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Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017

Dicker, Daniel; Nguyen, Grant; Abate, Degu; Abate, Lkidan Hassen; Abay, Solomon M.; Abbafati, Cristiana; Abbasi, Nooshin; Abbastabar, Hcdayat; Abd-Allah, Foad; Abdela, Jeinal; Abdelalim, Ahmed; Abdel-Rahman, Omar; Abdi, Alireza; Abdollahpour, Ibrahim; Abdulkader, Rizwan Suliankatchi; Abdurahman, Ahmed Abdulahi; Abebe, Haftom Temesgen; Abebe, Molla; Abebe, Zegeye; Abebo, Teshome Abuka; Aboyans, Victor; Abraha, Haftom Niguse; Abrham, Aklilu Roba; Abu-Raddad, Laith Jamal; Abu-Rmeileh, Niveen Ml; Mbessi, Manfred Mario Kokou Areas; Acharya, Pawan; Adebayo, Oladimeji M.; Adedeji, Isaac Akinkimmi; Adedoyin, Rufus Adesoji; Adekanmbi, Victor; Adetokunboh, Olatunji O.; Adhena, Beyene Meressa; Adhikari, Tara Banal; Adib, Mina G.; Adou, Arsene Kouablan; Adsuar, Jose C.; Afaridern, Mohsen; Afshin, Ashkan; Agarwal, Gina; Aggarwal, Rakesh; Aghayan, Sargis Agbasi; Agrawal, Sutapa; Agrawal, Anurag; Ahmadi, Mehdi; Ahmadi, Alireza; Ahmadieh, Hamid; Ahmed, Mohamed Lemine Cheikh Brahim; Ahmed, Sayem; Ahmed, Muktar Beshir; Aichour, Amani Nidhal; Aichour, Ibtihel; Aichour, Miloud Taki Eddine; Akanda, Ali S.; Akbari, Mohammad Esmaeil; Akibu, Mohammed; Akinyemi, Rufus Olusola; Akinyemiju, Tomi; Akseer, Nadia; Alandab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Alebel, Animut; Aleman, Alicia V.; Alene, Kefyalew Addis; Al-Eyadhy, Ayman; Ali, Raghib; Alijanzadely, Mehran; Alizadeh-Navaei, Reza; Aljunid, Syed Mohamed; Alkerwi, Ala'a; Alla, Francois; Allebeck, Peter; Allen, Christine A.; Alonso, Jordi; Al-Raddadi, Rajaa M.; Alsharif, Ubai; Altirkawi, Khalid; Alvis-Cituman, Nelson; Amare, Azmeraw T.; Amini, Erfan; Ammar, Walid; Amoako, Yaw Ampem; Anber, Nahla Hamed; Andrei, Catalina Liliana; Androudi, Sofia; Animut, Megbani Debalkie; Anjomshoa, Mina; Anlay, Degefaye Zelalem; Ansari, Hossein; Ansariadi, Ansariadi; Ansha, Mustafa Geleto; Antonio, Carl Abelardo T.; Appiah, Seth Christopher Yaw; Aremu, Olatunde; Areri, Habtarnu Abera; Arnlov, Johan; Aroma, Megha; Artaman, Al; Aryal, Krishna K.; Asadi-Lari, Mohsen; Asayesh, Hamid; Asfaw, Ephrem Tsegay; Asgedom, Solomon Weldegebreal; Assadi, Reza; Ataro, Zerihun; Atey, Tesfay Mehan Mehari; Athari, Seyyed Shamsadin; Atique, Suleman; Atre, Sachin R.; Atteraya, Madhu Sudhan; Attia, Engi F.; Ausloos, Marcel; Avila-Burgos, Leticia; Avokpaho, Euripide F. G. A.; Awasthi, Ash Ish; Awuah, Baffour; Quintanilla, Beatriz Paulina Ayala; Ayele, Henok Tadesse; Ayele, Yohanes; Ayer, Rakesh; Ayuk, Tam Be B.; Azzopardi, Peter S.; Azzopardi-Muscat, Natasha; Badali, Hamid; Badawi, Alaa; Balakrishnan, Kalpana; Bali, Ayele Geleto; Banach, Maciej; Banstola, Armit; Barac, Aleksandra; Barboza, Miguel A.; Barquera, Simon; Barrero, Lope H.; Basaleem, Huda; Bassat, Quique; Basu, Arindam; Basu, Sanjay; Baune, Bernhard T.; Bazargan-Hejazi, Shahrzad; Bedi, Neeraj; Beghi, Ettore; Behzadifar, Masoud; Behzadifar, Meysam; Bejot, Yannick; Bekele, Bayu Begashaw; Belachew, Abate Bekele; Belay, Aregawi Gebreyesus; Belay, Ezra; Belay, Saba Abraham; Belay, Yihalem Abebe; Bell, Michelle L.; Bello, Aminu K.; Bennett, Derrick A.; Bensenor, Isabela M.; Berhane, Adugnaw; Berman, Adam E.; Bernabe, Eduardo; Bernstein, Robert S.; Bertolacci, Gregory J.; Beuran, Mircea; Beyranvand, Tina; Bhala, Neeraj; Bhatia, Eesh; Bhatt, Samir; Bhattarai, Suraj; Bhaumik, Soumyadeeep; Bhutta, Zulfiqar A.; Biadgo, Belete; Bijani, Ali; Bikbov, Boris; Bililign, Nigus; Bin Sayeed, Muhammad Shandaat; Birlik, Sait Mentes; Birungi, Charles; Bisanzio, Donal; Biswas, Tuhin; Bjorge, Tone; Bleyer, Archie; Basara, Berrak Bora; Bose, Dipan; Bosetti, Cristina; Boufous, Soufiane; Bourne, Rupert; Brady, Oliver J.; Bragazzi, Nicola Luigi; Brant, Luisa C.; Brazinova, Alexandra; Breitborde, Nicholas J. K.; Brenner, Hermann; Britton, Gabrielle; Brugha, Traolach; Burke, Kristin E.; Busse, Reinhard; Butt, Zahid A.; Cahuana-Hurtado, Lucero; Callender, Charlton S. K. H.; Campos-Nonato, Ismael R.; Rincon, Julio Cesar Campuzano; Cano, Jorge; Car, Mate; Cardenas, Rosario; Caneras, Giulia; Canero, Juan J.; Carter, Austin; Carvalho, Felix; Casaneda-Orjuela, Carlos A.; Rivas, Jacqueline Castillo; Castro, Franz; Catala-Lopez, Ferran; Cavlin, Alanur; Cerin, Ester; Chaiah, Yazan; Champs, Ana Paula; Chang, Hsing-Yi; Chang, Jung-Chen; Chattopadhyay, Aparajita; Chaturvedi, Pankaj; Chen, Wanqing; Chiang, Peggy Pei-Chia; Chimed-Ochir, Odgerel; Chin, Ken Lee; Chisumpa, Vesper Hichilombwe; Chitheer, Abchilaal; Choi, Jee-Young J.; Christensen, Hanne; Christopher, Devasahayam J.; Chung, Sheng-Chia; Cicuttini, Flavia M.; Ciobanu, Liliana G.; Cirillo, Massimo; Claro, Rafael M.; Cohen, Aaron J.; Collado-Mateo, Daniel; Constantin, Maria-Magdalena; Conti, Sara; Cooper, Cyrus; Cooper, Leslie Trumbull; Cortesi, Paolo Angelo; Cortinovis, Monica; Cousin, Ewerton; Criqui, Michael H.; Cromwell, Elizabeth A.; Crowe, Christopher Stephen; Crump, John A.; Cucu, Alexandra; Cunningham, Matthew; Daba, Alemneh Kabeta; Dachew, Berihun Assefa; Dadi, Abel Fekaadu; Dandona, Lalit; Dandona, Rakhi; Dang, Anh Kim; Dargan, Paul I.; Daryani, Ahmad; Das, Siddharth K.; Das Gupta, Rajat; das Neves, Jose; Dasa, Tamirat Tesfaye; Dash, Aditya Prasad; Weaver, Nicole Davis; Davitoiu, Dragos Virgil; Davletov, Kairat; Dayama, Anand; de Courten, Barbora; De la Hoz, Fernando Pio; De Leo, Diego; De Neve, Jan-Walter; Degefa, Meaza Ginna; Degenhardt, Louisa; Degfie, Tizta T.; Deiparine, Selina; Dellavalle, Robert P.; Demoz, Gebre Teklemariam; Demtsu, Balem Betsu; Denova-Gutierrez, Edgar; Deribe, Kebede; Dervenis, Nikolaos; Des Jarlais, Don C.; Dessie, Getenet Ayalew; Dey, Subhojit; Dharmaratne, Samath Dhamminda; Dhimal, Meghnath; Ding, Eric L.; Djalalinia, Shirin; Doku, David Teye; Dolan, Kate A.; Donnelly, Christi A.; Dorsey, E. Ray; Douwes-Schultz, Dirk; Doyle, Kerrie E.; Drake, Thomas M.; Driscoll, Tim Robert; Dubey, Manisha; Dubljanin, Eleonora; Duken, Eyasu Ejeta; Duncan, Bruce B.; Duraes, Andre R.; Ebrahimi, Hedyeh; Ebrahimpour, Soheil; Edessa, Dumessa; Edvardsson, David; Eggen, Anne Elise; El Bcheraoui, Charbel; Zaki, Maysaa El Sayed; Elfaramawi, Mohammed; El-Khatib, Ziad; Ellingsen, Christian Lycke; Elyazar, Iqbal R. F.; Enayati, Ahmadali; Endries, Aman Yesuf Yesuf; Er, Benjamin; Ermakov, Sergey Petrovich; Eshrati, Babak; Eskandarieff, Sharareh; Esmaeili, Reza; Esteghamati, Alireza; Esteghamati, Sadaf; Fakhar, Matadi; Fakhim, Named; Farag, Tamer; Faramarzi, Mahbobelh; Fareed, Mohammad; Farhadi, Farzaneh; Farid, Talha A.; Farinha, Carla Sofia e Sa; Farioli, Andrea; Faro, Andre; Farvid, Maryam S.; Farzadfar, Farshad; Farzaei, Mohammad Hosein; Farzeli, Mir Sohail; Feigin, Valery L.; Feigl, Andrea B.; Feizy, Fariba; Fentahum, Netsanet; Fereshtehnejad, Seyed-Mohammad; Fernandes, Eduarda; Fernandes, Joao C.; Feyissa, Garumma Tolu; Fijabi, Daniel Obadare; Filip, Irina; Finegold, Samuel; Fischer, Florian; Flor, Luisa Sorio; Foigt, Nataliya A.; Ford, John A.; Foreman, Kyle J.; Harrod, Carla; Frank, Tahvi D.; Franklin, Richard Charles; Fukumoto, Takeshi; Fuller, John E.; Fullman, Nancy; Furst, Thomas; Furtado, Joao M.; Futran, Neal D.; Galan, Adriana; Gallus, Silvano; Gambashidze, Ketevan; Gamkrelidze, Amiran; Gankpe, Fortune Gbetoho; Garcia-Basteiro, Alberto L.; Garcia-Gordillo, Miguel A.; Gebre, Teshome; Gebre, Abadi Kahsu; Gebregergs, Gebremedhin Berne; Gebrehiwot, Tsegaye Tewelde; Gebremedhin, Amanuel Tesfay; Gelano, Tilayie Feto; Gelaw, Yalemzewod Assefa; Geleijnse, Johanna N.; Genova-Maleras, Ricard; Gessner, Bradford D.; Getachew, Sefonias; Gething, Peter W.; Gezae, Kebede Embaye; Ghadami, Mohammad Rasold; Ghadimi, Reza; Falavarjani, Khalil Ghasemi; Ghaserni-Kasman, Maryam; Ghiasvand, Hesam; Ghirnire, Mamata; Ghoshal, Aloke