Faculty Bibliography

BACKGROUND: The authors describe and evaluate the short-term effectiveness of a community-based program for dental caries prevention in children. METHODS: The authors enrolled pupils in the ForsythKids program after receiving informed consent. They targeted children at six Massachusetts elementary schools, grades 1 through 3, with pupil populations at high risk of developing caries. The children underwent examination by dentists using calibrated technique and received comprehensive preventive care from dental hygienists. The authors determined effectiveness by means of comparing results of the initial examination with those of a second examination performed six months later. RESULTS: At baseline, 70 percent of the 1,196 participating children had decayed or filled teeth. More troublingly, 42.1 percent of the primary teeth and 31.1 percent of the permanent teeth had untreated decay. Six months after preventive intervention, the proportion of teeth with new decay was reduced 52 percent in primary teeth and 39 percent in permanent teeth. Furthermore, the percentage of children with newly decayed or restored primary and permanent teeth was reduced by 25.4 percent and 53.2 percent, respectively. CONCLUSIONS: These results indicate that this care model relatively quickly can overcome multiple barriers to care and improve children's oral health. CLINICAL IMPLICATIONS: If widely implemented, comprehensive caries prevention programs such as ForsythKids could accomplish national health goals and reduce the need for new care providers and clinics.

DESIGN: This was a randomised, placebo-controlled trial with 6 months of follow-up. INTERVENTION: Patients received nonsurgical periodontal therapy and 3 months of the test treatment (low-dose doxycycline; LDD) or control (inactive identical placebo). OUTCOME MEASURE: The primary outcome was the change in the clinical attachment level (CAL) recorded from the cemento-enamel junction to the base of the probing pocket using a graduated UNC-15 probe (Hu Friedy, Chicago, Illinois, USA). Secondary outcomes included pocket depth, gingival recession and bleeding on probing recorded at six sites per tooth with the manual probe and ICTP (terminal carboxytelopeptide of type 1 collagen). RESULTS: The velocity of change was statistically significantly greater for the test group for CAL [-0.19 mm/ month; 95% confidence interval (CI), -0.34- -0.04; P 0.012] and probing depth (0.30 mm/ month; 95% CI, -0.42- -0.17; P 0.001). No differences were observed, however, for absolute change in clinical or biochemical markers at 6 months. CONCLUSIONS: Nonsurgical periodontal therapy in smokers can produce a substantial improvement in periodontal health but there is no evidence to support the use of LDD as an adjunct to their nonsurgical therapy. Quitting tobacco use continues to be of fundamental importance in improving the periodontal health of these individuals.

DATA SOURCES: The Cochrane Oral Health Group's Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase, Psychinfo, Ingenta and Cumulative Index to Nursing and Allied Health Literature were searched, along with the reference lists from relevant articles. The authors of eligible trials were contacted to identify further studies and obtain additional information. Four journals were searched by hand (Journal of Health Psychology, Psychology and Health, Psychology Health and Medicine, Health Psychology - Update). No language restriction was applied. STUDY SELECTION: Randomised controlled trials were selected that tested the effectiveness of interventions based on psychological models, comparing them with educational, attention or no active intervention controls, to improve adherence to oral hygiene in adults with either gingivitis or periodontitis. Only trials with at least 3 weeks' followup were included. Interventions aimed at encouraging smoking cessation were not included. DATA EXTRACTION AND SYNTHESIS: Titles and abstracts of studies that were potentially relevant to the review were independently screened by two review authors. Those that were clearly ineligible were rejected. For the remaining studies, the full paper was reviewed by two review authors and, where necessary, further information was sought from the author to verify eligibility. The quality of included studies was assessed using standard criteria. RESULTS: Four studies (of 344 participants) were found in which a psychological model or theory had been explicitly used as the basis for the design of the intervention. The overall quality of trials was low. Because of the heterogeneity of studies, both in terms of outcome measures and psychological models adopted, a meta-analysis was not possible. The four studies adopted four different theoretical frameworks, although there was some overlap in that three of the studies incorporated elements of Operant and Classical Conditioning. Psychological interventions resulted in improved plaque scores compared with no-intervention groups, and in one study compared with an attention control group. One study found decreased gingival bleeding in the active intervention group but no change in pocket depth or attachment loss after 4 months. Psychological interventions were associated with improved self-reported brushing and flossing in both the studies that assessed these behaviours. Only one study explored the impact of psychological interventions on beliefs and attitudes: the psychological intervention, when compared with educational and no-intervention controls, showed improved self-efficacy beliefs in relation to flossing, but no effect on dental knowledge or self-efficacy beliefs in relation to tooth brushing. CONCLUSIONS: There is some evidence from low-quality studies that psychological approaches to behaviour management, such as the use of reinforcement, goal setting and the provision of feedback, can improve oral hygiene and oral hygiene-related behaviours. The design of the interventions was weak and limited, however, and ignored key aspects of the theories. All the studies reported here also relied upon the provision of guidance by personnel other than the practitioner. There is no evidence that the use of such an approach by the practitioner with his or her patients would be beneficial. Thus, there is a need for greater methodological rigour in the design of trials in this area.

