Searched for: school:SOM
Department/Unit:Neuroscience Institute
Sensitive and robust chemical detection using an olfactory brain-computer interface
Shor, Erez; Herrero-Vidal, Pedro; Dewan, Adam; Uguz, Ilke; Curto, Vincenzo F; Malliaras, George G; Savin, Cristina; Bozza, Thomas; Rinberg, Dmitry
When it comes to detecting volatile chemicals, biological olfactory systems far outperform all artificial chemical detection devices in their versatility, speed, and specificity. Consequently, the use of trained animals for chemical detection in security, defense, healthcare, agriculture, and other applications has grown astronomically. However, the use of animals in this capacity requires extensive training and behavior-based communication. Here we propose an alternative strategy, a bio-electronic nose, that capitalizes on the superior capability of the mammalian olfactory system, but bypasses behavioral output by reading olfactory information directly from the brain. We engineered a brain-computer interface that captures neuronal signals from an early stage of olfactory processing in awake mice combined with machine learning techniques to form a sensitive and selective chemical detector. We chronically implanted a grid electrode array on the surface of the mouse olfactory bulb and systematically recorded responses to a large battery of odorants and odorant mixtures across a wide range of concentrations. The bio-electronic nose has a comparable sensitivity to the trained animal and can detect odors on a variable background. We also introduce a novel genetic engineering approach that modifies the relative abundance of particular olfactory receptors in order to improve the sensitivity of our bio-electronic nose for specific chemical targets. Our recordings were stable over months, providing evidence for robust and stable decoding over time. The system also works in freely moving animals, allowing chemical detection to occur in real-world environments. Our bio-electronic nose outperforms current methods in terms of its stability, specificity, and versatility, setting a new standard for chemical detection.
PMID: 34624799
ISSN: 1873-4235
CID: 5037662
A Miniaturized 256-Channel Neural Recording Interface with Area-Efficient Hybrid Integration of Flexible Probes and CMOS Integrated Circuits
Park, Sung-Yun; Kyounghwan, Na; Voroslakos, Mihaly; Song, Hyunsoo; Slager, Nathan; Oh, Sungjin; Seymour, John P; Buzsaki, Gyorgy; Yoon, Euisik
We report a miniaturized, minimally invasive high-density neural recording interface that occupies only a 1.53 mm2 footprint for hybrid integration of a flexible probe and a 256-channel integrated circuit chip. To achieve such a compact form factor, we developed a custom flip-chip bonding technique using anisotropic conductive film and analog circuit-under-pad in a tiny pitch of 75 m. To enhance signal-to-noise ratios, we applied a reference-replica topology that can provide the matched input impedance for signal and reference paths in low-noise aimpliers (LNAs). The analog front-end (AFE) consists of LNAs, buffers, programmable gain amplifiers, 10b ADCs, a reference generator, a digital controller, and serial-peripheral interfaces (SPIs). The AFE consumes 51.92 W from 1.2 V and 1.8 V supplies in an area of 0.0161 mm2 per channel, implemented in a 180 nm CMOS process. The AFE shows > 60 dB mid-band CMRR, 6.32 Vrms input-referred noise from 0.5 Hz to 10 kHz, and 48 M input impedance at 1 kHz. The fabricated AFE chip was directly flip-chip bonded with a 256-channel flexible polyimide neural probe and assembled in a tiny head-stage PCB. Full functionalities of the fabricated 256-channel interface were validated in both in vitro and in vivo experiments, demonstrating the presented hybrid neural recording interface is suitable for various neuroscience studies in the quest of large scale, miniaturized recording systems.