Gopal; Gill, Paramjit Singh; Gill, Tiffany K.; Gillum, Richard F.; Giussani, Giorgia; Goenka, Shifalika; Coll, Srinivas; Gomez, Ricardo Santiago; Gomez-Cabrera, Mari Carmen; Gomez-Dantes, Hector; Gona, Philimon N.; Goodridge, Amador; Gopalani, Sameer Vali; Goto, Atsushi; Goulart, Alessandra C.; Goulart, Barbara Niegia Garcia; Grada, Ayman; Grosso, Giuseppe; Gugnani, Harish Chander; Guimaraes, Andre Luiz Sena; Guo, Yuming; Gupta, Prakash C.; Gupta, Rahul; Gupta, Rajeev; Gupta, Tanush; Gyawali, Bishal; Haagsma, Juanita A.; Hachinski, Vladimir; Hafezi-Nejad, Nima; Hagos, Tekleberhan B.; Hailegiyorgis, Tewodros Tesfa; Hailu, Gessessew Bugssa; Haj-Mirzaian, Arya; Haj-Mirzaian, Arvin; Hamadeh, Randah R.; Hamidi, Sarver; Handal, Alexis J.; Hankey, Graeme J.; Harb, Hilda L.; Harikrishnan, Sivadasanpillai; Haririan, Hamidreza; Haro, Josep Maria; Hasan, Mehedi; Hassankhani, Hadi; Hassen, Hamid Yimam; Havmoeller, Rasmus; Hay, Roderick J.; Hay, Simon I.; He, Yihua; Hedayatizadeh-Omran, Akhar; Hegazy, Mohamed I.; Heibati, Behzad; Heidari, Mohsen; Hendrie, Delia; Henok, Andualem; Henry, Nathaniel J.; Heredia-Pi, Ileana; Herteliff, Claudiu; Heydarpour, Fatemeh; Heydarpour, Pouria; Heydarpour, Sousan; Hibstu, Desalegn Tsegaw; Hoek, Hans W.; Hole, Michael K.; Rad, Enayatollah Homaie; Hoogar, Praveen; Horino, Masako; Hosgood, H. Dean; Hosseini, Seyed Mostafa; Hosseinzadeh, Mehdi; Hostiuc, Sorin; Hostiuc, Mihaela; Hotez, Peter J.; Hoy, Damian C.; Hsairi, Mohamed; Htet, Aung Sae; Hu, Guoqing; Huang, John J.; Husseini, Abdullatif; Hussen, Mohammedaman Mama; Hutfless, Susan; Iburg, Kim Moesgaard; Igumbor, Elliman U.; Ikeda, Chad Thomas; Illesanmi, Olayinka Stephen; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Isehunwa, Oluwaseyi Oluwakemi; Islam, Sheikh Mohammed Shariful; Islam, Farhad; Jahangiry, Leila; Jahanmehr, Nader; Jain, Rajesh; Jain, Sudhir Kumar; Jakovljevic, Mihail; James, Spencer L.; Jayanbakht, Mehdi; Jayaraman, Sudha; Jayatilleke, Achala Upendra; Jee, Sun Ha; Jeemon, Panniyammakal; Jha, Ravi Prakash; Jha, Vivekanand; Ji, John S.; Johnson, Sarah Charlotte; Jonas, Jost B.; Joshi, Ankur; Jozwiak, Jacek Jerzy; Jungari, Suresh Banayya; Jurisson, Mikk; Madhanraj, K.; Kabir, Zubair; Kadel, Rajendra; Kahsay, Amaha; Kahssay, Molla; Kalani, Rizwan; Kapil, Umesh; Karami, Manoochehr; Matin, Behzad Karami; Karch, Andre; Karema, Corine; Karimi, Narges; Karimi, Seyed M.; Karimi-Sari, Hamidreza; Kasaeian, Arnir; Kassa, Getachew Mullu; Kassa, Tesfaye Dessale; Kassa, Zemenu Yohannes; Kassebaum, Nicholas J.; Katibeh, Marzieh; Katikireddi, Sitinivasa Vittal; Kaul, Anil; Kawakami, Norito; Kazemeini, Hossein; Kazemi, Zhila; Karyani, Ali Kazemi; Prakash, K. C.; Kebede, Seifu; Keiyoro, Peter Njenga; Kemp, Grant Rodgers; Kengne, Andre Pascal; Keren, Andre; Keresellidze, Maia; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khajavi, Alireza; Khalid, Nauman; Khalil, Ibrahim A.; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khan, Muhammad Shahzeb; Khan, Muhammad Ali; Khang, Young-Ho; Khanna, Tripti; Khater, Mona M.; Khatony, Alireza; Khazaie, Habibolah; Khoja, Abdullah T.; Khosravi, Ardeshir; Khosravi, Mohammad Hossein; Khubchandani, Jagdish; Kiadaliri, Aliasghar A.; Kibret, Getiye D. Dejenu; Kim, Cho-il; Kim, Daniel; Kim, Jun Y.; Kim, Young-Eun; Kimokoti, Ruth Nv; Kinfu, Yohannes; Kinra, Sanjay; Kisa, Adrian; Kissimova-Skarbek, Katarzyna; Kissoon, Niranjan; Kivimaki, Mika; Kleber, Marcus F.; Knibbs, Luke D.; Knudsen, Ann Kristin Skrindo; Kochhar, Sonali; Kokubo, Yoshihiro; Kolola, Tufa; Kopec, Jacek A.; Kosek, Margaret N.; Kosen, Soewarta; Koul, Parvaiz A.; Koyanagi, Ai; Kravchenko, Michael A.; Kristian, Kewal; Krishnaswami, Sanjay; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kudom, Andreas A.; Kuipers, Ernst J.; Kulikoff, Xie Rachel; Kumar, G. Anil; Kumar, Manasi; Kumar, Pushpendra; Kumsa, Fekede Asefa; Kutz, Michael J.; Lad, Sheetal D.; Lafranconi, Alessandra; Lal, Dharmesh Kumar; Lalloo, Ratilal; Lam, Hilton; Lami, Faris Hasan; Lan, Qing; Langan, Sinead M.; Lansingh, Van C.; Torisky, Sonia; Larson, Heidi Jane; Laryea, Dennis Odai; Lassi, Zohra S.; Latifi, Arman; Lavados, Pablo M.; Laxmaiah, Anita; Lazarus, Jeffrey V.; Lebedev, Georgy; Lee, Paul H.; Leigh, James; Leshargie, Cheru Tesema; Leta, Samson; Levi, Miriam; Li, Shanshan; Li, Yichong; Li, Xiaohong; Hang, Juan; Liang, Xiaofeng; Liben, Misgan Legesse; Lim, Lee-Ling; Lim, Stephen S.; Limenih, Miteku Andualem; Linn, Shai; Liu, Shiwei; Liu, Yang; Lodha, Rakesh; Logroscino, Giancarlo; Lonsdale, Chris; Lorch, Scott A.; Lorkowski, Stefan; Lotufo, Paulo A.; Lozano, Rafael; Lucas, Tim C. D.; Lunevicius, Raimundas; Lyons, Ronan A.; Ma, Stefan; Mabika, Crispin; Macarayam, Erlyn Rachelle King; Mackay, Mark T.; Maddison, Emilie R.; Maddison, Ralph; Madotto, Fabiana; Abd El Razek, Hassan Magdy; Abd El Razek, Muhammed Magdy; Maghavani, Dhaval P.; Majdan, Marek; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Malik, Manzoor Ahmad; Malta, Deborah Carvaho; Mamun, Abdullah A.; Manamo, Wondimu Ayele; Manda, Ana-Laura; Mansoumia, Mohammad Ali; Mantovani, Lorenzo Giovanni; Mapoma, Chabila Christopher; Marami, Dadi; Marayilla, Joemer C.; Marcenes, Wagner; Marina, Shakhnazarova; Martinez-Raga, Jose; Martins, Sheila C. O.; Martins-Melo, Francisco Rogerlandio; Marz, NXinfried; Marzan, Melvin B.; Mashamba-Thompson, Tivani Phosa; Masiye, Felix; Massenburg, Benjamin Ballard; Maulik, Pallab K.; Mazidi, Mohsen; McGrath, John J.; McKee, Martin; Mehata, Suresh; Mehendale, Sanjay Madhav; Mehndiratta, Man Mohan; Mehrotra, Ravi; Mehta, Kala M.; Mehta, Varshil; Mekonen, Tesfa; Mekonnen, Tefera Chane; Meles, Hagazi Gebre; Meles, Kidanu Gebremariam; Melese, Addisu; Melku, Mulugeta; Memiah, Peter T. N.; Memish, Ziad A.; Mendoza, Walter; Mengistu, Desalegn Tadese; Ntengistu, Getnet; Mensah, George A.; Mereta, Seid Tiku; Meretoja, Atte; Meretoja, Tuomo J.; Mestrovic, Tomislav; Mezgebe, Haftay Berhane; Miangotar, Yode; Miazgowski, Bartosz; Miazgowski, Tomasz; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Misganaw, Awoke Temesgen; Moazen, Babak; Moges, Nurilign Abebe; Mohammad, Karzan Abdulmuhsin; Mohammadi, Moslem; Mohammadifard, Noushin; Mohammadi-Khanaposhtani, Maryam; Mohammadnia-Afrouzi, Mousa; Mohammed, Shafiu; Mohammed, Mohammed A.; Mohan, Viswanathan; Mokdad, Ali H.; Molokhia, Mariam; Monasta, Lorenzo; Moradi, Ghobad; Moradi, Mahmoudreza; Moradi-Lakeh, Maziar; Moradinazar, Mehdi; Moraga, Paula; Morawska, Lidia; Velasquez, This Moreno; Morgado-da-Costa, Joana; Morrison, Shane Douglas; Mosapour, Abbas; Moschos, Marilita M.; Mousavi, Seyyed Meysam; Muche, Achenef Asmamaw; Muchie, Kindie Fentahun; Mueller, Ulrich Otto; Mukhopadhyay, Satinath; Mullany, Erin C.; Muller, Kate; Murhekar, Manoj; Murphy, Tasha B.; Murthy, G. V. S.; Murthy, Srinivas; Musa, Jonah; Musa, Kargartil Imran; Mustafa, Ghulam; Muthupandian, Saravanan; Nachega, Jean B.; Nagel, Gabriele; Naghavi, NIohsen; Naheed, Aliya; Nahvijou, Azin; Naik, Gurudatta; Nair, Sanjeev; Najafi, Farid; Nangia, Vinay; Nansseu, Jobert Richie; Nascimento, Bruno Ramos; Nawaz, Haseeb; Ncama, Busisiwe P.; Neamati, Nahid; Negoi, Ionut; Negoi, Ruxandra Irina; Neupane, Subas; Newton, Charles Richard James; Ngalesoni, Frida N.; Ngunjiri, Josephine W.; Ha Thu Nguyen; Huong Thanh Nguyen; Long Hoang Nguyen; Michele Nguyen; Trang Huyen Nguyen; Ningrum, Dina Nur Anggraini; Nirayo, Yirga Legesse; Nisar, Muhammad Imran; Nixon, Molly R.; Nolutshungu, Nomonde; Nomura, Shuhei; Norheim, Ole F.; Noroozi, Mehdi; Norrving, Bo; Noubiap, Jean Jacques; Nouri, Hamid Reza; Shiadeh, Malihe Nourollahpour; Nowroozi, Mohammad Reza; Nsoesie, Elaine O.; Nyasulu, Peter S.; Ofori-Asenso, Richard; Ogah, Okechukwu Samuel; Ogbo, Felix