Faculty Bibliography

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102

Endocrinology & metabolism (Seoul, Korea). 2020:35(1):36-43.DOI: 10.3803/EnM.2020.35.1.36

Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations

Guo, Yuqi; Cho, Sun Wook; Saxena, Deepak; Li, Xin
Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.
PMID: 32207262
ISSN: 2093-5978
CID: 4358712
iScience. 2020.DOI: 10.1016/j.isci.2020.100884

Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection

Pushalkar, Smruti; Paul, Bidisha; Li, Qianhao; Yang, Jian; Vasconcelos, Rebeca; Makwana, Shreya; González, Juan Muñoz; Shah, Shivm; Xie, Chengzhi; Janal, Malvin N; Queiroz, Erica; Bederoff, Maria; Leinwand, Joshua; Solarewicz, Julia; Xu, Fangxi; Aboseria, Eman; Guo, Yuqi; Aguallo, Deanna; Gomez, Claudia; Kamer, Angela; Shelley, Donna; Aphinyanaphongs, Yindalon; Barber, Cheryl; Gordon, Terry; Corby, Patricia; Li, Xin; Saxena, Deepak
The trend of e-cigarette use among teens is ever increasing. Here we show the dysbiotic oral microbial ecology in e-cigarette users influencing the local host immune environment compared with non-smoker controls and cigarette smokers. Using 16S rRNA high-throughput sequencing, we evaluated 119 human participants, 40 in each of the three cohorts, and found significantly altered beta-diversity in e-cigarette users (p = 0.006) when compared with never smokers or tobacco cigarette smokers. The abundance of Porphyromonas and Veillonella (p = 0.008) was higher among vapers. Interleukin (IL)-6 and IL-1β were highly elevated in e-cigarette users when compared with non-users. Epithelial cell-exposed e-cigarette aerosols were more susceptible for infection. In vitro infection model of premalignant Leuk-1 and malignant cell lines exposed to e-cigarette aerosol and challenged by Porphyromonas gingivalis and Fusobacterium nucleatum resulted in elevated inflammatory response. Our findings for the first time demonstrate that e-cigarette users are more prone to infection.
PMID: 32105635
ISSN: 2589-0042
CID: 4323572
BMC research notes. 2020:13(1).DOI: 10.1186/s13104-020-4886-8

School-based caries prevention and longitudinal trends in untreated decay: an updated analysis with Markov chains

Ruff, Ryan Richard; Saxena, Deepak; Niederman, Richard
OBJECTIVE:Dental caries (tooth decay) is the most prevalent childhood disease in the world. A school-based program for the prevention of dental caries providing bi-annual sealants, interim therapeutic restorations, and fluoride varnish to children aged 5-12 years was previously associated with a significant reduction in the prevalence of untreated tooth decay over time. The objective of this study was to explore potential nonlinear change in the risk of untreated decay in children receiving caries prevention. RESULTS:Across all study participants, there was a significant increase in the odds of untreated tooth decay over time (OR = 1.90, 95% CI 1.51, 2.39), but the rate of this risk rapidly decreased with each observational visit (OR = 0.87, 95% CI 0.93, 0.91). Overall effects substantially depended on the oral health status of participants at baseline: for children with untreated decay at their first observation, the odds of untreated decay over time was 0.39 (95% CI 0.27, 0.55). A quadratic change for this subpopulation showed that the per-visit decrease in decay was attenuated with each subsequent observation (OR = 1.12, 95% CI 1.04, 1.20).
PMID: 31924271
ISSN: 1756-0500
CID: 4257042
Clinical, cosmetic & investigational dentistry. 2020:12:327-333.DOI: 10.2147/CCIDE.S259158

Standardized Arrabidaea chica Extract Shows Cytoprotective Effects in Zoledronic Acid-Treated Fibroblasts and Osteoblasts

Wiziack Zago, Patricia Maria; Oliveira Sousa, Ilza Maria; Servat-Medina, Leila; Jorge, Michelle Pedroza; Lima Neto, Lidio Gonçalves; Hass, Viviane; Li, Xin; Tasca Gois Ruiz, Ana Lucia; Saxena, Deepak; Foglio, Mary Ann
Introduction/UNASSIGNED:standardized hydro alcoholic extract in vitro cytoprotective activity data on epithelial and osteoblastic cells exposed to zoledronic acid (ZA). Methods/UNASSIGNED:extract for 24h and 48 h. At both times, cells were submitted to viability assay and caspase 3/7 activation evaluation. Statistical analysis used one-way ANOVA and p=0.05. Results/UNASSIGNED:extract, cells showed higher viability values: 74.1%-82.3% for fibroblasts and 66% for pre-osteoblasts. Furthermore, the combined treatment presented lower caspase 3/7 activation in fibroblasts and pre-osteoblasts. Conclusion/UNASSIGNED:extract showed promising cytoprotective effects against ZA-induced damage actions; however, further in vitro and in vivo studies are required to establish the mechanism of action.
PMCID:7429228
PMID: 32848479
ISSN: 1179-1357
CID: 4615172
Lancet. 2020:396(10258):1135-1159.DOI:

Five insights from the Global Burden of Disease Study 2019 [Editorial]