PMID: 34191721
ISSN: 1558-2531
CID: 4926652
Greater male than female variability in regional brain structure across the lifespan
Wierenga, Lara M; Doucet, Gaelle E; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andreassen, Ole A; Anticevic, Alan; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; den Braber, Anouk; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Calhoun, Vince D; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Chaim-Avancini, Tiffany M; Ching, Christopher Rk; Clark, Vincent P; Conrod, Patricia J; Conzelmann, Annette; Crivello, Fabrice; Davey, Christopher G; Dickie, Erin W; Ehrlich, Stefan; Van't Ent, Dennis; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Fuentes-Claramonte, Paola; de Geus, Eco Jc; Di Giorgio, Annabella; Glahn, David C; Gotlib, Ian H; Grabe, Hans J; Gruber, Oliver; Gruner, Patricia; Gur, Raquel E; Gur, Ruben C; Gurholt, Tiril P; de Haan, Lieuwe; Haatveit, Beathe; Harrison, Ben J; Hartman, Catharina A; Hatton, Sean N; Heslenfeld, Dirk J; van den Heuvel, Odile A; Hickie, Ian B; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony C; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kalnin, Andrew J; Klein, Marieke; Koenders, Laura; KolskÃ¥r, Knut K; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lazaro, Luisa; Lebedeva, Irina S; Lee, Phil H; Lochner, Christine; Machielsen, Marise Wj; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Brenna C; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; van der Meer, Dennis; Menchón, José M; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Radua, Joaquim; Reif, Andreas; Richard, Geneviève; Roffman, Joshua L; Rosa, Pedro Gp; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Sim, Kang; Simmons, Andrew; Smoller, Jordan W; Sommer, Iris E; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Szeszko, Philip R; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Trollor, Julian N; Uhlmann, Anne; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Wang, Lei; Wang, Yang; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather C; Williams, Steven Cr; Wittfeld, Katharina; Wolf, Daniel H; Wright, Margaret J; Yoncheva, Yuliya N; Zanetti, Marcus V; Ziegler, Georg C; de Zubicaray, Greig I; Thompson, Paul M; Crone, Eveline A; Frangou, Sophia; Tamnes, Christian K
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
PMID: 33044802
ISSN: 1097-0193
CID: 4632482
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years
Dima, Danai; Modabbernia, Amirhossein; Papachristou, Efstathios; Doucet, Gaelle E; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andersson, Micael; Andreasen, Nancy C; Andreassen, Ole A; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Buckner, Randy L; Calhoun, Vincent; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Cervenka, Simon; Chaim-Avancini, Tiffany M; Ching, Christopher R K; Chubar, Victoria; Clark, Vincent P; Conrod, Patricia; Conzelmann, Annette; Crespo-Facorro, Benedicto; Crivello, Fabrice; Crone, Eveline A; Dale, Anders M; Davey, Christopher; de Geus, Eco J C; de Haan, Lieuwe; de Zubicaray, Greig I; den Braber, Anouk; Dickie, Erin W; Di Giorgio, Annabella; Doan, Nhat Trung; Dørum, Erlend S; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fatouros-Bergman, Helena; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Frodl, Thomas; Fuentes-Claramonte, Paola; Glahn, David C; Gotlib, Ian H; Grabe, Hans-Jörgen; Grimm, Oliver; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Gur, Rachel E; Gur, Ruben C; Harrison, Ben J; Hartman, Catharine A; Hatton, Sean N; Heinz, Andreas; Heslenfeld, Dirk J; Hibar, Derrek P; Hickie, Ian B; Ho, Beng-Choon; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jernigan, Terry L; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kahn, Rene; Kalnin, Andrew; Kanai, Ryota; Klein, Marieke; Klyushnik, Tatyana P; Koenders, Laura; Koops, Sanne; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lázaro, Luisa; Lebedeva, Irina; Lee, Won Hee; Lesch, Klaus-Peter; Lochner, Christine; Machielsen, Marise W J; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Colm; McDonald, Brenna C; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; Menchón, José M; Medland, Sarah E; Meyer-Lindenberg, Andreas; Naaijen, Jilly; Najt, Pablo; Nakao, Tomohiro; Nordvik, Jan E; Nyberg, Lars; Oosterlaan, Jaap; de la Foz, VÃctor Ortiz-García; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Potkin, Steven G; Radua, Joaquim; Reif, Andreas; Rinker, Daniel A; Roffman, Joshua L; Rosa, Pedro G P; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sánchez-Juan, Pascual; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Schmaal, Lianne; Schnell, Knut; Schumann, Gunter; Sim, Kang; Smoller, Jordan W; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Swagerman, Suzanne C; Tamnes, Christian K; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Tordesillas-Gutiérrez, Diana; Trollor, Julian N; Turner, Jessica A; Uhlmann, Anne; van den Heuvel, Odile A; van den Meer, Dennis; van der Wee, Nic J A; van Haren, Neeltje E M; Van't Ent, Dennis; van Erp, Theo G M; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Walton, Esther; Wang, Lei; Wang, Yang; Wassink, Thomas H; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather; Wierenga, Lara M; Williams, Steven C R; Wittfeld, Katharina; Wolf, Daniel H; Worker, Amanda; Wright, Margaret J; Yang, Kun; Yoncheva, Yulyia; Zanetti, Marcus V; Ziegler, Georg C; Thompson, Paul M; Frangou, Sophia
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
PMID: 33570244
ISSN: 1097-0193
CID: 4799802
Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity
Liu, Jing-Jing; Tsien, Richard W; Pang, Zhiping P
Hypothalamic melanin-concentrating hormone (MCH) polypeptide contributes to regulating energy homeostasis, sleep and memory, although the mechanistic bases of its effects are unknown. In this study, in mice, we uncovered the physiological mechanism underlying the functional role of MCH signaling in projections to the dorsolateral septum (dLS), a region involved in routing hippocampal firing rhythms and encoding spatial memory based on such rhythms. Firing activity within the dLS in response to dorsal CA3 (dCA3) excitation is limited by strong feed-forward inhibition (FFI). We found that MCH synchronizes dLS neuronal firing with its dCA3 inputs by enhancing GABA release, which subsequently reduces the FFI and augments dCA3 excitatory input strength, both via pre-synaptic mechanisms. At the functional level, our data reveal a role for MCH signaling in the dLS in facilitating spatial memory. These findings support a model in which peptidergic signaling within the dLS modulates dorsal hippocampal output and supports memory encoding.