Akpojene; Oh, In-Hwan; Okoro, Anselm; Oladimeji, Olanrewaju; Olagunju, Andrew T.; Olagunju, Tinuke O.; Olivares, Pedro R.; Olusanya, Bolajoko Olubuktmola; Olusanya, Jacob Olusegun; Ong, Sok King; Opio, John Nelson; Oren, Eyal; Ortiz, Justin R.; Ortiz, Alberto; Ota, Erika; Otstavnov, Stanislav S.; Overland, Simon; Owolabi, Mayowa Ojo; Oyekale, Abayomi Samuel; Mahesh, P. A.; Pacella, Rosana; Pakhale, Smita; Pakhare, Abhijit P.; Pana, Adrian; Panda, Basant Kumar; Panda-Jonas, Songhomitu; Pandey, Achyut Raj; Pandian, Jeyaraj Durai; Parisi, Andrea; Park, Eun-Kee; Parry, Charles D. H.; Parsian, Hadi; Patel, Shanti; Patle, Ajay; Patten, Scott B.; Patton, George C.; Paudel, Deepak; Pearce, Neil; Peprah, Emmanuel K.; Pereira, Alexandre; Pereira, David M.; Perez, Krystle M.; Perico, Norberto; Pervaiz, Aslam; Pesudovs, Konrad; Petri, William A.; Petzold, Max; Phillips, Michael R.; Pigott, David M.; Pillay, Julian David; Pirsaheb, Meghdad; Pishgar, Farhad; Plass, Dietrich; Polinder, Suzanne; Pond, Constance Dimity; Popova, Svetlana; Postma, Maarten J.; Pourmalek, Farshad; Pourshams, Akram; Poustchi, Hossein; Prabhakaran, Dorairaj; Prakash, V.; Prakash, Swayam; Prasad, Narayan; Qorbani, Mostafa; Quistberg, D. Alex; Radfar, Amir; Rafay, Anwar; Rafiei, Alireza; Rahim, Fakher; Rahimi, Kazem; Rahimi-Movaghar, Afarin; Rahimi-Movaghar, Vafa; Rahman, Mahfuzar; Rahman, Mohammad Hi Ur; Rahman, Muhammad Aziz; Rahman, Sajjad ur; Rai, Rajesh Kumar; Rajati, Patemeh; Rajsic, Sasa; Raju, Sree Bhushan; Ram, Usha; Ranabhat, Chhabi Lal; Ranjan, Prabhat; Ranta, Anna; Rasella, Davide; Rawaf, David Faith; Rawaf, Salman; Ray, Sarah E.; Razo-Garcia, Christian; Rego, Maria Albertina Santiago; Rehm, Juergen; Reiner, Robert C.; Reinig, Nickolas; Reis, Cesar; Remuzzi, Giuseppe; Renzaho, Andre M. N.; Resnikoff, Serge; Rezaei, Satan; Rezaeian, Shahab; Rezai, Mohammad Sadegh; Riahi, Seyed Mohammad; Ribeiro, Antonio Luiz P.; Riojas, Horacio; Rios-Blancas, Maria Jesus; Roba, Kedir Teji; Robinson, Stephen R.; Roever, Leonardo; Ronfani, Luca; Roshandel, Gholargreza; Roshchin, Denis; Rostami, Ali; Rothenbacher, Dietrich; Rubagotti, Enrico; Ruhago, George Mugambage; Saadat, Soheil; Sabde, Yogesh Damodar; Sachder, Perminder S.; Saddik, Basema; Sadeghi, Ehsan; Moghaddam, Sahar Saeedi; Safari, Hosein; Safari, Yahya; Safari-Faramani, Roya; Safdarian, Mandi; Safi, Sane; Safiri, Saeid; Sagar, Rajesh; Sahebkar, Amirhossein; Sahraian, Mohammad Ali; Sajadi, Haniye Sadat; Salahshoor, Mohamadreza; Salam, Nasir; Salama, Joseph S.; Salamati, Payman; Saldanha, Raphael de Freitas; Salimi, Yahya; Salimzadeh, Hamideh; Salz, Inbal; Sambala, Evanson Zondani; Samy, Abdallah M.; Sanabria, Juan; Nino, Maria Dolores Sanchez; Santos, Itarnar S.; Santos, Joao Vasco; Milicevic, Milena M. Santric; Jose, Bruno Piassi Sao; Sardana, Mayank; Sacker, Abdur Razzaque; Sarrafzadegan, Nizal; Sartorius, Benn; Sarvi, Shahabeddin; Sathian, Brijesh; Satpathy, Maheswar; Savic, Miloje; Sawant, Artmdhati R.; Sawhney, Monika; Saxena, Sonia; Sayyah, Mehdi; Scaria, Vinod; Schadffner, Fake; Schelonka, Kathryn; Schmidt, Maria Ines; Schneider, Ione J. C.; Schottker, Ben; Schutte, Aletta Elisabeth; Schwebel, David C.; Schwendicke, Falk; Scott, James G.; Sekerija, Mario; Sepanlou, Sadaf G.; Servan-Mori, Edson; Shabaninejad, Hosein; Shackelford, Katya Anne; Shafieesabet, Azadeh; Shaheen, Andra A.; Shaikh, Masood Ali; Shakir, Raad A.; Shams-Beyranvand, Mehran; Shamsi, MohammadBagher; Shamsizadeh, Modena; Sharafi, Heidar; Sharafi, Kiomars; Sharit, Mehdi; Sharif-Alhoseini, Mahdi; Sharma, Meenakshi; Sharma, Jayendra; Sharma, Rajesh; She, Jun; Sheikh, Aziz; Sheth, Kevin N.; Shi, Peilin; Shibuya, Kenji; Shifa, Gimia Temam; Shiferaw, Mekonnen Sissy; Shigematsu, Mika; Shiri, Rahman; Shirkoohi, Reza; Shiue, Ivy; Shokraneh, Farhad; Shrime, Mark C.; Shukla, Sharvari Rahul; Si, Si; Siabani, Soraya; Siddiqi, Tariq J.; Sigfusdottir, Inga Dora; Sigurvinsdottir, Rannveig; Silpakit, Nazis; Silva, Diego Augusto Santos; Silva, Joao Pedro; Silveira, Dayane Gabriele Alves; Singam, Narayana Sarma Venkata; Singh, Jasvinder A.; Singh, Virendra; Sinha, Anju Pradhan; Sinha, Dhirendra Narain; Sitas, Freddy; Skirbekk, Vegard; Sliwa, Karen; Soares Filho, Adauto Martins; Sobaih, Badr Hasan; Sobhani, Soheila; Soofi, Moslem; Soriano, Joan B.; Soyiri, Ireneous N.; Sposato, Luciano A.; Sreeramareddy, Chandrashekhar T.; Srinivasan, Vinay; Srivastava, Rakesh Kumar; Starodubov, Vladimir I.; Stathopoulou, Vasiliki; Steel, Nicholas; Stein, Dan J.; Steiner, Caitlyn; Stewart, Leo G.; Stokes, Mark A.; Sudaryanto, Agus; Sufiyan, Mu'awiyyah Babale; Sulo, Gerhard; Sunguya, Bruno F.; Sur, Patrick John; Sutradhar, Ipsita; Sykes, Bryan L.; Sylaja, P. N.; Sylte, Dillon O.; Szoeke, Cassandra F. I.; Tabares-Seisdedos, Rafael; Tabuchi, Takahiro; Tadakamadla, Santosh Kumar; Takahashi, Ken; Tandon, Nikhil; Tassew, Aberash Abay; Tassew, Segen Gebremeskel; Tavakkoli, Mohammad; Taveira, Nuno; Tawye, Vega Yimer; Tehrani-Banihashemi, Arash; Tekalign, Tigist Gashaw; Tekle, Merhawi Gebremedhin; Temesgen, Habtamu; Temsah, Mohamad-Hani; Temsah, Omar; Terkawi, Abdullah Sulieman; Teshale, Manaye Yihune; Tessema, Belay; Teweldemedhin, Mebrahtu; Thakur, Jarnail Singh; Thankappan, Kavumpurathu Raman; Thinmavukkarasu, Sathish; Thomas, Laura Anne; Thomas, Nihal; Thrift, Amanda G.; Tilahun, Binyam; To, Quyen G.; Tobe-Gai, Ruoyan; Tonelli, Marcello; Topor-Madry, Roman; Topouzis, Fotis; Torre, Anna E.; Tortajada-Girbes, Miguel; TIavani-Palone, Marcos Roberto; Towbin, Jeffrey A.; Bach Xuan Tran; Khanh Ban Tran; Tripathi, Suryakant; Tripathy, Srikanth Prasad; Truelsen, Thomas Clement; Nu Thi Truong; Tsadik, Afewerki Gehremeskel; Tsilimparis, Nikolaos; Car, Lorainne Tudor; Tuzcu, E. Murat; Tyrovolas, Stefanos; Ukwaja, Kingsley Nnanna; Ullah, Irfan; Usman, Muhammad Shaniq; Uthman, Olalekan A.; Uzun, Selen Begun; Vaduganathan, Muthiah; Vaezi, Afsane; Vaidya, Gaurang; Valdez, Pascual R.; Varavikova, Elena; Varughese, Santosh; Vasankari, Tommi Juhani; Vasconcelos, Ana Maria Nogales; Venketasubramanian, Narayanaswamy; Vidavalur, Ramesh; Villafaina, Santos; Violante, Francesco S.; Vladimirov, Sergey Konstantinovitch; Vlassov, Vasily; Vollset, Stein Emil; Vos, Theo; Vosoughi, Kia; Vujcic, Isidora S.; Wagner, Gregory R.; Wagnew, Fasil Shiferaw Wagnew; Waheed, Yasir; Wang, Yanping; Wang, Yuan-Pang; Wassie, Molla Mesele; Weiderpass, Elisabete; Weintraub, Robert G.; Weiss, Daniel J.; Weiss, Jordan; Weldegebreal, Fitsum; Weldegwergs, Kidu Gidey; Werdecker, Andrea; Westerman, Ronny; Whiteford, Harvey A.; Widecka, Justyna; Widecka, Katarzyna; Wijeratne, Tissa; Winkler, Andrea Sylvia; Wiysonge, Charles Shey; Wolfe, Charles D. A.; Wondemagegn, Sintayehu Ambachew; Wu, Shouling; Wyper, Grant M. A.; Xu, Gelin; Yadav, Rajaram; Yakob, Bereket; Yamada, Tomohide; Yan, Lijing L.; Yano, Yuichiro; Yaseri, Mehdi; Yasin, Jemal Yasin; Ye, Pengpeng; Yearwood, Jamal A.; Yentur, Gokalp Kadri; Yeshaneh, Alex; Yimer, Ebrahim M.; Yip, Paul; Yisma, Engida; Yonemoto, Naohiro; Yoon, Seok-Jun; York, Hunter W.; Yotebieng, Marcel; Younis, Mustafa Z.; Yousefifard, Mahmoud; Yu, Chuanhua; Zachariah, Geevar; Zadnik, Vesna; Zafar, Shamsa; Zaidi, Zoubida; Bin Zaman, Sojib; Zamani, Mohammad; Zare, Zohreh; Zeeb, Hajo; Zeleke, Mulugeta Molla; Zenebe, Zerihun Menlkalew; Zerfu, Taddese Alemu; Zhang, Kai; Zhang, Xueying; Thou, Maigeng; Zhu, Jun; Zodpey, Sanjay; Zucker, Inbar; Zuhlke, Liesl Joanna J.; Lopez, Alan D.; Gakidou, Emmanuela; Murray, Christopher J. I.
Background Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths in the GBD. The present iteration of the GBD, GBD 2017, improves on previous assessments and provides timely estimates of the mortality experience of populations globally.
ISI:000449710900003
ISSN: 0140-6736
CID: 3493212

