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The role of emergency department in the care of patients with serious, lifelimiting illness at the end of life [Meeting Abstract]

Ouchi, K; Richardson, L; Egorova, N; Grudzen, C
Background: Among older adults with Medicare, three-quarters made an ED visit in the last six months of life, and a third made a visit in the last month of life. Objectives: Describe ED and hospital use for those with advanced cancer, cardiac or pulmonary disease over the study period, including the proportions of ED visits by these patients in reference to the overall ED population. Second, we sought to describe the survival rates for these patients after their index ED visit, including the 30, 60, and 180 day along with their median survival. Methods: We used the New York Statewide Planning and Research Cooperative System (SPARCS), which provides comprehensive longitudinal information on in- and outpatient utilization that can be linked to the state death index. SPARCS and its ability to link medical claims data to the national death index makes it a unique setting in which to study ED use in such patients. Results: Our sample included all patients >18 years of age with at least one inpatient admission > 48 hours and an ICD-9 code consistent with advanced, incurable cancer, cardiac, and pulmonary diseases in New York State between 2005 and 2011 (N=193,145). The ED visit rate for our cohort increased yearly, from 1.97 visits/year in 2006, to 2.86 in 2011. The proportions of visits remained relatively similar over the study period (9.3%). 73% of the time, ED patients with advanced cancer were admitted; 14% of patients had an ICU stay during their hospitalization. Median survival for advanced cancer patients from the index ED visit was between 8.5 to 10.9 months during the study period. Such predictable mortality was observed in advanced cardiac / pulmonary disease group as well. (Table presented) Conclusion: There is a substantial proportion of patients with serious, life-limiting illness presenting to the ED. The subsequent inpatient health care utilization is high among these patients. There is a predictable mortality rates associated with the index ED visits for these patients. An ED visit may present a unique opportunity to capture these seriously ill patients with life-limiting illness to set their trajectory of end of life care
EMBASE:71879441
ISSN: 1069-6563
CID: 1600542

Emergency department-triggered palliative care in patients with metastatic solid tumors [Meeting Abstract]

Grudzen, C; Richardson, L D; Hu, M; Wang, B; Johnson, P; Morrison, R S
Background: The delivery of palliative care is not standard of care in most EDs. Preliminary data suggest that early palliative care consultation can decrease hospital length of stay and costs for select patients with advanced illness, and may extend life. Objectives: To compare quality of life, health care utilization, and survival for ED patients with advanced cancer randomized to EDinitiated palliative care consultation versus care as usual. Methods: DESI
EMBASE:71878856
ISSN: 1069-6563
CID: 1600622

Improving outcomes in older women? [Editorial]

Dodson, John A; Hochman, Judith S
PMCID:4493745
PMID: 25999101
ISSN: 1876-7605
CID: 1602852

Maternal obesity, caesarean delivery and caesarean delivery on maternal request: a cohort analysis from china

Zhou, Yubo; Blustein, Jan; Li, Hongtian; Ye, Rongwei; Zhu, Liping; Liu, Jianmeng
BACKGROUND: To quantify the association between maternal obesity and caesarean delivery, particularly caesarean delivery on maternal request (CDMR), a fast-growing component of caesarean delivery in many nations. METHODS: We followed 1 019 576 nulliparous women registered in the Perinatal Healthcare Surveillance System during 1993-2010. Maternal body mass index (BMI, kg/m(2) ), before pregnancy or during early pregnancy, was classified as underweight (<18.5), normal (18.5 to <23; reference), overweight (23 to <27.5), or obese (>/=27.5), consistent with World Health Organization guidelines for Asian people. The association between maternal obesity and overall caesarean and its subtypes was modelled using log-binomial regression. RESULTS: During the 18-year period, 404 971 (39.7%) caesareans and 93 927 (9.2%) CDMRs were identified. Maternal obesity was positively associated with overall caesarean and CDMR. Adjusted risk ratios for overall caesarean in the four ascending BMI categories were 0.96 [95% confidence interval (CI) 0.94, 0.97], 1.00 (Reference), 1.16 [95% CI 1.14, 1.18], 1.39 [95% CI 1.43, 1.54], and for CDMR were 0.95 [95% CI 0.94, 0.96], 1.00 (Reference), 1.20 [95% CI 1.18, 1.22], 1.48 [95% CI 1.433, 1.54]. Positive associations were consistently found in women residing in southern and northern provinces and in subgroups stratified by year of delivery, urban or rural residence, maternal age, education, level of delivering hospital, and birthweight. CONCLUSIONS: In a large Chinese cohort study, maternal obesity was associated with an increased risk of caesarean delivery and its subtypes, including CDMR. Given the rising global prevalence of obesity, and in view of the growth of CDMR, it seems likely that caesarean births will increase, unless there are changes in obstetrical practice.
PMID: 25827169
ISSN: 1365-3016
CID: 1579832

Does aortic valve sclerosis predicts the severity and complexity of coronary artery disease?

