Faculty Bibliography

Objective: This study examines the impact of the Family Connections (FC) intervention on preventing behavioral problems among urban, predominantly African American children at risk of neglect. Method: Secondary data analyses using mixed model analyses of variance (ANOVA) with repeated measures were used to examine gender differences in child behavior outcomes among 111 participating families across three time points (intake, closing, and 6 months following intervention participation). Results: From intake to closing, boys appeared to experience a larger decrease in internalizing and externalizing behaviors than girls. At 6-month follow-up, boys' behaviors remained stable relative to results at closing; girls showed a slight decrease in behaviors over the same period. Findings also indicate a greater decrease in problem behaviors for participants in the 9-month versus 3-month version of FC. Conclusions: Positive effects of the FC intervention for African American children indicate the potential of this prevention intervention to avert negative behavior trajectories.

Objective: The purpose of this study is to assess the reliability and validity of the North Carolina Family Assessment Scale (NCFAS) among families involved with youth mental health services. Methods: Using NCFAS data collected by child mental health intake workers with 158 families, factor analysis was conducted to assess factor structure, and thematic analysis of intake notes was used to test content validity. Results: This study found only three NCFAS subscales. The case notes included themes specific to youth with mental health needs that were not captured by current NCFAS items. Conclusions: This study suggests variation in the fit for the NCFAS in child mental health services compared to the measurement properties established in child welfare samples.

This study examined how restricted and repetitive behaviors and interests (RRBs) developed over time in a sample of children with autism spectrum disorders (ASD). One hundred ninety-two children referred for a diagnosis of autism at age 2, and 22 children with nonspectrum development disorders were evaluated with a battery of cognitive and diagnostic measures at age 2 and subsequently at ages 3, 5, and 9. Factor analysis of the RRB items on the Autism Diagnostic Interview-Revised revealed two RRB factors at each wave of data collection, one comprising 'repetitive sensorimotor' (RSM) behaviors and the other 'insistence on sameness' (IS) behaviors. For children with ASD, RSM scores remained relatively high over time, indicating consistent severity, whereas IS scores started low and increased over time, indicating worsening. Having a higher nonverbal intelligence (NVIQ) at age 2 was associated with milder concurrent RSM behaviors and with improvement in these behaviors over time. There was no relationship between NVIQ at age 2 and IS behaviors. However, milder social/communicative impairment, at age 2 was associated with more severe concurrent IS behaviors. Trajectory analysis revealed considerable heterogeneity in patterns of change over time for both kinds of behaviors. These findings are discussed in terms of their implications for our understanding of RRBs in ASD and other disorders, making prognoses about how RRBs will develop in children with ASD as they get older, and using RRBs to identify ASD phenotypes in genetic studies

Spontaneous very low frequency oscillations (< 0.5 Hz) occurring within widely distributed neuroanatomical systems have been increasingly analyzed in brain imaging studies. Whilst being more prominent in the resting brain, these slow waves also persist into task sessions and may potentially interfere with active goal-directed attention, leading to periodic lapses in attention during task execution. This work presents a new experimental framework and a multistage signal processing methodology - comprising blind source separation (BSS) coupled with a neural network feature extraction and classification method - developed for assessing variations in the slow wave characteristics in EEG data recorded during periods of quiet wakefulness (termed as 'rest'), and during visual tasks of various difficulty levels. Core results demonstrate that the amplitude and phase of the brain sources in the slow wave band share essential similarities during rest and task conditions, but are distinct enough to be classified separately. These slow wave variations are also significantly correlated with the level of cognitive attention assessed by task performance measures (such as reaction times and error rates). Moreover, the power of the brain sources in the slow wave band is attenuated during task, and the level of attenuation drops as the task difficulty level is increased, whilst the slow wave phase undergoes a change in structure (measured through entropy). The methodology and findings presented here provide a new basis for assessing neural activity during various mental conditions