Quality of informed consent in cancer clinical trials in India: A cross-sectional survey

Gota, Vikram; Nookala, Manjunath; Yadav, Akanksha; Menezes, Sonia Rebecca; Kannan, Sadhana; Ali, Raghib
Background:An 'informed consent' is a legal and ethical requirement for research involving human subjects. Studies assessing the validity of informed consent and determinants of its quality have highlighted problems in consent delivery and comprehension by trial participants. We report the findings of a questionnaire-based survey conducted to understand the quality of informed consent (QuIC) in cancer clinical trials. Methods:The survey was conducted in a single tertiary care cancer centre in India. Patients enrolled in phase 1, 2 or 3 interventional studies were administered the QuIC questionnaire by a trained study coordinator. The QuIC, expressed as knowledge score, was calculated from the proportion of correct responses expressed as a percentage. Results:The mean (SD) knowledge score was 60.46% (1 5.21%). It was considerably higher in industry-sponsored trials compared to investigator-initiated trials (65.32% v. 52.21%, respectively; p<0.001). Faith in the treating oncologist positively influenced the patients' decision to participate in a trial. Nearly 97% of the respondents anticipated better care, while 85% felt that the new drug/procedure would be better than the existing treatment. Free treatment emerged as a strong inducement for patients to take part in clinical trials. Patients were aware of their autonomy, and responses showed that none of the patients were coerced or unduly influenced to participate in clinical trials. Conclusion:Our study revealed important deficiencies in research participants' understanding of essential elements of informed consent. Thorough patient counselling is crucial to minimize 'therapeutic misconception' to preserve the validity of informed consent in cancer trials.
PMID: 31397364
ISSN: 0970-258x
CID: 4048302

Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Griswold, Max G.; Fullman, Nancy; Hawley, Caitlin; Arian, Nicholas; Zimsen, Stephanie R. M.; Tymeson, Hayley D.; Venkateswaran, Vidhya; Tapp, Austin Douglas; Forouzanfar, Mohammad H.; Salama, Joseph S.; Abate, Kalkidan Hassen; Abate, Degu; Abay, Solomon M.; Abbafati, Cristiana; Abdulkader, Rizwan Suliankatchi; Abebe, Zegeye; Aboyans, Victor; Abrar, Mohammed Mehdi; Acharya, Pawan; Adetokunboh, Olatunji O.; Adhikari, Tara Ballav; Adsuar, Jose C.; Afarideh, Mohsen; Agardh, Emilie Elisabet; Agarwal, Gina; Aghayan, Sargis Aghasi; Agrawal, Sutapa; Ahmed, Muktar Beshir; Akibu, Mohammed; Akinyemiju, Tomi; Akseer, Nadia; Al Asfoor, Deena H.; Al-Aly, Ziyad; Alahdab, Fares; Alam, Khurshid; Albujeer, Ammar; Alene, Kefyalew Addis; Ali, Raghib; Ali, Syed Danish; Alijanzadeh, Mehran; Aljunid, Syed Mohamed; Alkerwi, Ala'a; Allebeck, Peter; Alvis-Guzman, Nelson; Amare, Azmeraw T.; Aminde, Leopold N.; Ammar, Walid; Amoako, Yaw Ampem; Amul, Gianna Gayle Herrera; Andrei, Catalina Liliana; Angus, Colin; Ansha, Mustafa Geleto; Antonio, Carl Abelardo T.; Aremu, Olatunde; Arnlov, Johan; Artaman, Al; Aryal, Krishna K.; Assadi, Reza; Ausloos, Marcel; Avila-Burgos, Leticia; Avokpaho, Euripide F. G. A.; Awasthi, Ashish; Ayele, Henok Tadesse; Ayer, Rakesh; Ayuk, Tambe B.; Azzopardi, Peter S.; Badali, Hamid; Badawi, Alaa; Banach, Maciej; Barker-Collo, Suzanne Lyn; Barrero, Lope H.; Basaleem, Huda; Baye, Estifanos; Bazargan-Hejazi, Shahrzad; Bedi, Neeraj; Bejot, Yannick; Belachew, Abate Bekele; Belay, Saba Abraham; Bennett, Derrick A.; Bensenor, Isabela M.; Bernabe, Eduardo; Bernstein, Robert S.; Beyene, Addisu Shunu; Beyranvand, Tina; Bhaumik, Soumyadeeep; Bhutta, Zulfiqar A.; Biadgo, Belete; Bijani, Ali; Bililign, Nigus; Birlik, Sait Mentes; Birungi, Charles; Bizuneh, Hailemichael; Bjerregaard, Peter; Bjorge, Tone; Borges, Guilherme; Bosetti, Cristina; Boufous, Soufiane; Bragazzi, Nicola Luigi; Brenner, Hermann; Butt, Zahid A.; Cahuana-Hurtado, Lucero; Calabria, Bianca; Campos-Nonato, Ismael R.; Campuzano Rincon, Julio Cesar; Carreras, Giulia; Carrero, Juan J.; Carvalho, Felix; Castaneda-Orjuela, Carlos A.; Castillo Rivas, Jacqueline; Catala-Lopez, Ferran; Chang, Jung-Chen; Charlson, Fiona J.; Chattopadhyay, Aparajita; Chaturvedi, Pankaj; Chowdhury, Rajiv; Christopher, Devasahayam J.; Chung, Sheng-Chia; Ciobanu, Liliana G.; Claro, Rafael M.; Conti, Sara; Cousin, Ewerton; Criqui, Michael H.; Dachew, Berihun Assefa; Dargan, Paul, I; Daryani, Ahmad; Das Neves, Jose; Davletov, Kairat; De Castro, Filipa; De Courten, Barbora; De Neve, Jan-Walter; Degenhardt, Louisa; Demoz, Gebre Teklemariam; Des Jarlais, Don C.; Dey, Subhojit; Dhaliwal, Rupinder Singh; Dharmaratne, Samath Dhamminda; Dhimal, Meghnath; Doku, David Teye; Doyle, Kerrie E.; Dubey, Manisha; Dubljanin, Eleonora; Duncan, Bruce B.; Ebrahimi, Hedyeh; Edessa, Dumessa; Zaki, Maysaa El Sayed; Ermakov, Sergei Petrovich; Erskine, Holly E.; Esteghamati, Alireza; Faramarzi, Mahbobeh; Farioli, Andrea; Faro, Andre; Farvid, Maryam S.; Farzadfar, Farshad; Feigin, Valery L.; Felisbino-Mendes, Mariana Santos; Fernandes, Eduarda; Ferrari, Alize J.; Ferri, Cleusa P.; Fijabi, Daniel Obadare; Filip, Irina; Finger, Jonas David; Fischer, Florian; Flaxman, Abraham D.; Franklin, Richard Charles; Futran, Neal D.; Gallus, Silvano; Ganji, Morsaleh; Gankpe, Fortune Gbetoho; Gebregergs, Gebremedhin Berhe; Gebrehiwot, Tsegaye Tewelde; Geleijnse, Johanna M.; Ghadimi, Reza; Ghandour, Lilian A.; Ghimire, Mamata; Gill, Paramjit Singh; Ginawi, Ibrahim Abdelmageed; Giref, Ababi Zergaw Z.; Gona, Philimon N.; Gopalani, Sameer Vali; Gotay, Carolyn C.; Goulart, Alessandra C.; Greaves, Felix; Grosso, Giuseppe; Guo, Yuming; Gupta, Rahul; Gupta, Rajeev; Gupta, Vipin; Alma Gutierrez, Reyna; Gvs, Murthy; Hafezi-Nejad, Nima; Hagos, Tekleberhan Beyene; Hailu, Gessessew Bugssa; Hamadeh, Randah R.; Hamidi, Samer; Hankey, Graeme J.; Harb, Hilda L.; Harikrishnan, Sivadasanpillai; Maria Haro, Josep; Hassen, Hamid Yimam; Havmoeller, Rasmus; Hay, Simon, I; Heibati, Behzad; Henok, Andualem; Heredia-Pi, Ileana; Francisco Hernandez-Llanes, Norberto; Herteliu, Claudiu; Hibstu, Desalegn Ts Tsegaw; Hoogar, Praveen; Horita, Nobuyuki; Hosgood, H. Dean; Hosseini, Mostafa; Hostiuc, Mihaela; Hu, Guoqing; Huang, Hsiang; Husseini, Abdullatif; Idrisov, Bulat; Ileanu, Bogdan Vasile; Ilesanmi, Olayinka Stephen; Irvani, Seyed Sina Naghibi; Islam, Sheikh Mohammed Shariful; Jackson, Maria D.; Jakovljevic, Mihajlo; Jayatilleke, Achala Upendra; Jha, Ravi Prakash; Jonas, Jost B.; Jozwiak, Jacek Jerzy; Kabir, Zubair; Kadel, Rajendra; Kahsay, Amaha; Kapil, Umesh; Kasaeian, Amir; Kassa, Tesfaye D. Dessale; Katikireddi, Srinivasa Vittal; Kawakami, Norito; Kebede, Seifu; Kefale, Adane Teshome; Keiyoro, Peter Njenga; Kengne, Andre Pascal; Khader, Yousef; Khafaie, Morteza Abdullatif; Khalil, Ibrahim A.; Khan, Md Nuruzzaman; Khang, Young-Ho; Khater, Mona M.; Khubchandani, Jagdish; Kim, Cho-Il; Kim, Daniel; Kim, Yun Jin; Kimokoti, Ruth W.; Kisa, Adnan; Kivimaki, Mika; Kochhar, Sonali; Kosen, Soewarta; Koul, Parvaiz A.; Koyanagi, Ai; Krishan, Kewal; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kulkarni, Veena S.; Kumar, Pushpendra; Lafranconi, Alessandra; Balaji, Arjun Lakshmana; Lalloo, Ratilal; Lallukka, Tea; Lam, Hilton; Lami, Faris Hasan; Lan, Qing; Lang, Justin J.; Lansky, Sonia; Larsson, Anders O.; Latifi, Arman; Leasher, Janet L.; Lee, Paul H.; Leigh, James; Leinsalu, Mall; Leung, Janni; Levi, Miriam; Li, Yichong; Lim, Lee-Ling; Linn, Shai; Liu, Shiwei; Lobato-Cordero, Andrea; Lotufo, Paulo A.; King Macarayan, Erlyn Rachelle; Machado, Isis Eloah; Madotto, Fabiana; Abd El Razek, Hassan Magdy; Abd El Razek, Muhammed Magdy; Majdan, Marek; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Malta, Deborah Carvalho; Mapoma, Chabila Christopher; Martinez-Raga, Jose; Maulik, Pallab K.; Mazidi, Mohsen; Mckee, Martin; Mehta, Varshil; Meier, Toni; Mekonen, Tesfa; Meles, Kidanu Gebremariam; Melese, Addisu; Memiah, Peter T. N.; Mendoza, Walter; Mengistu, Desalegn Tadese; Mensah, George A.; Meretoja, Tuomo J.; Mezgebe, Haftay Berhane; Miazgowski, Tomasz; Miller, Ted R.; Mini, G. K.; Mirica, Andreea; Mirrakhimov, Erkin M.; Moazen, Babak; Mohammad, Karzan Abdulmuhsin; Mohammadifard, Noushin; Mohammed, Shafiu; Monasta, Lorenzo; Moraga, Paula; Morawska, Lidia; Jalu, Moti Tolera; Mousavi, Seyyed Meysam; Mukhopadhyay, Satinath; Musa, Kamarul Imran; Naheed, Aliya; Naik, Gurudatta; Najafi, Farid; Nangia, Vinay; Nansseu, Jobert Richie; Nayak, Mudavath Siva Durga Prasad; Nejjari, Chakib; Neupane, Subas; Neupane, Sudan Prasad; Ngunjiri, Josephine W.; Cuong Tat Nguyen; Long Hoang Nguyen; Trang Huyen Nguyen; Ningrum, Dina Nur Anggraini; Nirayo, Yirga Legesse; Noubiap, Jean Jacques; Ofori-Asenso, Richard; Ogbo, Felix Akpojene; Oh, In-Hwan; Oladimeji, Olanrewaju; Olagunju, Andrew T.; Olivares, Pedro R.; Olusanya, Bolajoko Olubukunola; Olusanya, Jacob Olusegun; Oommen, Anu Mary; Oren, Eyal; Orpana, Heather M.; Ortega-Altamirano, Doris D., V; Ortiz, Justin R.; Ota, Erika; Owolabi, Mayowa Ojo; Oyekale, Abayomi Samuel; Mahesh, P. A.; Pana, Adrian; Park, Eun-Kee; Parry, Charles D. H.; Parsian, Hadi; Patle, Ajay; Patton, George C.; Paudel, Deepak; Petzold, Max; Phillips, Michael R.; Pillay, Julian David; Postma, Maarten J.; Pourmalek, Farshad; Prabhakaran, Dorairaj; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Rafiei, Alireza; Rahim, Fakher; Rahimi-Movaghar, Afarin; Rahman, Mahfuzar; Rahman, Muhammad Aziz; Rai, Rajesh Kumar; Rajsic, Sasa; Raju, Sree Bhushan; Ram, Usha; Rana, Saleem M.; Ranabhat, Chhabi Lal; Rawaf, David Laith; Rawaf, Salman; Reiner, Robert C.; Reis, Cesar; Renzaho, Andre M. N.; Rezai, Mohammad Sadegh; Roever, Leonardo; Ronfani, Luca; Room, Robin; Roshandel, Gholamreza; Rostami, Ali; Roth, Gregory A.; Roy, Ambuj; Sabde, Yogesh Damodar; Saddik, Basema; Safiri, Saeid; Sahebkar, Amirhossein; Saleem, Zikria; Salomon, Joshua A.; Salvi, Sundeep Santosh; Sanabria, Juan; Dolores Sanchez-Nino, Maria; Santomauro, Damian Francesco; Santos, Itamar S.; Milicevic, Milena M. M. Santric; Sarker, Abdur Razzaque; Sarmiento-Suarez, Rodrigo; Sarrafzadegan, Nizal; Sartorius, Benn; Satpathy, Maheswar; Sawhney, Monika; Saxena, Sonia; Saylan, Mete; Schaub, Michael P.; Schmidt, Maria Ines; Schneider, Ione J. C.; Schoettker, Ben; Schutte, Aletta Elisabeth; Schwendicke, Falk; Sepanlou, Sadaf G.; Shaikh, Masood A. Ali; Sharif, Mehdi; She, Jun; Sheikh, Aziz; Shen, Jiabin; Shiferaw, Mekonnen Sisay; Shigematsu, Mika; Shiri, Rahman; Shishani, Kawkab; Shiue, Ivy; Shukla, Sharvari Rahul; Sigfusdottir, Inga Dora; Santos Silva, Diego Augusto; Da Silva, Natacha Torres; Alves Silveira, Dayane Gabriele; Sinha, Dhirendra Narain Narain; Sitas, Freddy; Soares Filho, Adauto Martins; Soofi, Moslem; Sorensen, Reed J. D.; Soriano, Joan B.; Sreeramareddy, Chandrashekhar T.; Steckling, Nadine; Stein, Dan J.; Sufiyan, Mu'awiyyah Babale; Sur, Patrick J.; Sykes, Bryan L.; Tabares-Seisdedos, Rafael; Tabuchi, Takahiro; Tavakkoli, Mohammad; Tehrani-Banihashemi, Arash; Tekle, Merhawi Gebremedhin; Thapa, Subash; Thomas, Nihal; Topor-Madry, Roman; Topouzis, Fotis; Tran, Bach Xuan; Troeger, Christopher E.; Truelsen, Thomas Clement; Tsilimparis, Nikolaos; Tyrovolas, Stefanos; Ukwaja, Kingsley Nnanna; Ullah, Irfan; Uthman, Olalekan A.; Valdez, Pascual R.; Van Boven, Job F. M.; Vasankari, Tommi Juhani; Venketasubramanian, Narayanaswamy; Violante, Francesco S.; Vladimirov, Sergey Konstantinovitch; Vlassov, Vasily; Vollset, Stein Emil; Vos, Theo; Wagnew, Fasil Wagnew Shiferaw; Waheed, Yasir; Wang, Yuan-Pang; Weiderpass, Elisabete; Weldegebreal, Fitsum; Weldegwergs, Kidu Gidey; Werdecker, Andrea; Westerman, Ronny; Whiteford, Harvey A.; Widecka, Justyna; Wijeratne, Tissa; Wyper, Grant M. A.; Xu, Gelin; Yamada, Tomohide; Yano, Yuichiro; Ye, Pengpeng; Yimer, Ebrahim M.; Yip, Paul; Yirsaw, Biruck Desalegn; Yisma, Engida; Yonemoto, Naohiro; Yoon, Seok-Jun; Yotebieng, Marcel; Younis, Mustafa Z.; Zachariah, Geevar; Zaidi, Zoubida; Zamani, Mohammad; Zhang, Xueying; Zodpey, Sanjay; Mokdad, Ali H.; Naghavi, Mohsen; Murray, Christopher J. L.; Gakidou, Emmanuela
Background Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older.
ISI:000445098800025
ISSN: 0140-6736
CID: 3319182

