Effects of increasing osmolality on rat ileal smooth muscle
Schiff, J D; Overweg, N I
The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.
PMID: 7193468
ISSN: 0031-6768
CID: 3659842
Neuromuscular blocking drugs
Chapter by: Schiff, Joel D
in: Pharmacology and therapeutics for dentistry by Neidle, Enid Anne; Kroeger, Donald C; Yagiela, John A (Eds)
St. Louis : C.V. Mosby Co., 1980
pp. ?-?
ISBN: 9780801636356
CID: 3538592