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Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies

Nguyen, Khanh-Dung H; Pihur, Vasyl; Ganesh, Santhi K; Rakha, Ankit; Cooper, Richard S; Hunt, Steven C; Freedman, Barry I; Coresh, Joe; Kao, W H Linda; Morrison, Alanna C; Boerwinkle, Eric; Ehret, Georg B; Chakravarti, Aravinda
RATIONALE: Hypertension affects approximately 30% of adults in industrialized countries and is the major risk factor for cardiovascular disease. OBJECTIVE: We sought to study the genetic effect of coding and conserved noncoding variants in syndromic hypertension genes on systolic blood pressure (BP) and diastolic BP to assess their overall impact on essential hypertension. METHODS AND RESULTS: We resequenced 11 genes (AGT, CYP11B1, CYP17A1, HSD11B2, NR3C1, NR3C2, SCNN1A, SCNN1B, SCNN1G, WNK1, and WNK4) in 560 European American (EA) and African American ancestry GenNet participants with extreme systolic BP. We investigated genetic associations of 2535 variants with BP in 19997 EAs and in 6069 African Americans in 3 types of analyses. First, we studied the combined effects of all variants in GenNet. Second, we studied 1000 Genomes imputed polymorphic variants in 9747 EA and 3207 African American Atherosclerosis Risk in Communities subjects. Finally, we genotyped 37 missense and common noncoding variants in 6591 EAs and in 6521 individuals (3659 EA/2862 African American) from the CLUE and Family Blood Pressure Program studies, respectively. None of the variants individually reached significant false-discovery rates
PMCID:3548950
PMID: 23149595
ISSN: 1524-4571
CID: 2747102

SOCIOECONOMIC PATTERNING OF HYPERTENSION IN GRENADA [Meeting Abstract]

Roberts, Eric; Quarles, Leigh; Vedanthan, Rajesh; Lewis, Marcelle; Hunn, Marilyn; Farkouh, Michael; Fuster, Valentin; Boden-Albala, Bernadette
ISI:000319870300651
ISSN: 0002-9262
CID: 2740352

Maternal depressive symptoms and child obesity in low-income urban families

Gross, Rachel S; Velazco, Nerissa K; Briggs, Rahil D; Racine, Andrew D
OBJECTIVE: To characterize the relationship between maternal depressive symptoms and child weight status, obesity-promoting feeding practices, and activity-related behaviors in low-income urban families. METHODS: We conducted a cross-sectional survey of mothers with 5-year-old children receiving pediatric care at a federally qualified community health center. We used regression analyses to examine the relationship between maternal depressive symptoms (trichotomized: none, mild, moderate to severe) and 1) child weight status; 2) obesity-promoting feeding practices, including mealtime practices and feeding styles; and 3) activity-related behaviors, including sleep time, screen time, and outdoor playtime. RESULTS: The sample included 401 mother-child pairs (78.3% response rate), with 23.4% of mothers reporting depressive symptoms (15.7% mild, 7.7% moderate to severe). Mothers with moderate to severe depressive symptoms were more likely to have overweight and obese children than mothers without depressive symptoms (adjusted odds ratio 2.62; 95% confidence interval 1.02-6.70). Children of mildly depressed mothers were more likely to consume sweetened drinks and to eat out at restaurants and were less likely to eat breakfast than children of nondepressed mothers. Mothers with depressive symptoms were less likely to set limits, to use food as a reward, to restrict their child's intake, and to model healthy eating than nondepressed mothers. Children with depressed mothers had less sleep and outdoor playtime per day than children of nondepressed mothers. CONCLUSIONS: Maternal depressive symptoms are associated with child overweight and obese status and with several obesity-promoting practices. These results support the need for maternal depression screening in pediatric obesity prevention programs. Further research should explore how to incorporate needed mental health support.
PMID: 23830021
ISSN: 1876-2867
CID: 2720632

Performance standards for restaurants : a new approach to addressing the obesity Epidemic

Cohen, Deborah; Bhatia, Rajiv; Story, Mary T; Sugarman, Stephen D; Wootan, Margo; Economos, Christina D; Van Horn, Linda; Whitsel, Laurie P; Roberts, Susan; Powell, Lisa M; Odoms-Young, Angela; Williams, Jerome D; Elbel, Brian; Harris, Jennifer; Kappagoda, Manel; Champagne, Catherine M; Shields, Kathleen; Lesser, Lenard I; Fox, Tracy; Becker, Nancy
2013
ISBN: 9780833081490
CID: 2702932

WHY DO ADOLESCENTS AND PARENTS PARTICIPATE IN RESEARCH? [Meeting Abstract]

McGregor, Kyle A; Hall, James A
ISI:000314104000194
ISSN: 1054-139x
CID: 2690072

FACTORS AFFECTING THE HEALTH LITERACY OF HISPANIC ADULTS LIVING IN THE US [Meeting Abstract]