PMCID:8741735
PMID: 34980924
ISSN: 1546-1726
CID: 5106932
Neurophotonic tools for microscopic measurements and manipulation: status report
Abdelfattah, Ahmed S; Ahuja, Sapna; Akkin, Taner; Allu, Srinivasa Rao; Brake, Joshua; Boas, David A; Buckley, Erin M; Campbell, Robert E; Chen, Anderson I; Cheng, Xiaojun; ÄŒižmár, Tomáš; Costantini, Irene; De Vittorio, Massimo; Devor, Anna; Doran, Patrick R; El Khatib, Mirna; Emiliani, Valentina; Fomin-Thunemann, Natalie; Fainman, Yeshaiahu; Fernandez-Alfonso, Tomas; Ferri, Christopher G L; Gilad, Ariel; Han, Xue; Harris, Andrew; Hillman, Elizabeth M C; Hochgeschwender, Ute; Holt, Matthew G; Ji, Na; Kılıç, Kıvılcım; Lake, Evelyn M R; Li, Lei; Li, Tianqi; Mächler, Philipp; Miller, Evan W; Mesquita, Rickson C; Nadella, K M Naga Srinivas; Nägerl, U Valentin; Nasu, Yusuke; Nimmerjahn, Axel; OndráÄková, Petra; Pavone, Francesco S; Perez Campos, Citlali; Peterka, Darcy S; Pisano, Filippo; Pisanello, Ferruccio; Puppo, Francesca; Sabatini, Bernardo L; Sadegh, Sanaz; Sakadzic, Sava; Shoham, Shy; Shroff, Sanaya N; Silver, R Angus; Sims, Ruth R; Smith, Spencer L; Srinivasan, Vivek J; Thunemann, Martin; Tian, Lei; Tian, Lin; Troxler, Thomas; Valera, Antoine; Vaziri, Alipasha; Vinogradov, Sergei A; Vitale, Flavia; Wang, Lihong V; UhlÃÅ™ová, Hana; Xu, Chris; Yang, Changhuei; Yang, Mu-Han; Yellen, Gary; Yizhar, Ofer; Zhao, Yongxin
PMCID:9047450
PMID: 35493335
ISSN: 2329-423x
CID: 5215772
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years
Frangou, Sophia; Modabbernia, Amirhossein; Williams, Steven C R; Papachristou, Efstathios; Doucet, Gaelle E; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andersson, Micael; Andreasen, Nancy C; Andreassen, Ole A; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Buckner, Randy L; Calhoun, Vincent; Canales-RodrÃguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Cervenka, Simon; Chaim-Avancini, Tiffany M; Ching, Christopher R K; Chubar, Victoria; Clark, Vincent P; Conrod, Patricia; Conzelmann, Annette; Crespo-Facorro, Benedicto; Crivello, Fabrice; Crone, Eveline A; Dale, Anders M; Davey, Christopher; de Geus, Eco J C; de Haan, Lieuwe; de Zubicaray, Greig I; den Braber, Anouk; Dickie, Erin W; Di Giorgio, Annabella; Doan, Nhat Trung; Dørum, Erlend S; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fatouros-Bergman, Helena; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Frodl, Thomas; Fuentes-Claramonte, Paola; Glahn, David C; Gotlib, Ian H; Grabe, Hans-Jörgen; Grimm, Oliver; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Gur, Rachel E; Gur, Ruben C; Harrison, Ben J; Hartman, Catharine A; Hatton, Sean N; Heinz, Andreas; Heslenfeld, Dirk J; Hibar, Derrek P; Hickie, Ian B; Ho, Beng-Choon; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony; Jernigan, Terry L; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kahn, Rene; Kalnin, Andrew; Kanai, Ryota; Klein, Marieke; Klyushnik, Tatyana P; Koenders, Laura; Koops, Sanne; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lázaro, Luisa; Lebedeva, Irina; Lee, Won Hee; Lesch, Klaus-Peter; Lochner, Christine; Machielsen, Marise W J; Maingault, Sophie; Martin, Nicholas G; Martínez-ZalacaÃn, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Colm; McDonald, Brenna C; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; Menchón, José M; Medland, Sarah E; Meyer-Lindenberg, Andreas; Naaijen, Jilly; Najt, Pablo; Nakao, Tomohiro; Nordvik, Jan E; Nyberg, Lars; Oosterlaan, Jaap; de la Foz, VÃctor Ortiz-García; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Potkin, Steven G; Radua, Joaquim; Reif, Andreas; Rinker, Daniel A; Roffman, Joshua L; Rosa, Pedro G P; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sánchez-Juan, Pascual; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Schmaal, Lianne; Schnell, Knut; Schumann, Gunter; Sim, Kang; Smoller, Jordan