Bhatt, Hemal; Sanghani, Dharmesh; Julliard, Kell; Fernaine, George
AIM: We assessed the association of aortic valve sclerosis (AVS) with atherosclerotic risk factors and severity and complexity of coronary artery disease (CAD). METHODS: In this retrospective study, a total of 482 eligible patients were divided into 2 groups: AVS present and AVS absent. All major cardiovascular risk factors and coronary lesion characteristics were included. RESULTS: Age was the only independent predictor of AVS. AVS was not independently associated with the number of obstructive vessels, degree of lesion obstruction and SYNTAX score. CONCLUSION: AVS is probably a benign marker of age-related degenerative changes in the heart independent of the severity and complexity of CAD.
PMCID:4495668
PMID: 26138181
ISSN: 0019-4832
CID: 1703342

Health-Risk Behaviors in Teens Investigated by U.S. Child Welfare Agencies

Heneghan, Amy; Stein, Ruth E K; Hurlburt, Michael S; Zhang, Jinjin; Rolls-Reutz, Jennifer; Kerker, Bonnie D; Landsverk, John; McCue Horwitz, Sarah
PURPOSE: The aim of this study was to examine prevalence and correlates of health-risk behaviors in 12- to 17.5-year-olds investigated by child welfare and compare risk-taking over time and with a national school-based sample. METHODS: Data from the National Survey of Child and Adolescent Well-Being (NSCAW II) were analyzed to examine substance use, sexual activity, conduct behaviors, and suicidality. In a weighted sample of 815 adolescents aged 12-17.5 years, prevalence and correlates for each health-risk behavior were calculated using bivariate analyses. Comparisons to data from NSCAW I and the Youth Risk Behavior Survey were made for each health-risk behavior. RESULTS: Overall, 65.6% of teens reported at least one health-risk behavior with significantly more teens in the 15- to 17.5-year age group reporting such behaviors (81.2% vs. 54.4%; p /=64 reported at least one health-risk behavior. The prevalence of smoking was lower than in NSCAW I (10.5% vs. 23.2%; p
PMCID:5564320
PMID: 25744208
ISSN: 1054-139x
CID: 1480852

Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G; Liu, Mengling; Cheng, Xin; Parvez, Faruque; Islam, Tariqul; Ahmed, Alauddin; Rakibuz-Zaman, Muhammad; Jiang, Jieying; Roy, Shantanu; Paul-Brutus, Rachelle; Slavkovich, Vesna; Islam, Tariqul; Levy, Diane; VanderWeele, Tyler J; Pierce, Brandon L; Graziano, Joseph H; Ahsan, Habibul; Chen, Yu
BACKGROUND: Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited. OBJECTIVE: We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs) in 17 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction. METHOD: We conducted a prospective case-cohort study nested in the Health Effects of Arsenic Longitudinal Study, with a random subcohort of 1,375 subjects and 447 incident fatal and nonfatal cases of CVD. Well-water arsenic was measured in 2000 at baseline. The CVD cases, 56 of which occurred in the subcohort, included 238 coronary heart disease cases, 165 stroke cases, and 44 deaths due to other CVD identified during follow-up from 2000 to 2012. RESULTS: Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (Padj = 0.0002) and rs3176867 in VCAM1 (Padj = 0.035), were significant for CVD after adjustment for multiple testing. Compared with those with GC or CC genotype in rs281432 and lower well-water arsenic, the adjusted hazard ratio (aHR) for CVD was 1.82 (95% CI: 1.31, 2.54) for a 1-SD increase in well-water arsenic combined with the GG genotype, which was greater than expected given aHRs of 1.08 and 0.96 for separate effects of arsenic and the genotype alone, respectively. Similarly, the joint aHR for arsenic and the rs3176867 CC genotype was 1.34 (95% CI: 0.95, 1.87), greater than expected given aHRs for their separate effects of 1.02 and 0.84, respectively. CONCLUSIONS: Associations between CVD and arsenic exposure may be modified by genetic variants related to endothelial dysfunction.
PMCID:4421763
PMID: 25575156
ISSN: 1552-9924
CID: 1529322