Abbafati, Cristiana; Abbas, Kaja M.; Abbasi, Mohammad; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; Abd-Allah, Foad; Abdelalim, Ahmed; Abdollahi, Mohammad; Abdollahpour, Ibrahim; Abedi, Aidin; Abedi, Parisa; Abegaz, Kedir Hussein; Abolhassani, Hassan; Abosetugn, Akine Eshete; Aboyans, Victor; Abrams, Elissa M.; Abreu, Lucas Guimaraes; Abrigo, Michael R. M.; Abu Haimed, Abdulaziz Khalid; Abualhasan, Ahmed; Abu-Gharbieh, Eman; Abu-Raddad, Laith Jamal; Abushouk, Abdelrahman I.; Acebedo, Alyssa; Ackerman, Ilana N.; Adabi, Maryam; Adair, Tim; Adamu, Abdu A.; Adebayo, Oladimeji M.; Adedeji, Isaac Akinkunmi; Adekanmbi, Victor; Adelson, Jaimie D.; Adeoye, Abiodun Moshood; Adetokunboh, Olatunji O.; Adham, Davoud; Advani, Shailesh M.; Afarideh, Mohsen; Afshari, Mahdi; Afshin, Ashkan; Agardh, Emilie E.; Agarwal, Gina; Agasthi, Pradyumna; Agesa, Kareha M.; Aghaali, Mohammad; Aghamir, Seyed Mohammad Kazem; Agrawal, Anurag; Ahmad, Tauseef; Ahmadi, Alireza; Ahmadi, Keivan; Ahmadi, Mehdi; Ahmadieh, Hamid; Ahmadpour, Ehsan; Ahmed, Muktar Beshir; Aji, Budi; Akalu, Temesgen Yihunie; Akinyemi, Rufus Olusola; Akinyemiju, Tomi; Akombi, Blessing; Akunna, Chisom Joyqueenet; Alahdab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Alam, Noore; Alam, Samiah; Alam, Tahiya; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Albertson, Samuel B.; Alcalde-Rabanal, Jacqueline Elizabeth; Alema, Niguse Meles; Alemu, Biresaw Wassihun; Alemu, Yihun Mulugeta; Alhabib, Khalid F.; Alhassan, Robert Kaba; Ali, Muhammad; Ali, Saqib; Alicandro, Gianfranco; Alijanzadeh, Mehran; Alinia, Cyrus; Alipour, Vahid; Alizade, Hesam; Aljunid, Syed Mohamed; Alla, Francois; Allebeck, Peter; Almadi, Majid Abdulrahman Hamad; Almasi, Ali; Almasi-Hashiani, Amir; Almasri, Nihad A.; Al-Mekhlafi, Hesham M.; Almulhim, Abdulaziz M.; Alonso, Jordi; Al-Raddadi, Rajaa M.; Altirkawi, Khalid A.; Alumran, Arwa Khalid; Alvis-Guzman, Nelson; Alvis-Zakzuk, Nelson J.; Amare, Azmeraw T.; Amare, Bekalu; Amini, Saeed; Amini-Rarani, Mostafa; Aminorroaya, Arya; Amiri, Fatemeh; Amit, Arianna Maever L.; Amugsi, Dickson A.; Amul, Gianna Gayle Herrera; Anbesu, Etsay Woldu; Ancuceanu, Robert; Anderlini, Deanna; Anderson, Jason A.; Andrei, Catalina Liliana; Andrei, Tudorel; Androudi, Sofia; Angus, Colin; Anjomshoa, Mina; Ansari, Fereshteh; Ansari, Iman; Ansari-Moghaddam, Alireza; Antonazzo, Ippazio Cosimo; Antonio, Carl Abelardo T.; Antony, Catherine M.; Antriyandarti, Ernoiz; Anvari, Davood; Anwer, Razique; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arab-Zozani, Morteza; Aravkin, Aleksandr Y.; Arba, Aseb Arba Kinfe; Aremu, Olatunde; Ariani, Filippo; Aripov, Timur; Armoon, Bahram; Arnlov, Johan; Arowosegbe, Oluwaseyi Olalekan; Aryal, Krishna K.; Arzani, Afsaneh; Asaad, Malke; Asadi-Aliabadi, Mehran; Asadi-Pooya, Ali A.; Asgari, Samaneh; Asghari, Babak; Jafarabadi, Mohammad Asghari; Ashbaugh, Charlie; Assmus, Michael; Atafar, Zahra; Athari, Seyyed Shamsadin; Atnafu, Desta Debalkie; Atout, Maha Moh\d Wahbi; Atre, Sachin R.; Atteraya, Madhu Sudhan; Ausloos, Floriane; Ausloos, Marcel; Avila-Burgos, Leticia; Avokpaho, Euripide Frinel Gbenato Arthur; Quintanilla, Beatriz Paulina Ayala; Ayano, Getinet; Ayanore, Martin Amogre; Aynalem, Getie Lake; Aynalem, Yared Asmare; Ayza, Muluken Altaye; Azari, Samad; Azarian, Ghasem; Azene, Zelalem Nigussie; Azhar, Gulrez; Azzopardi, Peter S.; Darshan, B. B.; Babaee, Ebrahim; Badawi, Alaa; Badiye, Ashish D.; Bagherzadeh, Mojtaba; Bagli, Eleni; Bahrami, Mohammad Amin; Baig, Atif Amin; Bairwa, Mohan; Bakhshaei, Mohammad Hossein; Bakhtiari, Ahad; Bakkannavar, Shankar M.; Balachandran, Arun; Balakrishnan, Senthilkumar; Balalla, Shivanthi; Balassyano, Shelly; Baldasseroni, Alberto; Ball, Kylie; Ballew, Shoshana H.; Balzi, Daniela; Banach, Maciej; Banerjee, Srikanta K.; Banik, Palash Chandra; Bannick, Marlena S.; Bante, Agegnehu Bante; Bante, Simachew Animen; Baraki, Adhanom Gebreegziabher; Barboza, Miguel A.; Barker-Collo, Suzanne Lyn; Barnighausen, Till Winfried; Barrero, Lope H.; Barthelemy, Celine M.; Barua, Lingkan; Barzegar, Akbar; Basaleem, Huda; Bassat, Quique; Basu, Sanjay; Baune, Bernhard T.; Bayati, Mohsen; Baye, Bayisa Abdissa; Bazmandegan, Gholamreza; Becker, Jacob S.; Bedi, Neeraj; Beghi, Ettore; Behzadifar, Masoud; Bejot, Yannick; Bekuma, Tariku Tesfaye Tesfaye; Bell, Michelle L.; Bello, Aminu K.; Bender, Rose G.; Bennett, Derrick A.; Bennitt, Fiona B.; Bensenor, Isabela M.; Benziger, Catherine P.; Berhe, Kidanemaryam; Berman, Adam E.; Bernabe, Eduardo; Bernstein, Robert S.; Bertolacci, Gregory J.; Bhagavathula, Akshaya Srikanth; Bhageerathy, Reshmi; Bhala, Neeraj; Bhandari, Dinesh; Bhardwaj, Pankaj; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Bhattarai, Suraj; Bhutta, Zulfiqar A.; Bibi, Sadia; Biehl, Molly H.; Bijani, Ali; Bikbov, Boris; Bilano, Ver; Bin Sayeed, Muhammad Shahdaat; Biondi, Antonio; Birihane, Binyam Minuye; Bisanzio, Donal; Bisignano, Catherine; Biswas, Raaj Kishore; Bitew, Helen; Bjorge, Tone; Bockarie, Moses John; Bohlouli, Somayeh; Bohluli, Mehdi; Bojia, Hunduma Amensisa; Bolla, Srinivasa Rao; Boloor, Archith; Boon-Dooley, Alexandra S.; Borges, Guilherme; Borzi, Antonio Maria; Borzouei, Shiva; Bose, Dipan; Bosetti, Cristina; Boufous, Soufiane; Bourne, Rupert; Brady, Oliver J.; Braithwaite, Dejana; Brauer, Michael; Brayne, Carol; Breitborde, Nicholas J. K.; Breitner, Susanne; Brenner, Hermann; Breusov, Alexey