W; Sommer, Iris; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Swagerman, Suzanne C; Tamnes, Christian K; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Tordesillas-Gutiérrez, Diana; Trollor, Julian N; Turner, Jessica A; Uhlmann, Anne; van den Heuvel, Odile A; van den Meer, Dennis; van der Wee, Nic J A; van Haren, Neeltje E M; van 't Ent, Dennis; van Erp, Theo G M; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Walton, Esther; Wang, Lei; Wang, Yang; Wassink, Thomas H; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather; Wierenga, Lara M; Wittfeld, Katharina; Wolf, Daniel H; Worker, Amanda; Wright, Margaret J; Yang, Kun; Yoncheva, Yulyia; Zanetti, Marcus V; Ziegler, Georg C; Thompson, Paul M; Dima, Danai
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
PMID: 33595143
ISSN: 1097-0193
CID: 4799902
Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure
Hoogman, Martine; van Rooij, Daan; Klein, Marieke; Boedhoe, Premika; Ilioska, Iva; Li, Ting; Patel, Yash; Postema, Merel C; Zhang-James, Yanli; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume; Banaschewski, Tobias; Bau, Claiton H D; Behrmann, Marlene; Bellgrove, Mark A; Brandeis, Daniel; Brem, Silvia; Busatto, Geraldo F; Calderoni, Sara; Calvo, Rosa; Castellanos, Francisco X; Coghill, David; Conzelmann, Annette; Daly, Eileen; Deruelle, Christine; Dinstein, Ilan; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Epstein, Jeffery N; Fair, Damien A; Fitzgerald, Jacqueline; Freitag, Christine M; Frodl, Thomas; Gallagher, Louise; Grevet, Eugenio H; Haavik, Jan; Hoekstra, Pieter J; Janssen, Joost; Karkashadze, Georgii; King, Joseph A; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lerch, Jason P; Lesch, Klaus-Peter; Louza, Mario R; Luna, Beatriz; Mattos, Paulo; McGrath, Jane; Muratori, Filippo; Murphy, Clodagh; Nigg, Joel T; Oberwelland-Weiss, Eileen; O'Gorman Tuura, Ruth L; O'Hearn, Kirsten; Oosterlaan, Jaap; Parellada, Mara; Pauli, Paul; Plessen, Kerstin J; Ramos-Quiroga, J Antoni; Reif, Andreas; Reneman, Liesbeth; Retico, Alessandra; Rosa, Pedro G P; Rubia, Katya; Shaw, Philip; Silk, Tim J; Tamm, Leanne; Vilarroya, Oscar; Walitza, Susanne; Jahanshad, Neda; Faraone, Stephen V; Francks, Clyde; van den Heuvel, Odile A; Paus, Tomas; Thompson, Paul M; Buitelaar, Jan K; Franke, Barbara
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
PMID: 32420680
ISSN: 1097-0193
CID: 4446612
Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney
Sexton, Claire E; Anstey, Kaarin J; Baldacci, Filippo; Barnum, C J; Barron, Anna M; Blennow, Kaj; Brodaty, Henry; Burnham, Samantha; Elahi, Fanny M; Götz, Jürgen; Jeon, Yun-Hee; Koronyo-Hamaoui, Maya; Landau, Susan M; Lautenschlager, Nicola T; Laws, Simon M; Lipnicki, Darren M; Lu, Hanzhang; Masters, Colin L; Moyle, Wendy; Nakamura, Akinori; Pasinetti, Giulio Maria; Rao, Naren; Rowe, Christopher; Sachdev, Perminder S; Schofield, Peter R; Sigurdsson, Einar M; Smith, Kate; Srikanth, Velandai; Szoeke, Cassandra; Tansey, Malú G; Whitmer, Rachel; Wilcock, Donna; Wong, Tien Y; Bain, Lisa J; Carrillo, Maria C
The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.
PMID: 34058063
ISSN: 1552-5279
CID: 4911832
Single-cell delineation of lineage and genetic identity in the mouse brain
Bandler, Rachel C; Vitali, Ilaria; Delgado, Ryan N; Ho, May C; Dvoretskova, Elena; Ibarra Molinas, Josue S; Frazel, Paul W; Mohammadkhani, Maesoumeh; Machold, Robert; Maedler, Sophia; Liddelow, Shane A; Nowakowski, Tomasz J; Fishell, Gord; Mayer, Christian
During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia1,2. The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.
PMID: 34912118
ISSN: 1476-4687
CID: 5106272