This article presents theory and rationale for game-based cognitive-behavioral therapy (GB-CBT), an integrative group modality for treating elementary school-aged children who have been sexually abused. GB-CBT incorporates evidence-based elements from cognitive-behavioral therapy, play therapy, and group therapy. The model's curriculum contains topics that have been demonstrated to be effective for treating child sexual abuse, including communication skills, emotional expression skills, psycho-education about child abuse, exposure and processing of sexual abuse, and self-protection and coping skills. Treatment is delivered in a fun and engaging manner utilizing developmentally appropriate games (DAGs) as the primary therapeutic technique. GB-CBT was designed to address behavioral problems and symptoms typically associated with child sexual abuse and aims to enhance children's knowledge of abuse and self-protection skills

Norepinephrine (NE) is thought to play a key role in fear and anxiety, but its role in amygdala-dependent Pavlovian fear conditioning, a major model for understanding the neural basis of fear, is poorly understood. The lateral nucleus of the amygdala (LA) is a critical brain region for fear learning and regulating the effects of stress on memory. To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DbetaH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (betaARs), one that predominately recognizes neurons (betaAR 248) and the other astrocytes (betaAR 404), to characterize the microenvironments of DbetaH and betaAR. By electron microscopy, most DbetaH terminals did not make synapses, but when they did, they formed both asymmetric and symmetric synapses. By light microscopy, betaARs were present in both neurons and astrocytes. Confocal microscopy revealed that both excitatory and inhibitory neurons express betaAR248. By electron microscopy, betaAR 248 was present in neuronal cell bodies, dendritic shafts and spines, and some axon terminals and astrocytes. When in dendrites and spines, betaAR 248 was frequently concentrated along plasma membranes and at post-synaptic densities of asymmetric (excitatory) synapses. betaAR 404 was expressed predominately in astrocytic cell bodies and processes. These astrocytic processes were frequently interposed between unlabeled terminals or ensheathed asymmetric synapses. Our findings provide a morphological basis for understanding ways in which NE may modulate transmission by acting via synaptic or non-synaptic mechanisms in the LA

The ongoing Israeli-Palestinian conflict has taken its toll on both sides. Prominent among peace building initiatives is the Parents Circle-Families Forum, a cross-community peace building project of bereaved families. We examine the grieving process and emotional well-being of a sample of 21 Israeli Jews and Palestinians living in the West Bank, who have lost their loved ones in the context of ongoing war and armed conflict. We also investigate whether the positive attitudes and emotions toward the opposing groups can serve as protective factors associated with prolonged grief disorder (PGD). The most prominent finding of our study is that some attitudes (e.g., a positive attitude toward peace, being hopeful about the future, the ability to forgive the opposing group) can be considered protective factors associated with PGD. People-to-people peace building initiatives, such as the Parents Circle-Families Forum, reinforce these factors. Furthermore, they provide their members with social support and a strong sense of mutual commitment and responsibility, facilitating their grieving process, and emotional well-being.

Beta-adrenergic receptors (betaARs) have long been associated with fear disorders and with learning and memory. However, the contribution of these receptors to Pavlovian fear conditioning, a leading behavioral model for studying fear learning and memory, is still poorly understood. The aim of this study was to investigate the involvement of betaAR activation in the acquisition, consolidation and expression of fear conditioning. We focused on manipulations of betaARs in the lateral nucleus of the amygdala (LA) because of the well-established contribution of this area to fear conditioning. Specifically, we tested the effects of intra-LA microinfusions of the betaAR antagonist, propranolol, on learning and memory for auditory Pavlovian fear conditioning in rats. Pre-training propranolol infusions disrupted the initial acquisition, short-term memory (STM), and long-term memory (LTM) for fear conditioning, but infusions immediately after training had no effect. Further, infusion of propranolol prior to testing fear responses did not affect fear memory expression. These findings indicate that amygdala betaARs are important for the acquisition but not the consolidation of fear conditioning.