V.; Briant, Paul Svitil; Briggs, Andrew M.; Briko, Andrey Nikolaevich; Briko, Nikolay Ivanovich; Britton, Gabrielle B.; Brugha, Traolach; Bryazka, Dana; Buchbinder, Rachelle; Bumgarner, Blair R.; Burkart, Katrin; Burnett, Richard Thomas; Nagaraja, Sharath Burugina; Busse, Reinhard; Butt, Zahid A.; Caetano dos Santos, Florentino Luciano; Cahill, Leah E.; Cahuana-Hurtado, Lucero; Cai, Tianji; Callender, Charlton S. K. H.; Camera, Luis Alberto; Campos-Nonato, Ismael R.; Rincon, Julio Cesar Campuzano; Cao, Jackie; Car, Josip; Cardenas, Rosario; Carreras, Giulia; Carrero, Juan J.; Carvalho, Felix; Castaldelli-Maia, Joao Mauricio; Castaneda-Orjuela, Carlos A.; Castelpietra, Giulio; Castle, Chris D.; Castro, Emma; Castro, Franz; Catala-Lopez, Ferran; Causey, Kate; Cederroth, Christopher R.; Cercy, Kelly M.; Cerin, Ester; Chalek, Julian; Chandan, Joht Singh; Chang, Alex R.; Chang, Angela Y.; Chang, Jung-Chen; Chang, Kai-Lan; Charan, Jaykaran; Charlson, Fiona J.; Chattu, Vijay Kumar; Chaturvedi, Sarika; Cherbuin, Nicolas; Chimed-Ochir, Odgerel; Chin, Ken Lee; Chirinos-Caceres, Jesus Lorenzo; Cho, Daniel Youngwhan; Choi, Jee-Young Jasmine; Christensen, Hanne; Chu, Dinh-Toi; Chung, Michael T.; Chung, Sheng-Chia; Cicuttini, Flavia M.; Ciobanu, Liliana G.; Cirillo, Massimo; Cislaghi, Beniamino; Classen, Thomas Khaled Dwayne; Cohen, Aaron J.; Collins, Emma L.; Comfort, Haley; Compton, Kelly; Conti, Sara; Cooper, Owen R.; Corso, Barbara; Cortesi, Paolo Angelo; Costa, Vera Marisa; Cousin, Ewerton; Cowden, Richard G.; Cowie, Benjamin C.; Cromwell, Elizabeth A.; Croneberger, Andrew J.; Cross, Di H.; Cross, Marita; Crowe, Christopher Stephen; Cruz, Jessica A.; Cummins, Steven; Cunningham, Matthew; Dahlawi, Saad M. A.; Dai, Haijiang; Dai, Hancheng; Damasceno, Albertino Antonio Moura; Damiani, Giovanni; D\Amico, Emanuele; Dandona, Lalit; Dandona, Rakhi; Daneshpajouhnejad, Parnaz; Dangel, William James; Danielsson, Anna-Karin; Gela, Jiregna Darega; Dargan, Paul I.; Darwesh, Aso Mohammad; Daryani, Ahmad; Das, Jai K.; Das Gupta, Rajat; Das Neves, Jose; Dash, Aditya Prasad; Davey, Gail; Davila-Cervantes, Claudio Alberto; Davis, Adrian C.; Davitoiu, Dragos Virgil; Davletov, Kairat; De Leo, Diego; De Neve, Jan-Walter; Dean, Frances E.; DeCleene, Nicole K.; Deen, Amanda; Degenhardt, Louisa; DeLang, Marissa; Dellavalle, Robert Paul; Demeke, Feleke Mekonnen; Demoz, Gebre Teklemariam; Demsie, Desalegn Getnet; Denova-Gutierrez, Edgar; Dereje, Nebiyu Dereje; Deribe, Kebede; Dervenis, Nikolaos; Desai, Rupak; Desalew, Assefa; Dessie, Getenet Ayalew; Deuba, Keshab; Dharmaratne, Samath Dhamminda; Dhungana, Govinda Prasad; Dianatinasab, Mostafa; da Silva, Diana Dias; Diaz, Daniel; Forooshani, Zahra Sadat Dibaji; Dichgans, Martin; Didarloo, Alireza; Dingels, Zachary V.; Dippenaar, Ilse N.; Dirac, M. Ashworth; Djalalinia, Shirin; Do, Hoa Thi; Dokova, Klara; Doku, David Teye; Dolecek, Christiane; Dolgert, Andrew J.; Dorostkar, Fariba; Doshi, Chirag P.; Doshi, Pratik P.; Doshmangir, Leila; Douiri, Abdel; Doxey, Matthew C.; Doyle, Kerrie E.; Driscoll, Tim Robert; Dubljanin, Eleonora; Dunachie, Susanna J.; Duncan, Bruce B.; Duraes, Andre Rodrigues; Eagan, Arielle Wilder; Ebrahimi, Hedyeh; Kalan, Mohammad Ebrahimi; Edvardsson, David; Effiong, Andem; Ehrlich, Joshua R.; El Nahas, Nevine; El Sayed, Iman; Zaki, Maysaa El Sayed; El Tantawi, Maha; Elbarazi, Iffat; Elgendy, Islam Y.; Elhabashy, Hala Rashad; El-Jaafary, Shaimaa I.; Elsharkawy, Aisha; Elyazar, Iqbal R. F.; Emamian, Mohammad Hassan; Emmons-Bell, Sophia; Erskine, Holly E.; Eshrati, Babak; Eskandari, Khalil; Eskandarieh, Sharareh; Esmaeilnejad, Saman; Esmaeilzadeh, Firooz; Esteghamati, Alireza; Esteghamati, Sadaf; Estep, Kara; Etemadi, Arash; Etisso, Atkilt Esaiyas; Ezekannagha, Oluchi; Fanzo, Jessica; Farag, Tamer; Farahmand, Mohammad; Faraj, Anwar; Faraon, Emerito Jose A.; Fareed, Mohammad; Faridnia, Roghiyeh; Farinha, Carla Sofia e Sa; Farioli, Andrea; Faris, Pawan Sirwan; Faro, Andre; Faruque, Mithila; Farzadfar, Farshad; Fattahi, Nazir; Fazaeli, Ali Akbar; Fazlzadeh, Mehdi; Feigin, Valery L.; Feldman, Rachel; Fereshtehnejad, Seyed-Mohammad; Fernandes, Eduarda; Ferrara, Giannina; Ferrara, Pietro; Ferrari, Alize J.; Ferreira, Manuela L.; Feyissa, Garumma Tolu; Filip, Irina; Fischer, Florian; Fisher, James L.; Fitzgerald, Ryan; Flohr, Carsten; Flor, Luisa Sorio; Foigt, Nataliya A.; Folayan, Morenike Oluwatoyin; Fomenkov, Artem Alekseevich; Force, Lisa M.; Fornari, Carla; Foroutan, Masoud; Fox, Jack T.; Francis, Joel Msafiri; Frank, Tahvi D.; Franklin, Richard Charles; Freitas, Marisa; Fu, Weijia; Fukumoto, Takeshi; Fukutaki, Kai; Fuller, John E.; Fullman, Nancy; Furtado, Joao M.; Gad, Mohamed M.; Gaidhane, Abhay Motiramji; Gakidou, Emmanuela; Galles, Natalie C.; Gallus, Silvano; Gamkrelidze, Amiran; Garcia-Basteiro, Alberto L.; Gardner, William M.; Geberemariyam, Biniyam Sahiledengle; Gebrehiwot, Abiyu Mekonnen; Gebremedhin, Ketema Bizuwork; Gebremeskel, Gebreamlak Gebremedhn; Gebremeskel, Leake G.; Gebresillassie, Begashaw Melaku; Gebreslassie, Assefa Ayalew Ayalew Ayalew; Geramo, Yilma Chisha Dea; Geremew, Abraham; Hayoon, Anna Gershberg; Gesesew, Hailay Abrha; Gething, Peter W.; Gezae, Kebede Embaye; Ghadimi, Maryam; Ghadiri, Keyghobad; Ghaffarifar, Fatemeh; Ghafourifard, Mansour; Ghajar, Alireza; Ghamari, Farhad; Ghashghaee, Ahmad; Ghiasvand, Hesam; Ghith, Nermin; Gholamian, Asadollah; Ghosh, Rakesh; Giampaoli, Simona; Gilani, Syed