Searched for: school:SOM
Department/Unit:Neuroscience Institute
Familial dysautonomia (Riley-Day syndrome)
Chapter by: Norcliffe-Kaufmann, Lucy; Kaufmann, Horacio
in: Primer on the Autonomic Nervous System, Fourth Edition by
[S.l.] : Elsevier, 2022
pp. 527-531
ISBN: 9780323854931
CID: 5447152
Trends in ASD Pharmacological Research: An Analysis of ClinicalTrials.gov
Cervantes, Paige E.; Conlon, Greta R.; Shalev, Rebecca A.; Castellanos, F. Xavier
Despite decades of research, both understanding and availability of pharmacological interventions for autistic people are limited. We examined characteristics of pharmacological trials on ClinicalTrials.gov (N = 235) to elucidate trends, identify gaps, and suggest future research directions. We observed that trials predominantly sampled school-aged children and adolescents and focused largely on core autism symptoms, neglecting younger children and adults as well as associated symptom domains often identified by stakeholders as treatment priorities. A variety of intervention agents were trialed, with nearly 60% appearing in just one study. Notably, in line with previous research, there was little consistency in outcome measures used, with the majority (58.9%) used in only one trial. Innovation in research strategies is urgently needed; potential directions for such changes are discussed.
SCOPUS:85122512584
ISSN: 2195-7177
CID: 5145062
Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited)
Chapter by: Ko, Eunah; Kim, Kanghwan; Voroslakos, Mihaly; Oh, Sungjin; Buzsaki, Gyorgy; Wise, Kensall D.; Yoon, Euisk
in: Technical Digest - International Electron Devices Meeting, IEDM by
[S.l.] : Institute of Electrical and Electronics Engineers Inc., 2022
pp. 2911-2914
ISBN: 9781665489591
CID: 5424792
Epilepsy
Chapter by: Scharfman, Helen E.; Peterson, Allison; Binder, Devin K.
in: Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition by
[S.l.] : Elsevier, 2022
pp. 753-780
ISBN: 9780323898256
CID: 5369582
Myocardial stunning and takotsubo cardiomyopathy
Chapter by: Norcliffe-Kaufmann, Lucy
in: Primer on the Autonomic Nervous System, Fourth Edition by
[S.l.] : Elsevier, 2022
pp. 489-494
ISBN: 9780323854931
CID: 5447122
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years
Dima, Danai; Modabbernia, Amirhossein; Papachristou, Efstathios; Doucet, Gaelle E; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andersson, Micael; Andreasen, Nancy C; Andreassen, Ole A; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Buckner, Randy L; Calhoun, Vincent; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Cervenka, Simon; Chaim-Avancini, Tiffany M; Ching, Christopher R K; Chubar, Victoria; Clark, Vincent P; Conrod, Patricia; Conzelmann, Annette; Crespo-Facorro, Benedicto; Crivello, Fabrice; Crone, Eveline A; Dale, Anders M; Davey, Christopher; de Geus, Eco J C; de Haan, Lieuwe; de Zubicaray, Greig I; den Braber, Anouk; Dickie, Erin W; Di Giorgio, Annabella; Doan, Nhat Trung; Dørum, Erlend S; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fatouros-Bergman, Helena; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Frodl, Thomas; Fuentes-Claramonte, Paola; Glahn, David C; Gotlib, Ian H; Grabe, Hans-Jörgen; Grimm, Oliver; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Gur, Rachel E; Gur, Ruben C; Harrison, Ben J; Hartman, Catharine A; Hatton, Sean N; Heinz, Andreas; Heslenfeld, Dirk J; Hibar, Derrek P; Hickie, Ian B; Ho, Beng-Choon; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jernigan, Terry L; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kahn, Rene; Kalnin, Andrew; Kanai, Ryota; Klein, Marieke; Klyushnik, Tatyana P; Koenders, Laura; Koops, Sanne; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lázaro, Luisa; Lebedeva, Irina; Lee, Won Hee; Lesch, Klaus-Peter; Lochner, Christine; Machielsen, Marise W J; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Colm; McDonald, Brenna C; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; Menchón, José M; Medland, Sarah E; Meyer-Lindenberg, Andreas; Naaijen, Jilly; Najt, Pablo; Nakao, Tomohiro; Nordvik, Jan E; Nyberg, Lars; Oosterlaan, Jaap; de la Foz, VÃctor Ortiz-García; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Potkin, Steven G; Radua, Joaquim; Reif, Andreas; Rinker, Daniel A; Roffman, Joshua L; Rosa, Pedro G P; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sánchez-Juan, Pascual; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Schmaal, Lianne; Schnell, Knut; Schumann, Gunter; Sim, Kang; Smoller, Jordan W; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Swagerman, Suzanne C; Tamnes, Christian K; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Tordesillas-Gutiérrez, Diana; Trollor, Julian N; Turner, Jessica A; Uhlmann, Anne; van den Heuvel, Odile A; van den Meer, Dennis; van der Wee, Nic J A; van Haren, Neeltje E M; Van't Ent, Dennis; van Erp, Theo G M; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Walton, Esther; Wang, Lei; Wang, Yang; Wassink, Thomas H; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather; Wierenga, Lara M; Williams, Steven C R; Wittfeld, Katharina; Wolf, Daniel H; Worker, Amanda; Wright, Margaret J; Yang, Kun; Yoncheva, Yulyia; Zanetti, Marcus V; Ziegler, Georg C; Thompson, Paul M; Frangou, Sophia
