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Lesion network mapping of mania symptoms caused by focal brain lesions [Meeting Abstract]

Talmasov, D; Cotovio, G; Barahona-Correa, J B; Hsu, J; Senova, S; Ribeiro, R; Soussand, L; Velosa, A; Silva, V C E; Rost, N; Wu, O; Cohen, A L; Oliveira-Maia, A J; Fox, M D
Background: While mania is characteristic of Bipolar I Disorder, it has been reported following focal brain lesions for nearly a century. The localization of secondary manic symptoms is poorly understood, as mania has been reported following damage to multiple brain locations.
Objective(s): We utilize the human connectome to study cases of mania following focal brain lesions, provide insight into brain regions responsible for manic symptoms, and identify potential therapeutic targets.
Method(s): We identified two independent patient cohorts with mania attributed to focal brain lesions; a literature cohort from published case-reports (n=41) and a clinical cohort from chart review (n=15). Lesion locations were mapped onto a common brain atlas. The network of brain regions functionally connected to each lesion location was computed using normative human connectome data (resting-state fMRI, n=1000). Results were compared to lesion locations not associated with mania (n=569), lesion locations associated with symptoms potentially related to mania (n=274), and transcranial magnetic stimulation sites reported to induce/relieve mania symptoms.
Result(s): Lesion locations associated with mania were heterogeneous; no single brain region was lesioned in all or even most cases. However, these lesion locations showed a unique pattern of connectivity to the right-sided orbitofrontal cortex, right inferior temporal gyrus and right frontal pole. This connectivity profile was reproducible across independent cohorts, matched that of lesions associated with co-morbid symptoms, and aligned with effects of therapeutic brain stimulation on mania symptoms.
Conclusion(s): Brain lesions associated with mania are characterized by a specific pattern of brain connectivity that appears relevant for understanding co-morbid symptoms and identifying therapeutic targets
EMBASE:633964006
ISSN: 1531-8249
CID: 4803482

Inclusion of a social worker in the health care team : an integrated case presentation of treatment of a pregnant teen

Chapter by: Schenkel, Andrew; Cohen, Alexis; Gordy, Caroline; Leffel, Alyson; Thompson, Jamie; Espinosa, Liney
in: Clinical & Educational Scholarship Showcase by
[New York NY : NYU College of Dentistry. NYU Academy of Distinguished Educators], 2012
pp. 22-22
ISBN: n/a
CID: 350252

The Influence Of Acculturation On Oral Health Care Decisions, Treatment Planning, And Patient Management In A Migrant/Immigrant Population

Chapter by: Cohen, Alexis; Hernandez Jarez, Gema; Gordy, Caroline; Schenkel, Andrew
in: Clinical & Educational Scholarship Showcase by
[New York NY : NYU College of Dentistry. NYU Academy of Distinguished Educators], 2011
pp. 6-6
ISBN: n/a
CID: 151814