Amir; Gill, Paramjit Singh; Gill, Tiffany K.; Gillum, Richard F.; Ginawi, Ibrahim Abdelmageed; Ginindza, Themba G.; Gitimoghaddam, Mojgan; Giussani, Giorgia; Glagn, Mustefa; Glushkova, Ekaterina Vladimirovna; Gnedovskaya, Elena V.; Godinho, Myron Anthony; Goharinezhad, Salime; Golechha, Mahaveer; Goli, Srinivas; Gomez, Ricardo Santiago; Gona, Philimon N.; Gopalani, Sameer Vali; Goren, Emily; Gorini, Giuseppe; Gorman, Taren M.; Gottlich, Harrison Chase; Goudarzi, Houman; Goudarzian, Amir Hossein; Goulart, Alessandra C.; Goulart, Barbara Niegia Garcia; Grada, Ayman; Greaves, Felix; Grivna, Michal; Grosso, Giuseppe; Gubari, Mohammed Ibrahim Mohialdeen; Gudi, Nachiket; Gugnani, Harish Chander; Guimaraes, Andre Luiz Sena; Guimaraes, Rafael Alves; Guled, Rashid Abdi; Gultie, Teklemariam; Guo, Gaorui; Guo, Yuming; Gupta, Rahul; Gupta, Rajeev; Sharan, Subodh; Gupta, Tarun; Haagsma, Juanita A.; Hachinski, Vladimir; Haddock, Beatrix; Hafezi-Nejad, Nima; Hafiz, Abdul; Hagins, Hailey; Haile, Lydia M.; Haile, Teklehaimanot Gereziher; Haj-Mirzaian, Arvin; Haj-Mirzaian, Arya; Hall, Brian J.; Halvaei, Iman; Hamadeh, Randah R.; Abdullah, Kanaan Hamagharib; Hameed, Sajid; Hamidi, Samer; Hamilton, Erin B.; Hammer, Melanie S.; Han, Chieh; Han, Hannah; Handiso, Demelash Woldeyohannes; Hanif, Asif; Hankey, Graeme J.; Haririan, Hamidreza; Haro, Josep Maria; Harvey, James D.; Hasaballah, Ahmed I.; Hasan, Md Mehedi; Hasanpoor, Edris; Hasanzadeh, Amir; Hashemian, Maryam; Hashi, Abdiwahab; Hassan, Amr; Hassan, Shoaib; Hassanipour, Soheil; Hassankhani, Hadi; Havmoeller, Rasmus J.; Hay, Roderick J.; Hay, Simon I.; Hayat, Khezar; Heibati, Behzad; Heidari, Behnam; Heidari, Golnaz; Heidari-Soureshjani, Reza; Hendrie, Delia; Henny, Kiana; Henok, Andualem; Henrikson, Hannah J.; Henry, Nathaniel J.; Herbert, Molly E.; Herteliu, Claudiu; Heydarpour, Fatemeh; Hird, Thomas R.; Ho, Hung Chak; Hoek, Hans W.; Hole, Michael K.; Holla, Ramesh; Hollingsworth, Bruce; Hoogar, Praveen; Hopf, Kathleen Pillsbury; Horita, Nobuyuki; Hosgood, H. Dean; Hossain, Naznin; Hosseini, Mostafa; Hosseinzadeh, Mehdi; Hostiuc, Mihaela; Hostiuc, Sorin; Househ, Mowafa; Hoy, Damian G.; Hsairi, Mohamed; Hsiao, Thomas; Hsieh, Vivian Chia-Rong; Hu, Guoqing; Hu, Kejia; Huda, Tanvir M.; Hugo, Fernando N.; Humayun, Ayesha; Hussain, Rabia; Huynh, Chantal K.; Hwang, Bing-Fang; Iannucci, Vincent C.; Iavicoli, Ivo; Ibeneme, Charles Ugochukwu; Ibitoye, Segun Emmanuel; Ikeda, Nayu; Ikuta, Kevin S.; Ilesanmi, Olayinka Stephen; Ilic, Irena M.; Ilic, Milena D.; Imani-Nasab, Mohammad Hasan; Inbaraj, Leeberk Raja; Ippolito, Helen; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Irvine, Caleb Mackay Salpeter; Islam, M. Mofizul; Islam, MdMohaimenul; Islam, Sheikh Mohammed Shariful; Islami, Farhad; Iso, Hiroyasu; Ivers, Rebecca Q.; Iwu, Chidozie C. D.; Iwu, Chinwe Juliana; Iyamu, Ihoghosa Osamuyi; Jaafari, Jalil; Jacobsen, Kathryn H.; Jadidi-Niaragh, Farhad; Jafari, Hussain; Jafarinia, Morteza; Jahagirdar, Deepa; Jahani, Mohammad Ali; Jahanmehr, Nader; Jakovljevic, Mihajlo; Jalali, Amir; Jalilian, Farzad; James, Spencer L.; Janjani, Hosna; Janodia, Manthan Dilipkumar; Javaheri, Tahereh; Javidnia, Javad; Jayatilleke, Achala Upendra; Jeemon, Panniyammakal; Jenabi, Ensiyeh; Jha, Ravi Prakash; Jha, Vivekanand; Ji, John S.; Jia, Peng; Johansson, Lars; John, Oommen; John-Akinola, Yetunde O.; Johnson, Catherine Owens; Johnson, Sarah Charlotte; Jonas, Jost B.; Joo, Tamas; Joshi, Ankur; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Jurisson, Mikk; Kabir, Ali; Kabir, Zubair; Kalani, Hamed; Kalani, Rizwan; Kalankesh, Leila R.; Kalhor, Rohollah; Kamath, Aruna M.; Kamiab, Zahra; Kanchan, Tanuj; Kapoor, Neeti; Matin, Behzad Karami; Karanikolos, Marina; Karch, Andre; Karim, Mohd Anisul; Karimi, Salah Eddin; Karimi, Seyed Asaad; Karimi, Seyed M.; Kasa, Ayele Semachew; Kassa, Getachew Mullu; Kassebaum, Nicholas J.; Katikireddi, Srinivasa Vittal; Kawakami, Norito; Kayode, Gbenga A.; Karyani, Ali Kazemi; Keddie, Suzanne H.; Keiyoro, Peter Njenga; Keller, Cathleen; Kemmer, Laura; Kendrick, Parkes J.; Kereselidze, Maia; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khalid, Nauman; Khammarnia, Mohammad; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khan, Maseer; Khang, Young-Ho; Khatab, Khaled; Khater, Amir M.; Khater, Mona M.; Khatib, Mahalaqua Nazli; Khayamzadeh, Maryam; Khazaei, Salman; Khazaie, Habibolah; Khodayari, Mohammad Taghi; Khoja, Abdullah T.; Khubchandani, Jagdish; Khundkar, Roba; Kianipour, Neda; Kieling, Christian; Kim, Cho-Il; Kim, Daniel; Kim, Young-Eun; Kim, Yun Jin; Kimokoti, Ruth W.; Kinfu, Yohannes; Kisa, Adnan; Kisa, Sezer; Kissimova-Skarbek, Katarzyna; Kissoon, Niranjan; Kivimaki, Mika; Kneib, Cameron J.; Knibbs, Luke D.; Knight, Megan; Knudsen, Ann Kristin Skrindo; Kocarnik, Jonathan M.; Kochhar, Sonali; Koh, David S. Q.; Kohler, Stefan; Kolola, Tufa; Komaki, Hamidreza; Kopec, Jacek A.; Korotkova, Anna V.; Korshunov, Vladimir Andreevich; Kosen, Soewarta; Kotlo, Anirudh; Koul, Parvaiz A.; Koyanagi, Ai; Kraemer, Moritz U. G.; Kravchenko, Michael A.; Krishan, Kewal; Krohn, Kris J.; Kromhout, Hans; Shaji, K. S.; Defo, Barthelemy Kuate; Bicer, Burcu Kucuk; Kugbey, Nuworza; Kulkarni, Vaman; Kumar, G. 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ISI:000579154000005
ISSN: 0140-6736
CID: 4677342
Lancet. 2020:396(10258):1250-1284.DOI:

