Faculty Bibliography

Reviews the volume edited by Takakuwa et al (2004), a collection of 22 autobiographical stories by medical students and recent medical graduates who attempt to share their experiences in medical school. Several of the stories follow the structure of a personal reflection that leads quickly and simply to a quick and simple lesson. The best of the stories in this book illuminate the personal struggles of people involved in the attempt to remain individual in a general system, a system whose shape is sometimes too rigid to fit the diverse contents it aims to mold.

This study evaluated the psychometric properties of the Social Experience Questionnaire (SEQ) in a sample of 1158 adolescents aged 13-17 years. Confirmatory factor analysis fit indices supported the hypothesized three-factor model of the SEQ that assesses overt and relational victimization, and prosocial behaviors from peers. Analyses of gender differences revealed that boys reported being overtly victimized more than girls, and girls reported greater receipt of prosocial behaviors from peers than boys. No gender differences in relational victimization were found. The internal consistency was adequate across gender, and test-retest stability over 12 months was modest. Intercorrelations among overt and relational victimization subscales suggest that these subscales assess related, but relatively independent constructs of peer victimization. These findings support the use of the SEQ with adolescents

The purpose of this article is to describe the development of a family-based intervention designed to target the harmful effects of exposure to family and community violence on urban youth and their parents. The program, "Supporting Urban Residents to be Violence-Free in a Violent Environment (SURVIVE)," is a 12-week multiple family group (MEG) intervention modeled upon similar children's mental health programs implemented with urban youth of color and their families in several major U.S. cities. The design and implementation of the SURVIVE Community Project were guided by a collaborative partnership between community members, including mental health professionals, teachers, and parents from the Bronx, and an interdisciplinary team of university-based researchers. In order to establish the feasibility and relevance of the program for urban communities, 25 families with children ages 7-11 participated in a pilot test of the curriculum. The description of the SURVIVE Community Project provided here is based on this work, and includes a discussion of facilitation issues. Implications for family-based intervention targeting urban children and families affected by violence are highlighted.

BACKGROUND: Schizophrenia is etiologically heterogeneous. It is anticipated, but unproven, that subgroups will differ in neuropathology and that neuroimaging may reveal these differences. The optimal imaging condition may be at rest, where greater variability is observed than during cognitive tasks, which more consistently reveal hypofrontality. We previously demonstrated symptom and physiologic differences between familial and sporadic schizophrenia patients and hypothesized that the groups would show different resting regional cerebral blood flow (rCBF) patterns. METHODS: Ten familial and sixteen sporadic schizophrenia patients and nine comparison subjects had single photon emission computed tomography imaging during passive visual fixation. Images were spatially normalized into Talairach coordinates and analyzed for group rCBF differences using SPM with a Z value threshold of 2.80, p < .001. RESULTS: The subgroups had similar age, gender, illness duration, and medication treatment. Sporadic patients had hypofrontality (anterior cingulate, paracingulate cortices, left dorsolateral and inferior-orbitofrontal), whereas familial patients had left temporoparietal hypoperfusion; all of these regions show resting activity in healthy subjects. Both groups hyperperfused the cerebellum/pons and parahippocampal gyrus; additional hyperperfusion for sporadic patients was observed in the fusiform; familial patients also hyperperfused the hippocampus, dentate, uncus, amygdala, thalamus, and putamen. CONCLUSIONS: Familial and sporadic schizophrenia patients had different resting rCBF profiles, supporting the hypothesis that certain subgroups have distinct neural underpinnings. Different neuropathologic processes among subgroups of schizophrenia patients may account for the prior contradictory results of resting imaging studies

In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR). The present investigation (i) replicates research in adults showing that 5-HTTLPR variation moderates the development of depression after stress, (ii) extends the finding to children, and (iii) demonstrates the ability of social supports to further moderate risk for depression. Maltreated children with the s/s genotype and no positive supports had the highest depression ratings, scores that were twice as high as the non-maltreated comparison children with the same genotype. However, the presence of positive supports reduced risk associated with maltreatment and the s/s genotype, such that maltreated children with this profile had only minimal increases in their depression scores. These findings are consistent with emerging preclinical and clinical data suggesting that the negative sequelae associated with early stress are not inevitable. Risk for negative outcomes may be modified by both genetic and environmental factors, with the quality and availability of social supports among the most important environmental factors in promoting resiliency in maltreated children, even in the presence of a genotype expected to confer vulnerability for psychiatric disorder

Depression involves either enhanced processing of negative stimuli or diminished processing of positive stimuli. We used functional magnetic resonance imaging to assess brain activation in depressed vs healthy participants. Fifteen participants diagnosed with major depressive disorder and 15 controls were scanned during a lexical decision task involving neutral, happy, sad, and threat-related words. For happy words, depressed subjects exhibited less activation than did controls to happy words in fronto-temporal and limbic regions. For sad words, depressed subjects showed more activation than did controls in the inferior parietal lobule and less activation in the superior temporal gyrus and cerebellum, suggesting a complex activation pattern that varies for neural sub-circuits that may be associated with different cognitive or behavioral processes.