Switzerland, 2017
pp. 19-38
ISBN: 978-3-319-50798-9
CID: 4781622
Using behavioral economics to improve dietary intake : alternatives to regulation, bans, and taxation
Chapter by: Bragg, Marie A; Elbel, Brian
in: Behavioral economics and healthy behaviors : key concepts and current research by Hanoch, Yaniv; Barnes, Andrew J; Rice, Thomas H [Eds]
Abingdon, Oxon ; New York, NY : Routledge, an imprint of the Taylor & Francis Group, 2017
pp. 91-105
ISBN: 9781315637938
CID: 2738602
Pre-Migration Trauma Exposure and Mental Health Functioning among Central American Migrants Arriving at the US Border
Keller, Allen; Joscelyne, Amy; Granski, Megan; Rosenfeld, Barry
In recent years, increasing numbers of families and individuals have arrived at the U.S. border from Central America, in particular, from Honduras, El Salvador, and Guatemala. This study sought to examine pre-migration trauma exposure and current mental health functioning of migrant families arriving at the U.S. border from the Northern Triangle region, with specific attention to the reasons offered for leaving their home country and the frequency with which migrant families appear to satisfy legal criteria for asylum We interviewed 234 adults in McAllen, Texas, using a structured interview and standardized questionnaires to assess exposure to trauma prior to migration, reasons for leaving their home country and symptoms of posttraumatic stress and depression. We found that 191 participants (83%) cited violence as a reason for fleeing their country, 119 individuals (69%) did not report the events to the police out of fear of gang-related retaliation or police corruption, and 90% (n = 204) reported being afraid to return to their native country. Based on self-report symptom checklists, 32% of the sample met diagnostic criteria for PTSD (n = 51), 24% for depression (n = 36), and 17% for both disorders (n = 25). Examining these data against the criteria for asylum in the U.S., we found that 70% of the overall sample (n = 159) met criteria for asylum, including 80% of those from El Salvador, 74% from Honduras, and 41% from Guatemala. These findings suggest that the majority of Central American migrants arriving at the U.S. border have significant mental health symptoms in response to violence and persecution, and warrant careful consideration for asylum status.
PMCID:5224987
PMID: 28072836
ISSN: 1932-6203
CID: 2400692
Huffpost, 2017
Drug Overdose, Addiction and Strategies Moving Forward
Roy, Lipi
(Website)CID: 2719252
Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
Soriano, Joan B.; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abera, Semaw Ferede; Agrawal, Anurag; Ahmed, Muktar Beshir; Aichour, Amani Nidhal; Aichour, Ibtihel; Aichour, Miloud Taki Eddine; Alam, Khurshid; Alam, Noore; Alkaabi, Juma M.; Al-Maskari, Fatma; Alvis-Guzman, Nelson; Amberbir, Alemayehu; Amoako, Yaw Ampem; Ansha, Mustafa Geleto; Anto, Josep M.; Asayesh, Hamid; Atey, Tesfay Mehari; Avokpaho, Euripide Frinel G. Arthur; Barac, Aleksandra; Basu, Sanjay; Bedi, Neeraj; Bensenor, Isabela M.; Berhane, Adugnaw; Beyene, Addisu Shunu; Bhutta, Zulfiqar A.; Biryukov, Stan; Boneya, Dube Jara; Brauer, Michael; Carpenter, David O.; Casey, Daniel; Christopher, Devasahayam Jesudas; Dandona, Lalit; Dandona, Rakhi; Dharmaratne, Samath D.; Huyen Phuc Do; Fischer, Florian; Geleto, Ayele; Ghoshal, Aloke Gopal; Gillum, Richard F.; Ginawi, Ibrahim Abdelmageem Mohamed; Gupta, Vipin; Hay, Simon I.; Hedayati, Mohammad T.; Horita, Nobuyuki; Hosgood, H. Dean; Jakovljevic, Mihajlo (Michael) B.; James, Spencer Lewis; Jonas, Jost B.; Kasaeian, Amir; Khader, Yousef Saleh; Khalil, Ibrahim A.; Khan, Ejaz Ahmad; Khang, Young-Ho; Khubchandani, Jagdish; Knibbs, Luke D.; Kosen, Soewarta; Koul, Parvaiz A.; Kumar, G. Anil; Leshargie, Cheru Tesema; Liang, Xiaofeng; Abd El Razek, Hassan Magdy; Majeed, Azeem; Malta, Deborah Carvalho; Manhertz, Treh; Marquez, Neal; Mehari, Alem; Mensah, George A.; Miller, Ted R.; Mohammad, Karzan Abdulmuhsin; Mohammed, Kedir Endris; Mohammed, Shafiu; Mokdad, Ali H.; Naghavi, Mohsen; Cuong Tat Nguyen; Nguyen, Grant; Quyen Le Nguyen; Trang Huyen Nguyen; Ningrum, Dina Nur Anggraini; Vuong Minh Nong; Obi, Jennifer Ifeoma; Odeyemi, Yewande E.; Ogbo, Felix Akpojene; Oren, Eyal; Mahesh, P. A.; Park, Eun-Kee; Patton, George C.; Paulson, Katherine; Qorbani, Mostafa; Quansah, Reginald; Rafay, Anwar; Rahman, Mohammad Hifz Ur; Rai, Rajesh Kumar; Rawaf, Salman; Reinig, Nik; Safiri, Saeid; Sarmiento-Suarez, Rodrigo; Sartorius, Benn; Savic, Miloje; Sawhney, Monika; Shigematsu, Mika; Smith, Mari; Tadese, Fentaw; Thurston, George D.; Topor-Madry, Roman; Tran, Bach Xuan; Ukwaja, Kingsley Nnanna; van Boven, Job F. M.; Vlassov, Vasiliy Victorovich; Vollset, Stein Emil; Wan, Xia; Werdecker, Andrea; Hanson, Sarah Wulf; Yano, Yuichiro; Yimam, Hassen Hamid; Yonemoto, Naohiro; Yu, Chuanhua; Zaidi, Zoubida; Zaki, Maysaa El Sayed; Murray, Christopher J. L.; Vos, Theo
ISI:000408367900018
ISSN: 2213-2600
CID: 4703082
Feasibility of Treating Hepatitis C in a Transient Jail Population
MacDonald, Ross; Akiyama, Matthew J; Kopolow, Aimee; Rosner, Zachary; McGahee, Wendy; Joseph, Rodrigue; Jaffer, Mohamed; Venters, Homer
Jails represent a critical component of the public health response to HCV elimination. We report on outcomes of 104 patients receiving HCV treatment from January 1, 2014 to June 30, 2016 in a large urban jail setting. Our data demonstrate that treatment in jails is feasible, but many barriers remain.
PMCID:5569928
PMID: 28852680
ISSN: 2328-8957
CID: 4533002