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Lozano, Rafael; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M.; Abbafati, Cristiana; Abbastabar, Hedayat; Abd-Allah, Foad; Abdollahi, Mohammad; Abedi, Aidin; Abolhassani, Hassan; Abosetugn, Akine Eshete; Abreu, Lucas Guimaraes; Abrigo, Michael R. M.; Abu Haimed, Abdulaziz Khalid; Abushouk, Abdelrahman I.; Adabi, Maryam; Adebayo, Oladimeji M.; Adekanmbi, Victor; Adelson, Jaimie D.; Adetokunboh, Olatunji O.; Adham, Davoud; Advani, Shailesh M.; Afshin, Ashkan; Agarwal, Gina; Agasthi, Pradyumna; Aghamir, Seyed Mohammad Kazem; Agrawal, Anurag; Ahmad, Tauseef; Akinyemi, Rufus Olusola; Alahdab, Fares; Al-Aly, Ziyad; Alam, Khurshid; Albertson, Samuel B.; Alemu, Yihun Mulugeta; Alhassan, Robert Kaba; Ali, Muhammad; Ali, Saqib; Alipour, Vahid; Aljunid, Syed Mohamed; Alla, Francois; Almadi, Majid Abdulrahman Hamad; Almasi, Ali; Almasi-Hashiani, Amir; Almasri, Nihad A.; Al-Mekhlafi, Hesham M.; Almulhim, Abdulaziz M.; Alonso, Jordi; Al-Raddadi, Rajaa M.; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Alvis-Zakzuk, Nelson J.; Amini, Saeed; Amini-Rarani, Mostafa; Amiri, Fatemeh; Amit, Arianna Maever L.; Amugsi, Dickson A.; Ancuceanu, Robert; Anderlini, Deanna; Andrei, Catalina Liliana; Androudi, Sofia; Ansari, Fereshteh; Ansari-Moghaddam, Alireza; Antonio, Carl Abelardo T.; Antony, Catherine M.; Antriyandarti, Ernoiz; Anvari, Davood; Anwer, Razique; Arabloo, Jalal; Arab-Zozani, Morteza; Aravkin, Aleksandr Y.; Aremu, Olatunde; Arnlov, Johan; Asaad, Malke; Asadi-Aliabadi, Mehran; Asadi-Pooya, Ali A.; Ashbaugh, Charlie; Athari, Seyyed Shamsadin; Atout, Maha Moh\d Wahbi; Ausloos, Marcel; Avila-Burgos, Leticia; Quintanilla, Beatriz Paulina Ayala; Ayano, Getinet; Ayanore, Martin Amogre; Aynalem, Getie Lake; Aynalem, Yared Asmare; Ayza, Muluken Altaye; Azari, Samad; Azzopardi, Peter S.; Darshan, B. B.; Babaee, Ebrahim; Badiye, Ashish D.; Bahrami, Mohammad Amin; Babaee, Ebrahim; Badiye, Ashish D.; Bahrami, Mohammad Amin; Baig, Atif Amin; Bakhshaei, Mohammad Hossein; Bakhtiari, Ahad; Bakkannavar, Shankar M.; Balachandran, Arun; Balassyano, Shelly; Banach, Maciej; Banerjee, Srikanta K.; Banik, Palash Chandra; Bante, Agegnehu Bante; Bante, Simachew Animen; Barker-Collo, Suzanne Lyn; Barnighausen, Till Winfried; Barrero, Lope H.; Bassat, Quique; Basu, Sanjay; Baune, Bernhard T.; Bayati, Mohsen; Baye, Bayisa Abdissa; Bedi, Neeraj; Beghi, Ettore; Behzadifar, Masoud; Bekuma, Tariku Tesfaye Tesfaye; Bell, Michelle L.; Bensenor, Isabela M.; Berman, Adam E.; Bernabe, Eduardo; Bernstein, Robert S.; Bhagavathula, Akshaya Srikanth; Bhandari, Dinesh; Bhardwaj, Pankaj; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Bhattarai, Suraj; Bhutta, Zulfiqar A.; Bijani, Ali; Bikbov, Boris; Bilano, Ver; Biondi, Antonio; Birihane, Binyam Minuye; Bockarie, Moses John; Bohlouli, Somayeh; Bojia, Hunduma Amensisa; Bolla, Srinivasa Rao Rao; Boloor, Archith; Brady, Oliver J.; Braithwaite, Dejana; Briant, Paul Svitil; Briggs, Andrew M.; Briko, Nikolay Ivanovich; Nagaraja, Sharath Burugina; Busse, Reinhard; Butt, Zahid A.; Luciano Caetano dos Santos, Florentino; Cahuana-Hurtado, Lucero; Camera, Luis Alberto; Cardenas, Rosario; Carreras, Giulia; Carrero, Juan J.; Carvalho, Felix; Castaldelli-Maia, Joao Mauricio; Castaneda-Orjuela, Carlos A.; Castelpietra, Giulio; Castro, Franz; Catala-Lopez, Ferran; Causey, Kate; Cederroth, Christopher R.; Cercy, Kelly M.; Cerin, Ester; Chandan, Joht Singh; Chang, Angela Y.; Charan, Jaykaran; Chattu, Vijay Kumar; Chaturvedi, Sarika; Chin, Ken Lee; Cho, Daniel Youngwhan; Choi, Jee-Young Jasmine; Christensen, Hanne; Chu, Dinh-Toi; Chung, Michael T.; Ciobanu, Liliana G.; Cirillo, Massimo; Comfort, Haley; Compton, Kelly; Cortesi, Paolo Angelo; Costa, Vera Marisa; Cousin, Ewerton; Dahlawi, Saad M. A.; Damiani, Giovanni; Dandona, Lalit; Dandona, Rakhi; Gela, Jiregna Darega; Darwesh, Aso Mohammad; Daryani, Ahmad; Dash, Aditya Prasad; Davey, Gail; Davila-Cervantes, Claudio Alberto; Davletov, Kairat; De Neve, Jan-Walter; Denova-Gutierrez, Edgar; Deribe, Kebede; Dervenis, Nikolaos; Desai, Rupak; Dharmaratne, Samath Dhamminda; Dhungana, Govinda Prasad; Dianatinasab, Mostafa; da Silva, Diana Dias; Diaz, Daniel; Dippenaar, Ilse N.; Hoa Thi Do; Dorostkar, Fariba; Doshmangir, Leila; Duncan, Bruce B.; Duraes, Andre Rodrigues; Eagan, Arielle Wilder; Edvardsson, David; El Sayed, Iman; El Tantawi, Maha; Elgendy, Islam Y.; Elyazar, Iqbal R. F.; Eskandari, Khalil; Eskandarieh, Sharareh; Esmaeilnejad, Saman; Esteghamati, Alireza; Ezekannagha, Oluchi; Farag, Tamer; Farahmand, Mohammad; Faraon, Emerito