ERG is a novel and reliable marker for endothelial cells in central nervous system tumors

Haber, Matthew A; Iranmahboob, Amir; Thomas, Cheddhi; Liu, Mengling; Najjar, Amanda; Zagzag, David
ETS-related gene (ERG) is a transcription factor that has been linked to angiogenesis. Very little research has been done to assess ERG expression in central nervous system (CNS) tumors. We evaluated 57 CNS tumors, including glioblastomas (GBMs) and hemangioblastomas (HBs), as well as two arteriovenous malformations and four samples of normal brain tissue with immunohistochemistry using a specific ERG rabbit monoclonal antibody. In addition, immunostains for CD31, CD34, and alpha-smooth muscle actin (alpha-SMA) were performed on all samples. CD31 demonstrated variable and sometimes weak immunoreactivity for endothelial cells. Furthermore, in 1 case of a GBM, CD34 stained not only endothelial cells, but also tumor cells. In contrast, we observed that ERG was only expressed in the nuclei of endothelial cells, for example, in the hyperplastic vascular complexes that comprise the glomeruloid microvascular proliferation seen in GBMs. Conversely, alpha-SMA immunoreactivity was identified in the abluminal cells of these hyperplastic vessels. Quantitative evaluation with automated methodology and custom Matlab 2008b software was used to calculate percent staining of ERG in each case. We observed significantly higher quantitative expression of ERG in HBs than in other CNS tumors. Our results show that ERG is a novel, reliable, and specific marker for endothelial cells within CNS tumors that can be used to better study the process of neovascularization.
PMCID:4542182
PMID: 25881913
ISSN: 0722-5091
CID: 1533212

Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers: Potential Implications for the Choosing Wisely Campaign

Makarov, Danil V; Soulos, Pamela R; Gold, Heather T; Yu, James B; Sen, Sounok; Ross, Joseph S; Gross, Cary P
IMPORTANCE: The association between regional norms of clinical practice and appropriateness of care is incompletely understood. Understanding regional patterns of care across diseases might optimize implementation of programs like Choosing Wisely, an ongoing campaign to decrease wasteful medical expenditures. OBJECTIVE: To determine whether regional rates of inappropriate prostate and breast cancer imaging were associated. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study using the the Surveillance, Epidemiology, and End Results-Medicare linked database. We identified patients diagnosed from 2004 to 2007 with low-risk prostate (clinical stage T1c/T2a; Gleason score,
PMCID:4707944
PMID: 26181021
ISSN: 2374-2445
CID: 1668982

Gender differences in aortic neck morphology in patients with abdominal aortic aneurysms undergoing evar [Meeting Abstract]

Ayo, D; Blumberg, S N; Gaing, B; Baxter, A; Rockman, C; Mussa, F; Maldonado, T
Introduction and Objectives: Prior studies have alluded to gender differences in aortic neck morphology resulting in anatomic exclusion of some women from EVAR. The objective of this study is to correlate gender differences in aortic neck morphology and changes in the neck and aneurysm sac after EVAR. Methods: A retrospective review of consecutive EVARs performed for infrarenal AAA was conducted from 2004 to 2013 at a single institution. Pre- and post-operative imaging studies were utilized to measure aortic neck length and diameter, shape, and angulation, aneurysm sac diameter. Volumetric analysis of neck thrombus burden was performed using TeraRecon. Results: 146 patients met inclusion criteria 21% were women with a mean age of 75.5 (p=0.724) with comparable baseline comorbidities to men. Neck angulation was greater in women 23.9degreevs 13.5degree (P<0.028). The percent thrombus of the aortic neck was greater in female patients at 35.7% vs 30%(P=0.02). Preoperative AAA diameter was 5.8 in female and 5.5 in males (p=0.348). Abdominal aneurysm sacs were smaller in women at 1 year follow up (4.2cm vs. 5.1cm, P<0.002). In addition, although not statistically significant, reintervention rates post-EVAR for type 1 leaks were higher in men (3.5% vs. 0% P=0.27). Neck shape, changes in neck diameter, neck length, percent oversizing of graft where not significantly different between gender (table 1). Conclusions: Although female patients have more hostile aortic neck morphology compared to males, AAAs post-EVAR have acceptable sac regression and reintervention rates. Long term follow up is necessary to further validate findings
EMBASE:615207328
ISSN: 1615-5947
CID: 2534382