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Diagnosis of Biofilm-Associated Peri-Implant Disease Using a Fluorescence-Based Approach

Hwang, Geelsu; Blatz, Markus B; Wolff, Mark S; Steier, Liviu
Dental implants have become a routine component of daily dental practice and the demand for dental implants is expected to increase significantly in the future. Despite the high success rates of dental implants, failures do occur, resulting in discomfort, rampant destruction of the oral health, or painful and costly surgical replacement of a failed implant. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of the peri-implant mucositis. Such peri-implant-soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. Although early diagnosis and accurate identification of risk factors are extremely important to effectively prevent peri-implant diseases, current systematic reviews revealed that a uniform classification and diagnostic methodology for peri-implantitis are lacking. Recent progress on fluorescence-based technology enabled rapid diagnosis of the disease and effective removal of plaques. Here, we briefly review biofilm-associated peri-implant diseases and propose a fluorescence-based approach for more accurate and objective diagnoses. A fluorescence-based diagnosis tool through headlights combined with special-filtered dental loupes may serve as a hands-free solution for both precise diagnosis and effective removal of plaque-biofilms.
PMID: 33673438
ISSN: 2304-6767
CID: 4823342

Perspectives on meeting the COVID-19 testing challenge: A dental school collaborative

Donoff, R. Bruce; Poznansky, Mark; Kochman, David; Lieberthal, Bruce; Bhansali, Seema; Neale, Allison; Bryant, Daniel; Glickman, Robert; Moursi, Amr; Feldman, Cecile A.; Fine, Daniel; Kess, Steve; Alfano, Michael C.; Levy, Ari; Ismail, Amid; Rams, Thomas; Reddy, Michael; Gansky, Stuart; Ramneek, Rai; McCauley, Laurie K.; Eber, Robert; Wolff, Mark; Krumholz, Harlan
ISSN: 0022-0337
CID: 4612212

Patient aggression toward dental students

Rhoades, Kimberly A; Heyman, Richard E; Eddy, J Mark; Fat, Sammie Jo; Haydt, Nicole C; Glazman, Jacqueline E; Dispirito, Zachary F; Rascon, Allison N; Guerrera, Charlotte M; Wolff, Mark S
Aggression from patients is one of the risks faced by healthcare workers during a typical work week. This risk begins during training. Although rates of patient aggression have been estimated for nursing students and medical residents, studies of aggression toward dental students have not been conducted. To begin to address this knowledge gap, we surveyed 160 D.D.S. student dentists in their third- or fourth years who were attending a large urban college of dentistry during the 2018-2019 academic year. Each class had approximately 375 students, leading to a response rate of 21%. Approximately 28% of students reported experiencing at least 1 instance of physical aggression, 86% reported experiencing at least 1 instance of verbal aggression, and 36% reported experiencing at least 1 instance of reputational aggression. There were no differences in rates of experienced aggression by age or gender, but Hispanic or Latinx students were more likely to experience physical and reputational aggression than non-Hispanic White or Asian students. We discuss implications for dental education, including modifications to training clinic procedures and curriculum additions or modifications that may help prepare students to prevent and address patient aggression within the dental clinic environment.
PMID: 32022267
ISSN: 1930-7837
CID: 4301072

Comorbid conditions are a risk for osteonecrosis of the jaw unrelated to antiresorptive therapy

Fleisher, Kenneth E; Janal, Malvin N; Albstein, Nicole; Young, James; Bikhazi, Vanessa; Schwalb, Shlomit; Wolff, Mark; Glickman, Robert S
OBJECTIVE:is associated with one or more particular comorbidities. STUDY DESIGN/METHODS:or DH lesion to a control patient who had a history of dentoalveolar surgery with uneventful healing and no history of antiresorptive therapy. Comorbidity data included medical conditions and smoking. RESULTS:and DH than in controls [M(SD) = 1.94 (1.2) and 2.0 (1.3) vs 1.26 (0.89); both P < .001]. CONCLUSIONS:and DH.
PMID: 30449690
ISSN: 2212-4411
CID: 3479252

Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association

Slayton, Rebecca L; Urquhart, Olivia; Araujo, Marcelo W B; Fontana, Margherita; Guzmán-Armstrong, Sandra; Nascimento, Marcelle M; Nový, Brian B; Tinanoff, Norman; Weyant, Robert J; Wolff, Mark S; Young, Douglas A; Zero, Domenick T; Tampi, Malavika P; Pilcher, Lauren; Banfield, Laura; Carrasco-Labra, Alonso
BACKGROUND:An expert panel convened by the American Dental Association Council on Scientific Affairs and the Center for Evidence-Based Dentistry conducted a systematic review and formulated evidence-based clinical recommendations for the arrest or reversal of noncavitated and cavitated dental caries using nonrestorative treatments in children and adults. TYPES OF STUDIES REVIEWED/METHODS:The authors conducted a systematic search of the literature in MEDLINE and Embase via Ovid, Cochrane CENTRAL, and Cochrane database of systematic reviews to identify randomized controlled trials reporting on nonrestorative treatments for noncavitated and cavitated carious lesions. The authors used the Grading of Recommendations Assessment, Development and Evaluation approach to assess the certainty in the evidence and move from the evidence to the decisions. RESULTS:The expert panel formulated 11 clinical recommendations, each specific to lesion type, tooth surface, and dentition. Of the most effective interventions, the panel provided recommendations for the use of 38% silver diamine fluoride, sealants, 5% sodium fluoride varnish, 1.23% acidulated phosphate fluoride gel, and 5,000 parts per million fluoride (1.1% sodium fluoride) toothpaste or gel, among others. The panel also provided a recommendation against the use of 10% casein phosphopeptide-amorphous calcium phosphate. CONCLUSIONS AND PRACTICAL IMPLICATIONS/UNASSIGNED:Although the recommended interventions are often used for caries prevention, or in conjunction with restorative treatment options, these approaches have shown to be effective in arresting or reversing carious lesions. Clinicians are encouraged to prioritize use of these interventions based on effectiveness, safety, and feasibility.
PMID: 30261951
ISSN: 1943-4723
CID: 3333342

Dentists: Critical aspects of their own and their community's disaster preparedness plan

Glotzer, David L; Perelman, Sharon C; Wolff, Mark S
The weather-related disasters in 2017 in Texas, Florida, Puerto Rico, the 2017-2018 wildfire seasons in California and Hurricanes Florence and Michael in 2018 have challenged all healthcare professionals, to have plans in place to protect their facility, patients, and staff from all possible hazards. These were "slowly developing" events, with enormous media coverage, and yet the results were still horrific. The need to have both a good evacuation plan and a good shelter-in-place plan has previously been dramatically demonstrated. When planning for disasters, it is critical for healthcare providers to understand the nature of a particular event and its possible consequences. When the concern arises about either an individual medical facility, or a whole community's well-being, a proper response requires significant levels of preparedness, education, and training. Comprehension of the threat and an understanding of the resources available to combat an event can significantly mitigate the possible damage. This article reviews a dental school curriculum to prepare students to respond to such contingencies while describing the goals, and sources for a disaster preparedness syllabus.
PMID: 30821342
ISSN: 1932-149x
CID: 3699022

Assessment of cuspal deflection and volumetric shrinkage of different bulk fill composites using non-contact phase microscopy and micro-computed tomography

Prager, Martin; Pierce, Mark; Atria, Pablo J; Sampaio, Camila; Cáceres, Eduardo; Wolff, Mark; Giannini, Marcelo; Hirata, Ronaldo
The understanding of cuspal deflection and volumetric shrinkage of resin composites is necessary to assess and improve the placement techniques of resin-based materials. The aim of this study was to investigate the cuspal deflection and its relationship with volumetric polymerization shrinkage of different bulk-fill resin composites. The investigation was conducted using non-contact phase microscopy and micro-computed tomography. Thirty custom-milled aluminum blocks were fabricated for microscopy analysis and thirty-six tooth models with standardized Class I cavities were used for micro-computed tomography analysis. Results showed that high-viscosity composites present higher cuspal deflection compared to bulk-fill composites. The filler loading of resin composites seems to have an effect on cusp deflection, since the higher the filler content percentage, the higher the cusp deflection. On the other hand, it seems to have an opposite effect on volumetric shrinkage, since higher filler loadings produced lower volumetric shrinkage percentages.
PMID: 29375091
ISSN: 1881-1361
CID: 2934002

Dental Students' Preferences in Career Paths Using Match, Job, and Income Data [Meeting Abstract]

Lee, Ellen; Chin, Brian; Wolff, Mark S; Chen, Anthony Kar Ki; Chen, Gia
ISSN: 1930-7837
CID: 2934132

Benefits of Peer Assessment in Dental Education and Professional Practice [Meeting Abstract]

Rodriguez-Cardenas, Maria P; Estafan, Denise; Allen, Kenneth L; Wolff, Mark S
ISSN: 1930-7837
CID: 2934142

Introduction to ICNARA 3

Fontana, M; Wolff, M; Featherstone, J D
PMID: 29355407
ISSN: 1544-0737
CID: 2927452