Jose A.; Sofia e Sa Farinha, Carla; Farioli, Andrea; Faris, Pawan Sirwan; Faro, Andre; Fazlzadeh, Mehdi; Feigin, Valery L.; Fernandes, Eduarda; Ferrara, Pietro; Feyissa, Garumma Tolu; Filip, Irina; Fischer, Florian; Fisher, James L.; Flor, Luisa Sorio; Foigt, Nataliya A.; Folayan, Morenike Oluwatoyin; Fomenkov, Artem Alekseevich; Foroutan, Masoud; Francis, Joel Msafiri; Fu, Weijia; Fukumoto, Takeshi; Furtado, Joao M.; Gad, Mohamed M.; Gaidhane, Abhay Motiramji; Gakidou, Emmanuela; Galles, Natalie C.; Gallus, Silvano; Gardner, William M.; Geberemariyam, Biniyam Sahiledengle; Gebrehiwot, Abiyu Mekonnen; Gebremeskel, Gebreamlak Gebremedhn; Gebremeskel, Leake G.; Gesesew, Hailay Abrha; Ghadiri, Keyghobad; Ghafourifard, Mansour; Ghashghaee, Ahmad; Ghith, Nermin; Gholamian, Asadollah; Gilani, Syed Amir; Gill, Paramjit Singh; Gill, Tiffany K.; Ginindza, Themba G.; Gitimoghaddam, Mojgan; Giussani, Giorgia; Glagn, Mustefa; Gnedovskaya, Elena V.; Godinho, Myron Anthony; Goharinezhad, Salime; Gopalani, Sameer Vali; Goudarzian, Amir Hossein; Goulart, Barbara Niegia Garcia; Gubari, Mohammed Ibrahim Mohialdeen; Guimaraes, Rafael Alves; Guled, Rashid Abdi; Gultie, Teklemariam; Guo, Yuming; Gupta, Rahul; Gupta, Rajeev; Hafezi-Nejad, Nima; Hafiz, Abdul; Haile, Teklehaimanot Gereziher; Hamadeh, Randah R.; Hameed, Sajid; Hamidi, Samer; Han, Chieh; Han, Hannah; Handiso, Demelash Woldeyohannes; Hanif, Asif; Hankey, Graeme J.; Haro, Josep Maria; Hasaballah, Ahmed I.; Hasan, Md. Mehedi; Hashi, Abdiwahab; Hassan, Amr; Hassan, Shoaib; Hassanipour, Soheil; Hassankhani, Hadi; Havmoeller, Rasmus J.; Hay, Simon I.; Hayat, Khezar; Heidari, Golnaz; Heidari-Soureshjani, Reza; Hendrie, Delia; Herteliu, Claudiu; Hird, Thomas R.; Ho, Hung Chak; Hole, Michael K.; Holla, Ramesh; Hoogar, Praveen; Hopf, Kathleen Pillsbury; Horita, Nobuyuki; Hossain, Naznin; Hosseini, Mostafa; Hosseinzadeh, Mehdi; Hostiuc, Mihaela; Hostiuc, Sorin; Househ, Mowafa; Hsieh, Vivian Chia-rong; Hu, Guoqing; Huda, Tanvir M.; Humayun, Ayesha; Hwang, Bing-Fang; Iavicoli, Ivo; Ibitoye, Segun Emmanuel; Ikeda, Nayu; Ilesanmi, Olayinka Stephen; Ilic, Irena M.; Ilic, Milena D.; Inbaraj, Leeberk Raja; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Irvine, Caleb Mackay Salpeter; Islam, M. Mofizul; Islam, Sheikh Mohammed Shariful; Islami, Farhad; Iso, Hiroyasu; Iwu, Chidozie C. D.; Iwu, Chinwe Juliana; Jaafari, Jalil; Jadidi-Niaragh, Farhad; Jafarinia, Morteza; Jahagirdar, Deepa; Jahani, Mohammad Ali; Jahanmehr, Nader; Jakovljevic, Mihajlo; Janjani, Hosna; Javaheri, Tahereh; Jayatilleke, Achala Upendra; Jenabi, Ensiyeh; Jha, Ravi Prakash; Jha, Vivekanand; Ji, John S.; Jia, Peng; John-Akinola, Yetunde O.; Jonas, Jost B.; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Jurisson, Mikk; Kabir, Zubair; Kalankesh, Leila R.; Kalhor, Rohollah; Kamath, Aruna M.; Kanchan, Tanuj; Kapoor, Neeti; Matin, Behzad Karami; Karanikolos, Marina; Karimi, Seyed M.; Kassebaum, Nicholas J.; Katikireddi, Srinivasa Vittal; Kayode, Gbenga A.; Keiyoro, Peter Njenga; Khader, Yousef Saleh; Khammarnia, Mohammad; Khan, Ejaz Ahmad; Khan, Maseer; Khang, Young-Ho; Khatab, Khaled; Khater, Amir M.; Khater, Mona M.; Khatib, Mahalaqua Nazli; Khayamzadeh, Maryam; Khubchandani, Jagdish; Kianipour, Neda; Kim, Young-Eun; Kim, Yun Jin; Kimokoti, Ruth W.; Kinfu, Yohannes; Kisa, Adnan; Kissimova-Skarbek, Katarzyna; Kivimaki, Mika; Kneib, Cameron J.; Kocarnik, Jonathan M.; Kochhar, Sonali; Kohler, Stefan; Kopec, Jacek A.; Korotkova, Anna V.; Korshunov, Vladimir Andreevich; Kosen, Soewarta; Kotlo, Anirudh; Koul, Parvaiz A.; Koyanagi, Ai; Krishan, Kewal; Krohn, Kris J.; Kugbey, Nuworza; Kulkarni, Vaman; Kumar, G. Anil; Kumar, Manasi; Kumar, Nithin; Kurmi, Om P.; Kusuma, Dian; Kyu, Hmwe Hmwe; La Vecchia, Carlo; Lacey, Ben; Lal, Dharmesh Kumar; Lalloo, Ratilal; Landires, Ivan; Lansingh, Van Charles; Larsson, Anders O.; Lasrado, Savita; Lau, Kathryn Mei-Ming; Lauriola, Paolo; Lazarus, Jeffrey V.; Ledesma, Jorge R.; Lee, Paul H.; Lee, Shaun Wen Huey; Leever, Andrew T.; LeGrand, Kate E.; Leigh, James; Leonardi, Matilde; Li, Shanshan; Lim, Lee-Ling; Lim, Stephen S.; Liu, Xuefeng; Logroscino, Giancarlo; Lopez, Alan D.; Lopukhov, Platon D.; Lotufo, Paulo A.; Lu, Alton; Ma, Jianing; Madadin, Mohammed; Mahasha, Phetole Walter; Mahmoudi, Morteza; Majeed, Azeem; Malagon-Rojas, Jeadran N.; Maleki, Shokofeh; Malta, Deborah Carvalho; Mansouri, Borhan; Mansournia, Mohammad Ali; Martini, Santi; Martins-Melo, Francisco