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
PMID: 33570244
ISSN: 1097-0193
CID: 4799802
Neurophotonic tools for microscopic measurements and manipulation: status report
Abdelfattah, Ahmed S; Ahuja, Sapna; Akkin, Taner; Allu, Srinivasa Rao; Brake, Joshua; Boas, David A; Buckley, Erin M; Campbell, Robert E; Chen, Anderson I; Cheng, Xiaojun; ÄŒižmár, Tomáš; Costantini, Irene; De Vittorio, Massimo; Devor, Anna; Doran, Patrick R; El Khatib, Mirna; Emiliani, Valentina; Fomin-Thunemann, Natalie; Fainman, Yeshaiahu; Fernandez-Alfonso, Tomas; Ferri, Christopher G L; Gilad, Ariel; Han, Xue; Harris, Andrew; Hillman, Elizabeth M C; Hochgeschwender, Ute; Holt, Matthew G; Ji, Na; Kılıç, Kıvılcım; Lake, Evelyn M R; Li, Lei; Li, Tianqi; Mächler, Philipp; Miller, Evan W; Mesquita, Rickson C; Nadella, K M Naga Srinivas; Nägerl, U Valentin; Nasu, Yusuke; Nimmerjahn, Axel; OndráÄková, Petra; Pavone, Francesco S; Perez Campos, Citlali; Peterka, Darcy S; Pisano, Filippo; Pisanello, Ferruccio; Puppo, Francesca; Sabatini, Bernardo L; Sadegh, Sanaz; Sakadzic, Sava; Shoham, Shy; Shroff, Sanaya N; Silver, R Angus; Sims, Ruth R; Smith, Spencer L; Srinivasan, Vivek J; Thunemann, Martin; Tian, Lei; Tian, Lin; Troxler, Thomas; Valera, Antoine; Vaziri, Alipasha; Vinogradov, Sergei A; Vitale, Flavia; Wang, Lihong V; UhlÃÅ™ová, Hana; Xu, Chris; Yang, Changhuei; Yang, Mu-Han; Yellen, Gary; Yizhar, Ofer; Zhao, Yongxin
PMCID:9047450
PMID: 35493335
ISSN: 2329-423x
CID: 5215772
Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure
Hoogman, Martine; van Rooij, Daan; Klein, Marieke; Boedhoe, Premika; Ilioska, Iva; Li, Ting; Patel, Yash; Postema, Merel C; Zhang-James, Yanli; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume; Banaschewski, Tobias; Bau, Claiton H D; Behrmann, Marlene; Bellgrove, Mark A; Brandeis, Daniel; Brem, Silvia; Busatto, Geraldo F; Calderoni, Sara; Calvo, Rosa; Castellanos, Francisco X; Coghill, David; Conzelmann, Annette; Daly, Eileen; Deruelle, Christine; Dinstein, Ilan; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Epstein, Jeffery N; Fair, Damien A; Fitzgerald, Jacqueline; Freitag, Christine M; Frodl, Thomas; Gallagher, Louise; Grevet, Eugenio H; Haavik, Jan; Hoekstra, Pieter J; Janssen, Joost; Karkashadze, Georgii; King, Joseph A; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lerch, Jason P; Lesch, Klaus-Peter; Louza, Mario R; Luna, Beatriz; Mattos, Paulo; McGrath, Jane; Muratori, Filippo; Murphy, Clodagh; Nigg, Joel T; Oberwelland-Weiss, Eileen; O'Gorman Tuura, Ruth L; O'Hearn, Kirsten; Oosterlaan, Jaap; Parellada, Mara; Pauli, Paul; Plessen, Kerstin J; Ramos-Quiroga, J Antoni; Reif, Andreas; Reneman, Liesbeth; Retico, Alessandra; Rosa, Pedro G P; Rubia, Katya; Shaw, Philip; Silk, Tim J; Tamm, Leanne; Vilarroya, Oscar; Walitza, Susanne; Jahanshad, Neda; Faraone, Stephen V; Francks, Clyde; van den Heuvel, Odile A; Paus, Tomas; Thompson, Paul M; Buitelaar, Jan K; Franke, Barbara
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
PMID: 32420680
ISSN: 1097-0193
CID: 4446612
Greater male than female variability in regional brain structure across the lifespan
Wierenga, Lara M; Doucet, Gaelle E; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andreassen, Ole A; Anticevic, Alan; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; den Braber, Anouk; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Calhoun, Vince D; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Chaim-Avancini, Tiffany M; Ching, Christopher Rk; Clark, Vincent P; Conrod, Patricia J; Conzelmann, Annette; Crivello, Fabrice; Davey, Christopher G; Dickie, Erin W; Ehrlich, Stefan; Van't Ent, Dennis; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Fuentes-Claramonte, Paola; de Geus, Eco Jc; Di Giorgio, Annabella; Glahn, David C; Gotlib, Ian H; Grabe, Hans J; Gruber, Oliver; Gruner, Patricia; Gur, Raquel E; Gur, Ruben C; Gurholt, Tiril P; de Haan, Lieuwe; Haatveit, Beathe; Harrison, Ben