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Cutaneous skin manifestation following messenger RNA Moderna SARS-CoV-2 vaccine with dermal hypersensitivity reaction histopathology

Chopra, Shara; Kim, Yesul; Flamm, Alexandra
PMCID:8363508
PMID: 34414254
ISSN: 2352-5126
CID: 5399242

Angiosarcoma Clinically Mimicking a Targetoid Hemosiderotic Hemangioma

Nam, Hannah; Lim, Jordan; Flamm, Alexandra
ORIGINAL:0016421
ISSN: 2574-1624
CID: 5412522

Heroin-induced Ulcer Mimicking Pyoderma Gangrenosum

Patel, Deep; Mardini, Jennifer; Chu, Christopher; Disse, Max; Flamm, Alexandra
ORIGINAL:0016422
ISSN: 2574-1624
CID: 5412532

Allergic Contact Dermatitis and Concomitant Dermatologic Diseases: A Retrospective Study

Hereford, Brittainy; Maczuga, Steven; Flamm, Alexandra
BACKGROUND:Allergic contact dermatitis (ACD) can exist in the setting of other dermatologic conditions. It is known that the treatment of these conditions can cause ACD, increasing both diagnostic and treatment difficulty. OBJECTIVE:The aim of this study was to determine the frequency of common dermatologic conditions in the setting of ACD and in specific patient populations. METHODS:A retrospective database study was completed using Truven Health to collect information on patch-tested ACD patients. Demographics and diagnostic information were retrieved. Of those with ACD, the presence of 15 dermatologic diagnoses was investigated. Subanalyses were conducted for each condition, including International Classification of Diseases, 10th Revision code specificity, demographics, and diagnostic information. RESULTS:A total of 6380 patients (76.83% female) were given a diagnosis of ACD via patch testing. Of those with concomitant disease, those most common include atopic dermatitis (23.98%), urticaria (16.69%), and acne (11.51%). Eight of the concomitant conditions were found to have statistical significance in comparing the average age of ACD diagnosis with the selected diagnoses (α = 0.05). CONCLUSIONS:Common dermatologic diseases can exist concomitantly with ACD, many of which can be treated by compounds that precipitate or worsen preexisting ACD. The average age of the diagnosis varies from concomitant diagnoses, which can contribute to difficulty in ACD diagnosis and treatment.
PMID: 33273231
ISSN: 2162-5220
CID: 5399202

E/M Coding in 2021: The Times (and More) Are A-Changin'

Flamm, Alexandra; Bridges, Alina; Siegel, Daniel M
Major revisions for commonly reported office and outpatient evaluation and management (E/M) codes were implemented on January 1, 2021, by the American Medical Association and Centers for Medicare and Medicaid Services. The goal of these changes was to simplify and streamline these service codes, with time and medical decision-making (MDM) now being the sole determinants of the overall E/M level. We present an overview of the new guidelines, requirements, and code descriptors to aid in accurate documentation and billing. Additional resources are provided if further billing and coding questions arise.
PMID: 34314312
ISSN: 2326-6929
CID: 5399222

Cost and diagnostic characteristics of toxicodendron dermatitis in the USA: a retrospective cross-sectional analysis [Letter]

Zomorodi, N; Butt, M; Maczuga, S; Marks, J; Flamm, A
PMID: 32294234
ISSN: 1365-2133
CID: 5412412

Reply to "Comment on 'Histopathologic features distinguishing secondary syphilis from its mimickers'" [Comment]

Flamm, Alexandra; Alcocer, Veronica Merelo; Kazlouskaya, Viktoryia; Kwon, Eun Ji; Elston, Dirk
PMID: 32278802
ISSN: 1097-6787
CID: 5399172

Occupational Contact Dermatitis: Evaluation and Management Considerations

Hollins, Lauren Claire; Flamm, Alexandra
This article provides an overview of the evaluation and management of occupational contact dermatitis, including how to evaluate a patient with suspected occupational contact dermatitis. Patch testing, how to perform a site visit, and how to properly manage using preventative measures, prescribed therapies, and patient education are discussed.
PMID: 32475511
ISSN: 1558-0520
CID: 5399182

Occupational Contact Dermatitis: Common Occupational Allergens

Chu, Christopher; Marks, James G; Flamm, Alexandra
The prevalence of occupational contact dermatitis is estimated to be between 6.7% and 10.6% and can lead to missed work and job loss. Although treatment may provide temporary relief, identifying the culprit allergen may help the clinician counsel on how to avoid or reduce exposure. Some of the most common high-risk occupations for allergic contact dermatitis include agricultural workers, construction workers, health care workers, hairdressers, mechanics, and machinists. In this article, we discuss the common occupational exposures of these high-risk professions, and summarize the common culprit allergens.
PMID: 32475512
ISSN: 1558-0520
CID: 5399192

Characterization of the inflammatory features of central centrifugal cicatricial alopecia

Flamm, Alexandra; Moshiri, Ata S; Roche, Fritzlaine; Onyekaba, Ginikanwa; Nguyen, Jennifer; James, Alaina J; Taylor, Susan; Seykora, John T
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that primarily affects women of African descent. Although histopathological features of CCCA have been described, the pathophysiology of this disease remains unclear. To better understand the components of CCCA pathophysiology, we evaluated the composition of the inflammatory infiltrate, the distribution of Langerhans cells (LCs), and the relationship between fibrosis and perifollicular vessel distribution. Our data indicate that CCCA is associated with a CD4-predominant T-cell infiltrate with increased LCs extending into the lower hair follicle. Fibroplasia associated with follicular scarring displaces blood vessels away from the outer root sheath epithelium. These data indicate that CCCA is an inflammatory scarring alopecia with unique pathophysiologic features that differentiate it from other lymphocytic scarring processes.
PMCID:7401378
PMID: 32068905
ISSN: 1600-0560
CID: 5386102