Rogerlandio; Martopullo, Ira; Massenburg, Benjamin Ballard; Mastrogiacomo, Claudia I.; Mathur, Manu Raj; McAlinden, Colm; McKee, Martin; Medina-Solis, Carlo Eduardo; Meharie, Birhanu Geta; Mehndiratta, Man Mohan; Nasab, Entezar Mehrabi; Mehri, Fereshteh; Mehrotra, Ravi; Mekonnen, Teferi; Melese, Addisu; Memiah, Peter T. N.; Mendoza, Walter; Menezes, Ritesh G.; Mensah, George A.; Meretoja, Atte; Meretoja, Tuomo J.; Mestrovic, Tomislav; Miazgowski, Bartosz; Michalek, Irmina Maria; Mirrakhimov, Erkin M.; Mirzaei, Maryam; Mirzaei-Alavijeh, Mehdi; Mitchell, Philip B.; Moazen, Babak; Moghadaszadeh, Masoud; Mohamadi, Efat; Mohammad, Dara K.; Mohammad, Yousef; Mezerji, Naser Mohammad Gholi; Mohammadian-Hafshejani, Abdollah; Mohammed, Jemal Abdu; Mohammed, Shafiu; Mokdad, Ali H.; Monasta, Lorenzo; Mondello, Stefania; Moradi, Masoud; Moradi-Lakeh, Maziar; Moradzadeh, Rahmatollah; Moraga, Paula; Morgado-da-Costa, Joana; Morrison, Shane Douglas; Mosapour, Abbas; Mosser, Jonathan F.; Khaneghah, Amin Mousavi; Muriithi, Moses K.; Mustafa, Ghulam; Nabhan, Ashraf F.; Naderi, Mehdi; Nagarajan, Ahamarshan Jayaraman; Naghavi, Mohsen; Naghshtabrizi, Behshad; Naimzada, Mukhammad David; Nangia, Vinay; Nansseu, Jobert Richie; Nayak, Vinod C.; Nazari, Javad; Ndejjo, Rawlance; Negoi, Ionut; Negoi, Ruxandra Irina; Neupane, Subas; Ngari, Kiirithio N.; Nguefack-Tsague, Georges; Ngunjiri, Josephine W.; Cuong Tat Nguyen; Diep Ngoc Nguyen; Huong Lan Thi Nguyen; Nnaji, Chukwudi A.; Nomura, Shuhei; Norheim, Ole F.; Noubiap, Jean Jacques; Nowak, Christoph; Nunez-Samudio, Virginia; Oiu, Adrian O.; Ogbo, Felix Akpojene; Oghenetega, Onome Bright; Oh, In-Hwan; Okunga, Emmanuel Wandera; Oladnabi, Morteza; Olagunju, Andrew T.; Olusanya, Bolajoko Olubukunola; Olusanya, Jacob Olusegun; Oluwasanu, Mojisola Morenike; Bali, Ahmed Omar; Omer, Muktar Omer; Ong, Kanyin Liane; Onwujekwe, Obinna E.; Ortega-Altamirano, Doris V.; Ortiz, Alberto; Ostojic, Sergej M.; Otstavnov, Nikita; Otstavnov, Stanislav S.; Overland, Simon; Owolabi, Mayowa O.; Padubidri, Jagadish Rao; Pakhale, Smita; Palladino, Raffaele; Pana, Adrian; Panda-Jonas, Songhomitra; Pangaribuan, Helena Ullyartha; Pathak, Mona; Patton, George C.; Paudel, Sagun; Toroudi, Hamidreza Pazoki; Pease, Spencer A.; Peden, Amy E.; Pennini, Alyssa; Peprah, Emmanuel K.; Pereira, Jeevan; Pigott, David M.; Pilgrim, Thomas; Pilz, Tessa M.; Pinheiro, Marina; Piradov, Michael A.; Pirsaheb, Meghdad; Pokhrel, Khem Narayan; Postma, Maarten J.; Pourjafar, Hadi; Pourmalek, Farshad; Kalhori, Reza Pourmirza; Pourshams, Akram; Prada, Sergio I.; Pribadi, Dimas Ria Angga; Pupillo, Elisabetta; Syed, Zahiruddin Quazi; Radfar, Amir; Rafiee, Ata; Rafiei, Alireza; Raggi, Alberto; Rahim, Fakher; Rahman, Muhammad Aziz; Rajabpour-Sanati, Ali; Rana, Saleem Muhammad; Ranabhat, Chhabi Lal; Rao, Sowmya J.; Rasella, Davide; Rashedi, Vahid; Rath, Goura Kishor; Rathi, Priya; Rawaf, David Laith; Rawaf, Salman; Rawal, Lal; Rawassizadeh, Reza; Razo, Christian; Renjith, Vishnu; Renzaho, Andre M. N.; Reshmi, Bhageerathy; Rezaei, Nima; Riahi, Seyed Mohammad; Ribeiro, Daniel Cury; Rickard, Jennifer; Roberts, Nicholas L. S.; Roever, Leonardo; Romoli, Michele; Ronfani, Luca; Roshandel, Gholamreza; Rubagotti, Enrico; Rwegerera, Godfrey M.; Sabour, Siamak; Sachdev, Perminder S.; Saddik, Basema; Sadeghi, Ehsan; Sadeghi, Masoumeh; Safari, Yahya; Sagar, Rajesh; Sahebkar, Amirhossein; Sahraian, Mohammad Ali; Sajadi, S. Mohammad; Salahshoor, Mohammad Reza; Salem, Hosni; Salem, Marwa Rashad; Salomon, Joshua A.; Kafil, Hossein Samadi; Samy, Abdallah M.; Sanabria, Juan; Santric-Milicevic, Milena M.; Saraswathy, Sivan Yegnanarayana Iyer; Sarmiento-Suarez, Rodrigo; Sartorius, Benn; Sarveazad, Arash; Sathian, Brijesh; Sathish, Thirunavukkarasu; Sattin, Davide; Savic, Miloje; Sawyer, Susan M.; Saxena, Deepak; Sbarra, Alyssa N.; Schaeffer, Lauren E.; Schiavolin, Silvia; Schmidt, Maria Ines; Schutte, Aletta Elisabeth; Schwebel, David C.; Schwendicke, Falk; Seedat, Soraya; Sha, Feng; Shahabi, Saeed; Shaheen, Amira A.; Shaikh, Masood Ali; Shamsizadeh, Morteza; Shannawaz, Mohammed; Sharafi, Kiomars; Sharara, Fablina; Sharifi, Hamid; Shaw, David H.; Sheikh, Aziz; Sheikhtaheri, Abbas; Shetty, B. Suresh Kumar; Shibuya, Kenji; Shiferaw, Wondimeneh Shibabaw; Shigematsu, Mika; Shin, Jae Il; Shiri, Rahman; Shirkoohi, Reza; Shivakumar, K. 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ISI:000579154000009
ISSN: 0140-6736
CID: 4677352
Nature. 2019:574(7777):264-267.DOI: 10.1038/s41586-019-1608-2