Types of tobacco consumption and the oral microbiome in the United Arab Emirates Healthy Future (UAEHFS) Pilot Study

Vallès, Yvonne; Inman, Claire K; Peters, Brandilyn A; Ali, Raghib; Wareth, Laila Abdel; Abdulle, Abdishakur; Alsafar, Habiba; Anouti, Fatme Al; Dhaheri, Ayesha Al; Galani, Divya; Haji, Muna; Hamiz, Aisha Al; Hosani, Ayesha Al; Houqani, Mohammed Al; Junaibi, Abdulla Al; Kazim, Marina; Kirchhoff, Tomas; Mahmeed, Wael Al; Maskari, Fatma Al; Alnaeemi, Abdullah; Oumeziane, Naima; Ramasamy, Ravichandran; Schmidt, Ann Marie; Weitzman, Michael; Zaabi, Eiman Al; Sherman, Scott; Hayes, Richard B; Ahn, Jiyoung
Cigarette smoking alters the oral microbiome; however, the effect of alternative tobacco products remains unclear. Middle Eastern tobacco products like dokha and shisha, are becoming globally widespread. We tested for the first time in a Middle Eastern population the hypothesis that different tobacco products impact the oral microbiome. The oral microbiome of 330 subjects from the United Arab Emirates Healthy Future Study was assessed by amplifying the bacterial 16S rRNA gene from mouthwash samples. Tobacco consumption was assessed using a structured questionnaire and further validated by urine cotinine levels. Oral microbiome overall structure and specific taxon abundances were compared, using PERMANOVA and DESeq analyses respectively. Our results show that overall microbial composition differs between smokers and nonsmokers (p = 0.0001). Use of cigarettes (p = 0.001) and dokha (p = 0.042) were associated with overall microbiome structure, while shisha use was not (p = 0.62). The abundance of multiple genera were significantly altered (enriched/depleted) in cigarette smokers; however, only Actinobacillus, Porphyromonas, Lautropia and Bifidobacterium abundances were significantly changed in dokha users whereas no genera were significantly altered in shisha smokers. For the first time, we show that smoking dokha is associated to oral microbiome dysbiosis, suggesting that it could have similar effects as smoking cigarettes on oral health.
PMCID:6063860
PMID: 30054546
ISSN: 2045-2322
CID: 3206682

Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

Mokdad, Ali H.; Khalil, Ibrahim; Collison, Michael; El Bcheraoui, Charbel; Charara, Raghid; Moradi-Lakeh, Maziar; Afshin, Ashkan; Krohn, Kristopher J.; Daoud, Farah; Chew, Adrienne; Kassebaum, Nicholas J.; Colombara, Danny; Cornaby, Leslie; Ehrenkranz, Rebecca; Foreman, Kyle J.; Fraser, Maya; Frostad, Joseph; Kemmer, Laura; Kulikoff, Xie Rachel; Kutz, Michael; Kyu, Hmwe H.; Liu, Patrick; Mikesell, Joseph; Nguyen, Grant; Rao, Puja C.; Silpakit, Naris; Sligar, Amber; Smith, Alison; Stanaway, Jeffrey D.; Arnlov, Johan; Abate, Kalkidan Hassen; Kiadaliri, Aliasghar Ahmad; Alam, Khurshid; Alasfoor, Deena; Ali, Raghib; Alizadeh-Navaei, Reza; Alraddadi, Rajaa; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Anber, Nahla; Ansari, Hossein; Antonio, Carl Abelardo T.; Anwari, Palwasha; Artaman, Al; Asayesh, Hamid; Asgedom, Solomon Weldegebreal; Azzopardi, Peter; Bacha, Umar; Barac, Aleksandra; Barker-Collo, Suzanne L.; Bedi, Neeraj; Beghi, Ettore; Bennett, Derrick A.; Bhutta, Zulfiqar A.; Bisanzio, Donal; Castaneda-Orjuela, Carlos A.; Estanislao Castro, Ruben; Danawi, Hadi; Deribe, Kebede; Deribew, Amare; Jarlais, Don C. Des; deVeber, Gabrielle A.; Dey, Subhojit; Dharmaratne, Samath D.; Djalalinia, Shirin; Huyen Phuc Do; Esteghamati, Alireza; Farvid, Maryam S.; Fereshtehnejad, Seyed-Mohammad; Fischer, Florian; Gebrehiwot, Tsegaye Tewelde; Giussani, Giorgia; Gona, Philimon N.; Hafezi-Nejad, Nima; Hamadeh, Randah Ribhi; Hamidi, Samer; Hoy, Damian G.; Hu, Guoqing; John, Denny; Jonas, Jost B.; Karimi, Seyed M.; Kasaeian, Amir; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Kim, Daniel; Kim, Yun Jin; Kinfu, Yohannes; Larson, Heidi J.; Latif, Asma Abdul; Leasher, Janet L.; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Abd El Razek, Mohammed Magdy; Majeed, Azeem; Malekzadeh, Reza; Memish, Ziad A.; Mendoza, Walter; Mezgebe, Haftay Berhane; Miller, Ted R.; Monasta, Lorenzo; Quyen Le Nguyen; Obermeyer, Carla Makhlouf; Ortiz, Alberto; Papachristou, Christina; Park, Eun-Kee; Pereira, Claudia C.; Petzold, Max; Pereira, David M.; Phillips, Michael Robert; Pourmalek, Farshad; Qorbani, Mostafa; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rai, Rajesh Kumar; Rana, Saleem M.; Rawaf, David Laith; Rawaf, Salman; Renzaho, Andre M. N.; Rezaei, Satar; Rezai, Mohammad Sadegh; Ronfani, Luca; Roshandel, Gholamreza; Ruhago, George Mugambage; Safdarian, Mahdi; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sanabria, Juan Ramon; Sartorius, Benn; Schwebel, David C.; Seedat, Soraya; Sepanlou, Sadaf G.; Setegn, Tesfaye; Shaheen, Amira; Shaikh, Masood Ali; Shamsizadeh, Morteza; Shiri, Rahman; Skirbekk, Vegard; Sobaih, Badr H. A.; Sreeramareddy, Chandrashekhar T.; Stathopoulou, Vasiliki; Abdulkader, Rizwan Suliankatchi; Tehrani-Banihashemi, Arash; Temsah, Mohamad-Hani; Thakur, Arabia. J. S.; Thomson, Alan J.; Tran, Bach Xuan; Truelsen, Thomas; Ukwaja, Kingsley Nnanna; Uthman, Olalekan A.; Vasankari, Tommi; Vlassov, Vasiliy Victorovich; Weiderpass, Elisabete; Weintraub, Robert G.; Werdecker, Andrea; Yaghoubi, Mohsen; Yaseri, Mehdi; Yonemoto, Naohiro; Younis, Mustafa Z.; Yu, Chuanhua; Jumaan, Aisha O.; Vos, Theo; Hay, Simon I.; Naghavi, Mohsen; Wang, Haidong; Murray, Christopher J. L.
Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study.
ISI:000433519400009
ISSN: 1661-8556
CID: 3608362

Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study

Mokdad, Ali H.; Azzopardi, Peter; Cini, Karly; Kennedy, Elissa; Sawyer, Susan; El Bcheraoui, Charbel; Charara, Raghid; Khalil, Ibrahim; Moradi-Lakeh, Maziar; Collison, Michael; Afifi, Rima A.; Al-Raiby, Jamela; Krohn, Kristopher J.; Daoud, Farah; Chew, Adrienne; Afshin, Ashkan; Foreman, Kyle J.; Kassebaum, Nicholas J.; Kutz, Michael; Kyu, Hmwe H.; Liu, Patrick; Olsen, Helen E.; Smith, Alison; Stanaway, Jeffrey D.; Wang, Haidong; Arnlov, Johan; Kiadaliri, Aliasghar Ahmad; Alam, Khurshid; Alasfoor, Deena; Ali, Raghib; Alizadeh-Navaei, Reza; Al-Raddadi, Rajaa; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Anber, Nahla; Antonio, Carl Abelardo T.; Anwari, Palwasha; Artaman, Al; Asayesh, Hamid; Barker-Collo, Suzanne L.; Bedi, Neeraj; Beghi, Ettore; Bennett, Derrick A.; Bensenor, Isabela M.; Bhutta, Zulfiqar A.; Butt, Zahid A.; Castaneda-Orjuela, Carlos A.; Catala-Lopez, Ferran; Charlson, Fiona J.; Danawi, Hadi; De Leo, Diego; Degenhardt, Louisa; Denno, Donna; Deribe, Kebede; Jarlais, Don C. Des; Dey, Subhojit; Dharmaratne, Samath D.; Djalalinia, Shirin; Erskine, Holly E.; Fereshtehnejad, Seyed-Mohammad; Ferrari, Alize J.; Fischer, Florian; Gebrehiwot, Tsegaye Tewelde; Geleijnse, Johanna M.; Gona, Philimon N.; Gugnani, Harish Chander; Gupta, Rajeev; Hamadeh, Randah Ribhi; Hamidi, Samer; Maria Haro, Josep; Hay, Roderick J.; Hearps, Stephen J. C.; Hendrie, Delia; Hotez, Peter J.; Hu, Guoqing; Jonas, Jost B.; Karch, Andre; Karimi, Seyed M.; Kasaeian, Amir; Kebede, Seifu; Kengne, Andre Pascal; Khan, Ejaz Ahmad; Khosravi, Ardeshir; Khubchandani, Jagdish; Kokubo, Yoshihiro; Kopec, Jacek A.; Kosen, Soewarta; Larson, Heidi J.; Larsson, Anders; Leasher, Janet L.; Leung, Janni; Li, Yongmei; Lotufo, Paulo A.; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Majdzadeh, Reza; Majeed, Azeem; Memiah, Peter; Memish, Ziad A.; Mendoza, Walter; Mhimbira, Francis Apolinary; Miller, Ted R.; Mitchell, Philip B.; Monasta, Lorenzo; Obermeyer, Carla Makhlouf; Oh, In-Hwan; Olusanya, Bolajoko Olubukunola; Ortiz, Alberto; Park, Eun-Kee; Parry, Matti; Pereira, David M.; Phillips, Michael Robert; Pourmalek, Farshad; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rai, Rajesh Kumar; Rana, Saleem M.; Rawaf, David Laith; Rawaf, Salman; Reavley, Nicola; Renzaho, Andre M. N.; Rezaei, Satar; Sadegh-Rezai, Mohammad; Rios-Zertuche, Diego; Roshandel, Gholamreza; Rothenbacher, Dietrich; Safdarian, Mahdi; Safi, Sare; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sanabria, Juan Ramon; Santomauro, Damian; Sartorius, Benn; Schwebel, David C.; Seedat, Soraya; Sepanlou, Sadaf G.; Setegn, Tesfaye; Shaheen, Amira; Shaikh, Masood Ali; Shiri, Rahman; Sigfusdottir, Inga Dora; Singh, Jasvinder A.; Sobaih, Badr H. A.; Sreeramareddy, Chandrashekhar T.; Abdulkader, Rizwan Suliankatchi; Tehrani-Banihashemi, Arash; Temsah, Mohamad-Hani; Terkawi, Abdullah Sulieman; Thomson, Alan J.; Tonelli, Marcello; Topor-Madry, Roman; Tran, Bach Xuan; Ukwaja, Kingsley Nnanna; Uthman, Olalekan A.; Vasankari, Tommi; Venketasubramanian, Narayanaswamy; Vlassov, Vasiliy Victorovich; Vollset, Stein Emil; Weiderpass, Elisabete; Weintraub, Robert G.; Werdecker, Andrea; Whiteford, Harvey A.; Yano, Yuichiro; Yaseri, Mehdi; Yonemoto, Naohiro; Younis, Mustafa Z.; Yu, Chuanhua; Jumaan, Aisha O.; Vos, Theo; Hay, Simon I.; Naghavi, Mohsen; Patton, George C.; Murray, Christopher J. L.
The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10-24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs.
ISI:000433519400010
ISSN: 1661-8556
CID: 3608372