DATA SOURCES: Medline and the Cochrane Central Register of Controlled Trials were used to identify sources of data. STUDY SELECTION: Title and abstracts were screened independently. Randomised controlled clinical trials of >6 months duration that used gingivitis or plaque levels as outcome measures were selected. DATA EXTRACTION AND SYNTHESIS: The mean values and standard deviations were extracted. In studies where standard errors of the mean were reported, standard deviations were calculated by the authors based on the sample size. Weighted means of baseline and of end of trial were calculated with the software Cochrane Collaboration Review Manager (version 4.2; The Cochrane Collaboration, Oxford, England) using a random-effects model. A meta-analysis for stannous fluoride (SnF) mouth rinse and dentifrice/ mouthrinse formulations was not performed because there were insufficient data. RESULTS: Fifteen papers were included in the review. For SnF dentifrices, a statistically significant reduction in gingivitis was noted in comparison with control [weighted mean difference (WMD), 0.15 (gingival index) and 0.21 (gingivitis severity index); test for heterogeneity P<0.00001, I(2)=91.1% and P 50.03, I(2)= 80.1%, respectively]. There were inconsistent results for plaque reduction. On using the plaque index, no differences were found, whereas meta-analysis of the Turesky index gave a WMD of 0.31 (P 50.01; test for heterogeneity P 0.0001, I(2)=91.7%). CONCLUSIONS: The use of SnF dentifrices results in greater gingivitis and plaque reduction compared with a conventional dentifrice. The precise magnitude of this effect was difficult to assess because of a high level of heterogeneity in study outcomes.

The purpose of this review was two-fold: (a) to determine which retrograde obturation material(s) best prevents dye/ink penetration in vitro; and (b) to determine whether in vitro results agree with in vivo results. A MEDLINE search was conducted to identify in vitro studies published between January 1966 and October, week 4, 2003, conducted on human teeth, and published in English, German, or French language, testing the resistance to retrograde penetration of retrograde filling materials. The MEDLINE search identified 278 published articles. Of those, 115 studies examined the resistance to penetration of various retrograde filling materials, in vitro. Thirty-four studies met all the inclusion and validity criteria. The results indicate that, beyond 10 days in vitro, the most effective retrofilling materials, when measured by dye/ink penetration are: composites>glass ionomer cement>amalgam>orthograde gutta-percha>EBA. The results of these in vitro studies are not congruent with in vivo study results, suggesting a need to re-evaluate the clinical validity and importance of in vitro studies.

Improving health and well-being from the consideration of isolated studies is problematic. Systematic reviews have been developed to address this problem and may include a quantitative data synthesis in the form of a meta-analysis, or a cumulative meta-analysis. The value of systematic reviews depends greatly on the availability and quality of the results of primary research. The objective of the current project was to demonstrate the technique of cumulative meta-analysis in dentistry using data from a previously published systematic review. The process highlights an issue that some trials could not be synthesized due to the lack of reporting of measures of variation. This represents a potential source of bias. Investigators are encouraged to consider their trials as part of an information continuum and to report sufficient detail to permit the trials' incorporation into subsequent syntheses.