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

Aykut, Berk; Pushalkar, Smruti; Chen, Ruonan; Li, Qianhao; Abengozar, Raquel; Kim, Jacqueline I; Shadaloey, Sorin A; Wu, Dongling; Preiss, Pamela; Verma, Narendra; Guo, Yuqi; Saxena, Anjana; Vardhan, Mridula; Diskin, Brian; Wang, Wei; Leinwand, Joshua; Kurz, Emma; Kochen Rossi, Juan A; Hundeyin, Mautin; Zambrinis, Constantinos; Li, Xin; Saxena, Deepak; Miller, George
Bacterial dysbiosis accompanies carcinogenesis in malignancies such as colon and liver cancer, and has recently been implicated in the pathogenesis of pancreatic ductal adenocarcinoma (PDA)1. However, the mycobiome has not been clearly implicated in tumorigenesis. Here we show that fungi migrate from the gut lumen to the pancreas, and that this is implicated in the pathogenesis of PDA. PDA tumours in humans and mouse models of this cancer displayed an increase in fungi of about 3,000-fold compared to normal pancreatic tissue. The composition of the mycobiome of PDA tumours was distinct from that of the gut or normal pancreas on the basis of alpha- and beta-diversity indices. Specifically, the fungal community that infiltrated PDA tumours was markedly enriched for Malassezia spp. in both mice and humans. Ablation of the mycobiome was protective against tumour growth in slowly progressive and invasive models of PDA, and repopulation with a Malassezia species-but not species in the genera Candida, Saccharomyces or Aspergillus-accelerated oncogenesis. We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, whereas deletion of MBL or C3 in the extratumoral compartment-or knockdown of C3aR in tumour cells-were both protective against tumour growth. In addition, reprogramming of the mycobiome did not alter the progression of PDA in Mbl- (also known as Mbl2) or C3-deficient mice. Collectively, our work shows that pathogenic fungi promote PDA by driving the complement cascade through the activation of MBL.
PMID: 31578522
ISSN: 1476-4687
CID: 4116342
Advances in dental research. 2019:30(1):11-15.DOI: 10.1177/0022034519872475

Novel Nicotine Delivery Systems

Kumar, P S; Clark, P; Brinkman, M C; Saxena, D
Electronic nicotine delivery systems (ENDS) are devices that contain a power source, a heating element, and a tank or cartridge containing an "e-liquid," which is a mixture of nicotine and flavoring in a glycerol-propylene glycol vehicle. Their increasing popularity among adolescents might be attributed to aggressive marketing in physical venues, social media outlets, as well as irreversible changes caused by nicotine in the developing brains of youth and young adults, predisposing them to addictive behaviors. Adolescent ENDS users were 4 times more likely to initiate cigarette smoking, and the odds of quitting smoking were lower and, in many instances, delayed for those using ENDS. ENDS also renormalize cigarette-like behaviors, such as inhaling/exhaling smoke. The oral cavity is the initial point of contact of ENDS and the first affected system in humans. Oral health depends on an intricate balance in the interactions between oral bacteria and the human immune system, and dysbiosis of oral microbial communities underlies the etiology of periodontitis, caries, and oral cancer. Emerging evidence from subjects with periodontitis as well as periodontally healthy subjects demonstrates that e-cigarette use is associated with a compositional and functional shift in the oral microbiome, with an increase in opportunistic pathogens and virulence traits.
PMID: 31538804
ISSN: 1544-0737
CID: 4097702
Cancer discovery. 2019:9(9):1288-1305.DOI: 10.1158/2159-8290.CD-19-0161

Innate αβ T cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming

Hundeyin, Mautin; Kurz, Emma; Mishra, Ankita; Kochen Rossi, Juan Andres; Liudahl, Shannon M; Leis, Kenna R; Mehrotra, Harshita; Kim, Mirhee; Torres, Luisana E; Ogunsakin, Adesola; Link, Jason; Sears, Rosalie C; Sivagnanam, Shamilene; Goecks, Jeremy; Islam, Km Sadeq; Dolgalev, Igor; Savadkar, Shivraj; Wang, Wei; Aykut, Berk; Leinwand, Joshua; Diskin, Brian; Adam, Salma; Israr, Muhammad; Gelas, Maeliss; Lish, Justin; Chin, Kathryn; Farooq, Mohammad Saad; Wadowski, Benjamin; Wu, Jingjing; Shah, Suhagi; Adeegbe, Dennis O; Pushalkar, Smruti; Vasudevaraja, Varshini; Saxena, Deepak; Wong, Kwok-Kin; Coussens, Lisa M; Miller, George
Unconventional T lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role of TCRαβ+CD4-CD8-NK1.1- innate αβ T-cells (iαβTs) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ~10% of T-lymphocytes infiltrating PDA in mice and humans. Intra-tumoral iαβTs express a distinct TCR-repertoire and profoundly immunogenic phenotype compared to their peripheral counterparts and conventional lymphocytes. iαβTs comprised ~75% of the total intra-tumoral IL-17+ cells. Moreover, iαβT cell adoptive transfer is protective in both murine models of PDA and human organotypic systems. We show iαβT cells induce a CCR5-dependent immunogenic macrophage reprogramming, thereby enabling marked CD4+ and CD8+ T cell expansion/activation and tumor protection. Collectively, iαβTs govern fundamental intra-tumoral crosstalk between innate and adaptive immune populations and are attractive therapeutic targets.
PMID: 31266770
ISSN: 2159-8290
CID: 3968062
Current opinion in virology. 2019:37:37-43.DOI: 10.1016/j.coviro.2019.05.007

Virome and bacteriome: two sides of the same coin

Stern, Jonathan; Miller, George; Li, Xin; Saxena, Deepak
Although bacterial dysbiosis has been previously associated with carcinogenesis and HIV infection, the impact of the virome and these disease states has been less well studied. In this review, we will summarize what is known about the interplay between both the bacterial and the viral components of the microbiome on cancer and HIV pathogenesis. Bacterial dysbiosis has been associated with carcinogenesis such as colorectal cancer (CRC), hepatocellular carcinoma (HCC), lung cancer, breast cancer, and gastric cancer. The dysbiotic pathogenesis may be species-based or community-based and can have varying mechanisms of carcinogenesis. The human virome was also associated with certain cancers. Viruses, such as cytomegalovirus (CMV), Human herpesvirus 8 (HHV-8), human papilloma virus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Epstein-Barr virus (EBV), all had associations with cancers. It was also reported that an altered bacteriophage community may lead to carcinogenesis by allowing opportunistic, oncogenic bacteria to proliferate in a gastrointestinal biofilm. This mechanism shows the importance of analyzing the bacteriome and the virome concurrently as their interactions can provide insight into new mechanisms in the pathogenesis of not only cancer, but other diseases as well. The enteric bacteriome was shown to be distinctly altered in immunocompromised HIV-infected individuals, and highly active antiretroviral therapy (HAART) was shown to at least partially reverse the alterations that HIV causes in the bacteriome. Studies have shown that the progression to HIV is associated with changes in the plasma concentration of commensal viruses. HIV also acts synergistically with multiple other viruses, such as HPV, EBV, varicella zoster virus (VZV), and HHV-8. Although it has been shown that HIV infection leads to enteric virome expansion in humans, most of the research on HIV's effect on the virome was conducted in non-human primates, and there is a lack of research on the effect of HAART on the virome. Virome-wide analysis is necessary for identifying novel viral etiologies. There is currently a wealth of information on the bacteriome and its associations with cancer and HIV, but more research should be conducted on the virome's associations and reaction to HAART as well as the bacteriome-virome interactions that may play a major role in pathogenesis and recovery.
PMID: 31177014
ISSN: 1879-6265
CID: 3929642