The UAE healthy future study: a pilot for a prospective cohort study of 20,000 United Arab Emirates nationals

Abdulle, Abdishakur; Alnaeemi, Abdullah; Aljunaibi, Abdullah; Al Ali, Abdulrahman; Al Saedi, Khaled; Al Zaabi, Eiman; Oumeziane, Naima; Al Bastaki, Marina; Al-Houqani, Mohammed; Al Maskari, Fatma; Al Dhaheri, Ayesha; Shah, Syed M; Loney, Tom; El-Sadig, Mohamed; Oulhaj, Abderrahim; Wareth, Leila Abdel; Al Mahmeed, Wael; Alsafar, Habiba; Hirsch, Benjamin; Al Anouti, Fatme; Yaaqoub, Jamila; Inman, Claire K; Al Hamiz, Aisha; Al Hosani, Ayesha; Haji, Muna; Alsharid, Teeb; Al Zaabi, Thekra; Al Maisary, Fatima; Galani, Divya; Sprosen, Tim; El Shahawy, Omar; Ahn, Jiyoung; Kirchhoff, Tomas; Ramasamy, Ravichandran; Schmidt, Ann Marie; Hayes, Richard; Sherman, Scott; Ali, Raghib
BACKGROUND:The United Arab Emirates (UAE) is faced with a rapidly increasing burden of non-communicable diseases including obesity, diabetes, and cardiovascular disease. The UAE Healthy Future study is a prospective cohort designed to identify associations between risk factors and these diseases amongst Emiratis. The study will enroll 20,000 UAE nationals aged ≥18 years. Environmental and genetic risk factors will be characterized and participants will be followed for future disease events. As this was the first time a prospective cohort study was being planned in the UAE, a pilot study was conducted in 2015 with the primary aim of establishing the feasibility of conducting the study. Other objectives were to evaluate the implementation of the main study protocols, and to build adequate capacity to conduct advanced clinical laboratory analyses. METHODS:Seven hundred sixty nine UAE nationals aged ≥18 years were invited to participate voluntarily in the pilot study. Participants signed an informed consent, completed a detailed questionnaire, provided random blood, urine, and mouthwash samples and were assessed for a series of clinical measures. All specimens were transported to the New York University Abu Dhabi laboratories where samples were processed and analyzed for routine chemistry and hematology. Plasma, serum, and a small whole blood sample for DNA extraction were aliquoted and stored at -80 °C for future analyses. RESULTS:Overall, 517 Emirati men and women agreed to participate (68% response rate). Of the total participants, 495 (95.0%), 430 (82.2%), and 492 (94.4%), completed the questionnaire, physical measurements, and provided biological samples, respectively. CONCLUSIONS:The pilot study demonstrated the feasibility of recruitment and completion of the study protocols for the first large-scale cohort study designed to identify emerging risk factors for the major non-communicable diseases in the region.
PMCID:5755402
PMID: 29304844
ISSN: 1471-2458
CID: 2899502

Patterns of tobacco use in the United Arab Emirates Healthy Future (UAEHFS) pilot study

Al-Houqani, Mohammed; Leinberger-Jabari, Andrea; Al Naeemi, Abdullah; Al Junaibi, Abdullah; Al Zaabi, Eiman; Oumeziane, Naima; Kazim, Marina; Al Maskari, Fatima; Al Dhaheri, Ayesha; Abdel Wareth, Leila; Al Mahmeed, Wael; Alsafar, Habiba; Al Anouti, Fatme; Abdulle, Abdishakur; Inman, Claire K; Al Hamiz, Aisha; Haji, Muna; Ahn, Jiyoung; Kirchhoff, Tomas; Hayes, Richard B; Ramasamy, Ravichandran; Schmidt, Ann Marie; El Shahawy, Omar; Weitzman, Michael; Ali, Raghib; Sherman, Scott
INTRODUCTION/BACKGROUND:Self-reported tobacco use in the United Arab Emirates is among the highest in the region. Use of tobacco products other than cigarettes is widespread, but little is known about specific behavior use patterns. There have been no studies that have biochemically verified smoking status. METHODS:The UAE Healthy Future Study (UAEHFS) seeks to understand the causes of non-communicable diseases through a 20,000-person cohort study. During the study pilot, 517 Emirati nationals were recruited to complete a questionnaire, provide clinical measurements and biological samples. Complete smoking data were available for 428 participants. Validation of smoking status via cotinine testing was conducted based on complete questionnaire data and matching urine samples for 399 participants, using a cut-off of 200ng/ml to indicate active smoking status. RESULTS:Self-reported tobacco use was 36% among men and 3% among women in the sample. However, biochemical verification of smoking status revealed that 42% men and 9% of women were positive for cotinine indicating possible recent tobacco use. Dual and poly-use of tobacco products was fairly common with 32% and 6% of the sample reporting respectively. CONCLUSIONS:This is the first study in the region to biochemically verify tobacco use self-report data. Tobacco use in this study population was found to be higher than previously thought, especially among women. Misclassification of smoking status was more common than expected. Poly-tobacco use was also very common. Additional studies are needed to understand tobacco use behaviors and the extent to which people may be exposed to passive tobacco smoke. IMPLICATIONS/CONCLUSIONS:This study is the first in the region to biochemically verify self-reported smoking status.
PMCID:5976156
PMID: 29847569
ISSN: 1932-6203
CID: 3136292

The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study

Inman, Claire K; Aljunaibi, Abdullah; Koh, Hyunwook; Abdulle, Abdishakur; Ali, Raghib; Alnaeemi, Abdullah; Al Zaabi, Eiman; Oumeziane, Naima; Al Bastaki, Marina; Al-Houqani, Mohammed; Al-Maskari, Fatma; Al Dhaheri, Ayesha; Shah, Syed M; Abdel Wareth, Laila; Al Mahmeed, Wael; Alsafar, Habiba; Al Anouti, Fatme; Al Hosani, Ayesha; Haji, Muna; Galani, Divya; O'Connor, Matthew J; Ahn, Jiyoung; Kirchhoff, Tomas; Sherman, Scott; Hayes, Richard B; Li, Huilin; Ramasamy, Ravichandran; Schmidt, Ann Marie
Aims/UNASSIGNED:The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods/UNASSIGNED:517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results/UNASSIGNED:After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions/UNASSIGNED:The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.
PMCID:5691216
PMID: 29204365
ISSN: 2214-6237
CID: 2892882

Levels of soluble rage but not endogenous secretory (ES) rage differ between type 2 diabetic versus control subjects in the United Arab Emirates [Meeting Abstract]

Abdulle, A; Inman, C K; Saleh, A; Noshi, M; Galani, D; Abdelwareth, L; Alsafar, H; Elfatih, A; Al, shamsi H; Ali, R; Li, H; Ramasamy, R; Marie, Schmidt A; Benbarka, M M; Hassan, M H
Background: The United Arab Emirates (UAE) is experiencing increasing rates of obesity, type 2 diabetes (T2D) and its complications. We tested if soluble levels of cell surface-cleaved RAGE (sRAGE) or endogenous secretory RAGE (esRAGE), the product of alternative mRNA splicing of AGER, are associated with T2D and obesity in the UAE.
Method(s): A case-control study was performed in the Diabetes, Endocrinology and General Medical Clinics of the Sheikh Khalifa Medical City in Abu Dhabi. 216 T2D subjects and 215 controls (mean age 57.4+/-12.1 vs. 50.7+/-15.4 years, respectively) were enrolled. Plasma sRAGE and esRAGE levels, anthropomorphic characteristics and routine chemistries were measured. The relationship between sRAGE and esRAGE with obesity and T2D status was tested using a linear regression model.
Result(s): Univariate analyses comparing T2D case and control subjects revealed differences in sRAGE (1,033+/-545.3 vs. 1,169+/-664.1 pg/ml, respectively; p=0.02) but not esRAGE. Covariate adjustment revealed that differences in sRAGE were significant after correction for age and sex and additionally for waist-hip ratio (WHR); total cholesterol (TC), HDL; hsCRP; Vit D; or triglyceride (TG) levels separately. In cases or controls, we tested associations of body mass index (BMI) or WHR with sRAGE and esRAGE. In controls but not T2D cases, sRAGE and esRAGE were significantly associated with BMI, after correction for age and sex and additionally for eGFR; blood pressure; TC, HDL; hsCRP; Vit D; creatinine; TG and HbA1c in a combined model. In the case of WHR, in controls and T2D cases, there were no associations with sRAGE, but only in T2D cases, WHR was associated with esRAGE after correction for age and sex and blood pressure; TC, HDL; hsCRP, HbA1c, creatinine; TG, eGFR, Vit D and TG in a combined model.
Conclusion(s): Levels of sRAGE but not esRAGE distinguish T2D case vs. controls in the UAE population. Genetic and unique obesity-dependent factors may underlie lack of association between esRAGE in cases vs. controls, which may affect vulnerability to T2D and its complications in the UAE
EMBASE:633701273
ISSN: 1533-3450
CID: 4750412