J; Hartman, Catharina A; Hatton, Sean N; Heslenfeld, Dirk J; van den Heuvel, Odile A; Hickie, Ian B; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony C; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kalnin, Andrew J; Klein, Marieke; Koenders, Laura; KolskÃ¥r, Knut K; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lazaro, Luisa; Lebedeva, Irina S; Lee, Phil H; Lochner, Christine; Machielsen, Marise Wj; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Brenna C; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; van der Meer, Dennis; Menchón, José M; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Radua, Joaquim; Reif, Andreas; Richard, Geneviève; Roffman, Joshua L; Rosa, Pedro Gp; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Sim, Kang; Simmons, Andrew; Smoller, Jordan W; Sommer, Iris E; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Szeszko, Philip R; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Trollor, Julian N; Uhlmann, Anne; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Wang, Lei; Wang, Yang; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather C; Williams, Steven Cr; Wittfeld, Katharina; Wolf, Daniel H; Wright, Margaret J; Yoncheva, Yuliya N; Zanetti, Marcus V; Ziegler, Georg C; de Zubicaray, Greig I; Thompson, Paul M; Crone, Eveline A; Frangou, Sophia; Tamnes, Christian K
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
PMID: 33044802
ISSN: 1097-0193
CID: 4632482
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years
Frangou, Sophia; Modabbernia, Amirhossein; Williams, Steven C R; Papachristou, Efstathios; Doucet, Gaelle E; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andersson, Micael; Andreasen, Nancy C; Andreassen, Ole A; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Buckner, Randy L; Calhoun, Vincent; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Cervenka, Simon; Chaim-Avancini, Tiffany M; Ching, Christopher R K; Chubar, Victoria; Clark, Vincent P; Conrod, Patricia; Conzelmann, Annette; Crespo-Facorro, Benedicto; Crivello, Fabrice; Crone, Eveline A; Dale, Anders M; Davey, Christopher; de Geus, Eco J C; de Haan, Lieuwe; de Zubicaray, Greig I; den Braber, Anouk; Dickie, Erin W; Di Giorgio, Annabella; Doan, Nhat Trung; Dørum, Erlend S; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fatouros-Bergman, Helena; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Frodl, Thomas; Fuentes-Claramonte, Paola; Glahn, David C; Gotlib, Ian H; Grabe, Hans-Jörgen; Grimm, Oliver; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Gur, Rachel E; Gur, Ruben C; Harrison, Ben J; Hartman, Catharine A; Hatton, Sean N; Heinz, Andreas; Heslenfeld, Dirk J; Hibar, Derrek P; Hickie, Ian B; Ho, Beng-Choon; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jernigan, Terry L; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kahn, Rene; Kalnin, Andrew; Kanai, Ryota; Klein, Marieke; Klyushnik, Tatyana P; Koenders, Laura; Koops, Sanne; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lázaro, Luisa; Lebedeva, Irina; Lee, Won Hee; Lesch, Klaus-Peter; Lochner, Christine; Machielsen, Marise W J; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Colm; McDonald, Brenna C; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; Menchón, José M; Medland, Sarah E; Meyer-Lindenberg, Andreas; Naaijen, Jilly; Najt, Pablo; Nakao, Tomohiro; Nordvik, Jan E; Nyberg, Lars; Oosterlaan, Jaap; de la Foz, VÃctor Ortiz-García; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Potkin, Steven G; Radua, Joaquim; Reif, Andreas; Rinker, Daniel A; Roffman, Joshua L; Rosa, Pedro G P; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sánchez-Juan, Pascual; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Schmaal, Lianne; Schnell, Knut; Schumann, Gunter; Sim, Kang; Smoller, Jordan W; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Swagerman, Suzanne C; Tamnes, Christian K; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Tordesillas-Gutiérrez, Diana; Trollor, Julian N; Turner, Jessica A; Uhlmann, Anne; van den Heuvel, Odile A; van den Meer, Dennis; van der Wee, Nic J A; van Haren, Neeltje E M; van 't Ent, Dennis; van Erp, Theo G M; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Walton, Esther; Wang, Lei; Wang, Yang; Wassink, Thomas H; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather; Wierenga, Lara M; Wittfeld, Katharina; Wolf, Daniel H; Worker, Amanda; Wright, Margaret J; Yang, Kun; Yoncheva, Yulyia; Zanetti, Marcus V; Ziegler, Georg C; Thompson, Paul M; Dima, Danai
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
PMID: 33595143
ISSN: 1097-0193
CID: 4799902