Chakkalaka, Rosette; Sanders, Lee; Yin, Shonna; Perrin, Eliana M; Rothman, Russell L
ISI:000331939300180
ISSN: 1525-1497
CID: 2683532

Vested Interests in addiction research and policy. Alliance between tobacco and alcohol industries to shape public policy [Historical Article]

Jiang, Nan; Ling, Pamela
AIMS: The tobacco and alcohol industries share common policy goals when facing regulation, opposing policies such as tax increases and advertising restrictions. The collaboration between these two industries in the tobacco policy arena is unknown. This study explored if tobacco and alcohol companies built alliances to influence tobacco legislation and, if so, how those alliances worked. METHODS: Analysis of previously secret tobacco industry documents. FINDINGS: In the early 1980s, tobacco companies started efforts to build coalitions with alcohol and other industries to oppose cigarette excise taxes, clean indoor air policies and tobacco advertising and promotion constraints. Alcohol companies were often identified as a key partner and source of financial support for the coalitions. These coalitions had variable success interfering with tobacco control policy-making. CONCLUSIONS: The combined resources of tobacco and alcohol companies may have affected tobacco control legislation. These alliances helped to create the perception that there is a broader base of opposition to tobacco control. Advocates should be aware of the covert alliances between tobacco, alcohol and other industries and expose them to correct this misperception.
PMCID:3689428
PMID: 23587076
ISSN: 1360-0443
CID: 2645452

Impact of alcohol use and bar attendance on smoking and quit attempts among young adult bar patrons

Jiang, Nan; Ling, Pamela M
OBJECTIVES: We examined cigarette smoking and quit attempts in the context of alcohol use and bar attendance among young adult bar patrons with different smoking patterns. Methods. We used randomized time location sampling to collect data among adult bar patrons aged 21 to 26 years in San Diego, California (n = 1235; response rate = 73%). We used multinomial and multivariate logistic regression models to analyze the association between smoking and quit attempts and both drinking and binge drinking among occasional, regular, very light, and heavier smokers, controlling for age, gender, race/ethnicity, and education. RESULTS: Young adult bar patrons reported high rates of smoking and co-use of cigarettes and alcohol. Binge drinking predicted smoking status, especially occasional and very light smoking. All types of smokers reported alcohol use, and bar attendance made it harder to quit. Alcohol use was negatively associated with quit attempts for very light smokers, but positively associated with quitting among heavier smokers. CONCLUSIONS: Smoking and co-use of cigarettes and alcohol are common among young adult bar patrons, but there are important differences by smoking patterns. Tobacco interventions for young adults should prioritize bars and address alcohol use.
PMCID:3653637
PMID: 23488485
ISSN: 1541-0048
CID: 2645372

Participatory disease surveillance in Latin America

Chapter by: Johansson, Michael; Wojcik, Oktawia; Chunara, Rumi; Smolinski, Mark; Brownstein, John
in: WWW '13 Companion : proceedings of the 22nd International Conference on World Wide Web : May 13-17, 2013, Rio de Janeiro, Brazil by
New York : ACM, 2013
pp. 695-696
ISBN: 1450320384
CID: 2615042

Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update [Guideline]

Loren, Alison W; Mangu, Pamela B; Beck, Lindsay Nohr; Brennan, Lawrence; Magdalinski, Anthony J; Partridge, Ann H; Quinn, Gwendolyn; Wallace, W Hamish; Oktay, Kutluk
PURPOSE: To update guidance for health care providers about fertility preservation for adults and children with cancer. METHODS: A systematic review of the literature published from March 2006 through January 2013 was completed using MEDLINE and the Cochrane Collaboration Library. An Update Panel reviewed the evidence and updated the recommendation language. RESULTS: There were 222 new publications that met inclusion criteria. A majority were observational studies, cohort studies, and case series or reports, with few randomized clinical trials. After review of the new evidence, the Update Panel concluded that no major, substantive revisions to the 2006 American Society of Clinical Oncology recommendations were warranted, but clarifications were added. RECOMMENDATIONS: As part of education and informed consent before cancer therapy, health care providers (including medical oncologists, radiation oncologists, gynecologic oncologists, urologists, hematologists, pediatric oncologists, and surgeons) should address the possibility of infertility with patients treated during their reproductive years (or with parents or guardians of children) and be prepared to discuss fertility preservation options and/or to refer all potential patients to appropriate reproductive specialists. Although patients may be focused initially on their cancer diagnosis, the Update Panel encourages providers to advise patients regarding potential threats to fertility as early as possible in the treatment process so as to allow for the widest array of options for fertility preservation. The discussion should be documented. Sperm and embryo cryopreservation as well as oocyte cryopreservation are considered standard practice and are widely available. Other fertility preservation methods should be considered investigational and should be performed by providers with the necessary expertise.
PMCID:5321083
PMID: 23715580
ISSN: 1527-7755
CID: 2588742